Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D

Biochimie

Volumn 95, Issue 7, 2013, Pages 1379-1385

  Zhang, Yanfeng ^a,f   Gardberg, Anna S ^b,e   Edwards, Thomas E ^b,e   Sankaran, Banumathi ^c   Robinson, Howard ^d   Varnum, Susan M ^a   Buchko, Garry W ^a,e  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b Emerald BioStructures   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

^e SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Botulinum neurotoxin; Botulism; Endocytosis; Ganglioside; Protein; X ray crystallography

Indexed keywords

BOTULINUM TOXIN; ETHYLENE GLYCOL; SULFATE; TETRAETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HEAVY CHAIN; HYDROPHILICITY; HYDROPHOBICITY; MEMBRANE BINDING; MOSAICISM; NERVE CELL; NONHUMAN; PHOSPHOLIPID MEMBRANE; PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SEROTYPE;

AMINO ACID SEQUENCE; BINDING SITES; BOTULINUM TOXINS; CRYSTALLOGRAPHY, X-RAY; GANGLIOSIDES; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM BOTULINUM;

EID: 84878530224     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.03.006     Document Type: Article

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