Differential Mechanisms of Activation of the Ang Peptide Receptors AT1, AT2, and MAS: Using In Silico Techniques to Differentiate the Three Receptors

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Prokop, Jeremy W ^a   Santos, Robson A S ^b   Milsted, Amy ^a  

^a UNIVERSITY OF AKRON   (United States)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; ANGIOTENSIN[1-7]; MAS PROTEIN; UNCLASSIFIED DRUG; ACE PROTEIN, HUMAN; ANGIOTENSIN III; DIPEPTIDYL CARBOXYPEPTIDASE; G PROTEIN COUPLED RECEPTOR; ONCOPROTEIN; PEPTIDE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MAS-1; RENIN;

AMINO ACID SUBSTITUTION; ARTICLE; INTERNALIZATION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; RECEPTOR BINDING; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; CHEMISTRY; HUMAN; MOLECULAR GENETICS; PROTEIN DOMAIN; PROTEIN TRANSPORT; STRUCTURAL HOMOLOGY;

AMINO ACID SEQUENCE; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN III; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, G-PROTEIN-COUPLED; RENIN; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84878625914     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065307     Document Type: Article

References (54)

1. DeMello WC, Frohlich ED (2010) Renin angiotensin system and cardiovascular disease. New York: Humana Press. 300p.
2. Zhou A, Carrell RW, Murphy MP, Wei Z, Yan Y, et al. (2010) A redox switch in angiotensinogen modulates angiotensin release. Nature 468: 108-111.
3. Morales R, Watier Y, Boxskei Z, (2012) Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor. J Mol Biol 421: 100-111.
4. Danser JAH, Batenburg WW, van Esch JH, (2007) Prorenin and the (pro)renin receptor-an update. Nephrol Dial Transplant 22: 1288-1292.
5. Santos RA, Ferreira AJ, Simoes e Silva AC, (2008) Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol 93: 519-527.
6. Zini S, Fournie-Zaluski MC, Chauvel E, Roques BP, Corvol P, et al. (1996) Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release. Proc Natl Acad Sci U S A 93: 11968-11973.
7. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE, (1991) Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 351: 233-236.
8. Steckelings UM, Paulis L, Namsolleck P, Unger T, (2012) AT2 receptor agonists: hypertension and beyond. Curr Opin Nephrol Hypertens 21: 142-146.
9. Ito M, Oliverio MI, Mannon PJ, Best CF, Maeda N, et al. (1995) Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A 92: 3521-3525.
10. Schorb W, Booz GW, Dostal DE, Conrad KM, Chang KC, et al. (1993) Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts. Circ Res 72: 1245-1254.
11. Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, et al. (1995) Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature. 377: 748-750.
12. Stoll M, Steckelings UM, Paul M, Bottari SP, Metzger R, et al. (1995) The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 95: 651-657.
13. Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR, (1988) The mas oncogene encodes an angiotensin receptor. Nature 335: 437-440.
14. Santos RA, Simoes e Silva AC, Maric C, Silva DM, et al. (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A 100: 8258-8263.
15. Gembardt F, Grajewski S, Vahl M, Schultheiss HP, Walther T, (2008) Angiotensin metabolites can stimulate receptors of the Mas-related genes family. Mol Cell Biochem 319: 115-123.
16. Underwood DJ, Strader CD, Rivero R, Patchett AA, Greenlee W, et al. (1994) Structural model of antagonist and agonist binding to the angiotensin II, AT1 subtype, G protein coupled receptor. Chem Biol 1: 211-221.
17. Baleanu-Gogonea C, Karnik S, (2006) Model of the whole rat AT1 receptor and the ligand-binding site. J Mol Model 12: 325-337.
18. Oliveira L, Costa-Neto CM, Nakaie CR, Schreier S, Shimuta SI, et al. (2007) The Angiotensin II AT1 Receptor Structure-Activity Correlations in the Light of Rhodopsin Structure. Physiol Rev 87: 565-592.
19. Nikiforovich GV, Marshall GR, (2001) 3D model for TM region of the AT-1 receptor in complex with angiotensin II independently validated by site-directed mutagenesis data. Biochem Biophys Res Commun 286: 1204-1211.
20. Sköld C, Nikiforovich G, Karlén A, (2008) Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor. J Mol Graph Model 26: 991-1003.
21. AbdAlla S, Lother H, Quitterer U, (2000) AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 407: 94-98.
22. Prinster SC, Hague C, Hall RA, (2005) Heterodimerization of g protein-coupled receptors: specificity and functional significance. Pharmacol Rev 57: 289-298.
23. Zhang Y, (2008) I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 9: 40.
24. Roy A, Kucukural A, Zhang Y, (2010) I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protocols 5: 725-738.
25. Duan Y, Wu C, Chowdhury S, Lee MC, Xiong G, et al. (2003) A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. J Comput Chem 24: 1999-2012.
26. Konagurthu AS, Whisstock JC, Stuckey PJ, Lesk AM, (2006) MUSTANG: A multiple structural alignment algorithm. Proteins 64: 559-574.
27. Spyroulias GA, Nikolakopoulou P, Tzakos A, Gerothanassis IP, Magafa V, et al. (2003) Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship. Eur J Biochem 270: 2163-2173.
28. Yamano Y, Ohyama K, Chaki S, Guo DF, Inagami T, (1992) Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis. Biochem Biophys Res Commun 187: 1426-1431.
29. Pulakat L, Tadessee AS, Dittus JJ, Gavini N, (1998) Role of Lys215 located in the fifth transmembrane domain of the AT2 receptor in ligand-receptor interaction. Regul Pept 73: 51-57.
30. Noda K, Saad Y, Karnik SS, (1995) Interaction of Phe8 of angiotensin II with Lys199 and His256 of AT1 receptor in agonist activation. J Biol Chem 270: 28511-28514.
31. Pérodin J, Deraet M, Auger-Messier M, Boucard AA, Rihakova L, et al. (2002) Residues 293 and 294 are ligand contact points of the human angiotensin type 1 receptor. Biochemistry 41: 14348-14356.
32. Zhang Y, Devries ME, Skolnick J, (2006) Structure modeling of all identified G protein-coupled receptors in the human genome. PLoS Comput Biol 2: e13.
33. Noda K, Feng YH, Liu XP, Saad Y, Husain A, et al. (1996) The active state of the AT1 angiotensin receptor is generated by angiotensin II induction. Biochemistry 35: 16435-16442.
34. Thomas WG, Qian H, Chang CS, Karnik S, (2000) Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state. J Biol Chem 275: 2893-2900.
35. Servant G, Laporte SA, Leduc R, Escher E, Guillemette G, (1997) Identification of angiotensin II-binding domains in the rat AT2 receptor with photolabled angiotensin analogs. J Biol Chem 272: 8653-8659.
36. Hunyady L, Vauquelin G, Vanderheyden P, (2003) Agonist induction and conformational selection during activation of a G-protein-coupled receptor. Trends Pharmacol Sci 24: 81-86.
37. Hines J, Fluharty SJ, Yee DK, (2003) Structural determinants for the activation mechanism of the angiotensin II type 1 receptor differ for phosphoinositide hydrolysis and mitogen-activated protein kinase pathways. Biochem Pharmacol 66: 251-262.
38. Holloway AC, Qian H, Pipolo L, Ziogas J, Miura S, et al. (2002) Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. Mol Pharmacol 61: 768-777.
39. Vauquelin G, Van Liefde I, (2005) G protein-coupled receptors: a count of 1001 conformations. Fundam Clin Pharmacol 19: 45-56.
40. Kobilka BK, Deupi X, (2007) Conformational complexity of G-protein-coupled receptors. Trends Pharmacol Sci 28: 397-406.
41. Aumelas A, Sakarellos C, Lintner K, Fermandjian S, Khosla MC, et al. (1985) Studies on angiotensin II and analogs: impact of substitution in position 8 on conformation and activity. Proc Natl Acad Sci U S A 82: 1881-1885.
42. Turner CA, Cooper S, Pulakat L, (1999) Role of the His273 located in the sixth transmembrane domain of the angiotensin II receptor subtype AT2 in ligand-receptor interaction. Biochem Biophys Res Commun 257: 704-707.
43. Kemp BA, Bell JF, Rottkamp DM, Howell NL, Shao W, et al. (2012) Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension 60: 387-395.
44. Padia SH, Carey RM, (2013) AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Pflugers Arch 465: 99-110.
45. Feng YH, Noda K, Saad Y, Liu XP, Husain A, et al. (1995) The Docking of Arg of Angiotensin II with Asp of AT Receptor Is Essential for Full Agonism. J Biol Chem 270: 12846-12850.
46. Yasuda N, Akazawa H, Qin Y, Zou Y, Komuro I, (2008) A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II. Naunyn Schmiedebergs Arch Pharmacol 377: 393-399.
47. Yasuda N, Miura S, Akazawa H, Tanaka T, Qin Y, et al. (2008) Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation. EMBO Rep 9: 179-186.
48. Ali MS, Sayeski PP, Dirksen LB, Hayzer DJ, Marrero MB, et al. (1997) Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. J Biol Chem 272: 23382-23388.
49. Ferre S, Franco R, (2010) Oligomerization of G protein-coupled receptors: A reality. Curr Opin Pharmacol 10: 1-5.
50. Szalai B, Barkai L, Turu G, Szidonya L, Varnai P, et al. (2012) Allosteric interactions within the AT1 angiotensin receptor homodimer: role of the conserved DRY motif. Biochem Pharacol 84: 477-485.
51. AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U, (2001) The Angiotensin II AT2 Receptor Is an AT1Receptor Antagonist. J Biol Chem 276: 39721-39726.
52. AbdAlla S, Lother H, el Massiery A, Quitterer U, (2001) Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness. Nat Med 7: 1003-1009.
53. Kostenis E, Milligan G, Christopoulos A, Sanchez-Ferrer CF, Heringer-Walther S, et al. (2005) G-Protein-Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor. Circulation 111: 1806-1813.
54. Rozenfeld R, Gupta A, Gagnidze K, Lim MP, Gomes I, et al. (2011) AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO 30: 2350-2363.