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Volumn 7, Issue 12, 2011, Pages 1441-1450

Evolving standards of care in advanced gastric cancer

Author keywords

chemotherapy; gastric cancer; HER1; HER2; mTOR; targeted therapy

Indexed keywords

ANTHRACYCLINE; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CISPLATIN; DNA TOPOISOMERASE INHIBITOR; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IRINOTECAN; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; METHOTREXATE; MITOMYCIN C; OXALIPLATIN; PANITUMUMAB; PLACEBO; SORAFENIB; SUNITINIB; TRASTUZUMAB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 82455162604     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.11.115     Document Type: Review
Times cited : (4)

References (62)
  • 1
  • 2
    • 0032439075 scopus 로고    scopus 로고
    • Survival of patients with oesophageal and gastric cancers in Europe
    • Faivre J, Forman D, Esteve J, Gatta G. Survival of patients with oesophageal and gastric cancers in Europe. Eur. J. Cancer 34(14), 2167-2175 (1998).
    • (1998) Eur. J. Cancer , vol.34 , Issue.14 , pp. 2167-2175
    • Faivre, J.1    Forman, D.2    Esteve, J.3    Gatta, G.4
  • 3
    • 33745726677 scopus 로고    scopus 로고
    • Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    • Cunningham D, Allum WH, Stenning SP et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N. Engl. J. Med. 355(1), 11-20 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , Issue.1 , pp. 11-20
    • Cunningham, D.1    Allum, W.H.2    Stenning, S.P.3
  • 4
    • 77954322183 scopus 로고    scopus 로고
    • Gastric cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Okines A, Verheij M, Allum W, Cunningham D, Cervantes A. Gastric cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 21(Suppl. 5), V50-V54 (2010).
    • (2010) Ann. Oncol. , vol.21 , Issue.SUPPL. 5
    • Okines, A.1    Verheij, M.2    Allum, W.3    Cunningham, D.4    Cervantes, A.5
  • 5
    • 0028959887 scopus 로고
    • Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer
    • Pyrhonen S, Kuitunen T, Nyandoto P, Kouri M. Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer. Br. J. Cancer 71(3), 587-591 (1995).
    • (1995) Br. J. Cancer , vol.71 , Issue.3 , pp. 587-591
    • Pyrhonen, S.1    Kuitunen, T.2    Nyandoto, P.3    Kouri, M.4
  • 6
    • 0027217474 scopus 로고
    • Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer
    • Murad AM, Santiago FF, Petroianu A, Rocha PR, Rodrigues MA, Rausch M. Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer. Cancer 72(1), 37-41 (1993).
    • (1993) Cancer , vol.72 , Issue.1 , pp. 37-41
    • Murad, A.M.1    Santiago, F.F.2    Petroianu, A.3    Rocha, P.R.4    Rodrigues, Ma.5    Rausch, M.6
  • 7
    • 8044236424 scopus 로고    scopus 로고
    • Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer
    • Glimelius B, Ekstrom K, Hoffman K et al. Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer. Ann. Oncol. 8(2), 163-168 (1997).
    • (1997) Ann. Oncol. , vol.8 , Issue.2 , pp. 163-168
    • Glimelius, B.1    Ekstrom, K.2    Hoffman, K.3
  • 9
    • 13244266683 scopus 로고    scopus 로고
    • Randomized multicenter Phase II trial of a biweekly regimen of fluorouracil and leucovorin (LV5FU2), LV5FU2 plus cisplatin, or LV5FU2 plus irinotecan in patients with previously untreated metastatic gastric cancer: A Federation Francophone de Cancerologie Digestive Group Study - FFCD 9803
    • Bouche O, Raoul JL, Bonnetain F et al. Randomized multicenter Phase II trial of a biweekly regimen of fluorouracil and leucovorin (LV5FU2), LV5FU2 plus cisplatin, or LV5FU2 plus irinotecan in patients with previously untreated metastatic gastric cancer: a Federation Francophone de Cancerologie Digestive Group Study - FFCD 9803. J. Clin. Oncol. 22(21), 4319-4328 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.21 , pp. 4319-4328
    • Bouche, O.1    Raoul, J.L.2    Bonnetain, F.3
  • 10
    • 63749118193 scopus 로고    scopus 로고
    • Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: A randomised Phase III noninferiority trial
    • Kang YK, Kang WK, Shin DB et al. Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised Phase III noninferiority trial. Ann. Oncol. 20(4), 666-673 (2009).
    • (2009) Ann. Oncol. , vol.20 , Issue.4 , pp. 666-673
    • Kang, Y.K.1    Kang, W.K.2    Shin, D.B.3
  • 11
    • 40749153540 scopus 로고    scopus 로고
    • S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): A Phase III trial
    • Koizumi W, Narahara H, Hara T et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a Phase III trial. Lancet Oncol. 9(3), 215-221 (2008).
    • (2008) Lancet Oncol. , vol.9 , Issue.3 , pp. 215-221
    • Koizumi, W.1    Narahara, H.2    Hara, T.3
  • 12
    • 77951888102 scopus 로고    scopus 로고
    • Multicenter Phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: The FLAGS trial
    • Ajani JA, Rodriguez W, Bodoky G et al. Multicenter Phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial. J. Clin. Oncol. 28(9), 1547-1553 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.9 , pp. 1547-1553
    • Ajani, J.A.1    Rodriguez, W.2    Bodoky, G.3
  • 13
    • 80052749477 scopus 로고    scopus 로고
    • Randomized Phase III study of S-1 alone versus S-1 plus docetaxel (DOC) in the treatment for advanced gastric cancer (AGC): The START trial
    • Presented at: San Francisco, CA, USA, 20-22 January
    • Kim YH, Koizumi V, Lee KH et al. Randomized Phase III study of S-1 alone versus S-1 plus docetaxel (DOC) in the treatment for advanced gastric cancer (AGC): The START trial. Presented at: 2011 Gastrointestinal Cancers Symposium. San Francisco, CA, USA, 20-22 January 2011.
    • (2011) 2011 Gastrointestinal Cancers Symposium
    • Kim, Y.H.1    Koizumi, V.2    Lee, K.H.3
  • 14
    • 38049047178 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • Cunningham D, Starling N, Rao S et al. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N. Engl. J. Med. 358(1), 36-46 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.1 , pp. 36-46
    • Cunningham, D.1    Starling, N.2    Rao, S.3
  • 15
    • 33750949065 scopus 로고    scopus 로고
    • Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: A report of the V325 Study Group
    • Van Cutsem E, Moiseyenko VM, Tjulandin S et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J. Clin. Oncol. 24(31), 4991-4997 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.31 , pp. 4991-4997
    • Van Cutsem, E.1    Moiseyenko, V.M.2    Tjulandin, S.3
  • 16
    • 0037090686 scopus 로고    scopus 로고
    • Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer
    • Ross P, Nicolson M, Cunningham D et al. Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J. Clin. Oncol. 20(8), 1996-2004 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , Issue.8 , pp. 1996-2004
    • Ross, P.1    Nicolson, M.2    Cunningham, D.3
  • 17
    • 77349105561 scopus 로고    scopus 로고
    • A randomised Phase II study of combination chemotherapy with epirubicin, cisplatin and capecitabine (ECX) or cisplatin and capecitabine (CX) in advanced gastric cancer
    • Yun J, Lee J, Park SH et al. A randomised Phase II study of combination chemotherapy with epirubicin, cisplatin and capecitabine (ECX) or cisplatin and capecitabine (CX) in advanced gastric cancer. Eur. J. Cancer 46(5), 885-891 (2010).
    • (2010) Eur. J. Cancer , vol.46 , Issue.5 , pp. 885-891
    • Yun, J.1    Lee, J.2    Park, S.H.3
  • 18
    • 84888873336 scopus 로고    scopus 로고
    • Irinotecan versus best supportive care (BSC) as second-line therapy in gastric cancer: A randomized Phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    • Presented at: Orlando, FL, USA, 29 May-2 June
    • Thuss-Patience PC, Kretzchmar A, Deist T et al. Irinotecan versus best supportive care (BSC) as second-line therapy in gastric cancer: a randomized Phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Presented at: 2009 ASCO Annual Meeting. Orlando, FL, USA, 29 May-2 June 2009.
    • (2009) 2009 ASCO Annual Meeting
    • Thuss-Patience, P.C.1    Kretzchmar, A.2    Deist, T.3
  • 19
    • 67349126229 scopus 로고    scopus 로고
    • A Phase II trial evaluating capecitabine and irinotecan as second line treatment in patients with oesophago-gastric cancer who have progressed on, or within 3 months of platinum-based chemotherapy
    • Leary A, Assersohn L, Cunningham D et al. A Phase II trial evaluating capecitabine and irinotecan as second line treatment in patients with oesophago-gastric cancer who have progressed on, or within 3 months of platinum-based chemotherapy. Cancer Chemother. Pharmacol. 64(3), 455-462 (2009).
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , Issue.3 , pp. 455-462
    • Leary, A.1    Assersohn, L.2    Cunningham, D.3
  • 20
    • 67349159701 scopus 로고    scopus 로고
    • Simplified FOLFIRI in pre-treated patients with metastatic gastric cancer
    • Lorizzo K, Fazio N, Radice D et al. Simplified FOLFIRI in pre-treated patients with metastatic gastric cancer. Cancer Chemother. Pharmacol. 64(2), 301-306 (2009).
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , Issue.2 , pp. 301-306
    • Lorizzo, K.1    Fazio, N.2    Radice, D.3
  • 21
    • 0035692526 scopus 로고    scopus 로고
    • A Phase II study of irinotecan with 5-fluorouracil and leucovorin in patients with previously untreated gastric adenocarcinoma
    • Blanke CD, Haller DG, Benson AB et al. A Phase II study of irinotecan with 5-fluorouracil and leucovorin in patients with previously untreated gastric adenocarcinoma. Ann. Oncol. 12(11), 1575-1580 (2001).
    • (2001) Ann. Oncol. , vol.12 , Issue.11 , pp. 1575-1580
    • Blanke, C.D.1    Haller, D.G.2    Benson, A.B.3
  • 22
    • 20344382967 scopus 로고    scopus 로고
    • Salvage chemotherapy with irinotecan, 5-fluorouracil and leucovorin for taxane- and cisplatin-refractory, metastatic gastric cancer
    • Kim ST, Kang WK, Kang JH et al. Salvage chemotherapy with irinotecan, 5-fluorouracil and leucovorin for taxane- and cisplatin-refractory, metastatic gastric cancer. Br. J. Cancer 92(10), 1850-1854 (2005).
    • (2005) Br. J. Cancer , vol.92 , Issue.10 , pp. 1850-1854
    • Kim, S.T.1    Kang, W.K.2    Kang, J.H.3
  • 23
    • 79952407394 scopus 로고    scopus 로고
    • Oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX-4) combination chemotherapy as a salvage treatment in advanced gastric cancer
    • Kim YS, Hong J, Sym SJ et al. Oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX-4) combination chemotherapy as a salvage treatment in advanced gastric cancer. Cancer Res. Treat. 42(1), 24-29 (2010).
    • (2010) Cancer Res. Treat. , vol.42 , Issue.1 , pp. 24-29
    • Kim, Y.S.1    Hong, J.2    Sym, S.J.3
  • 24
    • 38049103697 scopus 로고    scopus 로고
    • A Phase II study of docetaxel as salvage chemotherapy in advanced gastric cancer after failure of fluoropyrimidine and platinum combination chemotherapy
    • Lee JL, Ryu MH, Chang HM et al. A Phase II study of docetaxel as salvage chemotherapy in advanced gastric cancer after failure of fluoropyrimidine and platinum combination chemotherapy. Cancer Chemother. Pharmacol. 61(4), 631-637 (2008).
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , Issue.4 , pp. 631-637
    • Lee, J.L.1    Ryu, M.H.2    Chang, H.M.3
  • 25
    • 41549147442 scopus 로고    scopus 로고
    • Salvage chemotherapy with docetaxel and epirubicin for advanced/metastatic gastric cancer
    • Lim JY, Cho JY, Paik YH et al. Salvage chemotherapy with docetaxel and epirubicin for advanced/metastatic gastric cancer. Oncology 73(1-2), 2-8 (2007).
    • (2007) Oncology , vol.73 , Issue.1-2 , pp. 2-8
    • Lim, J.Y.1    Cho, J.Y.2    Paik, Y.H.3
  • 26
    • 0022588467 scopus 로고
    • Similarity of protein encoded by the human c-Erb-B-2 gene to epidermal growth factor receptor
    • Yamamoto T, Ikawa S, Akiyama T et al. Similarity of protein encoded by the human c-Erb-B-2 gene to epidermal growth factor receptor. Nature 319(6050), 230-234 (1986).
    • (1986) Nature , vol.319 , Issue.6050 , pp. 230-234
    • Yamamoto, T.1    Ikawa, S.2    Akiyama, T.3
  • 27
    • 0025881623 scopus 로고
    • Expression of c-ErbB-2 oncoprotein in gastric carcinoma. Immunoreactivity for c-ErbB-2 protein is an independent indicator of poor short-term prognosis in patients with gastric carcinoma
    • Yonemura Y, Ninomiya I, Ohoyama S et al. Expression of c-ErbB-2 oncoprotein in gastric carcinoma. Immunoreactivity for c-ErbB-2 protein is an independent indicator of poor short-term prognosis in patients with gastric carcinoma. Cancer 67(11), 2914-2918 (1991).
    • (1991) Cancer , vol.67 , Issue.11 , pp. 2914-2918
    • Yonemura, Y.1    Ninomiya, I.2    Ohoyama, S.3
  • 28
    • 77749273477 scopus 로고    scopus 로고
    • HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value - Conclusions from 924 cases of two independent series
    • Grabsch H, Sivakumar S, Gray S, Gabbert HE, Muller W. HER2 expression in gastric cancer: rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series. Cell Oncol. 32(1-2), 57-65 (2010).
    • (2010) Cell Oncol. , vol.32 , Issue.1-2 , pp. 57-65
    • Grabsch, H.1    Sivakumar, S.2    Gray, S.3    Gabbert, H.E.4    Muller, W.5
  • 29
    • 77954217471 scopus 로고    scopus 로고
    • Trastuzumab in gastric cancer
    • Okines AF, Cunningham D. Trastuzumab in gastric cancer. Eur. J. Cancer 46(11), 1949-1959 (2010).
    • (2010) Eur. J. Cancer , vol.46 , Issue.11 , pp. 1949-1959
    • Okines, A.F.1    Cunningham, D.2
  • 30
    • 67349222954 scopus 로고    scopus 로고
    • HER-2 amplification is highly homogenous in gastric cancer
    • Marx AH, Tharun L, Muth J et al. HER-2 amplification is highly homogenous in gastric cancer. Hum. Pathol. 40(6), 769-777 (2009).
    • (2009) Hum. Pathol. , vol.40 , Issue.6 , pp. 769-777
    • Marx, A.H.1    Tharun, L.2    Muth, J.3
  • 31
    • 70349327606 scopus 로고    scopus 로고
    • Comparative study on overexpression of HER2/neu and HER3 in gastric cancer
    • Zhang XL, Yang YS, Xu DP et al. Comparative study on overexpression of HER2/neu and HER3 in gastric cancer. World J. Surg. 33(10), 2112-2118 (2009).
    • (2009) World J. Surg. , vol.33 , Issue.10 , pp. 2112-2118
    • Zhang, X.L.1    Yang, Y.S.2    Xu, D.P.3
  • 32
    • 70450209516 scopus 로고    scopus 로고
    • Pathological features of advanced gastric cancer (GC): Relationship to human epidermal growth factor receptor 2 (HER2) positivity in the global screening programme of the ToGA trial
    • Presented at: Orlando, FL, USA, 29 May-2 June
    • Bang YJ, Chung HC, Xu J. Pathological features of advanced gastric cancer (GC): relationship to human epidermal growth factor receptor 2 (HER2) positivity in the global screening programme of the ToGA trial. Presented at: 2009 ASCO Annual Meeting. Orlando, FL, USA, 29 May-2 June 2009.
    • (2009) 2009 ASCO Annual Meeting
    • Bang, Y.J.1    Chung, H.C.2    Xu, J.3
  • 33
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A Phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a Phase 3, open-label, randomised controlled trial. Lancet 376(9742), 687-697 (2010).
    • (2010) Lancet , vol.376 , Issue.9742 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 34
    • 74049139094 scopus 로고    scopus 로고
    • Lapatinib: A review of its use in the treatment of HER2-overexpressing, trastuzumab-refractory, advanced or metastatic breast cancer
    • Frampton JE. Lapatinib: a review of its use in the treatment of HER2-overexpressing, trastuzumab-refractory, advanced or metastatic breast cancer. Drugs 69(15), 2125-2148 (2009).
    • (2009) Drugs , vol.69 , Issue.15 , pp. 2125-2148
    • Frampton, J.E.1
  • 35
    • 77649162889 scopus 로고    scopus 로고
    • Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo
    • Wainberg ZA, Anghel A, Desai AJ et al. Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin. Cancer Res. 16(5), 1509-1519 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.5 , pp. 1509-1519
    • Wainberg, Z.A.1    Anghel, A.2    Desai, A.J.3
  • 36
    • 72449149848 scopus 로고    scopus 로고
    • The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38
    • Labonte MJ, Manegold PC, Wilson PM et al. The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38. Int. J. Cancer 125(12), 2957-2969 (2009).
    • (2009) Int. J. Cancer , vol.125 , Issue.12 , pp. 2957-2969
    • Labonte, M.J.1    Manegold, P.C.2    Wilson, P.M.3
  • 37
    • 55949117201 scopus 로고    scopus 로고
    • The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines
    • Kim JW, Kim HP, Im SA et al. The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. Cancer Lett. 272(2), 296-306 (2008).
    • (2008) Cancer Lett. , vol.272 , Issue.2 , pp. 296-306
    • Kim, J.W.1    Kim, H.P.2    Im, S.A.3
  • 38
    • 79955683532 scopus 로고    scopus 로고
    • Lapatinib in combination with ECF/x in EGFR1 or HER2-overexpressing first-line metastatic gastric cancer (GC): A Phase II randomized placebo controlled trial (EORTC 40071)
    • Presented at: Chicago, IL, USA, 4-8 June
    • Roth A, Moehler MH, Mauer M et al. Lapatinib in combination with ECF/x in EGFR1 or HER2-overexpressing first-line metastatic gastric cancer (GC): a Phase II randomized placebo controlled trial (EORTC 40071). Presented at: 2010 ASCO Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
    • (2010) 2010 ASCO Annual Meeting
    • Roth, A.1    Moehler, M.H.2    Mauer, M.3
  • 39
    • 79960081156 scopus 로고    scopus 로고
    • Interim safety analysis from TYTAN: A Phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer
    • Presented at: Chicago, IL, USA, 4-8 June
    • Satoh T, Bang Y, Wang J et al. Interim safety analysis from TYTAN: a Phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer. Presented at: 2010 ASCO Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
    • (2010) 2010 ASCO Annual Meeting
    • Satoh, T.1    Bang, Y.2    Wang, J.3
  • 40
    • 33846629672 scopus 로고    scopus 로고
    • Multicenter Phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma
    • Shah MA, Ramanathan RK, Ilson DH et al. Multicenter Phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. J. Clin. Oncol. 24(33), 5201-5206 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.33 , pp. 5201-5206
    • Shah, M.A.1    Ramanathan, R.K.2    Ilson, D.H.3
  • 41
    • 77957160694 scopus 로고    scopus 로고
    • A Phase II study of bevacizumab, oxaliplatin, and docetaxel in locally advanced and metastatic gastric and gastroesophageal junction cancers
    • El-Rayes BF, Zalupski M, Bekai-Saab T et al. A Phase II study of bevacizumab, oxaliplatin, and docetaxel in locally advanced and metastatic gastric and gastroesophageal junction cancers. Ann. Oncol. 21(10), 1999-2004 (2010).
    • (2010) Ann. Oncol. , vol.21 , Issue.10 , pp. 1999-2004
    • El-Rayes, B.F.1    Zalupski, M.2    Bekai-Saab, T.3
  • 42
    • 82955241985 scopus 로고    scopus 로고
    • Phase II study of sunitinib as second-line treatment for advanced gastric cancer
    • Bang YJ, Kang YK, Kang WK et al. Phase II study of sunitinib as second-line treatment for advanced gastric cancer. Invest. New Drugs 29(6), 1449-1458 (2010).
    • (2010) Invest. New Drugs , vol.29 , Issue.6 , pp. 1449-1458
    • Bang, Y.J.1    Kang, Y.K.2    Kang, W.K.3
  • 43
    • 77955274505 scopus 로고    scopus 로고
    • MTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo
    • Fuereder T, Jaeger-Lansky A, Hoeflmayer D et al. mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo. Cancer Lett. 296(2), 249-256 (2010).
    • (2010) Cancer Lett. , vol.296 , Issue.2 , pp. 249-256
    • Fuereder, T.1    Jaeger-Lansky, A.2    Hoeflmayer, D.3
  • 44
    • 77954574658 scopus 로고    scopus 로고
    • Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203
    • Sun W, Powell M, O'Dwyer PJ, Catalano P, Ansari RH, Benson AB 3rd. Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. J. Clin. Oncol. 28(18), 2947-2951 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.18 , pp. 2947-2951
    • Sun, W.1    Powell, M.2    O'Dwyer, P.J.3    Catalano, P.4    Ansari, R.H.5    Benson III, A.B.6
  • 45
    • 78650704114 scopus 로고    scopus 로고
    • Prognostic significance of immunohistochemical expression of EGFR and c-ErbB-2 oncoprotein in curatively resected gastric cancer
    • Song HS, Do YR, Kim IH, Sohn SS, Kwon KY. Prognostic significance of immunohistochemical expression of EGFR and c-ErbB-2 oncoprotein in curatively resected gastric cancer. Cancer Res. Treat. 36(4), 240-245 (2004).
    • (2004) Cancer Res. Treat. , vol.36 , Issue.4 , pp. 240-245
    • Song, H.S.1    Do, Y.R.2    Kim, I.H.3    Sohn, S.S.4    Kwon, K.Y.5
  • 46
    • 61749089272 scopus 로고    scopus 로고
    • Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: Epidermal growth factor receptor (EGFR) associated with favourable survival
    • Kim JS, Kim MA, Kim TM et al. Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival. Br. J. Cancer 100(5), 732-738 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.5 , pp. 732-738
    • Kim, J.S.1    Kim, Ma.2    Kim, T.M.3
  • 47
    • 70349937924 scopus 로고    scopus 로고
    • Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study)
    • Pinto C, Di Fabio F, Barone C et al. Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study). Br. J. Cancer 101(8), 1261-1268 (2009).
    • (2009) Br. J. Cancer , vol.101 , Issue.8 , pp. 1261-1268
    • Pinto, C.1    Di Fabio, F.2    Barone, C.3
  • 48
    • 76349109904 scopus 로고    scopus 로고
    • Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: A Phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    • Lordick F, Luber B, Lorenzen S et al. Cetuximab plus oxaliplatin/ leucovorin/5-fluorouracil in first-line metastatic gastric cancer: a Phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Br. J. Cancer 102(3), 500-505 (2010).
    • (2010) Br. J. Cancer , vol.102 , Issue.3 , pp. 500-505
    • Lordick, F.1    Luber, B.2    Lorenzen, S.3
  • 49
    • 75549087436 scopus 로고    scopus 로고
    • Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients
    • Park SR, Kook MC, Choi IJ et al. Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients. Cancer Chemother. Pharmacol. 65(3), 579-587 (2010).
    • (2010) Cancer Chemother. Pharmacol. , vol.65 , Issue.3 , pp. 579-587
    • Park, S.R.1    Kook, M.C.2    Choi, I.J.3
  • 50
    • 77957552916 scopus 로고    scopus 로고
    • Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: Dose-finding study for the prospective multicenter, randomized, Phase II/III REAL-3 trial
    • Okines AF, Ashley SE, Cunningham D et al. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: dose-finding study for the prospective multicenter, randomized, Phase II/III REAL-3 trial. J. Clin. Oncol. 28(25), 3945-3950 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.25 , pp. 3945-3950
    • Okines, A.F.1    Ashley, S.E.2    Cunningham, D.3
  • 51
    • 84856037018 scopus 로고    scopus 로고
    • Efficacy of RAD001 (everolimus) against advanced gastric cancer with peritoneal dissemination
    • Taguchi F, Kodera Y, Katanasaka Y, Yanagihara K, Tamura T, Koizumi F. Efficacy of RAD001 (everolimus) against advanced gastric cancer with peritoneal dissemination. Invest. New Drugs 29(6), 1198-1205 (2010).
    • (2010) Invest. New Drugs , vol.29 , Issue.6 , pp. 1198-1205
    • Taguchi, F.1    Kodera, Y.2    Katanasaka, Y.3    Yanagihara, K.4    Tamura, T.5    Koizumi, F.6
  • 52
    • 77951221545 scopus 로고    scopus 로고
    • Rapamycin enhances chemotherapy-induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells
    • Shigematsu H, Yoshida K, Sanada Y et al. Rapamycin enhances chemotherapy-induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells. Int. J. Cancer 126(11), 2716-2725 (2010).
    • (2010) Int. J. Cancer , vol.126 , Issue.11 , pp. 2716-2725
    • Shigematsu, H.1    Yoshida, K.2    Sanada, Y.3
  • 53
    • 77951635629 scopus 로고    scopus 로고
    • Multicenter Phase II study of everolimus in patients with previously treated metastatic gastric cancer
    • Doi T, Muro K, Boku N et al. Multicenter Phase II study of everolimus in patients with previously treated metastatic gastric cancer. J. Clin. Oncol. 28(11), 1904-1910 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.11 , pp. 1904-1910
    • Doi, T.1    Muro, K.2    Boku, N.3
  • 54
    • 79957864676 scopus 로고    scopus 로고
    • Cetuximab with irinotecan, folinic acid and 5-fluorouracil as first-line treatment in advanced gastroesophageal cancer: A prospective multi-center biomarker-oriented Phase II study
    • Moehler M, Mueller A, Trarbach T et al. Cetuximab with irinotecan, folinic acid and 5-fluorouracil as first-line treatment in advanced gastroesophageal cancer: a prospective multi-center biomarker-oriented Phase II study. Ann. Oncol. 22(6), 1358-1366 (2010).
    • (2010) Ann. Oncol. , vol.22 , Issue.6 , pp. 1358-1366
    • Moehler, M.1    Mueller, A.2    Trarbach, T.3
  • 55
    • 33847663871 scopus 로고    scopus 로고
    • Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)
    • Pinto C, Di Fabio F, Siena S et al. Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). Ann. Oncol. 18(3), 510-517 (2007).
    • (2007) Ann. Oncol. , vol.18 , Issue.3 , pp. 510-517
    • Pinto, C.1    Di Fabio, F.2    Siena, S.3
  • 56
    • 79957539777 scopus 로고    scopus 로고
    • A prospective Phase II study of cetuximab in combination with XELOX (capecitabine and oxaliplatin) in patients with metastatic and/or recurrent advanced gastric cancer
    • Kim C, Lee JL, Ryu MH et al. A prospective Phase II study of cetuximab in combination with XELOX (capecitabine and oxaliplatin) in patients with metastatic and/or recurrent advanced gastric cancer. Invest. New Drugs 29(2), 366-373 (2009).
    • (2009) Invest. New Drugs , vol.29 , Issue.2 , pp. 366-373
    • Kim, C.1    Lee, J.L.2    Ryu, M.H.3
  • 57
    • 58749089260 scopus 로고    scopus 로고
    • Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer
    • Han SW, Oh DY, Im SA et al. Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer. Br. J. Cancer 100(2), 298-304 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.2 , pp. 298-304
    • Han, S.W.1    Oh, D.Y.2    Im, S.A.3


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