메뉴 건너뛰기




Volumn 36, Issue 3, 2013, Pages 247-257

Composite fatty acid ether amides suppress growth of liver cancer cells in vitro and in an in vivo allograft mouse model

Author keywords

AKT; Alkyl (alkenyl)oxy isopropylamino propanol (AIP); Apoptosis; Autophagy; beta spectrin; Hepatocellular carcinoma (HCC); Tumor allograft

Indexed keywords

[1 [(1 BENZYL 3 CYCLOPROPYLAMINO 2,3 DIOXOPROPYL)CARBAMOYL] 3 METHYLBUTYL]CARBAMIC ACID 2 (2 METHOXYETHOXY)ETHYL ESTER; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 9; FATTY ACID DERIVATIVE; PROTEIN KINASE B BETA; SPECTRIN; SPHINGOSINE KINASE 2;

EID: 84878548476     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-013-0132-x     Document Type: Article
Times cited : (3)

References (40)
  • 1
    • 84862565810 scopus 로고    scopus 로고
    • Cancer stem cells and novel targets for antitumor strategies
    • 22390767 10.2174/138161212800626120
    • G.J. Prud'homme, Cancer stem cells and novel targets for antitumor strategies. Curr. Pharm. Des. 18, 2838-2849 (2012)
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 2838-2849
    • Prud'Homme, G.J.1
  • 2
    • 84863715929 scopus 로고    scopus 로고
    • Cancer stem cells and their potential implications for the treatment of solid tumors
    • 22371125 10.1002/jso.23069 1:CAS:528:DC%2BC38XpvVehsro%3D
    • B.A. Grotenhuis, B.P. Wijnhoven, J.J. van Lanschot, Cancer stem cells and their potential implications for the treatment of solid tumors. J. Surg. Oncol. 106, 209-215 (2012)
    • (2012) J. Surg. Oncol. , vol.106 , pp. 209-215
    • Grotenhuis, B.A.1    Wijnhoven, B.P.2    Van Lanschot, J.J.3
  • 3
    • 79960439415 scopus 로고    scopus 로고
    • Biology of hepatic cancer stem cells
    • 21557770 10.1111/j.1440-1746.2011.06762.x 1:CAS:528:DC%2BC3MXhtV2qsbbN
    • C.M. Tong, S. Ma, X.Y. Guan, Biology of hepatic cancer stem cells. J. Gastroenterol. Hepatol. 26, 1229-1237 (2011)
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 1229-1237
    • Tong, C.M.1    Ma, S.2    Guan, X.Y.3
  • 4
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan, 2000
    • 11668491 10.1002/ijc.1440 1:CAS:528:DC%2BD3MXntVGlu78%3D
    • D.M. Parkin, F. Bray, J. Ferlay, P. Pisani, Estimating the world cancer burden: Globocan, 2000. Int. J. Cancer 94, 153-156 (2001)
    • (2001) Int. J. Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 5
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: Worldwide incidence and trends
    • 15508102 10.1053/j.gastro.2004.09.011
    • F.X. Bosch, J. Ribes, M. Diaz, R. Cleries, Primary liver cancer: worldwide incidence and trends. Gastroenterology 127, S5-S16 (2004)
    • (2004) Gastroenterology , vol.127
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3    Cleries, R.4
  • 6
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • 14667750 10.1016/S0140-6736(03)14964-1
    • J.M. Llovet, A. Burroughs, J. Bruix, Hepatocellular carcinoma. Lancet 362, 1907-1917 (2003)
    • (2003) Lancet , vol.362 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 8
    • 39049121694 scopus 로고    scopus 로고
    • Hand-foot skin reaction in patients treated with sorafenib: A clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy
    • 18070211 10.1111/j.1365-2133.2007.08357.x 1:CAS:528:DC%2BD1cXktFeksrY%3D
    • C.H. Yang, W.C. Lin, C.K. Chuang, Y.C. Chang, S.T. Pang, Y.C. Lin, T.T. Kuo, J.J. Hsieh, J.W. Chang, Hand-foot skin reaction in patients treated with sorafenib: a clinicopathological study of cutaneous manifestations due to multitargeted kinase inhibitor therapy. Br. J. Dermatol. 158, 592-596 (2008)
    • (2008) Br. J. Dermatol. , vol.158 , pp. 592-596
    • Yang, C.H.1    Lin, W.C.2    Chuang, C.K.3    Chang, Y.C.4    Pang, S.T.5    Lin, Y.C.6    Kuo, T.T.7    Hsieh, J.J.8    Chang, J.W.9
  • 9
    • 79953221190 scopus 로고    scopus 로고
    • Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model
    • 21321535 10.1038/labinvest.2010.205 1:CAS:528:DC%2BC3MXjvFKgtLo%3D
    • M. Cao, Y. Xu, J.I. Youn, R. Cabrera, X. Zhang, D. Gabrilovich, D.R. Nelson, C. Liu, Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model. Lab Invest. 91, 598-608 (2011)
    • (2011) Lab Invest. , vol.91 , pp. 598-608
    • Cao, M.1    Xu, Y.2    Youn, J.I.3    Cabrera, R.4    Zhang, X.5    Gabrilovich, D.6    Nelson, D.R.7    Liu, C.8
  • 10
    • 79955764915 scopus 로고    scopus 로고
    • Novel therapeutic strategies for targeting liver cancer stem cells
    • 21552419 10.7150/ijbs.7.517 1:CAS:528:DC%2BC3MXlsl2gs78%3D
    • N. Oishi, X.W. Wang, Novel therapeutic strategies for targeting liver cancer stem cells. Int. J. Biol. Sci. 7, 517-535 (2011)
    • (2011) Int. J. Biol. Sci. , vol.7 , pp. 517-535
    • Oishi, N.1    Wang, X.W.2
  • 12
    • 33845981049 scopus 로고    scopus 로고
    • Successful therapy must eradicate cancer stem cells
    • 16931775 10.1634/stemcells.2006-0136 1:CAS:528:DC%2BD2sXkslCmuw%3D%3D
    • D. Dingli, F. Michor, Successful therapy must eradicate cancer stem cells. Stem Cells 24, 2603-2610 (2006)
    • (2006) Stem Cells , vol.24 , pp. 2603-2610
    • Dingli, D.1    Michor, F.2
  • 13
    • 77950672269 scopus 로고    scopus 로고
    • Targeting multiple kinase pathways: A change in paradigm
    • 20215532 10.1158/1078-0432.CCR-09-3182 1:CAS:528:DC%2BC3cXktFygu7w%3D
    • L. Gossage, T. Eisen, Targeting multiple kinase pathways: a change in paradigm. Clin. Cancer Res. 16, 1973-1978 (2010)
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1973-1978
    • Gossage, L.1    Eisen, T.2
  • 14
    • 79960934681 scopus 로고    scopus 로고
    • Survivin inhibition is critical for Bcl-2 inhibitor-induced apoptosis in hepatocellular carcinoma cells
    • 21829603 10.1371/journal.pone.0021980 1:CAS:528:DC%2BC3MXhtV2ju7rE
    • X. Zhao, O.O. Ogunwobi, C. Liu, Survivin inhibition is critical for Bcl-2 inhibitor-induced apoptosis in hepatocellular carcinoma cells. PLoS One 6, e21980 (2011)
    • (2011) PLoS One , vol.6 , pp. 21980
    • Zhao, X.1    Ogunwobi, O.O.2    Liu, C.3
  • 15
    • 54449089923 scopus 로고    scopus 로고
    • Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis
    • 18704924 10.1002/hep.22460 1:CAS:528:DC%2BD1cXht1Khu77E
    • H.J. Baek, S.C. Lim, K. Kitisin, W. Jogunoori, Y. Tang, M.B. Marshall, B. Mishra, T.H. Kim, K.H. Cho, S.S. Kim, L. Mishra, Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. Hepatology 48, 1128-1137 (2008)
    • (2008) Hepatology , vol.48 , pp. 1128-1137
    • Baek, H.J.1    Lim, S.C.2    Kitisin, K.3    Jogunoori, W.4    Tang, Y.5    Marshall, M.B.6    Mishra, B.7    Kim, T.H.8    Cho, K.H.9    Kim, S.S.10    Mishra, L.11
  • 17
    • 84855162699 scopus 로고    scopus 로고
    • Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis
    • 21388516 10.1111/j.1582-4934.2011.01290.x 1:CAS:528:DC%2BC38XhtVKls70%3D
    • Z. Wang, F. Liu, W. Tu, Y. Chang, J. Yao, W. Wu, X. Jiang, X. He, J. Lin, Y. Song, Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis. J. Cell Mol. Med. 16, 118-128 (2012)
    • (2012) J. Cell Mol. Med. , vol.16 , pp. 118-128
    • Wang, Z.1    Liu, F.2    Tu, W.3    Chang, Y.4    Yao, J.5    Wu, W.6    Jiang, X.7    He, X.8    Lin, J.9    Song, Y.10
  • 18
    • 34247110389 scopus 로고    scopus 로고
    • Hepatocellular carcinoma (HCC): An update
    • 17449346 10.1053/j.seminoncol.2007.01.007 1:CAS:528:DC%2BD2sXmtV2ku7c%3D
    • P. Rougier, E. Mitry, J.C. Barbare, J. Taieb, Hepatocellular carcinoma (HCC): an update. Semin. Oncol. 34, S12-S20 (2007)
    • (2007) Semin. Oncol. , vol.34
    • Rougier, P.1    Mitry, E.2    Barbare, J.C.3    Taieb, J.4
  • 19
    • 33748891391 scopus 로고    scopus 로고
    • Cancer stem cells
    • 16990388 10.1056/NEJMra061808 1:CAS:528:DC%2BD28XpvFKgtLY%3D
    • C.T. Jordan, M.L. Guzman, M. Noble, Cancer stem cells. N. Engl. J. Med. 355, 1253-1261 (2006)
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1253-1261
    • Jordan, C.T.1    Guzman, M.L.2    Noble, M.3
  • 21
    • 20344385260 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in cancer therapy
    • 15890640 10.3322/canjclin.55.3.178
    • I.M. Ghobrial, T.E. Witzig, A.A. Adjei, Targeting apoptosis pathways in cancer therapy. CA Cancer J. Clin. 55, 178-194 (2005)
    • (2005) CA Cancer J. Clin. , vol.55 , pp. 178-194
    • Ghobrial, I.M.1    Witzig, T.E.2    Adjei, A.A.3
  • 22
    • 7744235176 scopus 로고    scopus 로고
    • Targeting cell cycle and apoptosis for the treatment of human malignancies
    • 15530779 10.1016/j.ceb.2004.09.014 1:CAS:528:DC%2BD2cXpsVOrtbY%3D
    • A.M. Senderowicz, Targeting cell cycle and apoptosis for the treatment of human malignancies. Curr. Opin. Cell Biol. 16, 670-678 (2004)
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 670-678
    • Senderowicz, A.M.1
  • 24
    • 34047095297 scopus 로고    scopus 로고
    • The two TORCs and Akt
    • 17419990 10.1016/j.devcel.2007.03.020 1:CAS:528:DC%2BD2sXksVOhs7c%3D
    • P.T. Bhaskar, N. Hay, The two TORCs and Akt. Dev Cell 12, 487-502 (2007)
    • (2007) Dev Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 25
    • 13844273087 scopus 로고    scopus 로고
    • PI3 K-Akt pathway: Its functions and alterations in human cancer
    • 15505410 10.1023/B:APPT.0000045801.15585.dd 1:CAS:528: DC%2BD2cXovVKqu70%3D
    • M. Osaki, M. Oshimura, H. Ito, PI3 K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9, 667-676 (2004)
    • (2004) Apoptosis , vol.9 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 26
    • 77749342725 scopus 로고    scopus 로고
    • Survivin overexpression in HCC and liver cirrhosis differentially correlates with p-STAT3 and E-cadherin
    • 20054802 1:CAS:528:DC%2BC3cXislamt7g%3D
    • S. Peroukides, V. Bravou, A. Alexopoulos, J. Varakis, H. Kalofonos, H. Papadaki, Survivin overexpression in HCC and liver cirrhosis differentially correlates with p-STAT3 and E-cadherin. Histol. Histopathol. 25, 299-307 (2010)
    • (2010) Histol. Histopathol. , vol.25 , pp. 299-307
    • Peroukides, S.1    Bravou, V.2    Alexopoulos, A.3    Varakis, J.4    Kalofonos, H.5    Papadaki, H.6
  • 28
    • 84865508002 scopus 로고    scopus 로고
    • Interferon-gamma induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1)
    • 22056812 10.1016/j.canlet.2011.09.031 1:CAS:528:DC%2BC3MXhsFehu7bO
    • P. Li, Q. Du, Z. Cao, Z. Guo, J. Evankovich, W. Yan, Y. Chang, L. Shao, D.B. Stolz, A. Tsung, D.A. Geller, Interferon-gamma induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1). Cancer Lett. 314, 213-222 (2012)
    • (2012) Cancer Lett. , vol.314 , pp. 213-222
    • Li, P.1    Du, Q.2    Cao, Z.3    Guo, Z.4    Evankovich, J.5    Yan, W.6    Chang, Y.7    Shao, L.8    Stolz, D.B.9    Tsung, A.10    Geller, D.A.11
  • 29
    • 0032575377 scopus 로고    scopus 로고
    • Simultaneous degradation of alpha II- and beta II-spectrin by caspase 3 (CPP32) in apoptotic cells
    • 9712874 10.1074/jbc.273.35.22490 1:CAS:528:DyaK1cXlvValt7Y%3D
    • K.K. Wang, R. Posmantur, R. Nath, K. McGinnis, M. Whitton, R.V. Talanian, S.B. Glantz, J.S. Morrow, Simultaneous degradation of alpha II- and beta II-spectrin by caspase 3 (CPP32) in apoptotic cells. J. Biol. Chem. 273, 22490-22497 (1998)
    • (1998) J. Biol. Chem. , vol.273 , pp. 22490-22497
    • Wang, K.K.1    Posmantur, R.2    Nath, R.3    McGinnis, K.4    Whitton, M.5    Talanian, R.V.6    Glantz, S.B.7    Morrow, J.S.8
  • 30
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • 14744432 10.1016/S0092-8674(04)00046-7 1:CAS:528:DC%2BD2cXhtValsrY%3D
    • N.N. Danial, S.J. Korsmeyer, Cell death: critical control points. Cell 116, 205-219 (2004)
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 32
    • 34250824671 scopus 로고    scopus 로고
    • TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis
    • 17492404 10.1007/s10495-007-0073-9 1:CAS:528:DC%2BD2sXmvVyqurc%3D
    • L. Wang, C. Yu, Y. Lu, P. He, J. Guo, C. Zhang, Q. Song, D. Ma, T. Shi, Y. Chen, TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis. Apoptosis 12, 1489-1502 (2007)
    • (2007) Apoptosis , vol.12 , pp. 1489-1502
    • Wang, L.1    Yu, C.2    Lu, Y.3    He, P.4    Guo, J.5    Zhang, C.6    Song, Q.7    Ma, D.8    Shi, T.9    Chen, Y.10
  • 33
    • 79952694861 scopus 로고    scopus 로고
    • BH3-only proteins: Orchestrators of apoptosis
    • 21146563 10.1016/j.bbamcr.2010.11.024 1:CAS:528:DC%2BC3MXjsFCgs7g%3D
    • A. Shamas-Din, H. Brahmbhatt, B. Leber, D.W. Andrews, BH3-only proteins: orchestrators of apoptosis. Biochim. Biophys. Acta 1813, 508-520 (2011)
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 508-520
    • Shamas-Din, A.1    Brahmbhatt, H.2    Leber, B.3    Andrews, D.W.4
  • 34
    • 78751550257 scopus 로고    scopus 로고
    • Autophagy modulation for cancer therapy
    • 21263212 10.4161/cbt.11.2.14663 1:CAS:528:DC%2BC3MXislyhtbk%3D
    • Z.J. Yang, C.E. Chee, S. Huang, F. Sinicrope, Autophagy modulation for cancer therapy. Cancer Biol. Ther. 11, 169-176 (2011)
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 169-176
    • Yang, Z.J.1    Chee, C.E.2    Huang, S.3    Sinicrope, F.4
  • 35
    • 79955025768 scopus 로고    scopus 로고
    • Investigations of survivin: The past, present and future
    • 21196211 10.2741/3728 1:CAS:528:DC%2BC3MXisVGnuro%3D
    • C.H. Cheung, L. Cheng, K.Y. Chang, H.H. Chen, J.Y. Chang, Investigations of survivin: the past, present and future. Front. Biosci. 16, 952-961 (2011)
    • (2011) Front. Biosci. , vol.16 , pp. 952-961
    • Cheung, C.H.1    Cheng, L.2    Chang, K.Y.3    Chen, H.H.4    Chang, J.Y.5
  • 36
    • 10544238107 scopus 로고    scopus 로고
    • Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis
    • 8940103 10.1074/jbc.271.49.31075 1:CAS:528:DyaK28Xns1Wqt7Y%3D
    • D.M. Vanags, M.I. Porn-Ares, S. Coppola, D.H. Burgess, S. Orrenius, Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. J. Biol. Chem. 271, 31075-31085 (1996)
    • (1996) J. Biol. Chem. , vol.271 , pp. 31075-31085
    • Vanags, D.M.1    Porn-Ares, M.I.2    Coppola, S.3    Burgess, D.H.4    Orrenius, S.5
  • 37
    • 0030893206 scopus 로고    scopus 로고
    • Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis
    • 9051790 10.1097/00001756-199612200-00050 1:CAS:528:DyaK2sXhvFeksro%3D
    • R. Nath, K.J. Raser, K. McGinnis, R. Nadimpalli, D. Stafford, K.K. Wang, Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis. Neuroreport 8, 249-255 (1996)
    • (1996) Neuroreport , vol.8 , pp. 249-255
    • Nath, R.1    Raser, K.J.2    McGinnis, K.3    Nadimpalli, R.4    Stafford, D.5    Wang, K.K.6
  • 38
    • 0029854806 scopus 로고    scopus 로고
    • Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis
    • 8920967 1:CAS:528:DyaK28Xnt1Gmt7o%3D
    • R. Nath, K.J. Raser, D. Stafford, I. Hajimohammadreza, A. Posner, H. Allen, R.V. Talanian, P. Yuen, R.B. Gilbertsen, K.K. Wang, Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme- like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis. Biochem. J. 319, 683-690 (1996)
    • (1996) Biochem. J. , vol.319 , pp. 683-690
    • Nath, R.1    Raser, K.J.2    Stafford, D.3    Hajimohammadreza, I.4    Posner, A.5    Allen, H.6    Talanian, R.V.7    Yuen, P.8    Gilbertsen, R.B.9    Wang, K.K.10
  • 39
    • 0026030612 scopus 로고
    • Neuronal fodrin proteolysis occurs independently of excitatory amino acid-induced neurotoxicity
    • 1848081 10.1016/0896-6273(91)90252-U
    • A.M. Di Stasi, V. Gallo, M. Ceccarini, T.C. Petrucci, Neuronal fodrin proteolysis occurs independently of excitatory amino acid-induced neurotoxicity. Neuron 6, 445-454 (1991)
    • (1991) Neuron , vol.6 , pp. 445-454
    • Di Stasi, A.M.1    Gallo, V.2    Ceccarini, M.3    Petrucci, T.C.4
  • 40
    • 36148990505 scopus 로고    scopus 로고
    • The calpains: Modular designs and functional diversity
    • 17608959 10.1186/gb-2007-8-6-218
    • D.E. Croall, K. Ersfeld, The calpains: modular designs and functional diversity. Genome Biol. 8, 218 (2007)
    • (2007) Genome Biol. , vol.8 , pp. 218
    • Croall, D.E.1    Ersfeld, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.