Krüppel-like factor 6 (KLF6) promotes cell proliferation in skeletal myoblasts in response to TGFβ/Smad3 signaling

Skeletal Muscle

Volumn 3, Issue 1, 2013, Pages

  Dionyssiou, Mathew G ^a   Salma, Jahan ^a   Bevzyuk, Mariya ^a   Wales, Stephanie ^a   Zakharyan, Lusine ^a   McDermott, John C ^a,b  

^a YORK UNIVERSITY   (Canada)

^b YORK UNIVERSITY   (Canada)

Author keywords

Cell proliferation; Kr ppel like factor 6; Myoblasts; Transforming growth factor

Indexed keywords

EID: 84878586513     PISSN: None     EISSN: 20445040     Source Type: Journal    
DOI: 10.1186/2044-5040-3-7     Document Type: Article

References (35)

1. Schuh R, Aicher W, Gaul U, Cote S, Preiss A, Maier D, Seifert E, Nauber U, Schroder C, Kemler R, Jackle H. A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Cell 1986, 47:1025-1032. 10.1016/0092-8674(86)90817-2, 3096579.
2. Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biol 2003, 4:206. 10.1186/gb-2003-4-2-206, 151296, 12620113.
3. Koritschoner NP, Bocco JL, Panzetta-Dutari GM, Dumur CI, Flury A, Patrito LC. A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. J Biol Chem 1997, 272:9573-9580. 10.1074/jbc.272.14.9573, 9083102.
4. Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F, Keller G, Friedman SL. Developmental regulation of yolk sac hematopoiesis by Krüppel-like factor 6. Blood 2006, 107:1357-1365. 10.1182/blood-2005-05-1916, 1895396, 16234353.
5. Shields JM, Yang VW. Two potent nuclear localization signals in the gut enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. J Biol Chem 1997, 272:18504-7. 10.1074/jbc.272.29.18504, 2268085, 9218496.
6. Kojima S, Hayashi S, Shimokado K, Suzuki Y, Shimada J, Crippa MP, Friedman SL. Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells. Blood 2000, 95:1309-16.
7. Botella LM, Sanz-Rodriguez F, Komi Y, Fernandez A, Varela E, Garrido-Martin EM, Narla G, Friedman SL, Kojima S. TGF-β regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through Smad3-Sp1-KLF6 interaction. Biochem J 2009, 419:485-495. 10.1042/BJ20081434, 2882110, 19076057.
8. Haldar SM, Ibrahim OA, Jain MK. Krüppel-like Factors (KLFs) in muscle biology. J Mol Cell Cardiol 2000, 43:1-10.
9. Gehrau RC, D'Astolfo DS, Prieto C, Bocco JL, Koritschoner NP. Genomic organization and functional analysis of the gene encoding the Krüppel-like transcription factor KLF6. Biochim Biophys Acta 2005, 1730:137-46. 10.1016/j.bbaexp.2005.06.006, 16054710.
10. Nandan MO, Yang VW. The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. Histol Histopathol 2009, 24:1343-1355. 2753264, 19688699.
11. Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, Robson P, Zhong S, Ng HH. A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol 2008, 10:353-360. 10.1038/ncb1698, 18264089.
12. Suske G, Bruford E, Philipsen S. Mammalian SP/KLF transcription factors: bring in the family. Genomics 2005, 85:551-556. 10.1016/j.ygeno.2005.01.005, 15820306.
13. Holian J, Qi W, Kelly DJ, Zhang Y, Mreich E, Pollock CA, Chen XM. Role of Krüppel-like factor 6 in transforming growth factor-β1-induced epithelial-mesenchymal transition of proximal tubule cells. Am J Physiol Renal Physiol 2008, 259:F1388-F1396.
14. Salma J, McDermott JC. Suppression of a MEF2-KLF6 survival pathway by PKA signaling promotes apoptosis in embryonic hippocampal neurons. J Neurosci 2012, 32:2790-2803. 10.1523/JNEUROSCI.3609-11.2012, 22357862.
15. Blais A, Tsikitis M, Acosta-Alvear D, Sharan R, Kluger Y, Dynlacht BD. An initial blueprint for myogenic differentiation. Genes Dev 2005, 19:553-569. 10.1101/gad.1281105, 551576, 15706034.
16. Luo K, Lodish HF. Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J 1997, 16:1970-81. 10.1093/emboj/16.8.1970, 1169800, 9155023.
17. Liu D, Black BL, Derynck R. TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Gen Dev 2001, 15:2950-2966.
18. Kollias HD, McDermott JC. Transforming growth factor - β and myostatin signaling in skeletal muscle. J Appl Physiol 2008, 104:579-587.
19. Yue J, Mulder KM. Activation of the mitogen-activated protein kinase pathway by transforming growth factor-β. Methods Mol Biol 2000, 142:125-131.
20. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 1992, 70:93-104. 10.1016/0092-8674(92)90536-L, 1623525.
21. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003, 425:577-584. 10.1038/nature02006, 14534577.
22. Liu D, Kang JS, Derynck R. TGF-β-activated Smad3 represses MEF2-depedent transcription in myogenic differentiation. EMBO 2004, 23:1557-1566.
23. Liu D, Black BL, Derynck R. TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev 2001, 15:2950-2966. 10.1101/gad.925901, 312830, 11711431.
24. Jungert K, Buck A, Buchholz M, Wagner M, Adler G, Gres TM, Ellenrieder V. Smad-Sp1 complexes mediated TGFβ-induced early transcription of oncogenic Smad7 in pancreatic cancer cells. Carcinogenesis 2006, 27:2392-2401. 10.1093/carcin/bgl078, 16714330.
25. Kollias HD, Perry RL, Miyake T, Aziz A, McDermott JC. Smad7 promotes and enhances skeletal muscle differentiation. Mol Cell Biol 2006, 26:6248-6260. 10.1128/MCB.00384-06, 1592807, 16880533.
26. Miyake T, Alli NS, McDermott JC. Nuclear function of Smad7 promotes myogenesis. Mol Cell Biol 2010, 30:722-735. 10.1128/MCB.01005-09, 2812228, 19995910.
27. Perry RL, Parker MH, Rudnicki MA. Activated MEK1 binds the nuclear MyoD transcriptional complex to repress transactivation. Mol Cell 2001, 8:291-301. 10.1016/S1097-2765(01)00302-1, 11545732.
28. Du M, Perry RL, Nowacki NB, Gordon JW, Salma J, Zhao J, Aziz A, Chan J, Siu KW, McDermott JC. Protein Kinase A represses skeletal myogenesis by targeting myocyte enhancer-binding factor 2D. Mol Cell Biol 2008, 28:2952-2970. 10.1128/MCB.00248-08, 2293079, 18299387.
29. Perry RL, Yang C, Soora N, Salma J, Marback M, Naghibi L, Ilyas H, Chan J, Gordon JW, McDermott JC. Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1 alpha represses MEF2-dependent gene expression. Mol Cell Biol 2009, 29:3355-3366. 10.1128/MCB.00227-08, 2698741, 19364819.
30. Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M, Wang XF, Massague J. TGF beta signals through heteromeric protein kinase receptor complex. Cell 1992, 71:1003-1014. 10.1016/0092-8674(92)90395-S, 1333888.
31. Donoviel DB, Shield MA, Buskin JN, Haugen HS, Clegg CH, Hauschka SD. Analysis of muscle creatine kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice. Mol Cell Biol 1996, 16:1649-1658. 231151, 8657140.
32. Quinn ZA, Yang CC, Wrana JL, McDermott JC. Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res 2001, 29:732-742. 10.1093/nar/29.3.732, 30396, 11160896.
33. Jinnin M, Ihn H, Tamaki K. Characterization of SIS3, a novel and specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol 2006, 69:597-607.
34. Burks TN, Cohn RD. Role of TGF-β signaling in inherited and acquired myopathies. Skeletal Muscle 2011, 1:19. 10.1186/2044-5040-1-19, 3156642, 21798096.
35. Bouché M, Canipari R, Melchionna R, Willems D, Senni MI, Molinaro M. TGF-beta autocrine loop regulates cell growth and myogenic differentiation in human rhabdomyosarcoma cells. FASEB J 2000, 14:1147-58.