Effect of composition on biological fate of oil particles after intravenous injection of O/W lipid emulsions

Journal of Drug Targeting

Volumn 6, Issue 4, 1998, Pages 273-284

  Sakaeda, Toshiyuki ^a   Hirano, Koichiro ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Drug delivery system; O W lipid emulsions; Oil particles size; RES avoidance

Indexed keywords

DEXTRAN SULFATE; LIPID EMULSION; MEDIUM CHAIN TRIACYLGLYCEROL; OIL; PHOSPHOLIPID; POLYOXYETHYLENE; POLYSORBATE 80; SOYBEAN OIL; SURFACTANT; TRIACYLGLYCEROL; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EGG YOLK; INTRAVENOUS DRUG ADMINISTRATION; LIGHT SCATTERING; MALE; NONHUMAN; PARTICLE SIZE; PHOSPHOLIPID BLOOD LEVEL; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; RETICULOENDOTHELIAL SYSTEM; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0032423699     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869808996835     Document Type: Article

References (32)

1. Collins-Gold, L.C., Lyons, R.T. and Bartholow, L.C. (1990). Parenteral emulsions for drug delivery. Adv. Drug Delivery Rev., 5, 189-208.
2. Davis, S.S., Hadgraft, J. and Palin, K.J. (1985). Medical and pharmaceutical applications of emulsions. In Becher, P. (ed.). Encyclopedia of Emulsion Technology (Marcel Dekker, New York), pp. 159-238.
3. Davis, S.S., Washington, C., West, P., Illum, L., Liversidge, G., Sternson, L. and Kirsh, R. (1987). Lipid emulsions as drug delivery systems. Ann. NY. Acad. Sci., 507, 75-88.
4. Davis. S.S., Illum, L., Moghimi, S.M., Davies, M.C., Porter, C.J.H., Muir, I.S., Brindley, A., Christy, N.M., Norman, M.E., Williams, P. and Dunn, S.E. (1993). Microspheres for targeting drugs to specific body sites. J. Controlled Release, 24, 157-163.
5. Hansch, C., Leo, A., Unger, S.H., Kim, K.H., Nikaitani, D. and Lien, E.J. (1973). Aromatic substituent constants for structure-activity correlations. J. Med. Chem., 16, 1207-1216.
6. 1 and the application of them to lipid microsphere (LM) preparations. Jpn. J. Inflamm., 8, 243-246.
7. Illum, L., West, P., Washington, C. and Davis, S.S. (1989). The effect of stabilising agents on the organ distribution of lipid emulsions. Int. J. Pharm., 54, 41-49.
8. Iriyama, K. (1996). The metabolic distinctiveness of emulsified lipid particles in the bloodstream and its clinical implications. Surg. Today, 26, 673-678.
9. Leo, A., Jow, P.Y.C., Silipo, C. and Hansch, C. (1975). Calculation of hydrophobic constant (log P) from π and f constants. J. Med. Chem., 18, 865-868.
10. Losa, C., Marchal-Heussler, L., Orallo, F., Vila Jato, J.L. and Alonso, M.J. (1993). Design of new formulations for topical ocular administration: polymeric nanocapsules containing metipranolol. Pharm. Res., 10, 80-87.
11. Lundberg, B.B. (1997). A submicron lipid emulsion coated with amphipathic polyethylene glycol for parenteral administration of paclitaxel (Taxol). J. Pharm. Pharmacol., 49, 16-21.
12. Mizushima, Y. (1991). Lipo-prostaglandin preparations. Prostagl. Leukotr. Essent. Fatty Acids, 42, 1-6.
13. Mizushima, Y., Igarashi, R., Hoshi, K., Sim, A.K., Cleland, M.E., Hayashi, H. and Goto, J. (1987). Marked enhancement in antithrombolic activity of isocarbacyclin following its incorporation into lipid microspheres. Prostaglandins, 33, 161-168.
14. Moghimi, S.M., Porter, C.J.H., Muir, I.S., Illum, L. and Davis, S.S. (1991). Non-phagocytic uptake of intravenously injected microspheres in rat spleen: influence of particle size and hydrophilic coating. Biochem. Biophys. Res. Commun., 177, 861-866.
15. Moghimi, S.M., Muir, I.S., Illum, L., Davis, S.S. and Kolb-Bachofen, V. (1993). Coating particles with a block copolymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum. Biochim. Biophys. Acta, 1179, 157-165.
16. Moghimi, S.M. and Davis, S.S. (1994). Innovations in avoiding particle clearance from blood by Kupffer cells: cause for reflection. Crit. Rev. Ther. Drug Carrier Systems, 11, 31-59.
17. Oku, N. and Namba, Y. (1994). Long-circulating liposomes. Crit. Rev. Ther. Drug Carrier Systems, 11, 231-270.
18. Palin, K.J., Phillips, A.J. and Ning, A. (1986). The oral absorption of cefoxitin from oil and emulsion vehicles in rats. Int. J. Pharm., 33, 99-104.
19. Patel, K.R., Li, M.P. and Baldeschwieler, J.D. (1983). Suppression of liver uptake of liposomes by dextran sulfate 500. Proc. Natl. Acad. Sci. USA, 80, 6518-6522.
20. Pense, A.M., Vauthier, C., Puisieux, F. and Benoit, J.P. (1992). Microencapsulation of benzalkonium chloride. Int. J. Pharm., 81, 111-117.
21. Prankerd, R.J. and Stella, V.J. (1990). The use of oil-in-water emulsions as a vehicle for parenteral drug administation. J. Parent. Sci. Technol., 44, 139-149.
22. Sakaeda (nee Kakutani), T., Takahashi, K., Nishihara, Y. and Hirano, K. (1994). O/W lipid emulsions for parenteral drug delivery. I. Pharmacokinetics of the oil particles and incorporated sudan II. Biol. Pharm. Bull., 17, 1490-1495.
23. Sakaeda (nee Kakutani), T. and Hirano, K. (1995). O/W lipid emulsions for parenteral drug delivery. II. Effect of composition on pharmacokinetics of incorporated drug. J. Drug Targeting, 3, 221-230.
24. Sakaeda (nee Kakutani), T. and Hirano, K. (1998). O/W lipid emulsions for parenteral drug delivery. III. Lipophilicity necessary for incorporation in oil particles even after intravenous injection. J. Drug Targeting, in press.
25. Sakaeda (nee Kakutani), T., Kakushi, H., Shike, T., Takano, K., Harauchi, T., Hirata, M. and Hirano, K. (1998). O/W lipid emulsions for parenteral drug delivery. IV. Changes in the pharmacokinetics and pharmacodynamics of a highly lipophilic drug, menatetrenone. J. Drug Targeting, in press.
26. Souhami, R.L., Patel, H.M. and Ryman, B.E. (1981). The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes. Biochim. Biophys. Acta, 674, 354-371.
27. Singh, M. and Ravin, L.J. (1986). Parenteral emulsions as drug carrier systems. J. Parent. Sci. Technol., 40, 34-41.
28. Windler, E., Greeve, J., Robenek, H., Rinninger, F., Greten, H. and Jackle, S. (1996). Differences in the mechanisms of uptake and endocytosis of small and large chylomicron remnants by rat liver. Hepatology, 24, 344-351.
29. Xu, R. (1996). Particle size distribution analysis using light scattering. In. Knapp, J.Z., Barber, T.A. and Lieberman, A. (eds.), Liquid- and Surface-Borne Particle Measurement Handbook (Marcel Dekker Inc.), pp. 745-777.
30. Yamaguchi, T. and Mizushima, Y. (1994). Lipid microspheres for drug delivery from the pharmaceutical viewpoint. Crit. Rev. Ther. Drug Carrier Systems, 11, 215-229.
31. Yamaoka, K., Tanigawara, Y., Nakagawa, T. and Uno, T. (1981). A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn., -4, 879-885.
32. Yu, W., Tabosa do Egito, E.S., Barratt, G., Fessi, H., Devissaguet, J.P. and Puisieux, F. (1993). A novel approach to the preparation of injectable emulsions by a spontaneous emulsification process. Int. J. Pharm., 89, 139-146.