Evaluation of perturbations in serum thyroid hormones during human pregnancy due to dietary iodide and perchlorate exposure using a biologically based dose-response model

Toxicological Sciences

Volumn 133, Issue 2, 2013, Pages 320-341

  Lumen, Annie ^a,b   Mattie, David R ^c   Fisher, Jeffrey W ^b  

^a HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c WRIGHT PATTERSON AIR FORCE BASE   (United States)

Author keywords

BBDR HPT axis model; Fetus; Human pregnancy; Iiodide; Perchlorate; Thyroid hormones

Indexed keywords

IODIDE; LIOTHYRONINE; PERCHLORATE; THYROID HORMONE; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIETARY INTAKE; HOMEOSTASIS; HORMONE SYNTHESIS; HUMAN; HYPOTHYROIDISM; KIDNEY CLEARANCE; LIOTHYRONINE BLOOD LEVEL; NONHUMAN; PREGNANCY; THIRD TRIMESTER PREGNANCY; THYROID HORMONE BLOOD LEVEL; THYROID HORMONE METABOLISM; THYROXINE BLOOD LEVEL;

BBDR-HPT AXIS MODEL; FETUS; HUMAN PREGNANCY.; IODIDE; PERCHLORATE; THYROID HORMONES;

ADULT; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETUS; FOOD CONTAMINATION; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IODIDES; MATERNAL-FETAL EXCHANGE; MODELS, BIOLOGICAL; PERCHLORATES; PREGNANCY; THYROID GLAND; THYROID HORMONES;

EID: 84878494710     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft078     Document Type: Article

References (116)

1. Aboul-Khair, S. A., Crooks, J., Turnbull, A. C., and Hytten, F. E. (1964). The physiological changes in thyroid function during pregnancy. Clin. Sci. 27, 195-207.
2. Belshaw, B. E., Barandes, M., Becker, D. V., and Berman, M. (1974). A model of iodine kinetics in the dog. Endocrinology 95, 1078-1093.
3. Berson, S. A., and Yalow, R. S. (1955). The iodide trapping and binding functions of the thyroid. J. Clin. Invest. 34, 186-204.
4. Bianco, A. C., and Larsen, P. R. (2005). Intracellular pathways of iodothyroinine metabolism. In The Thyroid (L. E. Braverman and R. D. Utiger, Eds.), pp. 109-133. Lippincott-Williams & Wilkins, Philadelphia, PA.
5. Blount, B. C., Pirkle, J. L., Osterloh, J. D., Valentin-Blasini, L., and Caldwell, K. L. (2006). Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States. Environ. Health Perspect. 114, 1865-1871.
6. Braverman, L. E., He, X., Pino, S., Cross, M., Magnani, B., Lamm, S. H., Kruse, M. B., Engel, A., Crump, K. S., and Gibbs, J. P. (2005). The effect of perchlorate, thiocyanate, and nitrate on thyroid function in workers exposed to perchlorate long-term. J. Clin. Endocrinol. Metab. 90, 700-706.
7. Braverman, L. E., Pearce, E. N., He, X., Pino, S., Seeley, M., Beck, B., Magnani, B., Blount, B. C., and Firek, A. (2006). Effects of six months of daily low-dose perchlorate exposure on thyroid function in healthy volunteers. J. Clin. Endocrinol. Metab. 91, 2721-2724.
8. Brown, R. A., Al-Moussa, M., and Beck, J. (1986). Histometry of normal thyroid in man. J. Clin. Pathol. 39, 475-482.
9. Brown, R. P., Delp, M. D., Lindstedt, S. L., Rhomberg, L. R., and Beliles, R. P. (1997). Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 13, 407-484.
10. Brown, R. S., Huang, S. A., and Fisher, D. A. (2005). The maturation of thyroid function in the perinatal period and during childhood. In The Thyroid (L. E. Braverman and R. D. Utiger, Eds.), pp. 1013-1028. Lippincott-Williams & Wilkins, Philadelphia, PA.
11. Burrow, G. N. (1993). Thyroid function and hyperfunction during gestation. Endocr. Rev. 14, 194-202.
12. Caldwell, K. L., Makhmudov, A., Ely, E., Jones, R. L., and Wang, R. Y. (2011). Iodine status of the U.S. population, National Health and Nutrition Examination Survey, 2005-2006 and 2007-2008. Thyroid 21, 419-427.
13. Chanoine, J. P., Toppet, V., Lagasse, R., Spehl, M., and Delange, F. (1991). Determination of thyroid volume by ultrasound from the neonatal period to late adolescence. Eur. J. Pediatr. 150, 395-399.
14. Chapman, E. M., and Corner, G. W., Jr. (1948). The collection of radioactive iodine by the human fetal thyroid. J. Clin. Endocrinol. Metab. 8, 717-720.
15. Chopra, I. J. (1976). An assessment of daily production and significance of thyroidal secretion of 3, 3', 5'-triiodothyronine (reverse T3) in man. J. Clin. Invest. 58, 32-40.
16. Clewell, R. A., Merrill, E. A., Gearhart, J. M., Robinson, P. J., Sterner, T. R., Mattie, D. R., and Clewell, H. J., 3rd. (2007). Perchlorate and radioiodide kinetics across life stages in the human: Using PBPK models to predict dosimetry and thyroid inhibition and sensitive subpopulations based on developmental stage. J. Toxicol. Environ. Health Part A 70, 408-428.
17. Clewell, R. A., Merrill, E. A., Yu, K. O., Mahle, D. A., Sterner, T. R., Mattie, D. R., Robinson, P. J., Fisher, J. W., and Gearhart, J. M. (2003). Predicting fetal perchlorate dose and inhibition of iodide kinetics during gestation: A physiologically- based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat. Toxicol. Sci. 73, 235-255.
18. Costeira, M. J., Oliveira, P., Ares, S., Roque, S., de Escobar, G. M., and Palha, J. A. (2010). Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population. Thyroid 20, 995-1001.
19. de Escobar, G. M., Obregón, M. J., and del Rey, F. E. (2004). Maternal thyroid hormones early in pregnancy and fetal brain development. Best Pract. Res. Clin. Endocrinol. Metab. 18, 225-248.
20. Delange, F. (1998). Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control. Thyroid 8, 1185-1192.
21. Delange, F. (2001). Iodine deficiency as a cause of brain damage. Postgrad. Med. J. 77, 217-220.
22. Delange, F., Camus, M., and Ermans, A. M. (1972). Circulating thyroid hormones in endemic goiter. J. Clin. Endocrinol. Metab. 34, 891-895.
23. Delange, F. M., and Dunn, J. T. (2005). Iodine deficiency. In The Thyroid (L. E. Braverman and R. D. Utiger, Eds.), pp. 264-288. Lippincott-Williams & Wilkins, Philadelphia, PA.
24. Distefano, J. J., 3rd, and Fisher, D. A. (1976). Peripheral distribution and metabolism of the thyroid hormones: A primarily quantitative assessment. Pharmacol. Ther. B. 2, 539-570.
25. Dowling, J. T., Appleton, W. G., and Nicoloff, J. T. (1967). Thyroxine turnover during human pregnancy. J. Clin. Endocrinol. Metab. 27, 1749-1750.
26. Dumont, J. E., Ermans, A. M., Maenhaut, C., Coppée, F., and Stanbury, J. B. (1995). Large goitre as a maladaptation to iodine deficiency. Clin. Endocrinol. (Oxf) 43, 1-10.
27. Durand, J. (1938). Recherches sur l'elimination des perchlorates, sur leur repartition dans les organes et sur leur toxicite [Research on the elimination of perchlorate, its distribution in organs and its toxicity]. Bull. Soc. Chim. Biol. 20, 423-433.
28. Dussault, J., Row, V. V., Lickrish, G., and Volpé, R. (1969). Studies of serum triiodothyronine concentration in maternal and cord blood: Transfer of triiodothyronine across the human placenta. J. Clin. Endocrinol. Metab. 29, 595-603.
29. Eichler, O. (1929). Zur Pharmakologie der Perchloratwirkung [The pharmacology of the perchlorate effect]. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 144, 251-260.
30. Eisenberg, M., Samuels, M., and DiStefano, J. J., 3rd. (2008). Extensions, validation, and clinical applications of a feedback control system simulator of the hypothalamo-pituitary-thyroid axis. Thyroid 18, 1071-1085.
31. Eisenberg, M. C., Santini, F., Marsili, A., Pinchera, A., and DiStefano, J. J., 3rd. (2010). TSH regulation dynamics in central and extreme primary hypothyroidism. Thyroid 20, 1215-1228.
32. FAO and WHO. (2005). Vitamin and Mineral Requirements in Human Nutrition, 2nd ed. World Health Organization, Geneva.
33. Fisher, D. A., and Oddie, T. H. (1964). Whole-body counting of 131-i-labeled triiodothyronine. J. Clin. Endocrinol. Metab. 24, 733-739.
34. Fisher, D. A., Oddie, T. H., and Thompson, C. S. (1971). Thyroidal thyronine and non-thyronine iodine secretion in euthyroid subjects. J. Clin. Endocrinol. Metab. 33, 647-652.
35. Glinoer, D. (1997). The regulation of thyroid function in pregnancy: Pathways of endocrine adaptation from physiology to pathology. Endocr. Rev. 18, 404-433.
36. Glinoer, D. (2006). Iodine nutrition requirements during pregnancy. Thyroid 16, 947-948.
37. Glinoer, D., and Delange, F. (2000). The potential repercussions of maternal, fetal, and neonatal hypothyroxinemia on the progeny. Thyroid 10, 871-887.
38. Gluzman, B. E., and Niepomniszcze, H. (1983). Kinetics of the iodide trapping mechanism in normal and pathological human thyroid slices. Acta Endocrinol. 103, 34-39.
39. Greer, M. A., Goodman, G., Pleus, R. C., and Greer, S. E. (2002). Health effects assessment for environmental perchlorate contamination: The dose response for inhibition of thyroidal radioiodine uptake in humans. Environ. Health Perspect. 110, 927-937.
40. Habermann, J., Eversmann, T., Erhardt, F., Gottsmann, M., Ulbrecht, G., and Scriba, P. C. (1978). Increased urinary excretion of triiodothyronine (T3) and thyroxine (T4) and decreased serum thyreotropic hormone (TSH) induced by motion sickness. Aviat. Space. Environ. Med. 49(1 Pt 1), 58-61.
41. Haddow, J. E., Palomaki, G. E., Allan, W. C., Williams, J. R., Knight, G. J., Gagnon, J., O'Heir, C. E., Mitchell, M. L., Hermos, R. J., Waisbren, S. E., et al. (1999). Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N. Engl. J. Med. 341, 549-555.
42. Halnan, K. E. (1958). The radioiodine uptake of the human thyroid in pregnancy. Clin. Sci. 17, 281-290.
43. Henrichs, J., Bongers-Schokking, J. J., Schenk, J. J., Ghassabian, A., Schmidt, H. G., Visser, T. J., Hooijkaas, H., de Muinck Keizer-Schrama, S. M., Hofman, A., Jaddoe, V. V., et al. (2010). Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: The generation R study. J. Clin. Endocrinol. Metab. 95, 4227-4234.
44. Henry, G., Sobki, S. H., Al-Beshara, N. M., Harkonen, M. E., and Miller, H. R. (2000). Thyroid function in cord blood. Saudi Med. J. 21, 36-39.
45. Hodges, R. E., Evans, T. C., Bradbury, J. T., and Keettel, W. C. (1955). The accumulation of radioactive iodine by human fetal thyroids. J. Clin. Endocrinol. Metab. 15, 661-667.
46. Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., and Braverman, L. E. (2002). Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J. Clin. Endocrinol. Metab. 87, 489-499.
47. Huang, S. A., Dorfman, D. M., Genest, D. R., Salvatore, D., and Larsen, P. R. (2003). Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. J. Clin. Endocrinol. Metab. 88, 1384-1388.
48. Huber, D. R., Blount, B. C., Mage, D. T., Letkiewicz, F. J., Kumar, A., and Allen, R. H. (2011). Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data. J. Expo. Sci. Environ. Epidemiol. 21, 395-407.
49. Hume, R., Simpson, J., Delahunty, C., van Toor, H., Wu, S. Y., Williams, F. L., and Visser, T. J. (2004). Human fetal and cord serum thyroid hormones: Developmental trends and interrelationships. J. Clin. Endocrinol. Metab. 89, 4097-4103.
50. Hytten, F. E., and Leitch, I. (1971). The Physiology of Human Pregnancy, 2nd ed. Blackwell Scientific Publications Ltd, Oxford.
51. Inada, M., Kasagi, K., Kurata, S., Kazama, Y., Takayama, H., Torizuka, K., Fukase, M., and Soma, T. (1975). Estimation of thyroxine and triiodothyronine distribution and of the conversion rate of thyroxine to triiodothyronine in man. J. Clin. Invest. 55, 1337-1348.
52. Ishii, H., Inada, M., Tanaka, K., Mashio, Y., Naito, K., Nishikawa, M., Matsuzuka, F., Kuma, K., and Imura, H. (1982). Sequential deiodination of thyroxine in human thyroid gland. J. Clin. Endocrinol. Metab. 55, 890-896.
53. Kamm, G., and Drescher, G. (1973). [Demonstration of perchlorate in the urine]. Beitr. Gerichtl. Med. 30, 206-210.
54. Kaptein, E. M., Moore, G. E., Ferguson, D. C., and Hoenig, M. (1993). Thyroxine and triiodothyronine distribution and metabolism in thyroxinereplaced athyreotic dogs and normal humans. Am. J. Physiol. 264(1 Pt 1), E90-100.
55. Kiserud, T., Ebbing, C., Kessler, J., and Rasmussen, S. (2006). Fetal cardiac output, distribution to the placenta and impact of placental compromise. Ultrasound Obstet. Gynecol. 28, 126-136.
56. Kohn, M. C. (2000). Effects of TCDD on thyroid hormone homeostasis in the rat. Drug Chem. Toxicol. 23, 259-277.
57. Kooistra, L., Crawford, S., van Baar, A. L., Brouwers, E. P., and Pop, V. J. (2006). Neonatal effects of maternal hypothyroxinemia during early pregnancy. Pediatrics 117, 161-167.
58. Kosugi, S., Sasaki, N., Hai, N., Sugawa, H., Aoki, N., Shigemasa, C., Mori, T., and Yoshida, A. (1996). Establishment and characterization of a Chinese hamster ovary cell line, CHO-4J, stably expressing a number of Na+/I- symporters. Biochem. Biophys. Res. Commun. 227, 94-101.
59. Larsson, M., Pettersson, T., and Carlström, A. (1985). Thyroid hormone binding in serum of 15 vertebrate species: Isolation of thyroxine-binding globulin and prealbumin analogs. Gen. Comp. Endocrinol. 58, 360-375.
60. Laurberg, P. (1984). Mechanisms governing the relative proportions of thyroxine and 3,5,3'-triiodothyronine in thyroid secretion. Metabolism 33, 379-392.
61. Lee, R. H., Spencer, C. A., Mestman, J. H., Miller, E. A., Petrovic, I., Braverman, L. E., and Goodwin, T. M. (2009). Free T4 immunoassays are flawed during pregnancy. Am. J. Obstet. Gynecol. 200, 260 e261-e266.
62. Leung, A. M., Pearce, E. N., and Braverman, L. E. (2010). Perchlorate, iodine and the thyroid. Best Pract. Res. Clin. Endocrinol. Metab. 24, 133-141.
63. Liberman, C. S., Pino, S. C., Fang, S. L., Braverman, L. E., and Emerson, C. H. (1998). Circulating iodide concentrations during and after pregnancy. J. Clin. Endocrinol. Metab. 83, 3545-3549.
64. Loubière, L. S., Vasilopoulou, E., Bulmer, J. N., Taylor, P. M., Stieger, B., Verrey, F., McCabe, C. J., Franklyn, J. A., Kilby, M. D., and Chan, S. Y. (2010). Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction. Placenta 31, 295-304.
65. Luecke, R. H., Wosilait, W. D., and Young, J. F. (1995). Mathematical representation of organ growth in the human embryo/fetus. Int. J. Biomed. Comput. 39, 337-347.
66. Man, E. B., Brown, J. F., and Serunian, S. A. (1991). Maternal hypothyroxinemia: Psychoneurological deficits of progeny. Ann. Clin. Lab. Sci. 21, 227-239.
67. McLanahan, E. D., Andersen, M. E., Campbell, J. L., and Fisher, J. W. (2009). Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH. Environ. Health Perspect. 117, 731-738.
68. McLanahan, E. D., Andersen, M. E., and Fisher, J. W. (2008). A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary- thyroid axis in the adult rat: Evaluation of iodide deficiency. Toxicol. Sci. 102, 241-253.
69. Mendez, W., Dederick, E., and Cohen, J. (2010). Drinking water contribution to aggregate perchlorate intake of reproductive-age women in the United States estimated by dietary intake simulation and analysis of urinary excretion data. J. Expo. Sci. Environ. Epidemiol. 20, 288-297.
70. Merrill, E. A., Clewell, R. A., Robinson, P. J., Jarabek, A. M., Gearhart, J. M., Sterner, T. R., and Fisher, J. W. (2005). PBPK model for radioactive iodide and perchlorate kinetics and perchlorate-induced inhibition of iodide uptake in humans. Toxicol. Sci. 83, 25-43.
71. Merrill, E. A., Clewell, R. A., Gearhart, J. M., Robinson, P. J., Sterner, T. R., Yu, K. O., Mattie, D. R., and Fisher, J. W. (2003). PBPK predictions of perchlorate distribution and its effect on thyroid uptake of radioiodide in the male rat. Toxicol. Sci. 73, 256-269.
72. Moleti, M., Di Bella, B., Giorgianni, G., Mancuso, A., De Vivo, A., Alibrandi, A., Trimarchi, F., and Vermiglio, F. (2011a). Maternal thyroid function in different conditions of iodine nutrition in pregnant women exposed to mildmoderate iodine deficiency: An observational study. Clin. Endocrinol. (Oxf) 74, 762-768.
73. Moleti, M., Trimarchi, F., and Vermiglio, F. (2011b). Doubts and Concerns about Isolated Maternal Hypothyroxinemia. J. Thyroid Res. 2011, 463029.
74. Mollison, P. L., Veall, N., and Cutbush, M. (1950). Red cell and plasma volume in newborn infants. Arch. Dis. Child. 25, 242-253.
75. Morreale de Escobar, G., Obregon, M. J., and Escobar del Rey, F. (2000). Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J. Clin. Endocrinol. Metab. 85, 3975-3987.
76. Murray, C. W., Egan, S. K., Kim, H., Beru, N., and Bolger, P. M. (2008). US Food and Drug Administration's Total Diet Study: Dietary intake of perchlorate and iodine. J. Expo. Sci. Environ. Epidemiol. 18, 571-580.
77. Nicoloff, J. T., Low, J. C., Dussault, J. H., and Fisher, D. A. (1972). Simultaneous measurement of thyroxine and triiodothyronine peripheral turnover kinetics in man. J. Clin. Invest. 51, 473-483.
78. NRC. (2005). Health Implications of Perchlorate Ingestion. National Academies Press, Washington, DC.
79. Obregon, M. J., Calvo, R. M., Del Rey, F. E., and de Escobar, G. M. (2007). Ontogenesis of thyroid function and interactions with maternal function. Endocr. Dev. 10, 86-98.
80. Obregon, M. J., Escobar del Rey, F., and Morreale de Escobar, G. (2005). The effects of iodine deficiency on thyroid hormone deiodination. Thyroid 15, 917-929.
81. Oddie, T. H., Meade, J. H., Jr, and Fisher, D. A. (1966a). An analysis of published data on thyroxine turnover in human subjects. J. Clin. Endocrinol. Metab. 26, 425-436.
82. Oddie, T. H., Meade, J. H., Jr, Myhill, J., and Fisher, D. A. (1966b). Dependence of renal clearance of radioiodide on sex, age and thyroidal status. J. Clin. Endocrinol. Metab. 26, 1293-1296.
83. Patel, J., Landers, K., Li, H., Mortimer, R. H., and Richard, K. (2011). Delivery of maternal thyroid hormones to the fetus. Trends Endocrinol. Metab. 22, 164-170.
84. Patrick, L. (2008). Iodine: Deficiency and therapeutic considerations. Altern. Med. Rev. 13, 116-127.
85. Pearce, E. N., Alexiou, M., Koukkou, E., Braverman, L. E., He, X., Ilias, I., Alevizaki, M., and Markou, K. B. (2012). Perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women from Greece. Clin. Endocrinol. (Oxf) 77, 471-474.
86. Pearce, E. N., Spencer, C. A., Mestman, J. H., Lee, R. H., Bergoglio, L. M., Mereshian, P., He, X., Leung, A. M., and Braverman, L. E. (2011). Effect of environmental perchlorate on thyroid function in pregnant women from Córdoba, Argentina, and Los Angeles, California. Endocr. Pract. 17, 412-417.
87. Pop, V. J., Brouwers, E. P., Vader, H. L., Vulsma, T., van Baar, A. L., and de Vijlder, J. J. (2003). Maternal hypothyroxinaemia during early pregnancy and subsequent child development: A 3-year follow-up study. Clin. Endocrinol. (Oxf) 59, 282-288.
88. Pop, V. J., Kuijpens, J. L., van Baar, A. L., Verkerk, G., van Son, M. M., de Vijlder, J. J., Vulsma, T., Wiersinga, W. M., Drexhage, H. A., and Vader, H. L. (1999). Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin. Endocrinol. (Oxf) 50, 149-155.
89. Rayburn, W. F., Robinson, A., Braverman, L. E., He, X. M., Pino, S., Gargas, M. L., and Kinzell, J. H. (2008). Iodide concentrations in matched maternal serum, cord serum, and amniotic fluid from preterm and term human pregnancies. Reprod. Toxicol. 25, 129-132.
90. Rietjens, I. M., Louisse, J., and Punt, A. (2011). Tutorial on physiologically based kinetic modeling in molecular nutrition and food research. Mol. Nutr. Food Res. 55, 941-956.
91. Silva, J. E., and Silva, S. (1981). Interrelationships among serum thyroxine, triiodothyronine, reverse triiodothyronine, and thyroid-stimulating hormone in iodine-deficient pregnant women and their offspring: Effects of iodine supplementation. J. Clin. Endocrinol. Metab. 52, 671-677.
92. Smyth, P. P., Hetherton, A. M., Smith, D. F., Radcliff, M., and O'Herlihy, C. (1997). Maternal iodine status and thyroid volume during pregnancy: Correlation with neonatal iodine intake. J. Clin. Endocrinol. Metab. 82, 2840-2843.
93. Soldin, O. P., Soldin, D., and Sastoque, M. (2007). Gestation-specific thyroxine and thyroid stimulating hormone levels in the United States and worldwide. Ther. Drug Monit. 29, 553-559.
94. Steinmaus, C., Miller, M. D., and Smith, A. H. (2010). Perchlorate in drinking water during pregnancy and neonatal thyroid hormone levels in California. J. Occup. Environ. Med. 52, 1217-1524.
95. Stricker, R., Echenard, M., Eberhart, R., Chevailler, M. C., Perez, V., Quinn, F. A., and Stricker, R. (2007). Evaluation of maternal thyroid function during pregnancy: The importance of using gestational age-specific reference intervals. Eur. J. Endocrinol. 157, 509-514.
96. Téllez-Téllez, R., Michaud Chacón, P., Reyes Abarca, C., Blount, B. C., Van Landingham, C. B., Crump, K. S., and Gibbs, J. P. (2005). Long-term environmental exposure to perchlorate through drinking water and thyroid function during pregnancy and the neonatal period. Thyroid 15, 963-975.
97. Thorp, J. M., Jr, Norton, P. A., Wall, L. L., Kuller, J. A., Eucker, B., and Wells, E. (1999). Urinary incontinence in pregnancy and the puerperium: A prospective study. Am. J. Obstet. Gynecol. 181, 266-273.
98. Thorpe-Beeston, J. G., Nicolaides, K. H., and McGregor, A. M. (1992). Fetal thyroid function. Thyroid 2, 207-217.
99. Tonacchera, M., Viacava, P., Fanelli, G., Agretti, P., De Marco, G., De Servi, M., Di Cosmo, C., Chiovato, L., Pinchera, A., and Vitti, P. (2004). The sodium-iodide symporter protein is always present at a low expression and confined to the cell membrane in nonfunctioning nonadenomatous nodules of toxic nodular goitre. Clin. Endocrinol. (Oxf) 61, 40-45.
100. USEPA. (2005). Integrated Risk Information System for Perchlorate and Perchlorate Salts. Available at: http://www.epa.gov/iris/subst/1007.htm
101. USEPA. (2009). Inhibition of the Sodium-Iodide Symporter by Perchlorate: An Evaluation of Life Stage Sensitivity Using Physiologically-Based Pharmacokinetic (PBPK) Modeling. Draft for Review and Public Comment. EPA/600/R-08/106A. Office of Research and Development, USEPA, Washington, DC.
102. USEPA. (2011). Exposure Factors Handbook. National Center for Environmental Assessment, Washington, DC.
103. USEPA. (2012). Life Stage Considerations and Interpretation of Recent Epidemiological Evidence to Develop a Maximum Contaminant Level Goal for Perchlorate. Available at: http://yosemite.epa.gov/sab%5CSABPRODUCT.NSF/0/D3BB75D4297CA4698525794300522ACE/$File/Final+Perchlorate+White+Paper+05.29.12.pdf
104. Vadstrup, S. (1993). Comparative aspects of iodine conservation in mammals. Comp. Biochem. Physiol. Comp. Physiol. 106, 15-17.
105. Vermiglio, F., Lo Presti, V. P., Castagna, M. G., Violi, M. A., Moleti, M., Finocchiaro, M. D., Mattina, F., Artemisia, A., and Trimarchi, F. (1999). Increased risk of maternal thyroid failure with pregnancy progression in an iodine deficient area with major iodine deficiency disorders. Thyroid 9, 19-24.
106. Vermiglio, F., Lo Presti, V. P., Moleti, M., Sidoti, M., Tortorella, G., Scaffidi, G., Castagna, M. G., Mattina, F., Violi, M. A., Crisà, A., et al. (2004). Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries. J. Clin. Endocrinol. Metab. 89, 6054-6060.
107. Vulsma, T., Gons, M. H., and de Vijlder, J. J. (1989). Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N. Engl. J. Med. 321, 13-16.
108. Wang, Y., and Zhao, S. (2010). Vascular Biology of the Placenta. Morgan & Claypool Life Sciences, San Rafael, CA.
109. WHO, UNICEF, and ICCIDD. (2001). Assessment of the Iodine Deficiency Disorders and Monitoring Their Elimination. A Guide for Programme Managers. (WHO/NHD/01.1), 2nd ed, pp. 1-107. World Health Organization, Geneva.
110. Wolff, J., and Chaikoff, I. L. (1948). Plasma inorganic iodide as a homeostatic regulator of thyroid function. J. Biol. Chem. 174, 555-564.
111. Yan, Y. Q., Dong, Z. L., Dong, L., Wang, F. R., Yang, X. M., Jin, X. Y., Lin, L. X., Sun, Y. N., and Chen, Z. P. (2011). Trimester- and method-specific reference intervals for thyroid tests in pregnant Chinese women: Methodology, euthyroid definition and iodine status can influence the setting of reference intervals. Clin. Endocrinol. (Oxf) 74, 262-269.
112. Zimmermann, M. B. (2007). The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: A review. Thyroid 17, 829-835.
113. Zimmermann, M. B. (2009). Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: A review. Am. J. Clin. Nutr. 89, 668S-672S.
114. Zimmermann, M. B. (2011). The role of iodine in human growth and development. Semin. Cell Dev. Biol. 22, 645-652.
115. Zoeller, R. T., and Crofton, K. M. (2000). Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals. Neurotoxicology 21, 935-945.
116. Zoeller, R. T., and Rovet, J. (2004). Timing of thyroid hormone action in the developing brain: Clinical observations and experimental findings. J. Neuroendocrinol. 16, 809-818.