Does an elevated serum vitamin B12 level mask actual vitamin B12 deficiency in myeloproliferative disorders?

Clinical Lymphoma, Myeloma and Leukemia

Volumn 12, Issue 4, 2012, Pages 269-273

  Gauchan, Dron ^a,c   Joshi, Nitin ^a,c   Gill, Amandeep Singh ^a,c   Patel, Vishal ^a,d   Debari, Vincent A ^c   Guron, Gunwant ^b,c   Maroules, Michael ^a,c  

^a ST JOSEPH S REGIONAL MEDICAL CENTER   (United States)

^b ST MICHAEL S MEDICAL CENTER   (United States)

^c SETON HALL UNIVERSITY   (United States)

^d ST GEORGE S UNIVERSITY SCHOOL OF MEDICINE   (Grenada)

Author keywords

Cobalamin; Methylmalonic acid; Myeloproliferative disorders; Vitamin B 12

Indexed keywords

CYANOCOBALAMIN; METHYLMALONIC ACID;

ADULT; AGED; ARTICLE; BLOOD CELL COUNT; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CYANOCOBALAMIN DEFICIENCY; FEMALE; HEMATOLOGIC DISEASE; HUMAN; KIDNEY FUNCTION TEST; LIVER FUNCTION TEST; MALE; MYELOFIBROSIS; MYELOPROLIFERATIVE DISORDER; POLYCYTHEMIA VERA; PREVALENCE; SCREENING TEST; THROMBOCYTHEMIA; VITAMIN BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; HUMANS; METHYLMALONIC ACID; MIDDLE AGED; MYELOPROLIFERATIVE DISORDERS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84864209007     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2012.01.008     Document Type: Article

References (18)

1. W. Dameshek Some speculations on the myeloproliferative syndromes Blood 6 1951 372 375
2. A. Tefferi, J.W. Vardiman Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms Leucemia 22 2008 14 22
3. R. Kralovics, R.C. Skoda Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders Blood Rev 19 2005 1 13
4. A. Sharma, G. Buxi, S. Marwah JAK2-positive Philadelphia-negative myeloproliferative neoplasms Indian J Pathol Microbiol 54 2011 117 120
5. J. Mascarenhas, R. Hoffman Myeloproliferative neoplasms: new translational therapies Mt Sinai J Med 77 2010 667 683
6. M. Faurschou, O.J. Nielsen, M.K. Jensen High prevalence of hyperhomocysteinemia due to marginal deficiency of cobalamin or folate in chronic myeloproliferative disorders Am J Hematol 65 2000 136 140
7. R.A. Bowen, S.K. Drake, R. Vanjani Markedly increased vitamin B12 concentrations attributable to IgG-IgM-vitamin B12 immune complexes Clin Chem 52 2006 2107 2114
8. H. Gisslinger, F. Rodeghiero, M. Ruggeri Homocysteine levels in polycythaemia vera and essential thrombocythaemia Br J Haematol 105 1999 551 555
9. C.A. Hall The plasma disappearance of radioactive vitamin B12 in myeloproliferative diseases and other blood disorders Blood 18 1961 717 726
10. H.S. Gilbert, S. Krauss, B. Pasternack Serum vitamin B12 content and unsaturated vitamin B12-binding capacity in myeloproliferative disease Value in differential diagnosis and as indicators of disease activity Ann Intern Med 71 1969 719 729
11. A.A.M. Ermens, L.T. Vlasveld, J. Lindemans Significance of elevated cobalamin (vitamin B12) levels in blood Clin Biochem 36 2003 585 590
12. W. Herrmann, R. Obeid Causes and early diagnosis of vitamin B12 deficiency Dtsch Arztebl Int 105 2008 680 685
13. R. Carmel Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications and performance characteristics of cobalamin, methylmalonic acid and holotranscobalamin II Am J Clin Nutr 94 2011 348 358
14. W.J. Wiersinga, S.E. de Rooij, J.G. Huijmans Diagnosis of vitamin B12 deficiency revised Ned Tijdschr Geneeskd 149 2005 2789 2794
15. E. Bächli, J. Fehr Diagnosis of vitamin B12 deficiency: only apparently child's play Schweiz Med Wochenschr 129 1999 861 872
16. R. Obeid, A.L. Morkbak, W. Munz The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth Clin Chem 52 2006 263 269
17. R.L. Bailey, R. Carmel, R. Green Monitoring of vitamin B12 nutritional statue in the United States by using plasma methlmalonic acid and serum vitamin B12 Am J Clin Nutr 94 2011 552 561
18. T.D. McRae, M.L. Freedman Why vitamin B12 deficiency should be managed aggressively Geriatrics 44 1989 70 79