RNAi-mediated gene silencing of vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of gastric cancer in vivo in mice

Tumor Biology

Volumn 34, Issue 3, 2013, Pages 1493-1501

  Yao, Jibin ^a   Da, Mingxu ^b   Guo, Tiankang ^b   Duan, Yaoxing ^a   Zhang, Yongbin ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b GANSU PROVINCIAL HOSPITAL   (China)

Author keywords

Gastric cancer; Lymphangiogenesis; RNA interference; Vascular endothelial growth factor C

Indexed keywords

SHORT HAIRPIN RNA; VASCULOTROPIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GENETICS; CANCER INHIBITION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LYMPHANGIOGENESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STOMACH CANCER; TUMOR GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR C GENE; WESTERN BLOTTING;

EID: 84878685761     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0674-6     Document Type: Article

References (36)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108. doi: 10.3322/canjclin.55.2.74.
2. Hohenberger P, Gretschel S. Gastric cancer. Lancet. 2003;362(9380):305- 15. doi: 10.1016/s0140-6736(03)13975-x.
3. Kurtz JE, Dufour P. Evolving standards of care in advanced gastric cancer. Future Oncol. 2011;7(12):1441-50. doi: 10.2217/fon.11.115.
4. Lordick F, Schumacher G, Becker-Schiebe M. Gastric cancer - still many questions to be solved. MEMO. 2011;4(2):71-4.
5. Delaunoit T. Latest developments and emerging treatment options in the management of stomach cancer. Cancer Manag Res. 2011;3:257-66. doi: 10.2147/CMR.S12713.
6. Stoffel A. Targeted therapies for solid tumors: current status and future perspectives. BioDrugs. 2010;24(5):303-16. doi: 10.2165/11535880-000000000- 00000.
7. Nagahashi M, Ramachandran S, Rashid OM, Takabe K. Lymphangiogenesis: a new player in cancer progression. World J Gastroenterol. 2010;16(32):4003-12.
8. Da MX, Wu XT, Wang J, Guo TK, Zhao ZG, Luo T, et al. Expression of cyclooxygenase-2 and vascular endothelial growth factor-C correlates with lymphangiogenesis and lymphatic invasion in human gastric cancer. Arch Med Res. 2008;39(1):92-9. doi: s0140-6736(03)13975-x/j.arcmed.2007.06.021.
9. Zhu P, Zhang J, Chen Q, Wang J, Wang Y. Expression of vascular endothelial growth factor-C in gastric carcinoma and the effect of its antisense gene transfection on the proliferation of human gastric cancer cell line SGC-7901. Am J Surg. 2012;204(1):78-83. doi: s0140-6736(03)13975-x/j.amjsurg. 2011.06.056.
10. Tsutsumi S, Kuwano H, Shimura T, Morinaga N, Mochiki E, Asao T. Vascular endothelial growth factor C (VEGF-C) expression in pT2 gastric cancer. Hepatogastroenterology. 2005;52(62):629-32.
11. Karpanen T, Egeblad M, Karkkainen MJ, Kubo H, Yla-Herttuala S, Jaattela M, et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res. 2001;61(5):1786-90.
12. Shi X, Chen G, Xing H, Weng D, Bai X, Ma D. VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. Oncol Rep. 2007;18(1):241-7.
13. Ochi N, Matsuo Y, Sawai H, Yasuda A, Takahashi H, Sato M, et al. Vascular endothelial growth factor-C secreted by pancreatic cancer cell line promotes lymphatic endothelial cell migration in an in vitro model of tumor lymphangiogenesis. Pancreas. 2007;34(4):444-51.
14. Morita H, Ishikawa Y, Akishima-Fukasawa Y, Ito K, Akasaka Y, Nishimura C, et al. Histopathological predictor for regional lymph node metastasis in gastric cancer. Virchows Arch. 2009;454(2):143-51. doi: 10.1007/s00428-008-0717- 3.
15. Gao P, Zhou GY, Zhang QH, Su ZX, Zhang TG, Xiang L, et al. Lymphangiogenesis in gastric carcinoma correlates with prognosis. J Pathol. 2009;218(2):192-200. doi: 10.1002/path.2523.
16. Schoppmann S, Fenzl A, Schindl M, Bachleitner-Hofmann T, Nagy K, Gnant M, et al. Hypoxia inducible factor-1α correlates with VEGF-C expression and lymphangiogenesis in breast cancer. Breast Cancer Res Tr. 2006;99(2):135-41. doi: 10.1007/s10549-006-9190-3.
17. Dias S, Choy M, Alitalo K, Rafii S. Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood. 2002;99(6):2179-84.
18. Moehler M, Mueller A, Hartmann JT, Ebert MP, Al-Batran SE, Reimer P, et al. An open-label, multicentre biomarker-oriented AIO phase II trial of sunitinib for patients with chemo-refractory advanced gastric cancer. Eur J Cancer. 2011;47(10):1511-20. doi: s0140-6736(03)13975-x/j.ejca.2011.04.006.
19. Grishok A, Tabara H, Mello CC. Genetic requirements for inheritance of RNAi in C. elegans. Science. 2000;287(5462):2494-7. doi: 10.1126/science.287. 5462.2494.
20. Pennati M, Millo E, Gandellini P, Folini M, Zaffaroni N. RNA interference-mediated validation of surviving and Apollon/BRUCE as new therapeutic targets for cancer therapy. Curr Top Med Chem. 2012;12(2):69-78. doi: 10.1007/978-1-60327-547-7-15.
21. Harborth J, Elbashir SM, Bechert K, Tuschl T, Weber K. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci. 2001;114(24):4557-65.
22. Sui G, Soohoo C, el Affar B, Gay F, Shi Y, Forrester WC. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA. 2002;99(8):5515-20. doi: 10.1073/pnas.082117599.
23. Yu JY, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci USA. 2002;99(9):6047-52.
24. Phalon C, Rao DD, Nemunaitis J. Potential use of RNA interference in cancer therapy. Expert Rev Mol Med. 2010;12:e26. doi: 10.1017/S1462399410001584.
25. Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R, et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J. 2001;20(4):672-82. doi: 10.1093/emboj/20.4.672.
26. Enholm B, Paavonen K, Ristimäki A, Kumar V, Gunji Y, Klefstrom J, et al. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene. 1997;14(20):2475-83.
27. Li H, Adachi Y, Yamamoto H, Min Y, Ohashi H, Ii M, et al. Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45. Cancer. 2011;117(14):3135-47. doi: 10.1002/cncr.25893.
28. Katsuta M, Miyashita M, Makino H, Nomura T, Shinji S, Yamashita K, et al. Correlation of hypoxia inducible factor-1 alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. Exp Mol Pathol. 2005;78(2):123-30. doi: j.yexmp.2004.11.002/j.yexmp.2004.11.002.
29. Rao DD, Vorhies JS, Senzer N, Nemunaitis J. siRNA vs. shRNA: similarities and differences. Adv Drug Deliv Rev. 2009;61(9):746-59. doi: j.yexmp.2004.11.002/j.addr.2009.04.004.
30. Wang Z, Rao DD, Senzer N, Nemunaitis J. RNA interference and cancer therapy. Pharm Res. 2011;28(12):2983-95. doi: 10.1007/s11095-011-0604-5.
31. Polacheck WJ, Zervantonakis IK, Kamm RD. Tumor cell migration in complex microenvironments. Cell Mol Life Sci. 2012. doi: 10.1007/s00018-012-1115-1.
32. Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell. 2003;112(4):453-65. doi: j.yexmp.2004.11.002/S0092-8674(03)00120-X.
33. He M, Cheng Y, Li W, Liu QS, Liu JX, Huang JH, et al. Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade. Cancer. 2010;10:1710. doi: 10.1186/1471-2407-10-170.
34. Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY, et al. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell. 2006;9(3):209-23. doi: j.yexmp.2004.11.002/j.ccr.2006.02.018.
35. Zhao R, Liu XQ, Wu XP, Liu YF, Zhang ZY, Yang GY, et al. Vascular endothelial growth factor (VEGF) enhances gastric carcinoma invasiveness via integrin alpha(v)beta6. Cancer Lett. 2010;287(2):150-6. doi: j.yexmp.2004.11.002/j.canlet.2009.06.006.
36. Guo BL, Zhang YF, Luo GQ, Li LC, Zhang JG. Lentivirus-mediated small interfering RNA targeting VEGF-C inhibited tumor lymphangiogenesis and growth in breast carcinoma. Anat Rec Adv Integr Anat Evol Biol. 2009;292(5):633-9. doi: 10.1002/ar.20893.