Antitumor activity of magnetite nanoparticles: Influence of hydrocarbonated chain of saturated aliphatic monocarboxylic acids

Current Organic Chemistry

Volumn 17, Issue 8, 2013, Pages 831-840

  Voicu, Georgeta ^a   Andronescu, Ecaterina ^a   Grumezescu, Alexandru Mihai ^a   Huang, Keng Shiang ^b   Ficai, Anton ^a   Yang, Chih Hui ^b   Bleotu, Coralia ^c   Chifiriuc, Mariana Carmen ^d  

^a UNIVERSITY POLITEHNICA OF BUCHAREST   (Romania)

^b I SHOU UNIVERSITY   (Taiwan)

^c STEFAN S NICOLAU INSTITUTE OF VIROLOGY   (Romania)

^d UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

Anti tumor; Cancer therapy; Core@shell; Fatty acids; Nanofluids

Indexed keywords

CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; DRUG INTERACTIONS; FATTY ACIDS; MAGNETIC RESONANCE IMAGING; MAGNETITE; MAGNETITE NANOPARTICLES; NANOFLUIDICS; NANOMAGNETICS; TARGETED DRUG DELIVERY; TUMORS;

ANTI-TUMORS; ANTITUMOUR ACTIVITY; CANCER THERAPY; CORE SHELL; DRUG CARRIER; DRUG-DELIVERY SYSTEMS; MONOCARBOXYLIC ACIDS; NANOFLUIDS; SIDE EFFECT; TUMOR TREATMENT;

NANOSTRUCTURED MATERIALS;

EID: 84878644369     PISSN: 13852728     EISSN: None     Source Type: Journal    
DOI: 10.2174/1385272811317080008     Document Type: Article

References (131)

1. Rogach, A. L.; Talapin, D. V.; Shevchenko, E. V.; Kornowski, A.; Haase, M.; Weller, H. Organization of Matter on Different Size Scales: Monodisperse Nanocrystals and their Superstructures. Adv. Funct. Mater., 2002, 12, 653-664.
2. Schmid, G. Nanoparticles: from theory to application, Wiley-VCH, Weinheim, Germany, 2004.
3. Alivisatos, A.P. Semiconductor clusters, nanocrystals, and quantum dots. Science, 1996, 271, 933-937.
4. Itoh, H.; Sugimoto, T. Systematic control of size, shape, structure, and magnetic properties of uniform magnetite and maghemite particles, Journal of Colloid and Interface Science, 2003, 265 (2), 283-295.
5. Rogach, A. L.; Klar, T. A.; Lupton, J. M.; Meijerink, A.; Feldmann, J. Energy Transfer with Semiconductor Nanocrystals. J. Mater. Chem., 2009, 19, 1208-1221.
6. Jain, T.K.; Morales, M.A.; Sahoo, S.K.; Leslie-Pelecky, D.L.; Labhasetwar, V. Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharm., 2005, 2, 194-205.
7. Miller, M.M.; Prinz, G.A.; Cheng, S.F.; Bounnak, S. Detection of a micronsized magnetic sphere using a ring-shaped anisotropic magnetoresistancebased sensor: a model for a magnetoresistance-based biosensor. Appl. Phys. Lett., 2002, 81, 2211-2213.
8. Hu, K.W.; Liu, T.M.; Chung, K.Y.; Huang, K.S.; Hsieh, C.T.; Sun, C.K.; Yeh, C.S. Efficient NIR Hyperthermia and Intense Nonlinear Optical Imaging Contrast on the Gold Nanorod-in-Shell Nanostructures. J. Am. Chem. Soc. 2009, 131(40), 14186-14187.
9. Wang, C.Y.; Yang, C.H.; Lin, Y.S.; Chen, C.H.; Huang, K.S. Enhanced Anti-Inflammation Efficiency through High Intensity Focused Ultrasound-Mediated Pulsatile Drug Delivery of Diclofenac, Biomaterials, 2012, 33, 1547-1553.
10. Zeng, H.; Li, J.; Liu, J.P.; Wang, Z.L.; Sun, S. Exchange-coupled nanocomposite magnets by nanoparticle self-assembly. Nature, 2002, 420, 395-398.
11. Dumestre, F.; Chaudret, B.; Amiens, C.; Renaud, P.; Fejes, P. Superlattices of iron nanocubes synthesized from Fe[N(SiMe3)2]2. Science, 2004, 303(5659), 821-823.
12. Jacobs, K.; Zaziski, D.; Scher, E. C.; Herhold, A. B.; Alivisatos, A. P. Activation volumes for solid-solid transformations in nanocrystals. Science, 2001, 293(5536), 1803-1806.
13. Uhlén, M. Magnetic separation of DNA. Nature, 1989, 340, 733-734.
14. Sellmyer, D. J. Strong Magnets by Self-Assembly. Nature, 2002, 420, 374-375.
15. Jun, Y.W.; Lee, Y.H.; Cheon, J. Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Angew. Chem. Int. Ed., 2008, 47, 5122-5135.
16. Allen, T.M.; Cullis, P.R. Drug delivery systems: entering the mainstream. Science, 2004, 303, (5665), 1818-1822.
17. Mayo, J.T.; Yavuz, C.; Yean, S.; Cong, L.; Shipley, H.; Yu, W.; Falkner, J.; Kan, A.; Tomson, M.; Colvin, V. The effect of nanocrystalline magnetite size on arsenic removal. Sci. Technol. Adv. Mater., 2007, 8, 71-75.
18. 4nanoparticle-coated boron nitride nanotubes. J. Colloid Interface Sci., 2011, 359, 261-268.
19. Arruebo, M.; Rodrigo, F.P.; Ibarra, M.R.; Santamaria, J. Magnetic nanoparticles for drug delivery. Nanotoday, 2007, 2(3), 22-32.
20. Park, J.H.; Im, K.H.; Lee, S.H.; Kim, D.H. Preparation and characterization of magnetic chitosan particles for hyperthermia application. J. Magn. Magn. Mater., 2005, 293, 328-333.
21. Kim, D.H.; Lee, S.H.; IM, K.H.; Kim, K.N.; Kim, K.M.; Kim, K.D.; Park, H.; Shim, I.B.; Lee, Y.K. Biodistribution of chitosan-based magnetite suspensions for targeted hyperthermia in ICR mice. IEEE Tran. Magn., 2005, 41(10), 4158-4160.
22. Schweiger, C.; Pietzonka, C.; Heverhagen, J.; Kissel, T. Novel magnetic iron oxide nanoparticles coated with poly(ethylene imine)-g-poly(ethylene glycol) for potential biomedical application: Synthesis, stability, cytotoxicity and MR imaging. Int. J. Pharm. 2011, 408, 130
23. Medeiros, S.F.; Santos, A.M.; Fessi, H.; Elaissari, A. Stimuli-responsive magnetic particles for biomedical applications. Int. J. Pharm. 2011, 403, 139
24. 4Superparamagnetic Nanoparticles, and Tamoxifen. Lab Chip, 2009, 9, 961-965.
25. Lin, Y.S.; Huang, K.S.; Yang, C.H.; Wang, C.Y.; Yang, Y.S.; Hsu, H.C.; Liao, Y.J.; Tsai, C.W. Microfluidic Synthesis of Microfibers for Magnetic-Responsive Controlled Drug Release and Cell Culture. PloS One, 2012, 7, e33184.
26. Makhluf, S.B.; Qasem, R.; Rubinstein, S.; Gedanken, A.; Breitbart, H. Loading magnetic nanoparticles into sperm cells does not affect their functionality. Langmuir, 2006, 22, 9480-9482.
27. Theerdhala, S.; Bahadur, D.; Vitta, S.; Perkas, N.; Zhong, Z.; Gedanken, A. Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, L-arginine, for possible bio applications. Ultrason. Sonochem., 2010, 17(4), 730-737.
28. Ma, Z.Y.; Guan, Y.P.; Liu, X.Q.; Liu, H.Z. Covalent immobilization of albumin on micron-sized magnetic poly(methyl methacrylatedivinylbenzene-glycidyl methacrylate) microspheres prepared by modified suspension polymerization. Polym. Adv. Technol. 2005, 16, 554-558.
29. Willard, M.A.; Kurihara, L.K.; Carpenter, E.E.; Calvin, S.; Harris, V.G. Chemically prepared magnetic nanoparticles. Int. Mater. Rev. 2004, 49, 125.
30. Wang, Y.; Li, B.; Zhou, Y.; Jia, D. Chitosan-induced synthesis of magnetite nanoparticles via iron ions assembly. Polym. Adv. Technol., 2008, 19, 1256-1261.
31. Y.; Li, B.; Zhou, Y.; Jia, D. Chitosan-induced synthesis of magnetite nanoparticles via iron ions assembly. Polym. Adv. Technol., 2008, 19, 1256-1261.
32. Basak, S.; Chen, D.-R.; Biswas, P. Electrospray of ionic precursor solutions to synthesize iron oxide nanoparticles: modified scaling law. Chem. Eng. Sci. 2007, 62, 1263-1268.
33. Kim, E.H.; Lee, H.S.; Kwak, B.K.; Kim, B.K. Synthesis of ferrofluid with magnetic nanoparticles by sonochemical method for MRI contrast agent. J. Magn. Magn. Mater., 2005, 289, 328-330.
34. Chin, A.B.; Yaacob, I.I. Synthesis and characterization of magnetic iron oxide nanoparticles via w/o microemulsion and Massart's procedure. J. Mater. Process. Technol. 2007, 191, 235-237
35. Alvarez, G.S.; Muhammed, M.; Zagorodni, A.A. Novel flow injection synthesis of iron oxide nanoparticles with narrow size distribution. Chem. Eng. Sci. 2006, 61, 4625-4633.
36. Albornoz, C.; Jacobo, S.E. Preparation of a biocompatible magnetoc film from an aqueous ferrofluid. J. Magn. Magn. Mater. 2006, 305, 12-15.
37. Kimata, M.; Nakagawa, D.; Hasegawa, M. Preparation of monodisperse magnetic particles by hydrolysis of iron alkoxide. Powder Technol. 2003, 132, 112-118.
38. Wan, J., Chen, X.; Wang, Z.; Yang, X.; Qian, Y. A soft-template-assisted hydrothermal approach to single-crystal Fe3O4 nanorods. J. Cryst. Growth., 2005, 276, 571-576.
39. Xu, J.; Yang, H.; Fu, W.; Du, K.; Sui, Y.; Chen, J.; Zeng, Y.; Li, M.; Zou, G. Preparation and magnetic properties of magnetite nanoparticles by sol-gel method. J. Magnet. Magnet. Mater., 2007, 309, 307-311.
40. Chin, A.B.; Yaacob, I.I. Synthesis and characterization of magnetic iron oxide nanoparticles via w/o microemulsion and Massart's procedure. J. Mater. Process. Technol. 2007, 191, 235-237
41. Alvarez, G.S.; Muhammed, M.; Zagorodni, A.A. Novel flow injection synthesis of iron oxide nanoparticles with narrow size distribution. Chem. Eng. Sci. 2006, 61, 4625-4633.
42. Albornoz, C.; Jacobo, S.E. Preparation of a biocompatible magnetoc film from an aqueous ferrofluid. J. Magn. Magn. Mater. 2006, 305, 12-15.
43. Kimata, M.; Nakagawa, D.; Hasegawa, M. Preparation of monodisperse magnetic particles by hydrolysis of iron alkoxide. Powder Technol. 2003, 132, 112-118.
44. Wan, J., Chen, X.; Wang, Z.; Yang, X.; Qian, Y. A soft-template-assisted hydrothermal approach to single-crystal Fe3O4 nanorods. J. Cryst. Growth.,2005, 276, 571-576.
45. Xu, J.; Yang, H.; Fu, W.; Du, K.; Sui, Y.; Chen, J.; Zeng, Y.; Li, M.; Zou, G. Preparation and magnetic properties of magnetite nanoparticles by sol-gel method. J. Magnet. Magnet. Mater., 2007, 309, 307-311.
46. Jain, T.K.; Morales, M.A.; Sahoo, S.K.; Leslie, D.L.; Labhasetwar, V. Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharm. 2005, 2, 194-205.
47. Tural, B.; Ozkan, N.; Volkan, M. Preparation and characterization of polymer coated superparamagnetic magnetite nanoparticle agglomerates. J. Phys. Chem. Solids. 2009, 70, 860-866.
48. Faiyas, A.P.A.; Vinod, E.M.; Joseph, J.; Ganesan, R.; Pandey, R.K. Dependence of pH and surfactant effect in the synthesis of magnetite (Fe3O4) nanoparticles and its properties. J. Magn. Magn. Mater., 2010, 322, 400-404.
49. 4nanoparticles. J. Biomed. Mater. Res. Part A, 2007, 80A (2), 333-341.
50. Kosa, I. N.; Recnik, A.; Posfai, M. Novel methods for the synthesis of magnetite nanoparticles with special morphologies and textured assemblages. J. Nanopart. Res., 2012, 14(10),1150-1160.
51. Liang, M.T.; Wang, S.H.; Chang, Y.L.; Hsiang, H.I.; Huang, H.J.; Tsai, M.H.; Juan, W.C.; Lu, S.F. Iron oxide synthesis using a continuous hydrothermal and solvothermal system. Ceram. Int., 2010, 36, 1131-1135.
52. Chen, F.; Gao, Q.; Hong, G.; Ni, J. Synthesis and characterization of magnetite dodecahedron nanostructure by hydrothermal method J. Magnet. Magnet. Mater., 2008, 320, 1775-1780.
53. Haw, C.Y.; Mohamed, F.; Chia, C.H.; Radiman, S.; Zakaria, S.; Huang, N.M.; Lim, H.N. Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents. Ceram. Int., 2010, 36, 1417-1422.
54. 4) nanoparticles with the magnetic and electrochemical properties. J. Crys. Growth. 2008, 310, 5453-5457.
55. Márquez, F.; Campo, T.; Cotto, M.; Polanco, R.; Roque, R.; Fierro, P.; Sanz, J. M.; Elizalde, E.; Morant, C. Synthesis and Characterization of Monodisperse Magnetite Hollow Microspheres. Soft Nanosci. Lett. 2011, 1, 25-32.
56. Wu, M.; Xiong, Y.; Jia, Y.; Niu, H.; Qi, H.; Ye, J.; Chen, Q. Magnetic fieldassisted hydrothermal growth of chain-like nanostructure of magnetite. Chemical Physics Letters, 2005, 401, 374-379.
57. Liang, J.; Li, L.; Luo, M.; Fang, J.; Hu, Y. Synthesis and properties of magnetite Fe3O4 via a simple hydrothermal route, Solid State Sci. 2010, 12, 1422-1425.
58. Wang, M.; Thanou, M. Targeting nanoparticles to cancer. Pharmacol. Res., 2010, 62(2), 90-99.
59. Masoudi, A.; Madaah Hosseini, H.R.; Shokrgozar, M.A.; Ahmadi, R.; Oghabian, M.A. The effect of poly(ethylene glycol) coating on colloidal stability of superparamagnetic iron oxide nanoparticles as potential MRI contrast agent. Int. J. Pharm., 2012, 433(1-2), 129-141.
60. Huang, C.; Tang, Z.; Zhou, Y.; Zhou, X.; Jin, Y.; Li, D.; Yang, Y.; Zhou, S. Magnetic micelles as a potential platform for dual targeted drug delivery in cancer therapy. Int. J. Pharm., 2012, 429(1-2), 113-122.
61. Aleksenko, S.S.; Shmykov, A.Y.; Oszwałdowski, S.; Timerbaev, A.R. Interactions of tumour-targeting nanoparticles with proteins: potential of using capillary electrophoresis as a direct probe. Metallomics., 2012, 4(11), 1141-8.
62. Mantle, M.D. Quantitative magnetic resonance micro-imaging methods for pharmaceutical research. Int. J. Pharm. 2011, 417, 173-195.
63. Wang, H.; Wang, S.; Liao, Z.; Zhao, P.; Su, W.; Niu, R.; Chang, J. Folatetargeting magnetic core-shell nanocarriers for selective drug release and imaging. Int. J. Pharm. 2011, 430, 343.
64. García-Jimeno, S.; Escribano, E.; Queralt, J.; Estelrich, J. Magnetoliposomes prepared by reverse-phase followed by sequential extrusion: Characterization and possibilities in the treatment of inflammation. Int. J. Pharm., 2011, 405(1-2), 181-187.
65. Fan, C.; Gao, W.; Chen, Z.; Fan, H.; Li, M.; Deng, F.; Chen, Z. Tumor selectivity of stealth multi-functionalized superparamagnetic iron oxide nanoparticles. Int. J. Pharm., 2011, 404(1-2), 180-190.
66. Tataru, G.; Popa, M.; Desbrieres, J. Magnetic microparticles based on natural polymers. Int. J. Pharm., 2011, 404(1-2), 83-93.
67. Alphandéry, E.; Guyot, F.; Chebbi, I. Preparation of chains of magnetosomes, isolated from Magnetospirillum magneticum strain AMB-1 magnetotactic bacteria, yielding efficient treatment of tumors using magnetic hyperthermia. Int. J. Pharm., 2012, 434(1-2), 444-452.
68. Klostergaard, J.; Seeney, C.E. Magnetic nanovectors for drug delivery. Nanomed. 2012, 1, 37-50
69. Mihaiescu, D.E.; Horja, M.; Gheorghe, I.; Ficai, A.; Grumezescu, A.M.; Bleotu, C.; Chifiriuc, M.C. Water soluble magnetite nanoparticles for antimicrobial drugs delivery. Lett. Appl. NanoBioSci. 2012, 1(2), 45-49.
70. Mihaiescu, D.E.; Grumezescu, A.M.; Balaure, P.C.; Mogosanu, D.E.; Traistaru, V. Magnetic scaffold for drug targeting: evaluation of cephalosporins controlled release profile. Biointerface Res. Appl. Chem. 2011, 1(5), 191-195
71. Grumezescu, A.M.; Saviuc, C.; Holban, A.; Hristu, R.; Croitoru, C.; Stanciu, G.; Chifiriuc, C.; Mihaiescu, D.; Balaure, P.; Lazar, V. Magnetic chitosan for drug targeting and in vitro drug delivery response. Biointerface Res. Appl. Chem. 2011, 1(5), 160-165.
72. Grumezescu, A.M.; Ilinca, E.; Chifiriuc, C.; Mihaiescu, D.; Balaure, P.; Traistaru, V.; Mihaiescu, G. Influence of magnetic MWCNTs on the antimicrobial activity of cephalosporins. Biointerface Res. Appl. Chem. 2011, 1(4), 139-144.
73. Liu, Y.; Zhang, B.; Yan B. Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel. Int. J. Mol. Sci. 2011, 12(7), 4395-4413.
74. Mihaiescu, D.E.; Grumezescu, A.M.; Mogosanu, D.E.; Traistaru, V.; Balaure, P.C.; Buteica, A. Hybrid organic/inorganic nanomaterial for controlled cephalosporins release. Biointerface Res. Appl. Chem. 2011, 1(2), 041-047.
75. Phillips, M.A.; Gran, M.L.; Peppas, N.A. Targeted Nanodelivery of Drugs and Diagnostics. Nano Today., 2010, 5(2), 143-159.
76. Saviuc, C.; Grumezescu, A.M.; Holban, A.; Bleotu, C.; Chifiriuc, C.; Balaure, P.; Lazar, V. Phenotypical studies of raw and nanosystem embedded Eugenia carryophyllata buds essential oil antibacterial activity on Pseudomonas aeruginosa and Staphylococcus aureus strains. Biointerface Res. Appl. Chem. 2011, 1(3), 111-118.
77. Saviuc, C.; Grumezescu, A.M.; Holban, A.; Chifiriuc, C.; Mihaiescu, D.; Lazar, V. Hybrid nanostructurated material for biomedical applications. Biointerface Res. Appl. Chem. 2011, 1(2), 064-071.
78. Alexiou, C.; Arnold, W.; Klein, R.J.; Parak, F.G.; Hulin, P.; Bergemann, C.; Erhardt, W.; Wagenpfeil, S.; Lübbe, A.S. Locoregional cancer treatment with magnetic drug targeting. Cancer Res., 2000, 60, 6641-6648.
79. Kobayashi T. Cancer hyperthermia using magnetic nanoparticles. Biotechnol J., 2011, 6(11), 1342-7.
80. Kawai, N.; Ito, A.; Nakahara, Y.; Futakuchi, M.; Shirai, T.; Honda, H.; Kobayashi, T.; Kohri K. Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats. The Prostate., 2005, 64(4), 373-381.
81. Yanase, M.; Shinkai, M.; Honda, H.; Wakabayashi, T.; Yoshida, J.; Kobayashi T. Antitumor Immunity Induction by Intracellular Hyperthermia Using Magnetite Cationic Liposomes. Cancer Science., 1998, 89(7), 775-782.
82. Ito, A.; Kuga, Y.; Honda, H.; Kikkawa, H.; Horiuchi, A.; Watanabe, Y.; Kobayashi T. Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia. Cancer Lett., 2004, 212(2), 167-175.
83. Yoh, M.; Kenji, T.; Hitoshi, S.; Ekapop, V.; Shigeru, T. Antitumor activity of selective hyperthermia in tumor-bearing rats using thermosensitive magnetoliposomes as a new hyperthermic material. Drug Delivery, 1997, 4,1.
84. Hu, F.X.; Neoh, K.G.; Kang, E.T. Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles. Biomaterials, 2006, 27(33), 5725-33.
85. Koppolu, B.; Bhavsar, Z.; Wadajkar, A.S.; Nattama, S.; Rahimi, M.; Nwariaku, F.; Nguyen, K.T. Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancer. J. Biomed. Nanotechnol. 2012, 8(6): 983-90.
86. Sun, X.Y.; Liang, W.Q. Comparison on antitumor activity of cisplatin-loaded liposomes and nanoparticles in vitro. J Zheinjang Univer. Med. Sci. 2011, 40(4): 408-13.
87. Gindy, M.E.; Prud'homme, R.K. Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin. Drug Deliv. 2009, 6(8): 865-78.
88. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. J. Control Rel. 2000, 65: 271-284.
89. Yang, X.; Chen, L.; Han, B.; Yang, X.; Duan, H. Preparation of magnetite and tumor dual-targeting hollow polymer microspheres with pH-sensitivity for anticancer drug-carriers. Polymer, 2010, 51(12), 2533-2539.
90. McCarthy, J.R.; Weissleder, R. Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv. Drug. Deliv. Rev. 2008, 60(11): 1241-1251.
91. Chifiriuc, M.C.; Grumezescu, A.M.; Saviuc, C.; Croitoru, C.; Mihaiescu, D.E.; Lazar, V. Improved antibacterial activity of cephalosporins loaded in magnetic chitosan microspheres. Int. J. Pharm., 2012, 436(1-2), 201-205.
92. Grumezescu, A.M.; Andronescu, E.; Ficai, A.; Bleotu, C.; Mihaiescu, D.E. Chifiriuc, M.C. Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells. Int. J. Pharm. 2012, 43, 771-777.
93. Legrand, P.; Rioux V. The Complex and Important Cellular and Metabolic Functions of Saturated Fatty Acids. Lipids., 2010, 45(10), 941-946.
94. Paneva, D.; Manolova, N.; Argirova, M.; Rashkov, I. Antibacterial electrospun poly(ε-caprolactone)/ascorbyl palmitate nanofibrous materials. Int. J. Pharm. 2011, 416, 346.
95. Mitchell, D.A.; Vasudevan, A.; Linder, M.E.; Deschenes, R.J. Protein palmitoylation by a family of DHHC protein S-acyltransferases. J. Lipid Res. 2006, 47, 1118-1127.
96. Towler, D.A.; Gordon, J.I.; Adams, S.P.; Glaser, L. The biology and enzymology of eukaryotic protein acylation. Annu. Rev. Biochem., 1988, 57, 69-99.
97. Zha, J.; Weiler, S.; Oh, K.J.; Wei, M.C.; Korsmeyer, S.J. Posttranslational Nmyristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science. 2000, 290, 1761-1765.
98. Utsumi, T.; Sakurai, N.; Nakano, K.; Ishisaka, R. C-terminal 15 kDa fragment of cytoskeletal actin is posttranslationally N-myristoylated upon caspase-mediated cleavage and targeted to mitochondria. FEBS Lett. 2003, 539, 37-44.
99. Sakurai, N.; Utsumi, T. Posttranslational N-myristoylation is required for the anti-apoptotic activity of human tGelsolin, the C-terminal caspase cleavage product of human gelsolin. J. Biol. Chem. 2006, 281, 14288-14295.
100. Vilas, G.L.; Corvi, M.M.; Plummer, G.J.; Seime, A.M.; Lambkin, G.R.; Berthiaume, L.G. Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. Proc. Natl. Acad. Sci. USA. 2006, 103, 6542-6547.
101. Maurer-Stroh, S.; Gouda, M.; Novatchkova, M.; Schleiffer, A.; Schneider, G.; Sirota, F.L.; Wildpaner, M.; Hayashi, N.; Eisenhaber, F. MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins. Genome. Biol. 2004, 5,1-16.
102. Chen, C.A.; Manning, D.R. Regulation of G proteins by covalent modification. Oncogene. 2001, 20, 1643-1652.
103. Xu, C.; Chakravarty, K.; Kong, X.; Tuy, T.T.; Arinze, I.J.; Bone, F.; Massillon, D. Several transcription factors are recruited to the glucose-6-phosphatase gene promoter in response to palmitate in rat hepatocytes and H4IIE cells. J. Nutr., 2007, 137, 554-559.
104. Budick-Harmelin, N.; Anavi, S.; Madar, Z.; Tirosh, O. Fatty acids-stress attenuates gluconeogenesis induction and glucose production in primary hepatocytes. Lipids Health Dis., 2012, 9(11), 66.
105. Lee, J.Y.; Sohn, K.H.; Rhee, S.H.; Hwang, D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 2001, 276, 16683-16689.
106. Rada-Iglesias, A.; Enroth, S.; Ameur, A.; Koch, K.M.; Clelland, G.K.; Respuela-Alonso, P.; Wilcox,3 S.; Dovey, O.M.; Ellis, P.D.; Langford, C.F.; Dunham, I.; Komorowski, J.; Wadelius, C. Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes. Genome. Res., 2007, 17(6), 708-719.
107. Chen, J.; Ghazawi, F.M.; Bakkar, W.; Li, Q. Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B. Mol. Cancer. 2006, 5,71.
108. Belakavadi, M.; Prabhakar, B.T.; Salimath, B.P. Purification and characterization of butyrate-induced protein phosphatase involved in apoptosis of Ehrlich ascites tumor cells. Biochim. Biophys. Acta. 2007, 1770, 39-47.
109. Staiger, K.; Staiger, H.; Weigert, C.; Haas, C.; Haring, H.U.; Kellerer, M. Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-κB activation. Diabetes. 2006, 55, 3121-3126.
110. Beauchamp, E.; Tekpli, X.; Marteil, G.; Lagadic-Gossmann, D.; Legrand, P.; Rioux, V. N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid. Biochimie., 2009, 91, 1411-1419.
111. Maeda, M.; Scaglia, N.; Igal, R.A. Regulation of fatty acid synthesis and Delta9-desaturation in senescence of human fibroblasts. Life Sci. 2009, 84, 119-124.
112. Ford, J.H. Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging. Age (Dordr)., 2010, 32(2), 231-237.
113. Hunter, J.E.; Zhang, J.; Kris-Etherton, P.M. Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated and unsaturated fatty acids: a systematic review. Am. J. Clin. Nutr. 2010, 91, 46-63.
114. Sampath, H.; Miyazaki, M.; Dobrzyn, A.; Ntambi, J.M. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fatty acids. J. Biol. Chem. 2007, 282, 2483-2493.
115. Legrand, P.; Catheline, D.; Rioux, V.; Durand, G. Lauric acid is desaturated to C12:1n-3 by rat liver homogenate and hepatocytes. Lipids. 2002, 37, 569-572.
116. Hua, M.Y.; Yang, H.W.; Chuang, C.K.; Tsai, R.Y.; Chen, W.J.; Chuang, K.L.; Chang, Y.H.; Chuang, H.C.; Pang, S.T. Magnetic-nanoparticlemodified paclitaxel for targeted therapy for prostate cancer. Biomaterials. 2010, 31, 7355-7363.
117. Tapan, K.J.; Marco, A.M.; Sanjeeb, K.S.; Diandra, L.L.P.; Vinod, L. Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharm. 2005, 2, 194-205.
118. Sawant, R.R.; Vaze, O.S.; Rockwell, K.; Torchilin, V.P. Palmitoyl ascorbatemodified liposomes as nanoparticle platform for ascorbate-mediated cytotoxicity and paclitaxel co-delivery. Eur. J. Pharm. Biopharm. 2010, 75(3): 321-6.
119. Fang, J.; Seki, T.; Maeda, H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv. Drug Deliv. Rev. 2009, 61, 290-302.
120. McCarty MF, Barroso-Aranda J, Contreras F. Oxidative stress therapy for solid tumors-a proposal. Med. Hypotheses. 2010, 74, 1052-4.
121. Foy S.P.; Labhasetwar, V. Oh the Irony: Iron as a Cancer Cause or Cure? Biomaterials. 2011, 32(35): 9155-9158.
122. Müller, R.H.; Mäder, K.; Gohla, S. Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art. Eur. J. Pharm. Biopharm. 2000, 50: 161-177.
123. Mehnert, W.; Mäder, K. Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Deliv. Rev. 2001, 47:165-196.
124. Wong, H.L.; Bendayan, R.; Rauth, A.M.; Li, Y.; Wu, X.Y. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv. Drug Deliv. Rev. 2007, 59:491-504.
125. Puri, A.; Loomis, K.; Smith, B.; Lee, J.H.; Yavlovich, A.; Heldman, E.; Blumenthal, R. Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic. Crit. Rev. Ther. Drug. Carrier. Syst. 2009; 26(6): 523-580.
126. Grumezescu, A.M.; Ficai, A.; Mihaiescu, D.E.; Vasile, B.S.; Bleotu, C. Synthesis, characterization and bioevaluation of core/shell nanostructure, Lett. Appl. NanoBioSci. 2012, 1, 31-35.
127. Grumezescu, A.M.; Andronescu, E.; Ficai, A.; Yang, C.H.; Huang, K.S.; Vasile, B.S.; Voicu, G.; Mihaiescu, D.E.; Bleotu, C. Magnetic nanofluid with antitumoral properties, Lett. Appl. Nanobioscience., 2012, 1(3), 56-60.
128. Andronescu, E.; Ficai, M.; Voicu, G.; Manzu, D.; Ficai, A. Synthesis and characterization of collagen/hydroxyapatite-magnetite composite material for bone cancer treatment. J. Mater. Sci.-Mater. Med., 2010, 21(7), 2237-2242.
129. Wan, J.; Jiang, L.; Lü, Q.; Ke, L.; Li, X.; Tong, N. Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells. Biochem. Biophys. Res. Commun. 2010, 391(3), 1567-72.
130. Przybytkowski, E.; Behrendt, M.; Dubois, D.; Maysinger, D. Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability. FEBS J., 2009, 276(21), 6204-17.
131. Kharroubi, I.; Ladrière, L.; Cardozo, A.K.; Dogusan, Z.; Cnop, M.; Eizirik, D.L. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology., 2004, 145(11), 5087-96.