Immune complexes activate human endothelium involving the cell-signaling HMGB1-RAGE axis in the pathogenesis of lupus vasculitis

Laboratory Investigation

Volumn 93, Issue 6, 2013, Pages 626-638

  Sun, Wenping ^a   Jiao, Yulian ^a   Cui, Bin ^a   Gao, Xuejun ^a   Xia, Yu ^a   Zhao, Yueran ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

endothelial activation; HMGB1 RAGE axis; immune complexes; lupus vasculitis; NF B; systemic lupus erythematosus

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADVANCED GLYCATION END PRODUCT RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ADOLESCENT; ADULT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BLOOD SAMPLING; CELL MIGRATION; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; INFLAMMATION; MALE; MONOCYTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION; VASCULITIS; WESTERN BLOTTING;

ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, NEOPLASM; CELL SURVIVAL; CYTOKINES; ENDOTHELIUM, VASCULAR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HMGB1 PROTEIN; HUMANS; IMIDAZOLES; INTERCELLULAR ADHESION MOLECULE-1; LUPUS VASCULITIS, CENTRAL NERVOUS SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; SULFONES; TRANSCRIPTION FACTOR RELA; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; U937 CELLS; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84878540640     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2013.61     Document Type: Article

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