Route to destruction: Autophagosomes SNARE lysosomes

Journal of Cell Biology

Volumn 201, Issue 4, 2013, Pages 495-497

  Krämer, Helmut ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; MULTIPROTEIN COMPLEX; SNARE PROTEIN; SYNTAXIN; SYNTAXIN 17; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DESTRUCTION; CELL FRACTIONATION; CELL MATURATION; CELLULAR DISTRIBUTION; CONJUGATION; DROSOPHILA MELANOGASTER; ENDOSOME; GENETIC ANALYSIS; LYSOSOME; MEMBRANE FUSION; MOLECULAR IMAGING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; LYSOSOMES; NEURONS; PHAGOSOMES; QA-SNARE PROTEINS; R-SNARE PROTEINS; SNARE PROTEINS;

EID: 84878537792     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201304065     Document Type: Article

References (15)

1. Dilcher, M., B. Köhler, and G.F. von Mollard. 2001. Genetic interactions with the yeast Q-SNARE VTI1 reveal novel functions for the R-SNARE YKT6. J. Biol. Chem. 276:34537-34544. http://dx.doi.org/10.1074/jbc.M101551200
2. Filimonenko, M., S. Stuffers, C. Raiborg, A. Yamamoto, L. Malerød, E.M. Fisher, A. Isaacs, A. Brech, H. Stenmark, and A. Simonsen. 2007. Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J. Cell Biol. 179:485-500. http://dx.doi.org/10.1083/jcb.200702115
3. Fischer von Mollard, G., and T.H. Stevens. 1999. The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole. Mol. Biol. Cell. 10:1719-1732.
4. Hamasaki, M., N. Furuta, A. Matsuda, A. Nezu, A. Yamamoto, N. Fujita, H. Oomori, T. Noda, T. Haraguchi, Y. Hiraoka, et al. 2013. Autophagosomes form at ER-mitochondria contact sites. Nature. 495:389-393. http://dx.doi.org/10.1038/nature11910
5. Hara, T., K. Nakamura, M. Matsui, A. Yamamoto, Y. Nakahara, R. Suzuki-Migishima, M. Yokoyama, K. Mishima, I. Saito, H. Okano, and N. Mizushima. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 441:885-889. http://dx.doi.org/10.1038/nature04724
6. Ishihara, N., M. Hamasaki, S. Yokota, K. Suzuki, Y. Kamada, A. Kihara, T. Yoshimori, T. Noda, and Y. Ohsumi. 2001. Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol. Biol. Cell. 12:3690-3702.
7. Itakura, E., C. Kishi-Itakura, and N. Mizushima. 2012. The hairpin-type tailanchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell. 151:1256-1269. http://dx.doi.org/10.1016/j.cell.2012.11.001
8. Juhász, G., B. Erdi, M. Sass, and T.P. Neufeld. 2007. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 21:3061-3066. http://dx.doi.org/10.1101/gad.1600707
9. Klionsky, D.J., and Y. Ohsumi. 1999. Vacuolar import of proteins and organelles from the cytoplasm. Annu. Rev. Cell Dev. Biol. 15:1-32. http://dx.doi.org/10.1146/annurev.cellbio.15.1.1
10. Komatsu, M., S. Waguri, T. Chiba, S. Murata, J.-i. Iwata, I. Tanida, T. Ueno, M. Koike, Y. Uchiyama, E. Kominami, and K. Tanaka. 2006. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 441:880-884. http://dx.doi.org/10.1038/nature04723
11. Kroemer, G., G. Mariño, and B. Levine. 2010. Autophagy and the integrated stress response. Mol. Cell. 40:280-293. http://dx.doi.org/10.1016/j.molcel.2010.09.023
12. Mizushima, N., T. Yoshimori, and Y. Ohsumi. 2011. The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27:107-132. http://dx.doi.org/10.1146/annurev-cellbio-092910-154005
13. Ohashi, Y., and S. Munro. 2010. Membrane delivery to the yeast autophagosome from the Golgi-endosomal system. Mol. Biol. Cell. 21:3998-4008. http://dx.doi.org/10.1091/mbc.E10-05-0457
14. Rusten, T.E., T. Vaccari, K. Lindmo, L.M. Rodahl, I.P. Nezis, C. Sem-Jacobsen, F. Wendler, J.-P. Vincent, A. Brech, D. Bilder, and H. Stenmark. 2007. ESCRTs and Fab1 regulate distinct steps of autophagy. Curr. Biol. 17:1817-1825. http://dx.doi.org/10.1016/j.cub.2007.09.032
15. Takáts, S., P. Nagy, A. Varga, K. Pircs, M. Kárpáti, K. Varga, A.L. Kovács, K. Hegedu{double acute}s, and G. Juhász. 2013. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J. Cell Biol. 201:531-539.