Expression of the Growth Factor Progranulin in Endothelial Cells Influences Growth and Development of Blood Vessels: A Novel Mouse Model

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Toh, Huishi ^a   Cao, Mingju ^a   Daniels, Eugene ^b   Bateman, Andrew ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN RECEPTOR; PROGRANULIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BLEEDING; BRAIN HEMORRHAGE; CONTROLLED STUDY; DEATH; EMBRYO; ENDOTHELIUM CELL; FEMALE; FETUS; GENE EXPRESSION; IN VIVO STUDY; MALE; MOUSE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; SUBCUTANEOUS HEMORRHAGE; TRANSGENE; VASODILATATION;

ANIMALS; BLOOD VESSELS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE ORDER; GENETIC VECTORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOTYPE; PLACENTA; PREGNANCY; RECEPTOR, TIE-2; TRANSGENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

ANIMALIA; MUS;

EID: 84878578979     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064989     Document Type: Article

References (55)

1. Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, et al. (2009) The role of vascular endothelial growth factor in wound healing. Journal of Surgical Research 153: 347-358.
2. Bishop A, (2008) Role of oxygen in wound healing. Journal of Wound Care 17: 399-402.
3. Demir R, Yaba A, Huppertz B, (2010) Vasculogenesis and angiogenesis in the endometrium during menstrual cycle and implantation. Acta Histochemica 112: 203-214.
4. Andres AC, Djonov V, (2010) The mammary gland vasculature revisited. Journal of Mammary Gland Biology and Neoplasia 15: 319-328.
5. Cao Y, (2007) Angiogenesis modulates adipogenesis and obesity. Journal of Clinical Investigation 117: 2362-2368.
6. Lijnen HR, (2008) Angiogenesis and obesity. Cardiovascular Research 78: 286-293.
7. Papetti M, Herman IM, (2002) Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 282: C947-970.
8. Praidou A, Androudi S, Brazitikos P, Karakiulakis G, Papakonstantinou E, et al. (2010) Angiogenic growth factors and their inhibitors in diabetic retinopathy. Curr Diabetes Rev 6: 304-312.
9. Nakagawa T, Kosugi T, Haneda M, Rivard CJ, Long DA, (2009) Abnormal angiogenesis in diabetic nephropathy. Diabetes 58: 1471-1478.
10. Sullivan DC, Bicknell R, (2003) New molecular pathways in angiogenesis. British Journal of Cancer 89: 228-231.
11. He ZH, Ong CHP, Halper J, Bateman A, (2003) Progranulin is a mediator of the wound response. Nature Medicine 9: 225-229.
12. Bateman A, Bennett HP, (2009) The granulin gene family: from cancer to dementia. Bioessays 31: 1245-1254.
13. Ong CHP, Bateman A, (2003) Progranulin (Granulin-epithelin precursor, PC-cell derived growth factor, Acrogranin) in proliferation and tumorigenesis. Histology and Histopathology 18: 1275-1288.
14. Toh H, Chitramuthu BP, Bennett HP, Bateman A, (2011) Structure, function, and mechanism of progranulin; the brain and beyond. Journal of Molecular Neuroscience 45: 538-548.
15. Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, et al. (2011) Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. Journal of Clinical Investigation 121: 784-799.
16. Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, et al. (2006) Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 442: 916-919.
17. Cruts M, Gijselinck I, van der Zee J, Engelborghs S, Wils H, et al. (2006) Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature 442: 920-924.
18. Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, et al. (2002) Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell 111: 867-878.
19. Yin FF, Banerjee R, Thomas B, Zhou P, Qian LP, et al. (2010) Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. Journal of Experimental Medicine 207: 117-128.
20. Kessenbrock K, Frohlich L, Sixt M, Lammermann T, Pfister H, et al. (2008) Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest 118: 2438-2447.
21. Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, et al. (2011) The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332: 478-484.
22. Park B, Buti L, Lee S, Matsuwaki T, Spooner E, et al. (2011) Granulin is a soluble cofactor for toll-like receptor 9 signaling. Immunity 34: 505-513.
23. Daniel R, He ZH, Carmichael KP, Halper J, Bateman A, (2000) Cellular localization of gene expression for progranulin. Journal of Histochemistry & Cytochemistry 48: 999-1009.
24. Desmarais JA, Cao MJ, Bateman A, Murphy BD, (2008) Spatiotemporal expression pattern of progranulin in embryo implantation and placenta formation suggests a role in cell proliferation, remodeling, and angiogenesis. Reproduction 136: 247-257.
25. Davidson B, Alejandro E, Florenes VA, Goderstad JM, Risberg B, et al. (2004) Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma. Cancer 100: 2139-2147.
26. Gonzalez EM, Mongiat M, Slater SJ, Baffa R, Iozzo RV, (2003) A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth. Journal of Biological Chemistry 278: 38113-38116.
27. Li LQ, Min LS, Jiang Q, Ping JL, Li J, Dai LC, (2012) Progranulin expression in breast cancer with different intrinsic subtypes. Pathol Res Pract. Apr 15 208(4): 210-6.
28. Chen XY, Li JS, Liang QP, He DZ, Zhao J, (2008) Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance. Chinese Medical Journal 121: 881-886.
29. Wang M, Li G, Yin J, Lin T, Zhang J (2012) Progranulin overexpression predicts overall survival in patients with glioblastoma. Medical Oncology.
30. Tangkeangsirisin W, Serrero G, (2004) PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells. Carcinogenesis 25: 1587-1592.
31. Ho JC, Ip YC, Cheung ST, Lee YT, Chan KF, et al. (2008) Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. Hepatology 47: 1524-1532.
32. Ponce ML (2001) Angiogenesis Protocols; Murray J, editor. Totowa, NJ: Humana Press.
33. Schnurch H, Risau W, (1993) Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage. Development 119: 957-968.
34. Schlaeger TM, Bartunkova S, Lawitts JA, Teichmann G, Risau W, et al. (1997) Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 94: 3058-3063.
35. Evans V, Hatzopoulos A, Aird WC, Rayburn HB, Rosenberg RD, et al. (2000) Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics 2: 67-75.
36. Pereira R, Halford K, Sokolov BP, Khillan JS, Prockop DJ, (1994) Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1). Journal of Clinical Investigation 93: 1765-1769.
37. Miko I (2008) Phenotype Variability: Penetrance and Expressivity. Nature Education 1.
38. Drake CJ, Fleming PA, (2000) Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood 95: 1671-1679.
39. Person AD, Klewer SE, Runyan RB, (2005) Cell biology of cardiac cushion development. International Review of Cytology 243: 287-335.
40. Schroeder JA, Jackson LF, Lee DC, Camenisch TD, (2003) Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. J Mol Med (Berl) 81: 392-403.
41. Mongiat M, Fu J, Oldershaw R, Greenhalgh R, Gown AM, et al. (2003) Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. Journal of Biological Chemistry 278: 17491-17499.
42. Handler M, Yurchenco PD, Iozzo RV, (1997) Developmental expression of perlecan during murine embryogenesis. Developmental Dynamics 210: 130-145.
43. Segev A, Nili N, Strauss BH, (2004) The role of perlecan in arterial injury and angiogenesis. Cardiovascular Research 63: 603-610.
44. Hellstrom M, Kalen M, Lindahl P, Abramsson A, Betsholtz C, (1999) Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126: 3047-3055.
45. Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, et al. (2001) Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. Journal of Cell Biology 153: 543-553.
46. Zeng X, Wert SE, Federici R, Peters KG, Whitsett JA, (1998) VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo. Developmental Dynamics 211: 215-227.
47. Heazell AE, Moll SJ, Jones CJ, Baker PN, Crocker IP (2007) Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species. Placenta 28 Suppl A: S33-40.
48. Trampont P, Roudier M, Andrea AM, Nomal N, Mignot TM, et al. (2004) The placental-umbilical unit in sickle cell disease pregnancy: a model for studying in vivo functional adjustments to hypoxia in humans. Human Pathology 35: 1353-1359.
49. Khalid ME, Ali ME, Ali KZ, (1997) Full-term birth weight and placental morphology at high and low altitude. International Journal of Gynaecology and Obstetrics 57: 259-265.
50. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, et al. (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-6.
51. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, et al. (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435-439.
52. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, et al. (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439-442.
53. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, et al. (1996) Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87: 1171-80.
54. Abramsson A, Berlin O, Papayan H, Paulin D, Shani M, Betsholtz C, (2002) Analysis of mural cell recruitment to tumor vessels. Circulation 105: 112-7.
55. Silver LM (1995) Mouse Genetics Concepts and Applications: Oxford University Press.