TGF-β regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3-Sp1-KLF6 interaction

Biochemical Journal

Volumn 419, Issue 2, 2009, Pages 485-495

  Botella, Luisa M ^a   Sanz Rodriguez, Francisco ^b   Komi, Yusuke ^c   Fernandez L , Africa ^d   Varela, Elisa ^e   Garrido Martin, Eva M ^a   Narla, Goutham ^f   Friedman, Scott L ^f   Kojima, Soichi ^c  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c Chemical Biology Department   (Japan)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e FMI   (Switzerland)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alternative splicing; Endoglin; Growth regulation; Similar to mothers against decapentaplegic 3 specificity protein 1 kr pel like factor 6 interaction (Smad3 Sp1 KLF6 interaction; Transactivation; Transforming growth factor (TGF )

Indexed keywords

ALTERNATIVE SPLICING; BIOLOGICAL ACTIVITIES; CELL TYPES; CO-IMMUNOPRECIPITATION; CO-TRANSFECTION; DECAPENTAPLEGIC; ENDOGLIN; FLUORESCENCE RESONANCE ENERGY TRANSFER; GROWTH REGULATION; ISOFORMS; MALIGNANT PROGRESSION; SPECIFICITY PROTEIN 1; SPLICE VARIANTS; TARGET GENES; TRANSACTIVATION; TRANSCRIPTIONAL TARGETS; TRANSFORMING GROWTH FACTORS; TUMOUR SUPPRESSOR; VASCULAR INJURY; WILD TYPES;

BIOACTIVITY; CELL MEMBRANES; CYTOLOGY; ENDOTHELIAL CELLS; ENERGY TRANSFER; FLUORESCENCE; GENES; NUCLEIC ACIDS; PEPTIDES; TARGETS; TRANSCRIPTION FACTORS; TUMORS;

TRANSCRIPTION;

COLLAGEN; ENDOGLIN; GLUTATHIONE TRANSFERASE; KRUPPEL LIKE FACTOR 6; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA; KLF6 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; ONCOPROTEIN; SMAD3 PROTEIN, HUMAN;

ALTERNATIVE RNA SPLICING; ANGIOGENESIS; ANIMAL CELL; ARTICLE; BLOOD VESSEL INJURY; CANCER GROWTH; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; WILD TYPE; ANIMAL; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; FLOW CYTOMETRY; GENETICS; HELA CELL; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROTEIN BINDING;

ALTERNATIVE SPLICING; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; COLLAGEN; COS CELLS; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; SMAD3 PROTEIN; SP1 TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 64249153706     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081434     Document Type: Article

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