Association of TLR4 Gene rs2149356 Polymorphism with Primary Gouty Arthritis in a Case-Control Study

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Qing, Yu Feng ^a   Zhou, Jing Guo ^a   Zhang, Quan Bo ^a   Wang, Dong Sheng ^a   Li, Min ^a   Yang, Qi Bin ^a   Huang, Cui Ping ^a   Yin, Ling ^a   Pan, Shu Yue ^a   Xie, Wen Guang ^a   Zhang, Meng Yun ^a   Pu, Meng Jun ^a   Zeng, Mei ^a  

^a AFFILIATED HOSPITAL OF NORTH SICHUAN MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B100; GLOBULIN; GLUCOSE; INTERLEUKIN 1BETA; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ALLELE; ARTICLE; BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GOUT; HETEROZYGOTE; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFLAMMATION; LEUKOCYTE COUNT; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TLR4 GENE; TRIACYLGLYCEROL BLOOD LEVEL;

ARTHRITIS, GOUTY; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; ETHNIC GROUPS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLOBULINS; HUMANS; HYPERURICEMIA; INTERLEUKIN-11; INTERLEUKIN-1BETA; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84878495502     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064845     Document Type: Article

References (28)

1. Richette P, Bardin T, (2010) Gout. Lancet 375: 318-328.
2. Baker JF, Schumacher HR (2010 Update on gout and hyperuricemia. Int. J. Clin. Pract 64: 371-377.
3. Weaver AL, (2008) Epidemiology of gout. Cleve. Clin. J. Med 75: S9-12.
4. Miao Z, Li C, Chen Y, Zhao S, Wang Y, et al. (2008) Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China. J. Rheumatol 35: 1859-1864.
5. Annemans L, Spaepen E, Gaskin M, Bonnemaire M, Malier V, et al. (2008) Gout in the UK and Germany: prevalence, comorbidies and management in general practice 2000-2005. Ann. Rheum. Dis 67: 960-966.
6. Stark K, Reinhard W, Neureuther K, Wiedmann S, Sedlacek K, et al. (2008) Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS One 3: e1948.
7. Shin Y, Evans JE, Rock KL, (2003) Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425: 516-521.
8. Ghaemi-Oskouie F, Shi Y, (2011) The Role of Uric Acid as an Endogenous Danger Signal in Immunity and Inflammation. Curr Rheumatol Rep 13: 160-166.
9. Dalbeth N, Merriman T, (2009) Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout. Rheumatology (Oxford) 48: 222-226.
10. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, et al. (2009) Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 5: e1000504.
11. Miao ZM, Zhao SH, Wang YG, (2006) Epidemiological survey of hyperuricemia and gout in coastal areas of Shandong province. Chin J Endocrinol Metab 22: 421-425.
12. Martinon F, Mayor A, Tschopp J, (2009) The inflammasomes: guardians of the body. Annu Rev Immunol 27: 229-235.
13. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088.
14. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, et al. (1992) Cutting edge: Toll-like receptor (TLR) 4-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752.
15. Ohashi K, Burkart V, Flohé S, Kolb H, (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164: 558-561.
16. Radstake TR, Franke B, Hanssen S, Netea MG, Welsing P,et al. The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Arthritis Rheum 50: 999-1001.
17. Shen X, Shi R, Zhang H, Li K, Zhao Y, Zhang R, (2010) The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: a meta-analysis. Digestion 81: 69-77.
18. Ahmad-Nejad P, Mrabet-Dahbi S, Breuer K, Klotz M, Werfel T, et al. (2004) The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype. J Allergy Clin Immunol 11: 565-567.
19. Werner M, Topp R, Wimmer K, Richter K, Bischof W, et al. (2003) TLR4 gene variants modify endotoxin effects on asthma. J Allergy Clin Immunol 112: 323-330.
20. Abu-Maziad A, Schaa K, Bell EF, Dagle JM, Cooper M, et al. (2010) Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Pediatr Res 68: 323-329.
21. Lindström S, Hunter DJ, Grönberg H, Stattin P, Wiklund F, et al. (2010) Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies. Cancer Epidemiol Biomarkers Prev 19: 873-876.
22. Shibuya E, Meguro A, Ota M, Kashiwagi K, Mabuchi F, et al. (2008) Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma. Invest Ophthalmol Vis Sci 49: 4453-4457.
23. Wallace SL, Robinson H, Masi AT, Decker JL, McCarty DJ, et al. (1977) Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum 20: 895-900.
24. Lewis CM, (2002) Genetic association studies: design, analysis and interpretation. Brief Bioinform. 3: 146-153.
25. Stark K, Reinhard W, Neureuther K, Wiedmann S, Sedlacek K, et al. (2008) Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS One 3: e1948.
26. Cawthon RM, (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30: e47.
27. Gil ME, Coetzer TL, (2004) Real-time quantitative PCR of telomere length. Mol Biotechnol 27: 169-172.
28. Schmittgen TD, Livak KJ, (2008) Analyzing real-time PCR data by the comparative C (T) method. Nat Protoc 3: 1101-1108.