Clinical implications of high cobalamin blood levels for internal medecine;Implications cliniques de la découverte d'une hypervitaminémie B12 en médecine interne

Revue de Medecine Interne

Volumn 29, Issue 3, 2008, Pages 187-194

  Chiche, L ^a   Jean, R ^a   Romain, F ^a   Roux, F ^b   Thomas, G ^a   Canavese, S ^a   Branger, S ^a   Harle J R ^a   Durand, J M ^a  

^a HÔPITAL DE LA CONCEPTION   (France)

^b TIMONE HOSPITAL   (France)

Author keywords

Cobalamin; Hemopathies; Neoplasia; Vitamin B12

Indexed keywords

COBALAMIN; CYANOCOBALAMIN; BIOLOGICAL MARKER;

ARTICLE; BLOOD DISEASE; CHRONIC MYELOID LEUKEMIA; CLINICAL FEATURE; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DISEASE ASSOCIATION; HUMAN; KIDNEY FAILURE; LIVER DISEASE; MAJOR CLINICAL STUDY; MULTIPLE MYELOMA; MYELODYSPLASIA; MYELOPROLIFERATIVE DISORDER; VITAMIN SUPPLEMENTATION; ADULT; AGED; BLOOD; COMPARATIVE STUDY; EVALUATION; FEMALE; HEMATOLOGIC DISEASE; HOSPITAL PATIENT; INTERNAL MEDICINE; MALE; MIDDLE AGED; RETROSPECTIVE STUDY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; FEMALE; HEMATOLOGIC DISEASES; HEMATOLOGIC NEOPLASMS; HUMANS; INPATIENTS; INTERNAL MEDICINE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; VITAMIN B 12;

EID: 42149096540     PISSN: 02488663     EISSN: 17683122     Source Type: Journal    
DOI: 10.1016/j.revmed.2007.07.007     Document Type: Article

References (38)

1. Andres E., Affenberger S., Vinzio S., Noel E., Kaltenbach G., and Schlienger J.L. Carences en vitamine B12 chez l'adulte : étiologies, manifestations cliniques et traitement. Rev Med Interne 26 (2005) 938-946
2. Neale G. B12 binding proteins. Gut 31 (1990) 59-63
3. Hall C.A. Transport of vitamin B12 in man. Br J Haematol 16 (1969) 429-433
4. Hakami N., Neiman P.E., Canellos G.P., and Lazerson J. Neonatal megaloblastic anemia due to inherited transcobalamin II deficiency in two siblings. N Engl J Med 285 (1971) 1163-1170
5. Ermens A.A.M., Vlasveld L.T., and Lindemans J. Signifiance of elevated cobalamin levels in blood. Clin Biochem 36 (2003) 585-590
6. Solomon L.R. Disorders of cobalamin metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev 21 (2007) 113
7. Boisson F., Fremont S., Migeon C., Nodari F., Droesch S., Gerard P., et al. Human haptocorrin in hepatocellular carcinoma. Cancer Detect Prev 23 (1999) 89-96
8. Molad Y., Rachmilewitz B., Sidi Y., Pinkhas J., and Weinberger A. Serum transcobalamin and transcobalamin levels in systemic lupus erythematosus. Am J Med 88 (1989) 141-144
9. Grindulis K.A., Calverley M., and Cox C. Rheumatoid arthitis: is serum vitamin B12 high in active disease?. J Rheumatol 11 (1984) 211-212
10. Skouby A.P., Hippe E., and Olesen H. Antibody to transcobalamin II and B12 binding capacity in patients treated with hydroxycobalamin. Blood 38 (1971) 769-774
11. Gilbert H.S., and Weinreb N. Increased circulating levels of transcobalamin II in Gaucher disease. N Engl J Med 295 (1976) 1096
12. Fehr J., and De Vecchi P. Transcobalamin II: a marker for macrophage/histiocyte proliferation. Am J Clin Pathol 84 (1985) 291-296
13. Carmel R., and Hollander D. Extreme elevation of transcobalamin II levels in multiple myeloma and other disorders. Blood 51 (1978) 1057-1063
14. Arnalich F., Zamorano A.F., Martinez-Hernandez P., Pena J.M., Barbado F.J., and Vazquez J.J. Additional predictive value of serum unsaturated vitamin B12 proteins in multiple myeloma. J Med 21 (1990) 277-286
15. Vlasveld L.T. Low cobalamin levels in multiple myeloma: a retrospective study. Neth J Med 61 (2003) 249-252
16. Frater-Schroder M., Hitzig W.H., Grob P.J., and Kenny A.B. Increased unsaturated transcobalamine II in active autoimmune disease. Lancet 2 (1978) 238-239
17. Carmel R., Tatsis B., and Baril L. Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood. Blood (1977) 987-1000
18. de Haro L., Marquet J., Tonetti C., and Zittoun J. Hypervitaminémie B12 sérique due à un anticorps antitranscobalamine II : à propos d'un cas. Rev Med Interne 22 (2001) 1132-1133
19. Lambert D., Benhayoun S., Adjalla C., Gelot M.M., Renkes P., Gerard P., et al. Alcoholic cirrhosis and cobalamin metabolism. Digestion 58 (1997) 64-71
20. Baker H., Leevy C.B., DeAngelis B., Frank O., and Baker E.R. Cobalamin and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. J Am Coll Nutr 17 (1998) 235-238
21. Vlasveld L.T., van't Wout J.W., Meeuwissen P., and Castel A. High measured cobalamin concentration attribuable to an analytical problem in testing serum from a patient with pernicious anemia. Clin Chem 52 (2006) 157
22. Carmel R. Extreme elevation of serum transcobalamin I in patients with metastatic cancer. N Engl J Med 292 (1975) 282-284
23. Carmel R., and Eisenberg L. Serum vitamin B12 and transcobalamin abnormalities in patients with cancer. Cancer 40 (1977) 1348-1353
24. Chiche L., Molines C., Durand J.M., and Heim M. Hypervitaminémie B12 : les métastases ne sont pas loin.... Rev Med Interne 23 Suppl 1 (2002) 40s
25. Geissbuhler P., Mermillod B., and Rapin C.H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J Pain Symptom Manage 20 (2000) 93-103
26. Salles N., Herrmann F., Rapin C.H., and Sieber C. High vitamin B12 level: a strong predictor of mortality in ederly inpatients. JAGS 53 (2005) 917-918
27. Cassuto P., Ayraud N., Dujardin P., and Audoly P. PH chromosome and B12 hypervitaminemia whithout obvious symptom of chronic myeloid leukemia. Nouv Presse Med 1 (1972) 2769
28. Ermens A.A., Sonneveld P., Michiels J.J., and Lindemans J. Increased uptake and accumulation of cobalamin by multiple myeloma bone marrow cells as a possible cause of low serum cobalamin. Eur J Haematol 50 (1993) 57
29. Carmel R., Vasireddy H., Aurangzeb I., and George K. High serum cobalamin levels in the clinical setting: clinical associations and holo-transcobalamin changes. Clin Lab Haem 23 (2001) 365-371
30. Hofer L.J., and Elian K.M. Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease. Med Clin Exp 27 (2004) 10-13
31. Birn H., Nexo E., Christensen E.I., and Nielsen R. Diversity in rat tissue accumulation of vitamin B12 supports a distinct role for the kidney in vitamin B12 homeostasis. Nephrol Dial Transplant 18 (2003) 1095-1100
32. Hall C.A., and Wanko M. Increased transcobalamine I in a leukemoid reaction. J Lab Clin Med 78 (1971) 298-301
33. Zittoun J., Farcet J.P., Marquet J., Sultan C., and Zittoun R. Cobalamin and B12 binding proteins in hypereosinophilic syndromes and hypereosinophilia. Blood 63 (1984) 779-783
34. Gale D.P., Cobbold J.F., and Chataway J. Steroid-responsive functional B12 deficiency in association with functional transcobalamin II polymorphism 766C-G. Eur J Haematol 76 (2006) 75
35. Teplitsky V., Huminer D., Zoldan J., Pitlik S., Shohat M., and Mittelman M. Hereditary partial transcobalamin II deficiency with neurological mental and hematologic abnormalities in children and adults. Isr Med Assn J 5 (2003) 868
36. Reynolds E.H., Bottiglieri T., Laundy M., Stern J., Payan J., Linnell J., et al. Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein (new cause of an old syndrome). Arch Neurol 50 (1993) 739-742
37. Lindenbaum J., Savage D.G., Stabler S.P., and Allen R.H. Diagnosis of cobalamin deficiency: relative sensitivities of serum cobalamin,methylmalonic acid, and total homocysteine concentrations. Am J Hematol 34 (1990) 99-107
38. Hvas A.M., and Nexo E. Holotranscobalamin: a first choice assay for diagnosing early vitamin B12 deficiency. J Int Med 257 (2005) 289-298