Structure/function studies on a S-adenosyl-L-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis

Journal of Molecular Biology

Volumn 344, Issue 2, 2004, Pages 419-433

  Vévodová, Jitka ^a   Graham, Ross M ^b   Raux, Evelyne ^b   Schubert, Heidi L ^a,c   Roper, David I ^a,d   Brindley, Amanda A ^b   Ian Scott, A ^e   Roessner, Charles A ^e   Stamford, N Patrick J ^f   Elizabeth Stroupe, M ^g   Getzoff, Elizabeth D ^g   Warren, Martin J ^b   Wilson, Keith S ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e TEXAS A AND M UNIVERSITY   (United States)

^f UNIVERSITY OF SYDNEY   (Australia)

^g SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

cobA; cobalamin; metabolic pathway; Pseudomonas denitrificans

Indexed keywords

ADENOSYL METHIONINE DEPENDENT UROPORPHYRINOGEN III C METHYLTRANSFERASE; ALANINE; ASPARAGINE; ASPARTIC ACID; CHEMICAL COMPOUND; CHLORINE DERIVATIVE; COBALAMIN; COBALT DERIVATIVE; CYANOCOBALAMIN; ENZYME; LYSINE; METHIONINE; METHYLTRANSFERASE; PHENYLALANINE; PRECORRIN 1; PRECORRIN 2; PYRROLE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SYNTHETASE; THREONINE; TYROSINE; UNCLASSIFIED DRUG; UROPORPHYRINOGEN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; CATALYSIS; CONTROLLED STUDY; CRYSTAL; CRYSTALLOGRAPHY; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE; MOLECULAR MECHANICS; MUTAGENESIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE;

PSEUDOMONAS; PSEUDOMONAS DENITRIFICANS;

EID: 7444230375     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.09.020     Document Type: Article

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