RGS2 overexpression or Gi inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells

Journal of Molecular and Cellular Cardiology

Volumn 53, Issue 5, 2012, Pages 687-694

  Yang, Dongmei ^a   Lyashkov, Alexey E ^a   Li, Yue ^a   Ziman, Bruce D ^a   Lakatta, Edward G ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Action potential firing rate; Cultured adult rabbit sinoatrial node cells; PKA dependent protein phosphorylation; Type2 regulator of G protein signaling

Indexed keywords

ADENOVIRUS VECTOR; ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PERTUSSIS TOXIN; PHOSPHOLAMBAN; RGS2 PROTEIN; RYANODINE RECEPTOR 2; SERINE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME INHIBITION; GENE; GENE OVEREXPRESSION; GENETIC MANIPULATION; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; NONHUMAN; PACEMAKER NERVE CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; RECEPTOR UPREGULATION; RGS2 GENE; SIGNAL TRANSDUCTION; SINUS NODE;

ACTION POTENTIALS; ADENOVIRIDAE; ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM-BINDING PROTEINS; CELL SHAPE; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENETIC VECTORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; ISOPROTERENOL; PERTUSSIS TOXIN; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RABBITS; RECOMBINANT PROTEINS; RGS PROTEINS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SECOND MESSENGER SYSTEMS; SINOATRIAL NODE; TRANSFECTION;

ORYCTOLAGUS CUNICULUS;

EID: 84867403065     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.08.007     Document Type: Article

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