ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

Human Molecular Genetics

Volumn 22, Issue 13, 2013, Pages 2676-2688

  Vance, Caroline ^a   Scotter, Emma L ^a   Nishimura, Agnes L ^a   Troakes, Claire ^a   Mitchell, Jacqueline C ^a   Kathe, Claudia ^a   Urwin, Hazel ^a   Manser, Catherine ^b   Miller, Christopher C ^a,b   Hortobágyi, Tibor ^a   Dragunow, Mike ^c   Rogelj, Boris ^a,d   Shaw, Christopher E ^a  

^a Department of Clinical Neuroscience ^*  (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c THE UNIVERSITY OF AUCKLAND   (New Zealand)

^d JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

FUSED IN SARCOMA PROTEIN; MUTANT PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL FRACTIONATION; CELL INCLUSION; CELL STRAIN HEK293; CYTOPLASM; FIBROBLAST; GENE DISRUPTION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOTONEURON; NERVE CELL DEGENERATION; NUCLEAR LOCALIZATION SIGNAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; RNA PROCESSING; TISSUE SECTION;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE; CELL NUCLEOLUS; CYTOPLASMIC GRANULES; HUMANS; MOTOR NEURONS; MUTATION; NUCLEAR LOCALIZATION SIGNALS; PROTEIN BINDING; PROTEIN TRANSPORT; RATS; RNA-BINDING PROTEIN FUS; STRESS, PHYSIOLOGICAL;

EID: 84878565260     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt117     Document Type: Article

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