A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 377, Issue 4-6, 2008, Pages 393-399

  Yasuda, Noritaka ^a   Akazawa, Hiroshi ^a   Qin, Yingjie ^a   Zou, Yunzeng ^b   Komuro, Issei ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b FUDAN UNIVERSITY   (China)

Author keywords

Angiotensin II type 1 receptor blocker; Conformational change; Inverse agonist; Mechanical stress

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; CANDESARTAN; G PROTEIN COUPLED RECEPTOR; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; OLMESARTAN;

AUTOCRINE EFFECT; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; DRUG EFFICACY; HEART VENTRICLE HYPERTROPHY; HEART WORK; HUMAN; IN VITRO STUDY; MECHANICAL STRESS; MECHANORECEPTOR; NONHUMAN; PARACRINE SIGNALING;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENZIMIDAZOLES; CARDIOMEGALY; DRUG INVERSE AGONISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; RECEPTOR, ANGIOTENSIN, TYPE 1; STRESS, MECHANICAL; TETRAZOLES;

EID: 45849120232     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-007-0215-1     Document Type: Conference Paper

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