Inhibition of hepatocyte nuclear factor 1 and 4 alpha (HNF1α and HNF4α) as a mechanism of arsenic carcinogenesis

Archives of Toxicology

Volumn 87, Issue 6, 2013, Pages 1001-1012

  Pastoret, Anna ^a   Marcos, Ricard ^a,b   Sampayo Reyes, Adriana ^c   Saucedo Cardenas, Odila ^c   Lozano Garza, Gerardo H ^c   Hernandez, Alba ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Arsenic; Carcinogenesis; Dedifferentiation; Diabetes; Hamster; HepG2; HNF1 ; HNF4 ; Long term exposure

Indexed keywords

ARSENIC; ARSENITE SODIUM; GELATINASE A; GELATINASE B; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; NOTCH2 RECEPTOR; OCTAMER TRANSCRIPTION FACTOR 4;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF CARBOHYDRATE METABOLISM; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; ENZYME RELEASE; EPITHELIAL MESENCHYMAL TRANSITION; GLUCOSE METABOLISM; HISTOPATHOLOGY; LIN28 GENE; LIVER; LIVER CELL; NONHUMAN; NOTCH2 GENE; OCT3 GENE; OCT4 GENE; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYRIAN HAMSTER; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; ARSENITES; CARCINOGENS, ENVIRONMENTAL; CELL DIFFERENTIATION; CELL SURVIVAL; CRICETINAE; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FRUCTOSE-BISPHOSPHATE ALDOLASE; GLUCOSE; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; LIVER; MESOCRICETUS; OCTAMER TRANSCRIPTION FACTOR-3; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTO-ONCOGENE PROTEINS C-MYC; RECEPTOR, NOTCH2; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; SODIUM COMPOUNDS; TIME FACTORS;

CRICETINAE; MESOCRICETUS AURATUS;

EID: 84878732571     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0948-6     Document Type: Article

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