Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells

Nutrition and Cancer

Volumn 65, Issue SUPPL.1, 2013, Pages 36-43

  Singh, Narendra ^a   Nambiar, Dhanya ^b   Kale, Raosaheb K ^a,b   Singh, Rana P ^a,b  

^a CENTRAL UNIVERSITY OF GUJARAT   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE; USNIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DEATH; CELL GROWTH; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CLONOGENESIS; COLONY FORMATION; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUNG CARCINOMA; MITOCHONDRIAL MEMBRANE; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOFURANS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G1 PHASE; GENE EXPRESSION REGULATION; HUMANS; LICHENS; LUNG NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84878530453     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2013.785007     Document Type: Conference Paper

References (34)

1. World Health Organization. 2004. The global burden of disease. Retrieved from http://www.who.int/healthinfo/global-burden-disease/GBD-report-2004update- full.pdf
2. Ferlay, J, Shin, H R, Bray, F, Forman, D, Mathers, C. 2010. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127: 2893-2917.
3. Jemal, A, Bray, F, Center, M M, Ferlay, J, Ward, E. 2011. Global cancer statistics. CA Cancer J Clin, 61: 69-90.
4. Mateen, S, Tyagi, A, Agarwal, C, Singh, R P, and, Agarwal, R. 2010. Silibinin inhibits human non-small cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators. Mol Carcinog, 49: 247-258.
5. Ouédraogo, M, Charles, C, Ouédraogo, M, Guissou, I P, Stévigny, C. 2011. An overview of cancer chemopreventive potential and safety of proanthocyanidins. Nutr Cancer, 63: 1163-1173.
6. Russo, M, Spagnuolo, C, Tedesco, I, and, Russo, G L. 2010. Phytochemicals in cancer prevention and therapy: truth or dare?. Toxins, 2: 517-551.
7. Cocchietto, M, Skert, N, Nimis, P L, and, Sava, G. 2002. A review on usnic acid, an interesting natural compound. Naturwissenschaften, 89: 137-146. (Pubitemid 34478371)
8. Huneck, S. 1999. The significance of lichens and their metabolites. Naturwissenschaften, 86: 559-570. (Pubitemid 30009978)
9. Bačkorová, M, Bačkor, M, Mikeš, J, Jendželovský, R, and, Fedoročko, P. 2011. Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid. Toxicol In Vitro, 25: 37-44.
10. Ingólfsdóttir, K. 2002. Usnic acid. Phytochemistry, 61: 729-736.
11. Guo, L, Shi, Q, Fang, J L, Mei, N, Ali, A A. 2008. Review of usnic acid and Usnea barbata toxicity. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 26: 317-338. (Pubitemid 352790466)
12. ONeill, M A, Mayer, M, Murray, K E, Rolim-Santos, H M, Santos-Magalhães, N S. 2010. Does usnic acid affect microtubules in human cancer cells?. Braz J Biol, 70: 659-664.
13. Sanchez, W, Maple, J T, Burgart, L J, and, Kamath, P S. 2006. Severe hepatotoxicity associated with use of a dietary supplement containing usnic acid. Mayo Clin Proc, 81: 541-544.
14. Kupchan, S M, and, Kopperman, H L. 1975. l-usnic acid: Tumor inhibitor isolated from lichens. Experientia, 31: 625
15. Bhat, T A, Nambiar, D, Pal, A, Agarwal, R, and, Singh, R P. 2012. Fisetin inhibits various attributes of angiogenesis in vitro and in vivo implications for angioprevention. Carcinogenesis, 33: 385-393.
16. Burton, J D. 2005. The MTT assay to evaluate chemosensitivity. Methods Mol Med, 110: 69-78.
17. Franken, N A, Rodermond, H M, Stap, J, Haveman, J, and, van Bree, C. 2006. Clonogenic assay of cells in vitro. Nat Protoc, 1: 2315-2319.
18. Yim, D, Singh, R P, Agarwal, C, Lee, S, Chi, H. 2005. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res, 65: 1035-1044. (Pubitemid 40216466)
19. Luo, K W, Sun, J G, Chan, J Y, Yang, L, Wu, S H. 2011. Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways. Chemotherapy, 57: 449-459.
20. Varghese, L, Agarwal, C, Tyagi, A, Singh, R P, and, Agarwal, R. 2005. Silibinin efficacy against human hepatocellular carcinoma. Clin Cancer Res, 11: 8441-8448. (Pubitemid 41746959)
21. Williams, G H, and, Stoeber, K. 2012. The cell cycle and cancer. J Pathol, 226: 352-364.
22. Singh, T, Sharma, S D, and, Katiyar, S K. 2011. Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PLoS One, 6: e27444
23. De Paepe, B, Smet, J, Vanlander, A, Seneca, S, Lissens, W. 2012. Fluorescence imaging of mitochondria in cultured skin fibroblasts: a useful method for detection of oxidative phosphorylation defects. Pediatr Res, 72: 232-240. doi: 10.1038/pr.2012.84
24. Sheu, M J, Huang, G J, Wu, C H, Chen, J S, Chang, H Y. 2004. Ethanol extract of Dunaliella salina induces cell cycle arrest and apoptosis in A549 human non-small cell lung cancer cells. In Vivo, 212: 369-378.
25. Koparal, A T, Tüylü, B A, and, Türk, H. 2006. In vitro cytotoxic activities of (+)-usnic acid and (-)-usnic acid on V79, A549, and human lymphocyte cells and their non-genotoxicity on human lymphocytes. Nat Prod Res, 20: 1300-1307. (Pubitemid 47161214)
26. Preston, B D, Albertson, T M, and, Herr, A J. 2010. DNA replication fidelity and cancer. Semin Cancer Biol, 20: 281-293.
27. Baldi, A, De Luca, A, Esposito, V, Campioni, M, Spugnini, E P. 2011. Tumor suppressors and cell-cycle proteins in lung cancer. Patholog Res Int, 2011: 1-12. doi: 10.4061/2011/605042)
28. Bryja, V, Pacherník, J, Vondrácek, J, Soucek, K, Cajánek, L. 2008. Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin. Cell Prolif, 41: 875-893.
29. Hao, M, Chen, X, Zhang, T, Shen, T, Xie, Q. 2011. Impaired nuclear export of tumor-derived c-terminal truncated cyclin D1 mutant in ESCC cancer. Oncol Lett, 2: 1203-1211.
30. Wu, A, Wu, B, Guo, J, Luo, W, Wu, D. 2011. Elevated expression of CDK4 in lung cancer. J Transl Med, 9: 38
31. Abbas, T, and, Dutta, A. 2009. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer, 9: 400-414.
32. Bressenot, A, Marchal, S, Bezdetnaya, L, Garrier, J, Guillemin, F. 2009. Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma. J Histochem Cytochem, 57: 289-300.
33. Annunziata, C M, and, OShaughnessy, J. 2010. Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer. Clin Cancer Res, 16: 4517-4526.
34. Krishna, D R, and, Venkataramana, D. 1992. Pharmacokinetics of D(+)-usnic acid in rabbits after intravenous and oral administration. Drug Metab Dispos, 20: 909-911.