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Volumn 106, Issue 6, 2013, Pages 505-515

The pathophysiology of elevated vitamin b12 in clinical practice

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; TRANSCOBALAMIN;

EID: 84878631898     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hct051     Document Type: Review
Times cited : (143)

References (90)
  • 1
    • 42149096540 scopus 로고    scopus 로고
    • Implications cliniques de la découverte d'une hypervitaminémie B12 en médecine interne
    • Chiche L, Jean R, Romain F, Roux F, Thomas G, Canavese S, et al. Implications cliniques de la découverte d'une hypervitaminémie B12 en médecine interne. Rev Med Interne 2008; 29:187-94.
    • (2008) Rev Med Interne , vol.29 , pp. 187-194
    • Chiche, L.1    Jean, R.2    Romain, F.3    Roux, F.4    Thomas, G.5    Canavese, S.6
  • 2
    • 84866657517 scopus 로고    scopus 로고
    • Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels
    • Arendt JFB, Nexo E. Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels. PLoS ONE 2012; 9:e45979.
    • (2012) PLoS ONE , vol.9
    • Arendt, J.F.B.1    Nexo, E.2
  • 3
    • 84866562750 scopus 로고    scopus 로고
    • Concentrationplasmatique élevée de la vitamine B12: un indicateur des maladies hépatiques ou tumorales
    • Deneuville T, Mario N, Tiev KP, Tolédano C, Josselin-1e11 Mahr L, Gain M, et al. Concentrationplasmatique élevée de la vitamine B12: un indicateur des maladies hépatiques ou tumorales. Rev Med Interne 2009; 30(Suppl. 2):S73.
    • (2009) Rev Med Interne , vol.30 , Issue.SUPPL. 2
    • Deneuville, T.1    Mario, N.2    Tiev, K.P.3    Tolédano, C.4    Josselin-Mahr, L.5    Gain, M.6
  • 4
    • 0035544368 scopus 로고    scopus 로고
    • High serum cobalamin levels in the clinical setting-clinical associations and holo-transcobalamin changes
    • Carmel R, Vasireddy H, Aurangzeb I, George K. High serum cobalamin levels in the clinical setting-clinical associations and holo-transcobalamin changes. Clin Lab Haematol 2001; 23:365-71.
    • (2001) Clin Lab Haematol , vol.23 , pp. 365-371
    • Carmel, R.1    Vasireddy, H.2    Aurangzeb, I.3    George, K.4
  • 5
    • 84866526230 scopus 로고    scopus 로고
    • investigateurs. de l'étude BDOSE. Hypervitaminémies B12 en médecine interne: résultats de l'étude BDOSE.
    • Chiche L, Mancini J, Arlet JB, investigateurs. de l'étude BDOSE. Hypervitaminémies B12 en médecine interne: résultats de l'étude BDOSE. Rev Med Interne 2009; 30(Suppl. 4):S377.
    • (2009) Rev Med Interne , vol.30 , Issue.SUPPL. 4
    • Chiche, L.1    Mancini, J.2    Arlet, J.B.3
  • 6
    • 0008942464 scopus 로고
    • Blood regeneration following anemia, IV. Influence of meat, liver, and various extractives, alone or combined with standard diets
    • Whipple GH, Hooper CW, Robscheit FS. Blood regeneration following anemia. IV. Influence of meat, liver, and various extractives, alone or combined with standard diets. Am J Physiol 1920; 53:236-62.
    • (1920) Am J Physiol , vol.53 , pp. 236-262
    • Whipple, G.H.1    Hooper, C.W.2    Robscheit, F.S.3
  • 7
    • 0000500670 scopus 로고
    • Treatment of pernicious anemia by special diet
    • Minot GR, Murphy WP. Treatment of pernicious anemia by special diet. JAMA 1926; 87:470-6.
    • (1926) JAMA , vol.87 , pp. 470-476
    • Minot, G.R.1    Murphy, W.P.2
  • 8
    • 0008917001 scopus 로고
    • Response of reticulocytes to liver therapy: particularly in pernicious anemia
    • Minot GR, Murphy WP, Stetson RP. Response of reticulocytes to liver therapy: particularly in pernicious anemia. Am J Med Sci 1928; 175:581-99.
    • (1928) Am J Med Sci , vol.175 , pp. 581-599
    • Minot, G.R.1    Murphy, W.P.2    Stetson, R.P.3
  • 9
    • 0008913101 scopus 로고
    • Observations on etiologic relationship of achylia gastrica to pernicious anemia, I. Effect of administration to patients with pernicious anemia of contents of normal human stomach recovered after ingestion of beef muscle
    • Castle WB. Observations on etiologic relationship of achylia gastrica to pernicious anemia. I. Effect of administration to patients with pernicious anemia of contents of normal human stomach recovered after ingestion of beef muscle. Am J Med Sci 1929; 178:748-64.
    • (1929) Am J Med Sci , vol.178 , pp. 748-764
    • Castle, W.B.1
  • 10
    • 0008913101 scopus 로고
    • Observations on etiologic relationship of achylia gastrica to pernicious anemia, II. Effect of administration to patients with pernicious anemia of beef muscle after incubation with normal human gastric juice
    • Castle WB, Townsend WC, Heath CW. Observations on etiologic relationship of achylia gastrica to pernicious anemia. II. Effect of administration to patients with pernicious anemia of beef muscle after incubation with normal human gastric juice. Am J Med Sci 1929; 178:764-77.
    • (1929) Am J Med Sci , vol.178 , pp. 764-777
    • Castle, W.B.1    Townsend, W.C.2    Heath, C.W.3
  • 11
    • 0000024553 scopus 로고
    • Observations on etiologic relationship of achylia gastrica to pernicious anemia.III. Nature of reaction between normal human gastric juice and beef muscle leading to clinical improvement and increased blood formation similar to effect of liver feeding
    • Castle WB, Townsend WC, Heath CW. Observations on etiologic relationship of achylia gastrica to pernicious anemia. III. Nature of reaction between normal human gastric juice and beef muscle leading to clinical improvement and increased blood formation similar to effect of liver feeding. Am J Med Sci 1930; 180:305-35.
    • (1930) Am J Med Sci , vol.180 , pp. 305-335
    • Castle, W.B.1    Townsend, W.C.2    Heath, C.W.3
  • 12
    • 0008891343 scopus 로고
    • Observations on etiologic relationship of achylia gastrica to pernicious anemia. VI. Site of interaction of food (extrinsic) and gastric (intrinsic) factors: failure of in vitro incubation to produce thermostable hematopoietic principle
    • Castle WB, Heath CW, Strauss MB, Heinle RW. Observations on etiologic relationship of achylia gastrica to pernicious anemia.VI. Site of interaction of food (extrinsic) and gastric (intrinsic) factors: failure of in vitro incubation to produce thermostable hematopoietic principle. Am J Med Sci 1937; 294:618-25.
    • (1937) Am J Med Sci , vol.294 , pp. 618-625
    • Castle, W.B.1    Heath, C.W.2    Strauss, M.B.3    Heinle, R.W.4
  • 13
    • 85069120135 scopus 로고
    • Purification of anti-pernicious anemia factors from liver
    • Smith EL. Purification of anti-pernicious anemia factors from liver. Nature 1948; 161:638-9.
    • (1948) Nature , vol.161 , pp. 638-639
    • Smith, E.L.1
  • 15
    • 77049291754 scopus 로고
    • Studies on the vitamin B12-binding principle and other biocolloids of human gastric juice
    • Gärsbeck R. Studies on the vitamin B12-binding principle and other biocolloids of human gastric juice. Acta Med Scand 1956; 314(Suppl.):1-87.
    • (1956) Acta Med Scand , vol.314 , Issue.SUPPL. , pp. 1-87
    • Gärsbeck, R.1
  • 16
    • 84939685769 scopus 로고
    • Fractionation of human gastric juice and saliva employing starch electrophoresis
    • Gärsbeck R. Fractionation of human gastric juice and saliva employing starch electrophoresis. Gastroenterologia 1955; 84:99-102.
    • (1955) Gastroenterologia , vol.84 , pp. 99-102
    • Gärsbeck, R.1
  • 17
    • 0033237884 scopus 로고    scopus 로고
    • Discovery of vitamin B12 in the liver and its absorption factor in the stomach: a historical review
    • Okuda K. Discovery of vitamin B12 in the liver and its absorption factor in the stomach: a historical review. J Gastroenterol Hepatol 1999; 14:301-8.
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 301-308
    • Okuda, K.1
  • 18
    • 0000023394 scopus 로고
    • Gastric intrinsic factor and its function in the metabolism of vitamin B12
    • Glass GBJ. Gastric intrinsic factor and its function in the metabolism of vitamin B12. Physiol Rev 1963; 43:529-849.
    • (1963) Physiol Rev , vol.43 , pp. 529-849
    • Glass, G.B.J.1
  • 19
    • 0033056072 scopus 로고    scopus 로고
    • The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
    • Kozyraki R, Fyfe J, Kristiansen M, Gerdes C, Jacobsen C, Cui S, et al. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med 1999; 5:656-61.
    • (1999) Nat Med , vol.5 , pp. 656-661
    • Kozyraki, R.1    Fyfe, J.2    Kristiansen, M.3    Gerdes, C.4    Jacobsen, C.5    Cui, S.6
  • 20
    • 0037371866 scopus 로고    scopus 로고
    • Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia
    • Tanner SM, Aminoff M, Wright FA, Liyanarachchi S, Kuronen M, Saarinen A, et al. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. Nat Genet 2003; 33:426-9.
    • (2003) Nat Genet , vol.33 , pp. 426-429
    • Tanner, S.M.1    Aminoff, M.2    Wright, F.A.3    Liyanarachchi, S.4    Kuronen, M.5    Saarinen, A.6
  • 21
    • 1442357042 scopus 로고    scopus 로고
    • The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless
    • Fyfe FC, Madsen M, Hojrup P, Christensen EI, Tanner SM, de la Chapelle A, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 2004; 103:1573-9.
    • (2004) Blood , vol.103 , pp. 1573-1579
    • Fyfe, F.C.1    Madsen, M.2    Hojrup, P.3    Christensen, E.I.4    Tanner, S.M.5    de la Chapelle, A.6
  • 22
    • 34248165629 scopus 로고    scopus 로고
    • Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)
    • Gräsbeck R. Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria). Orphanet J Rare Dis 2006; 1:17.
    • (2006) Orphanet J Rare Dis , vol.1 , pp. 17
    • Gräsbeck, R.1
  • 24
    • 23644443199 scopus 로고    scopus 로고
    • Oral cobalamin (daily dose of 1000 mg) therapy for the treatment of patients with pernicious anemia.An open label study of 10 patients
    • Andrès E, Henoun Loukili N, Noel E, Maloisel F, Vinzio S, Kaltenbach G, et al. Oral cobalamin (daily dose of 1000 mg) therapy for the treatment of patients with pernicious anemia. An open label study of 10 patients. Curr Ther Res 2005; 66:13-22.
    • (2005) Curr Ther Res , vol.66 , pp. 13-22
    • Andrès, E.1    Henoun Loukili, N.2    Noel, E.3    Maloisel, F.4    Vinzio, S.5    Kaltenbach, G.6
  • 25
    • 33746326101 scopus 로고    scopus 로고
    • Oral pharmacologic doses of cobalamin may not be as effective as parenteral cobalamin therapy in reversing hyperhomocystinemia and methylmalonic acidemia in apparently normal subjects
    • Solomon LR. Oral pharmacologic doses of cobalamin may not be as effective as parenteral cobalamin therapy in reversing hyperhomocystinemia and methylmalonic acidemia in apparently normal subjects. Clin Lab Haematol 2006; 28:275-8.
    • (2006) Clin Lab Haematol , vol.28 , pp. 275-278
    • Solomon, L.R.1
  • 26
    • 0023266347 scopus 로고
    • Recommended dietary intakes (RDI) of vitamin B-12 in humans
    • Herbert V. Recommended dietary intakes (RDI) of vitamin B-12 in humans. Am J Clin Nutr 1987; 45:671-8.
    • (1987) Am J Clin Nutr , vol.45 , pp. 671-678
    • Herbert, V.1
  • 27
    • 0031410993 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men
    • Fenech MF, Dresoti IE, Rinaldi JR. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 1997; 18:1329-36.
    • (1997) Carcinogenesis , vol.18 , pp. 1329-1336
    • Fenech, M.F.1    Dresoti, I.E.2    Rinaldi, J.R.3
  • 28
    • 0031903189 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults
    • Fenech M, Aitken C, Rinaldi J. Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 1998; 19:1163-71.
    • (1998) Carcinogenesis , vol.19 , pp. 1163-1171
    • Fenech, M.1    Aitken, C.2    Rinaldi, J.3
  • 29
    • 22844440731 scopus 로고    scopus 로고
    • Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms.A pilot study
    • Kapiszewska M, Kalemba M, Wojciech U, Milewicz T. Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. A pilot study. J Nutr Biochem 2005; 16:467-78.
    • (2005) J Nutr Biochem , vol.16 , pp. 467-478
    • Kapiszewska, M.1    Kalemba, M.2    Wojciech, U.3    Milewicz, T.4
  • 30
    • 34047178356 scopus 로고    scopus 로고
    • Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment
    • Solomon LR. Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev 2007; 21:113-30.
    • (2007) Blood Rev , vol.21 , pp. 113-130
    • Solomon, L.R.1
  • 31
    • 34547203954 scopus 로고    scopus 로고
    • Clinical aspects of cobalamin deficiency in elderly patients.Epidemiology, causes, clinical manifestations, and treatment with special focus on oral cobalamin therapy
    • Andrès E, Vidal-Alaball J, Federici L, Loukili NH, Zimmer J, Kaltenbach G. Clinical aspects of cobalamin deficiency in elderly patients. Epidemiology, causes, clinical manifestations, and treatment with special focus on oral cobalamin therapy. Eur J Intern Med 2007; 18:456-62.
    • (2007) Eur J Intern Med , vol.18 , pp. 456-462
    • Andrès, E.1    Vidal-Alaball, J.2    Federici, L.3    Loukili, N.H.4    Zimmer, J.5    Kaltenbach, G.6
  • 33
    • 77951279490 scopus 로고    scopus 로고
    • Signes et symptômes de la carence en vitamine B12: revue critique de la littérature
    • Serraj K, Mecili M, Andres E. Signes et symptômes de la carence en vitamine B12: revue critique de la littérature. Méd Thé r 2010; 16:13-20.
    • (2010) Méd Thé r , vol.16 , pp. 13-20
    • Serraj, K.1    Mecili, M.2    Andres, E.3
  • 35
    • 0002140064 scopus 로고
    • Vitamin requirements in old age
    • Russel RM. Vitamin requirements in old age. Age Nutr 1992; 3:20-3.
    • (1992) Age Nutr , vol.3 , pp. 20-23
    • Russel, R.M.1
  • 36
    • 33947592822 scopus 로고    scopus 로고
    • Manifestations hématologiques de la carence en vitamine B12: données personnelles et revue de la littérature
    • Federici L, Henoun Loukili N, Zimmer J, Affenberger S, Maloisel F, Andrès E. Manifestations hématologiques de la carence en vitamine B12: données personnelles et revue de la littérature. Rev Med Interne 2007; 28:225-31.
    • (2007) Rev Med Interne , vol.28 , pp. 225-231
    • Federici, L.1    Henoun Loukili, N.2    Zimmer, J.3    Affenberger, S.4    Maloisel, F.5    Andrès, E.6
  • 37
    • 0242551230 scopus 로고    scopus 로고
    • Significance of elevated cobalamin (vitamin B12) levels in blood
    • Ermens AA, Vlasveld LT, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem 2003; 36:585-90.
    • (2003) Clin Biochem , vol.36 , pp. 585-590
    • Ermens, A.A.1    Vlasveld, L.T.2    Lindemans, J.3
  • 38
  • 39
    • 0023951544 scopus 로고
    • Depletion of serum holotranscobalamin II.An early sign of negative vitamin B12 balance
    • Herzlich B, Herbert V. Depletion of serum holotranscobalamin II. An early sign of negative vitamin B12 balance. Lab Invest 1988; 58:332-7.
    • (1988) Lab Invest , vol.58 , pp. 332-337
    • Herzlich, B.1    Herbert, V.2
  • 40
    • 0038507376 scopus 로고    scopus 로고
    • Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians
    • Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr 2003; 78:131-6.
    • (2003) Am J Clin Nutr , vol.78 , pp. 131-136
    • Herrmann, W.1    Schorr, H.2    Obeid, R.3    Geisel, J.4
  • 41
    • 0021134235 scopus 로고
    • Biochemistry and clinical chemistry of vitamin B12 transport and the related diseases
    • Grasbeck R. Biochemistry and clinical chemistry of vitamin B12 transport and the related diseases. J Clin Biochem 1984; 17:99-107.
    • (1984) J Clin Biochem , vol.17 , pp. 99-107
    • Grasbeck, R.1
  • 42
    • 0010384838 scopus 로고
    • Cobalamin binding glycoproteins
    • Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, eds, Bristol: Journal of Endocrinology Ltd.
    • Nicolas JP, Gueant JL, Frémont S. Cobalamin binding glycoproteins. In: Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, eds, Advances in Thomas Addison's Diseases. Bristol: Journal of Endocrinology Ltd., 1994:253-67.
    • (1994) Advances in Thomas Addison's Diseases , pp. 253-267
    • Nicolas, J.P.1    Gueant, J.L.2    Frémont, S.3
  • 43
    • 0014452421 scopus 로고
    • Intrinsic factor and the other vitamin B12 transport proteins
    • Gräsbeck R. Intrinsic factor and the other vitamin B12 transport proteins. Prog Hematol 1969; 6:233-60.
    • (1969) Prog Hematol , vol.6 , pp. 233-260
    • Gräsbeck, R.1
  • 44
    • 0016711863 scopus 로고
    • Human plasma R-type vitamin B12-binding proteins.I. Isolation and characterization of transcobalamin I, transcobalamin III and the normal granulocyte vitamin B12-binding protein
    • Burger RL, Mehlman CS, Allen RH. Human plasma R-type vitamin B12-binding proteins. I. Isolation and characterization of transcobalamin I, transcobalamin III and the normal granulocyte vitamin B12-binding protein. J Biol Chem 1975; 250:7700-6.
    • (1975) J Biol Chem , vol.250 , pp. 7700-7706
    • Burger, R.L.1    Mehlman, C.S.2    Allen, R.H.3
  • 45
    • 0029982447 scopus 로고    scopus 로고
    • Cobalamins: an update of fundamental and clinical data
    • Zittoun J. Cobalamins: an update of fundamental and clinical data. Hématologie 1996; 2:119-29.
    • (1996) Hématologie , vol.2 , pp. 119-129
    • Zittoun, J.1
  • 47
    • 15844429057 scopus 로고
    • Etiology of vitamin B12 (cobalamin) deficiency and staging of B12 status
    • Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, eds, Bristol: Journal of Endocrinology Ltd
    • Herbert V. Etiology of vitamin B12 (cobalamin) deficiency and staging of B12 status. In: Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, eds, Advances in Thomas Addison's Diseases. Bristol: Journal of Endocrinology Ltd, 1994:139-48.
    • (1994) Advances in Thomas Addison's Diseases , pp. 139-148
    • Herbert, V.1
  • 48
    • 35348923112 scopus 로고    scopus 로고
    • Comparison of automated assays for the determination of vitamin B12 in serum
    • Vogeser M, Lorenzl S. Comparison of automated assays for the determination of vitamin B12 in serum. Clin Biochem 2007; 40:1342-5.
    • (2007) Clin Biochem , vol.40 , pp. 1342-1345
    • Vogeser, M.1    Lorenzl, S.2
  • 49
    • 79959307152 scopus 로고    scopus 로고
    • Measurement of vitamin B12 concentration: a review of available methods
    • Karmi O, Zayed A, Baraghethi S, Qadi M, Ghanem R. Measurement of vitamin B12 concentration: a review of available methods. IIOAB J 2011; 2:23-32.
    • (2011) IIOAB J , vol.2 , pp. 23-32
    • Karmi, O.1    Zayed, A.2    Baraghethi, S.3    Qadi, M.4    Ghanem, R.5
  • 50
    • 0034090534 scopus 로고    scopus 로고
    • Current concepts in cobalamin deficiency
    • Carmel R. Current concepts in cobalamin deficiency. Annu Rev Med 2000; 51:357-75.
    • (2000) Annu Rev Med , vol.51 , pp. 357-375
    • Carmel, R.1
  • 51
    • 12844254924 scopus 로고    scopus 로고
    • Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing
    • Solomon LR. Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing. Blood 2005; 105:978-85.
    • (2005) Blood , vol.105 , pp. 978-985
    • Solomon, L.R.1
  • 52
    • 34547146470 scopus 로고    scopus 로고
    • Folate deficiency and plasma homocysteine during increased oxidative stress
    • Rogers EJ, Chen S, Chan A. Folate deficiency and plasma homocysteine during increased oxidative stress. N Engl J Med 2007; 357:421-2.
    • (2007) N Engl J Med , vol.357 , pp. 421-422
    • Rogers, E.J.1    Chen, S.2    Chan, A.3
  • 53
    • 79956095850 scopus 로고    scopus 로고
    • Diabetes as a cause of clinically significant functional cobalamin deficiency
    • Solomon LR. Diabetes as a cause of clinically significant functional cobalamin deficiency. Diabetes Care 2011; 34:1077-80.
    • (2011) Diabetes Care , vol.34 , pp. 1077-1080
    • Solomon, L.R.1
  • 54
    • 84867588251 scopus 로고    scopus 로고
    • More on failures of cobalamin assays in pernicious anemia
    • Solomon LR. More on failures of cobalamin assays in pernicious anemia. N Engl J Med 2012; 367:1570.
    • (2012) N Engl J Med , vol.367 , pp. 1570
    • Solomon, L.R.1
  • 56
    • 34047178356 scopus 로고    scopus 로고
    • Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment
    • Solomon LR. Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev 2007; 21:113-30.
    • (2007) Blood Rev , vol.21 , pp. 113-130
    • Solomon, L.R.1
  • 57
    • 0021995692 scopus 로고
    • Total corrinoid, cobalamin and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism
    • Kanazawa S, Herbert V. Total corrinoid, cobalamin and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest 1985; 53:108-10.
    • (1985) Lab Invest , vol.53 , pp. 108-110
    • Kanazawa, S.1    Herbert, V.2
  • 58
    • 0031596448 scopus 로고    scopus 로고
    • Cobalamin and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease
    • Baker H, Leevy CB, DeAngelis B, Frank O, Baker ER. Cobalamin and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. J Am Coll Nutr 1998; 17:235-8.
    • (1998) J Am Coll Nutr , vol.17 , pp. 235-238
    • Baker, H.1    Leevy, C.B.2    DeAngelis, B.3    Frank, O.4    Baker, E.R.5
  • 59
    • 0026666924 scopus 로고
    • Methylmalonic acid concentration in serum not affected in hepatic disease
    • Hagelskjaer L, Rasmussen K. Methylmalonic acid concentration in serum not affected in hepatic disease. Clin Chem 1992; 38:493-5.
    • (1992) Clin Chem , vol.38 , pp. 493-495
    • Hagelskjaer, L.1    Rasmussen, K.2
  • 61
    • 0017622262 scopus 로고
    • Serum vitamin B12 and transcobalamin abnormalities in patients with cancer
    • Carmel R, Eisenberg L. Serum vitamin B12 and transcobalamin abnormalities in patients with cancer. Cancer 1977; 40:1348-53.
    • (1977) Cancer , vol.40 , pp. 1348-1353
    • Carmel, R.1    Eisenberg, L.2
  • 62
    • 84864209007 scopus 로고    scopus 로고
    • Does an elevated serum vitamin B12 level mask actual vitamin B12 deficiency in myeloproliferative disorders
    • Gauchan D, Joshi N, Gill AS, Patel V, De Bari VA, Guron G, et al. Does an elevated serum vitamin B12 level mask actual vitamin B12 deficiency in myeloproliferative disorders? Clin Lymph Myel Leukemia 2012; 12:269-73.
    • (2012) Clin Lymph Myel Leukemia , vol.12 , pp. 269-273
    • Gauchan, D.1    Joshi, N.2    Gill, A.S.3    Patel, V.4    De Bari, V.A.5    Guron, G.6
  • 63
    • 0017684088 scopus 로고
    • Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood
    • Carmel R, Tatsis B, Baril L. Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood. Blood 1977; 49:987-1000.
    • (1977) Blood , vol.49 , pp. 987-1000
    • Carmel, R.1    Tatsis, B.2    Baril, L.3
  • 64
    • 33750456536 scopus 로고    scopus 로고
    • Markedly increased vitamin B12 concentrations attributable to IgG-IgM-vitamin B12 immune complexes
    • Bowen RA, Drake SK, Vanjani R, Huey ED, Grafman J, Horne MK 3rd. Markedly increased vitamin B12 concentrations attributable to IgG-IgM-vitamin B12 immune complexes. Clin Chem 2006; 52:2107-14.
    • (2006) Clin Chem , vol.52 , pp. 2107-2114
    • Bowen, R.A.1    Drake, S.K.2    Vanjani, R.3    Huey, E.D.4    Grafman, J.5    Horne, M.K.6
  • 65
    • 0014228965 scopus 로고
    • A new vitamin B12 binding protein in serum causing excessively high serum vitamin B12 values
    • Schwartz M, Bastrup-Madsen P. A new vitamin B12 binding protein in serum causing excessively high serum vitamin B12 values. Scand J Haematol 1968; 5:35-40.
    • (1968) Scand J Haematol , vol.5 , pp. 35-40
    • Schwartz, M.1    Bastrup-Madsen, P.2
  • 66
    • 0026628962 scopus 로고
    • Intérêt en hématologie du dosage des cobalamines
    • Rain JD. Intérêt en hématologie du dosage des cobalamines. Immunoanal Biol Spec 1992; 32:17-24.
    • (1992) Immunoanal Biol Spec , vol.32 , pp. 17-24
    • Rain, J.D.1
  • 67
    • 57949092291 scopus 로고    scopus 로고
    • Le syndrome de Non-Dissociation de la Vitamine B12 de ses Protéines Porteuses ou de Mal Digestion des cobalamines alimentaires
    • Serraj K, Vogel T, Federici L, Ciobanu E, Mecili M, Kaltenbach G, et al. Le syndrome de Non-Dissociation de la Vitamine B12 de ses Protéines Porteuses ou de Mal Digestion des cobalamines alimentaires. Presse Med 2009; 38:55-62.
    • (2009) Presse Med , vol.38 , pp. 55-62
    • Serraj, K.1    Vogel, T.2    Federici, L.3    Ciobanu, E.4    Mecili, M.5    Kaltenbach, G.6
  • 68
    • 0016844188 scopus 로고
    • Extreme elevation of serum transcobalamin I in patients with metastatic cancer
    • Carmel R. Extreme elevation of serum transcobalamin I in patients with metastatic cancer. N Engl J Med 1975; 292:282-4.
    • (1975) N Engl J Med , vol.292 , pp. 282-284
    • Carmel, R.1
  • 70
    • 0018186192 scopus 로고
    • Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast
    • Gimsing P, Hippe E. Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast. Scand J Haematol 1978; 21:243-9.
    • (1978) Scand J Haematol , vol.21 , pp. 243-249
    • Gimsing, P.1    Hippe, E.2
  • 72
    • 0022519356 scopus 로고
    • Transcobalamin I as a marker for fibrolamellar hepatoma
    • Wheeler K, Pritchard J, Luck W, Rossiter M. Transcobalamin I as a marker for fibrolamellar hepatoma. Med Ped Oncol 1986; 14:227-9.
    • (1986) Med Ped Oncol , vol.14 , pp. 227-279
    • Wheeler, K.1    Pritchard, J.2    Luck, W.3    Rossiter, M.4
  • 73
    • 20444476781 scopus 로고    scopus 로고
    • High vitamin B12 level: a strong predictor of mortality in elderly inpatients
    • Salles N, Herrmann F, Sakbani K, Rapin CH, Sieber C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr Soc 2005; 53:917-8.
    • (2005) J Am Geriatr Soc , vol.53 , pp. 917-918
    • Salles, N.1    Herrmann, F.2    Sakbani, K.3    Rapin, C.H.4    Sieber, C.5
  • 74
    • 0031760487 scopus 로고    scopus 로고
    • Cobalamin metabolism in chronic myelogenous leukemia
    • Gimsing P. Cobalamin metabolism in chronic myelogenous leukemia. Dan Med Bull 1998; 45:459-79.
    • (1998) Dan Med Bull , vol.45 , pp. 459-479
    • Gimsing, P.1
  • 76
    • 0642364982 scopus 로고    scopus 로고
    • Low cobalamin levels in multiple myeloma: a retrospective study
    • Vlasveld LT. Low cobalamin levels in multiple myeloma: a retrospective study. Neth J Med 2003; 61:249-52.
    • (2003) Neth J Med , vol.61 , pp. 249-252
    • Vlasveld, L.T.1
  • 77
    • 0028956013 scopus 로고
    • The cobalamin forms and analogues in plasma and myeloid cells during the course of chronic myelogenous leukemia related to the clinical condition
    • Gimsing P. The cobalamin forms and analogues in plasma and myeloid cells during the course of chronic myelogenous leukemia related to the clinical condition. Br J Haematol 1995; 89:812-9.
    • (1995) Br J Haematol , vol.89 , pp. 812-819
    • Gimsing, P.1
  • 79
    • 0021288983 scopus 로고
    • Cobalamin vitamin B12 (vitamin B12) and B12 binding proteins in hypereosinophilic syndromes and secondary eosinophilia
    • Zittoun J, Farcet JP, Marquet J, Sultan C, Zittoun R. Cobalamin vitamin B12 (vitamin B12) and B12 binding proteins in hypereosinophilic syndromes and secondary eosinophilia. Blood 1984; 63:779-83.
    • (1984) Blood , vol.63 , pp. 779-783
    • Zittoun, J.1    Farcet, J.P.2    Marquet, J.3    Sultan, C.4    Zittoun, R.5
  • 80
    • 0015252566 scopus 로고
    • Acute promyelocytic leukemia. A report of five cases with a comment on the diagnostic significance of serum vitamin B12 determination
    • Rachmilewitz D, Rachmilewitz EA, Polliack A, Herchko CA. Acute promyelocytic leukemia. A report of five cases with a comment on the diagnostic significance of serum vitamin B12 determination. Br J Haematol 1972; 22:87-92.
    • (1972) Br J Haematol , vol.22 , pp. 87-92
    • Rachmilewitz, D.1    Rachmilewitz, E.A.2    Polliack, A.3    Herchko, C.A.4
  • 81
    • 0026666924 scopus 로고
    • Methylmalonic acid concentration in serum not affected in hepatic disease
    • Hagelskjaer L, Rasmussen K. Methylmalonic acid concentration in serum not affected in hepatic disease. Clin Chem 1992; 38:493-5.
    • (1992) Clin Chem , vol.38 , pp. 493-495
    • Hagelskjaer, L.1    Rasmussen, K.2
  • 82
    • 77549086509 scopus 로고    scopus 로고
    • Functional vitamin B12 deficiency in alcoholics: an intriguing finding in a retrospective study of megaloblastic anemic patients
    • Fragasso A, Mannarella C, Ciancio A, Sacco A. Functional vitamin B12 deficiency in alcoholics: an intriguing finding in a retrospective study of megaloblastic anemic patients. Eur J Intern Med 2010; 21:97-100.
    • (2010) Eur J Intern Med , vol.21 , pp. 97-100
    • Fragasso, A.1    Mannarella, C.2    Ciancio, A.3    Sacco, A.4
  • 83
    • 1842739563 scopus 로고    scopus 로고
    • Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease
    • Hofer LJ, Elian KM. Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease. Med Clin Exp 2004; 27:10-3.
    • (2004) Med Clin Exp , vol.27 , pp. 10-13
    • Hofer, L.J.1    Elian, K.M.2
  • 84
    • 0017684088 scopus 로고
    • Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood
    • Carmel R, Tatsis B, Baril L. Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood. Blood 1977; 49:987-1000.
    • (1977) Blood , vol.49 , pp. 987-1000
    • Carmel, R.1    Tatsis, B.2    Baril, L.3
  • 85
    • 0027163152 scopus 로고
    • Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein
    • Reynolds EH, Bottiglieri T, Laundry M, Stern J, Payan J, Linnell J, et al. Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein. Arch Neurol 1993; 50:739-42.
    • (1993) Arch Neurol , vol.50 , pp. 739-742
    • Reynolds, E.H.1    Bottiglieri, T.2    Laundry, M.3    Stern, J.4    Payan, J.5    Linnell, J.6
  • 86
    • 0025099782 scopus 로고
    • Serum transcobalamin and transcobalamin levels in systemic lupus erythematosus
    • Molad Y, Rachmilewitz B, Sidi Y, Pinkhas J, Weinberger A. Serum transcobalamin and transcobalamin levels in systemic lupus erythematosus. Am J Med 1989; 88:141-4.
    • (1989) Am J Med , vol.88 , pp. 141-144
    • Molad, Y.1    Rachmilewitz, B.2    Sidi, Y.3    Pinkhas, J.4    Weinberger, A.5
  • 87
    • 0021249077 scopus 로고
    • Rheumatoid arthritis: is serum vitamin B12 high in active disease
    • Grindulis KA, Calverley M, Cox C. Rheumatoid arthritis: is serum vitamin B12 high in active disease. J Rheumatol 1984; 11:211-2.
    • (1984) J Rheumatol , vol.11 , pp. 211-212
    • Grindulis, K.A.1    Calverley, M.2    Cox, C.3
  • 88
    • 77949571194 scopus 로고    scopus 로고
    • Increased serum vitamin B12 levels are associated with adult-onset Still's disease with reactive macrophage activation syndrome
    • Kalyoncu U, Buyukasik Y, Akdogan A, Karadag O, Bilgen SA, Kiraz S, et al. Increased serum vitamin B12 levels are associated with adult-onset Still's disease with reactive macrophage activation syndrome. Joint Bone Spine 2010; 77:131-4.
    • (2010) Joint Bone Spine , vol.77 , pp. 131-134
    • Kalyoncu, U.1    Buyukasik, Y.2    Akdogan, A.3    Karadag, O.4    Bilgen, S.A.5    Kiraz, S.6
  • 89
    • 0021288983 scopus 로고
    • Cobalamin and B12 binding proteins in hypereosinophilic syndromes and hypereosinophilia
    • Zittoun J, Farcet JP, Marquet J, Sultan C, Zittoun R. Cobalamin and B12 binding proteins in hypereosinophilic syndromes and hypereosinophilia. Blood 1984; 63:779-83.
    • (1984) Blood , vol.63 , pp. 779-783
    • Zittoun, J.1    Farcet, J.P.2    Marquet, J.3    Sultan, C.4    Zittoun, R.5
  • 90
    • 84856197367 scopus 로고    scopus 로고
    • L'hypervitaminémie B12: physiopathologie et intérê t en pratique clinique
    • Serraj K, Mecili M, Housni I, Andrès E. L'hypervitaminémie B12: physiopathologie et intérê t en pratique clinique. Press Med 2011; 40:1120-7.
    • (2011) Press Med , vol.40 , pp. 1120-1127
    • Serraj, K.1    Mecili, M.2    Housni, I.3    Andrès, E.4


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