Bone morphogenetic protein 2 decreases TRPC expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells

American Journal of Physiology - Cell Physiology

Volumn 304, Issue 9, 2013, Pages

  Zhang, Yi ^a,b,c   Lu, Wenju ^a,b   Yang, Kai ^a,c   Xu, Lei ^a,c   Lai, Ning ^a,c   Tian, Lichun ^a   Jiang, Qian ^a   Duan, Xin ^d   Chen, Minsheng ^b   Wang, Jian ^a,c  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c DEPARTMENT OF PATHOLOGY   (United States)

^d FUWAI HOSPITAL   (China)

Author keywords

BMP2; Calcium signaling; Pulmonary arterial smooth muscle cells; Transient receptor potential canonical

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CALCIUM ION; MESSENGER RNA; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERIAL SMOOTH MUSCLE CELL; PULMONARY ARTERY; RAT; SMOOTH MUSCLE FIBER;

BMP2; CALCIUM SIGNALING; PULMONARY ARTERIAL SMOOTH MUSCLE CELLS; TRANSIENT RECEPTOR POTENTIAL CANONICAL;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CALCIUM; CALCIUM SIGNALING; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; MALE; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; RATS; RATS, WISTAR; RNA, SMALL INTERFERING; TRPC CATION CHANNELS;

RATTUS;

EID: 84878628185     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00036.2012     Document Type: Article

References (53)

1. Anderson L, Lowery JW, Frank DB, Novitskaya T, Jones M, Mortlock DP, Chandler RL, de Caestecker MP. Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol 298: R833-R842, 2010.
2. Ariano P, Dalmazzo S, Owsianik G, Nilius B, Lovisolo D. TRPC channels are involved in calcium-dependent migration and proliferation in immortalized GnRH neurons. Cell Calcium 49: 387-394, 2011.
3. Beech DJ. Emerging functions of 10 types of TRP cationic channel in vascular smooth muscle. Clin Exp Pharmacol Physiol 32: 597-603, 2005.
4. 2+entry dependent on TRPC1. Circ Res 93: 839-847, 2003.
5. 2+entry. Am J Physiol Cell Physiol 288: C872-C880, 2005.
6. Berridge MJ. Calcium signalling and cell proliferation. Bioessays 17: 491-500, 1995.
7. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynam-ics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4: 517-529, 2003.
8. Cioffi DL, Wu S, Stevens T. On the endothelial cell I(SOC). Cell Calcium 33: 323-336, 2003.
9. -/-mice. Mol Cell Biol 25: 6980-6989, 2005.
10. El Boustany C, Bidaux G, Enfissi A, Delcourt P, Prevarskaya N, Capiod T. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepa-tology 47: 2068-2077, 2008.
11. Fantozzi I, Huang W, Zhang J, Zhang S, Platoshyn O, Remillard CV, Thistlethwaite PA, Yuan JX. Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension. Exp Lung Res 31: 783-806, 2005.
12. 2+in human pulmonary arterial smooth muscle and endothelial cells. Am J Physiol Lung Cell Mol Physiol 296: L979-L986, 2009.
13. Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, Pozzi A, Baldwin HS, Johnson JE, de Caestecker MP. Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ Res 97: 496-504, 2005.
14. 2+entry in human pulmonary artery myocytes during proliferation. Am J Physiol Heart Circ Physiol 280: H746-H755, 2001.
15. Guo RW, Yang LX, Li MQ, Pan XH, Liu B, Deng YL. Stim1-and Orai1-mediated store-operated calcium entry is critical for angiotensin II-induced vascular smooth muscle cell proliferation. Cardiovasc Res 93: 360-370, 2012.
16. Harper JF, Harmon A. Plants, symbiosis and parasites: a calcium signalling connection. Nat Rev Mol Cell Biol 6: 555-566, 2005.
17. Hyvelin JM, Guibert C, Marthan R, Savineau JP. Cellular mechanisms and role of endothelin-1-induced calcium oscillations in pulmonary arte-rial myocytes. Am J Physiol Lung Cell Mol Physiol 275: L269-L282, 1998.
18. Karaki H, Ozaki H, Hori M, Mitsui-Saito M, Amano K, Harada K, Miyamoto S, Nakazawa H, Won KJ, Sato K. Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev 49: 157-230, 1997.
19. Kunichika N, Landsberg JW, Yu Y, Kunichika H, Thistlethwaite PA, Rubin LJ, Yuan JX. Bosentan inhibits transient receptor potential chan-nel expression in pulmonary vascular myocytes. Am J Respir Crit Care Med 170: 1101-1107, 2004.
20. 2+entry. Am J Physiol Lung Cell Mol Physiol 287: L962-L969, 2004.
21. 2+channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res 95: 496-505, 2004.
22. Louis M, Zanou N, Van Schoor M, Gailly P. TRPC1 regulates skeletal myoblast migration and differentiation. J Cell Sci 121: 3951-3959, 2008.
23. 2+]i in rat distal pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol 299: C1370-C1378, 2010.
24. Lu W, Ran P, Zhang D, Peng G, Li B, Zhong N, Wang J. Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol 298: C114-C123, 2010.
25. 2+responses to hypoxia. Am J Physiol Lung Cell Mol Physiol 295: L104-L113, 2008.
26. Machado RD, Pauciulo MW, Thomson JR, Lane KB, Morgan NV, Wheeler L, Phillips JA 3rd, Newman J, Williams D, Galie N, Manes A, McNeil K, Yacoub M, Mikhail G, Rogers P, Corris P, Humbert M, Donnai D, Martensson G, Tranebjaerg L, Loyd JE, Trembath RC, Nichols WC. BMPR2 haploinsufficiency as the inherited molecular mech-anism for primary pulmonary hypertension. Am J Hum Genet 68: 92-102, 2001.
27. 2+entry in agonist-induced pulmo-nary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 280: L870-L880, 2001.
28. Minke B, Cook B. TRP channel proteins and signal transduction. Physiol Rev 82: 429-472, 2002.
29. Miriyala S, Gongora Nieto MC, Mingone C, Smith D, Dikalov S, Harrison DG, Jo H. Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelax-ation. Circulation 113: 2818-2825, 2006.
30. Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC. Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-β1 and bone morphogenetic proteins. Cir-culation 104: 790-795, 2001.
31. 2+influx and contraction in rat pulmonary artery. Circ Res 89: 923-929, 2001.
32. Parekh AB, Putney JW Jr. Store-operated calcium channels. Physiol Rev 85: 757-810, 2005.
33. Poteser M, Groschner K. Studying subunit interaction and complex assembly of TRP channels. In: TRP Channels, edited by Xu MX. Boca Raton, FL: CRC, 2011, chapt. 4.
34. Remillard CV, Yuan JX. TRP channels, CCE, and the pulmonary vascular smooth muscle. Microcirculation 13: 671-692, 2006.
35. Robertson TP, Hague D, Aaronson PI, Ward JP. Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat. J Physiol 525: 669-680, 2000.
36. Shimoda LA, Sylvester JT, Sham JS. Inhibition of voltage-gated K? current in rat intrapulmonary arterial myocytes by endothelin-1. Am J Physiol Lung Cell Mol Physiol 274: L842-L853, 1998.
37. +current in rat pulmonary artery muscle cells. Am J Physiol Heart Circ Physiol 266: H365-H370, 1994.
38. Snetkov VA, Aaronson PI, Ward JP, Knock GA, Robertson TP. Capacitative calcium entry as a pulmonary specific vasoconstrictor mech-anism in small muscular arteries of the rat. Br J Pharmacol 140: 97-106, 2003.
39. 2+entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol 283: L144-L155, 2002.
40. Upton PD, Long L, Trembath RC, Morrell NW. Functional character-ization of bone morphogenetic protein binding sites and Smad1/5 activa-tion in human vascular cells. Mol Pharmacol 73: 539-552, 2008.
41. Wang J, Jiang Q, Wan L, Yang K, Zhang Y, Chen Y, Wang E, Lai N, Zhao L, Jiang H, Sun Y, Zhong N, Ran P, Lu W. Sodium tanshinone IIA sulfonate inhibits canonical transient receptor potential expression in pulmonary arterial smooth muscle from pulmonary hypertensive rats. Am J Respir Cell Mol Biol 48: 125-134, 2013.
42. Wang J, Shimoda LA, Sylvester JT. Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol 286: L848-L858, 2004.
43. 2+entry. Am J Physiol Lung Cell Mol Physiol 288: L1059-L1069, 2005.
44. 2+in pulmonary arterial smooth muscle cells. Circ Res 98: 1528-1537, 2006.
45. 2+and nonselective cation channels. Am J Physiol Lung Cell Mol Physiol 289: L5-L13, 2005.
46. Weissmann N, Dietrich A, Fuchs B, Kalwa H, Ay M, Dumitrascu R, Olschewski A, Storch U, Mederos y Schnitzler M, Ghofrani HA, Schermuly RT, Pinkenburg O, Seeger W, Grimminger F, Gudermann T. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci USA 103: 19093-19098, 2006.
47. 2+channels in native vascular smooth muscle cells. Circ Res 88: 84-87, 2001.
48. Young KA, Ivester C, West J, Carr M, Rodman DM. BMP signaling controls PASMC KVchannel expression in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol 290: L841-L848, 2006.
49. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 101: 13861-13866, 2004.
50. Yu Y, Sweeney M, Zhang S, Platoshyn O, Landsberg J, Rothman A, Yuan JX. PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol 284: C316-C330, 2003.
51. Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 285: L740-L754, 2003.
52. Zhang S, Remillard CV, Fantozzi I, Yuan JX. ATP-induced mitogen-esis is mediated by cyclic AMP response element-binding protein-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 287: C1192-C1201, 2004.
53. Zhu X, Chu PB, Peyton M, Birnbaumer L. Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. FEBS Lett 373: 193-198, 1995.