Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci

Nature Communications

Volumn 4, Issue , 2013, Pages

  Hiratsuka, Sachie ^a,b   Ishibashi, Sachie ^a   Tomita, Takeshi ^a   Watanabe, Akira ^c,f   Akashi Takamura, Sachiko ^d   Murakami, Masato ^d,g   Kijima, Hiroshi ^e,h   Miyake, Kensuke ^d   Aburatani, Hiroyuki ^c   Maru, Yoshiro ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f KYOTO UNIVERSITY   (Japan)

^g Avail Biomedical Research Institute   (Switzerland)

^h HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN A; CHEMOKINE RECEPTOR CCR2; FIBRINOGEN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN MD 2; SERUM AMYLOID A; TOLL LIKE RECEPTOR 4;

GENE EXPRESSION; PERMEABILITY; RODENT; SECRETION; SIGNAL; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CELL HOMING; CONTROLLED STUDY; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PERMEABILITY; PRIMARY TUMOR; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR CELL; UPREGULATION;

ANIMALS; CAPILLARY PERMEABILITY; CELL LINE, TUMOR; CHEMOKINE CCL2; ENDOTHELIAL CELLS; FIBRINOGEN; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; LEUKOCYTES; LUNG; LYMPHOCYTE ANTIGEN 96; MICE; NEOPLASM METASTASIS; NEOPLASMS; ORGAN CULTURE TECHNIQUES; RECEPTORS, CCR2; S100 PROTEINS; SERUM AMYLOID A PROTEIN; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

MUS;

EID: 84878688232     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2856     Document Type: Article

References (40)

1. Couzin, J. Medicine - Tracing the steps of metastasis, cancer's menacing ballet. Science 299, 1002-1006 (2003)
2. Fidler, I. J. Timeline - The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat. Rev. Cancer 3, 453-458 (2003) (Pubitemid 37328849)
3. Kang, Y. B. & Massague, J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118, 277-279 (2004) (Pubitemid 39061108)
4. Almog, N. Molecular mechanisms underlying tumor dormancy. Cancer Lett. 294, 139-146 (2010)
5. Psaila, B. & Lyden, D. The metastatic niche: adapting the foreign soil. Nat. Rev. Cancer 9, 285-293 (2009)
6. Hiratsuka, S. Vasculogenensis, angiogenesis and special features of tumor blood vessels. Front. Biosci. Landmark 16, 1413-1427 (2011)
7. Hiratsuka, S. et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2, 289-300 (2002) (Pubitemid 41043963)
8. Hiratsuka, S., Watanabe, A., Aburatani, H. & Maru, Y. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat. Cell. Biol. 8, 1365-1375 (2006)
9. Hiratsuka, S. et al. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell. Biol. 10, 1349-1355 (2008)
10. Huang, Y. et al. Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis. Cancer Res. 69, 7529-7537 (2009)
11. Kaplan, R. N. et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438, 820-827 (2005) (Pubitemid 41753060)
12. Kim, S. et al. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457, 102-106 (2009)
13. Erler, J. T. et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 15, 35-44 (2009)
14. Hood, J. L., Roman, S. S. & Wickline, S. A. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 71, 3792-3801 (2011)
15. Jung, T. et al. CD44v6 dependence of premetastatic niche preparation by exosomes. Neoplasia 11, 1093-1105 (2009)
16. Grange, C. et al. Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res. 71, 5346-5356 (2011)
17. Schlappack, O. K., Baur, M., Steger, G., Dittrich, C. & Moser, K. The clinical course of lung metastases from breast cancer. Klin Wochenschr 66, 790-795 (1988)
18. Jaklitsch, M. T. et al. Sequential thoracic metastasectomy prolongs survival by re-establishing local control within the chest. J. Thorac. Cardiovasc. Surg. 121, 657-667 (2001)
19. Hiratsuka, S. et al. Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin upregulation. Proc. Natl Acad. Sci. USA 108, 3725-3730 (2011)
20. Raman, D., Baugher, P. J., Thu, Y. M. & Richmond, A. Role of chemokines in tumor growth. Cancer Lett. 256, 137-165 (2007) (Pubitemid 47418345)
21. Yadav, A., Saini, V. & Arora, S. MCP-1: Chemoattractant with a role beyond immunity: A review. Clin. Chim. Acta 411, 1570-1579 (2010)
22. Tyagi, N., Roberts, A. M., Dean, W. L., Tyagi, S. C. & Lominadze, D. Fibrinogen induces endothelial cell permeability. Mol. Cell. Biochem. 307, 13-22 (2008) (Pubitemid 350238642)
23. Wygrecka, M., Jablonska, E., Guenther, A., Preissner, K. T. & Markart, P. Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases. Thromb. Haemost. 99, 494-501 (2008) (Pubitemid 351549285)
24. Kim, H. -J. et al. Identification of S100A8 and S100A9 as serological markers for colorectal cancer. J. Proteome Res. 8, 1368-1379 (2009)
25. Kim, S. & Karin, M. Role of TLR2-dependent inflammation in metastatic progression. Year Immunol. 1217, 191-206 (2011)
26. Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384 (2010)
27. Kawai, T. & Akira, S. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity. Immunity 34, 637-650 (2011)
28. Park, B. S. et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458, 1191-1195 (2009)
29. Manavalan, B., Basith, S. & Choi, S. Similar structures but different roles - an updated perspective on TLR structures. Front. Physiol. 2, 41 (2011)
30. Arefieva, T. I., Kukhtina, N. B., Antonova, O. A. & Krasnikova, T. L. MCP-1- stimulated chemotaxis of monocytic and endothelial cells is dependent on activation of different signaling cascades. Cytokine 31, 439-446 (2005) (Pubitemid 41242768)
31. Wolf, M. J. et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 22, 91-105 (2012)
32. Hadden, J. W. Immunodeficiency and cancer: prospects for correction. Int. Immunopharmacol. 3, 1061-1071 (2003) (Pubitemid 36830851)
33. Luo, J. L., Maeda, S., Hsu, L. C., Yagita, H. & Karin, M. Inhibition of NF-kappa B in cancer cells converts inflammation-induced tumor growth mediated by TNF alpha to TRAIL-mediated tumor regression. Cancer Cell 6, 297-305 (2004) (Pubitemid 39222042)
34. Craig, M. J. & Loberg, R. D. CCL2 (Monocyte Chemoattractant Protein-1) in cancer bone metastases. Cancer Metastasis Rev. 25, 611-619 (2006) (Pubitemid 46071867)
35. Qian, B. -Z. et al. CCL2 recruits inflammatory monocytes to facilitate breasttumour metastasis. Nature 475, 222-225 (2011)
36. Granot, Z. et al. Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20, 300-314 (2011)
37. Nagai, Y. et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3, 667-672 (2002) (Pubitemid 34752476)
38. Hoshino, K. et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162, 3749-3752 (1999) (Pubitemid 29314747)
39. Ewens, A., Mihich, E. & Ehrke, M. J. Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma. Anticancer Res. 25, 3905-3915 (2005) (Pubitemid 41665163)
40. Sobczak, M., Dargatz, J. & Chrzanowska-Wodnicka, M. Isolation and culture of pulmonary endothelial cells from neonatal mice. J. Visual. Exp 46, e2316 (2010).