Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility"

American Journal of Physiology - Cell Physiology

Volumn 304, Issue 10, 2013, Pages

  Lakatta, Edward G ^a   Yaniv, Yael ^a   Maltsev, Victor A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHANNEL NAV1.5;

CARDIOVASCULAR FUNCTION; CIRCADIAN RHYTHM; DISEASE PREDISPOSITION; EDITORIAL; ELECTROCARDIOGRAM; GENE EXPRESSION REGULATION; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; MOLECULAR CLOCK; NONHUMAN; PRIORITY JOURNAL; QRS COMPLEX;

ANIMALS; ARNTL TRANSCRIPTION FACTORS; ARRHYTHMIAS, CARDIAC; CIRCADIAN RHYTHM; MYOCYTES, CARDIAC; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL;

EID: 84878638825     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00072.2013     Document Type: Editorial

References (19)

1. Binah O, Weissman A, Itskovitz-Eldor J, Rosen MR. Integrating beat rate variability: from single cells to hearts. Heart Rhythm. doi:10.1016/j.hrthm.2013.02.013. [Epub ahead of print].
2. Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME. Disruption of the circadian clock within the cardiomy-ocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol 294: H1036-H1047, 2008.
3. + ATPase. Cell Calcium 49: 56-65, 2011.
4. Dessauer CW, Posner BA, Gilman AG. Visualizing signal transduction: receptors, G-proteins, and adenylate cyclases. Clin Sci (Lond) 91: 527-537, 1996.
5. Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol 72: 517-549, 2010.
6. Durgan DJ, Tsai JY, Grenett MH, Pat BM, Ratcliffe WF, Villegas-Montoya C, Garvey ME, Nagendran J, Dyck JR, Bray MS, Gamble KL, Gimble JM, Young ME. Evidence suggesting that the cardiomyo-cyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol Int 28: 187-203, 2011.
7. Ko ML, Shi L, Grushin K, Nigussie F, Ko GY. Circadian profiles in the embryonic chick heart: L-type voltage-gated calcium channels and signal-ing pathways. Chronobiol Int 27: 1673-1696, 2010.
8. + clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res 106: 659-673, 2010.
9. Lei M, Jones SA, Liu J, Lancaster MK, Fung SS, Dobrzynski H, Camelliti P, Maier SK, Noble D, Boyett MR. Requirement of neuronal-and cardiac-type sodium channels for murine sinoatrial node pacemaking. J Physiol 559: 835-848, 2004.
10. Liu J, Sirenko S, Juhaszova M, Ziman B, Shetty V, Rain S, Shukla S, Spurgeon HA, Vinogradova TM, Maltsev VA, Lakatta EG. A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling. J Mol Cell Cardiol 51: 730-739, 2011.
11. Maltsev VA, Undrovinas A. Late sodium current in failing heart: friend or foe? Prog Biophys Mol Biol 96: 421-451, 2007.
12. Mandel Y, Weissman A, Schick R, Barad L, Novak A, Meiry G, Goldberg S, Lorber A, Rosen MR, Itskovitz-Eldor J, Binah O. Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior. Circulation 125: 883-893, 2012.
13. Papadatos GA, Wallerstein PM, Head CE, Ratcliff R, Brady PA, Benndorf K, Saumarez RC, Trezise AE, Huang CL, Vandenberg JI, Colledge WH, Grace AA. Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci USA 99: 6210-6215, 2002.
14. Remme CA, Verkerk AO, Hoogaars WM, Aanhaanen WT, Scicluna BP, Annink C, van den Hoff MJ, Wilde AA, van Veen TA, Veldkamp MW, de Bakker JM, Christoffels VM, Bezzina CR. The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium. Basic Res Cardiol 104: 511-522, 2009.
15. Schroder EA, Lefta M, Zhang X, Bartos D, Feng HZ, Zhao Y, Patwardhan A, Jin JP, Esser KA, Delisle BP. The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility. Am J Physiol Cell Physiol (January 30, 2013). doi:10.1152/ajpcell.00383.2012.
16. Siepka SM, Yoo SH, Park J, Lee C, Takahashi JS. Genetics and neurobiology of circadian clocks in mammals. Cold Spring Harb Symp Quant Biol 72: 251-259, 2007.
17. Ter Keurs HE, Boyden PA. Calcium and arrhythmogenesis. Physiol Rev 87: 457-506, 2007.
18. Yang D, Lyashkov AE, Li Y, Ziman BD, Lakatta EG. RGS2 overex-pression or Giinhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells. J Mol Cell Cardiol 53: 687-694, 2012.
19. + -regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand. J Mol Cell Cardiol 51: 740-748, 2011.