G protein-coupled receptor dimers: Look like their parents, but act like teenagers!

Journal of Receptors and Signal Transduction

Volumn 33, Issue 3, 2013, Pages 135-138

  Wertman, Jaime ^a   Dupré, Denis J ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Chaperones; GPCR dimerization; GPCR trafficking; GPCRs

Indexed keywords

CHAPERONE; G PROTEIN COUPLED RECEPTOR; HETERODIMER; HOMODIMER; RAB PROTEIN; SCAFFOLD PROTEIN;

CELL MEMBRANE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONFERENCE PAPER; DIMERIZATION; ENDOPLASMIC RETICULUM; ENERGY TRANSFER; HUMAN; INTERNALIZATION; NONHUMAN; OLIGOMERIZATION; PDZ DOMAIN; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

HUMANS; MOLECULAR CHAPERONES; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84878586254     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.3109/10799893.2012.759591     Document Type: Conference Paper

References (30)

1. White JH, Wise A, Main MJ, et al. Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 1998;396:679-82. (Pubitemid 29003946)
2. Jones KA, Borowsky B, Tamm JA, et al. GAGA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 1998;396:674-9. (Pubitemid 29003945)
3. Sullivan R, Chateauneuf A, Coulombe N, et al. Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor. J Pharmacol Exp Ther 2000;293:460-7. (Pubitemid 30244095)
4. Salahpour A, Angers S, Mercier JF, et al. Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting. J Biol Chem 2004;284:22641-8.
5. Fotiadis D, Liang Y, Filipek S, et al. Atomic-force microscopy: rhodopsin dimers in native disc membranes. Nature 2003;421:127-8. (Pubitemid 36090969)
6. Rivero-Müller A, Chou YY, Ji I, et al. Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation. Proc Natl Acad Sci USA 2010;107:2319-24.
7. Kern A, Albarran-Zeckler R, Walsh HE, Smith RG. Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron 2012;73:317-32.
8. Gupta A, Mulder J, Gomes I, et al. Increased abundance of opioid receptor heteromers after chronic morphine administration. Sci Signal 2010;3:ra54.
9. Dupré DJ, Baragli A, Rebois RV, et al. Signaling complexes associated with adenylyl cyclase II are assembled during their biosynthesis. Cell Signal 2007;19:481-9. (Pubitemid 46107799)
10. Dupré DJ, Hammad MM, Holland P, Wertman J. Role of chaperones in G protein coupled receptors signaling complex assembly. In: Dupré DJ, Hébert TE, Jockers R, eds. GPCR signaling complexes-synthesis assembly, trafficking and specificity. New York: Springer; 2012:23-42.
11. Brady AE, Limbird LE. G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction. Cell Signal 2002;14:297-309. (Pubitemid 34164685)
12. Bermak JC, Li M, Bullock C, Zhou QY. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat Cell Biol 2001;3:492-8. (Pubitemid 32422085)
13. Leclerc PC, Auger-Messier M, Lanctot PM, et al. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology 2002;143:4702-10. (Pubitemid 35397612)
14. Hammad MM, Dupré DJ. Chaperones contribute to G protein coupled receptor oligomerization, but do not participate in the assembly of the G protein with the receptor signaling complex. J Mol Signal 2010;5:16.
15. Kuang Y, Pang W, Zheng Y, Dupré DJ. NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production. Eur J Immunol 2012;42:299-310.
16. Bouvier M. Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2001;2:274-86. (Pubitemid 33673068)
17. Saito H, Kubota M, Roberts RW, et al. RTP family members induce functional expression of mammalian odorant receptors. Cell 2004;119:679-91. (Pubitemid 39535755)
18. Décaillot FM, Rozenfeld R, Gupta A, Devi LA. Cell surface targeting of the m-d opioid receptor heterodimers by RTP4. Proc Natl Acad Sci USA 2008;105:16045-50.
19. Kaykas A, Yang-Snyder J, Heroux M, et al. Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nat Cell Biol 2004;6:52-8. (Pubitemid 38425730)
20. Calebiro D, de Filippis T, Lucchi S, et al. Intracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance. Hum Mol Genet 2005;14:2991-3002. (Pubitemid 41535464)
21. Benkirane M, Jin DY, Chun RF, et al. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J Biol Chem 1997;272:30603-6. (Pubitemid 27527488)
22. Shioda T, Nakayama EE, Tanaka Y, et al. Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5. J Virol 2001;75:3462-8. (Pubitemid 32225909)
23. Dong C, Filipeanu CM, Duvernay MT, Wu G. Regulation of G protein-coupled receptor export trafficking. Biochim Biophys Acta 2007;1768:853-70. (Pubitemid 46452538)
24. Dupré DJ, Hébert TE. Biosynthesis and trafficking of seven transmembrane receptors signaling complexes. Cell Signal 2006; 18:1549-59. (Pubitemid 44219073)
25. Achour L, Scott MG, Shirvani H, et al. CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface. Blood 2009;113:1938-47.
26. Charette N, Holland P, Frazer J, et al. Dependence on difference Rab GTPases for the trafficking of CXCR4 and CCR5 homo or heterodimers between the endoplasmic reticulum and plasma membrane in jurkat cells. Cell Signal 2011;23:1738-49.
27. Hall RA, Lefkowitz RJ. Regulation of G protein-coupled receptor signaling by scaffold proteins. Circ Res 2002;91:672-80. (Pubitemid 35204949)
28. Ferguson SS. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 2001;53:1-24. (Pubitemid 32173106)
29. Hammad MM, Kuang Y, Yan R, et al. Na+/Ca+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction, but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer. J Biol Chem 2010;285:34653-64.
30. Delhaye M, Gravot A, Ayinde D, et al. Identification of a postendocytic sorting sequence in CCR5. Mol Pharmacol 2007; 72:1497-507. (Pubitemid 350146087)