Immature dendritic cells in multiple myeloma are prone to osteoclast-like differentiation through interleukin-17A stimulation

British Journal of Haematology

Volumn 161, Issue 6, 2013, Pages 821-831

  Tucci, Marco ^a   Stucci, Stefania ^a   Savonarola, Annalisa ^a   Ciavarella, Sabino ^a   Cafforio, Paola ^a   Dammacco, Franco ^a   Silvestris, Franco ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Dendritic cells; IL17A; Multiple myeloma; Myeloma bone disease; Osteoclasts

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; PROTEIN FOS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MFAB; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW; CELL TRANSDIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DENDRITIC CELL; DOWN REGULATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; OC GENE; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BONE MARROW; BONE RESORPTION; CELL TRANSDIFFERENTIATION; DENDRITIC CELLS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-17; MULTIPLE MYELOMA; OSTEOCLASTS; RECEPTORS, INTERLEUKIN-17;

EID: 84878476529     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12333     Document Type: Article

References (37)

1. Adamopoulos, I.E., Chao, C., Geissler, R., Laface, D., Blumenschein, W., Iwakura, Y., McClanahan, T. & Bowman, E.P. (2010) Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors. Arthritis research and therapy, 12, R29.
2. Alexandrakis, M.G., Pappa, C.A., Miyakis, S., Sfiridaki, A., Kafousi, M., Alegakis, A. & Stathopoulos, E.N. (2006) Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma. European journal of internal medicine, 17, 412-416.
3. Baraliakos, X. & Braun, J. (2012) Biologic therapies for spondyloarthritis: what is new? Current rheumatology reports, 14, 422-427.
4. Braga, W.N.T., Atanackovic, D. & Colleoni, G.W.B. (2012) The role of regulatory T cells and Th17 cells in multiple myeloma. Clinical and developmental immunology, 2012, 293479.
5. Busquets-Perez, N., Marzo-Ortega, M. & Emery, P. (2013) Emerging drugs for axial spondyloartritis including ankylosing spondylitis. Expert opinion on emerging drugs, 18, 71-86.
6. Chauhan, D., Singh, A.V., Brahmandam, M., Carrasco, R., Bandi, M., Hideshima, T., Bianchi, G., Podar, K., Tai, Y.T., Mitsiades, C., Raje, N., Jaye, D.L., Kumar, S.K., Richardson, P., Munshi, N. & Anderson, K.C. (2009) Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. Cancer Cell, 16, 309-323.
7. Coury, F., Annels, N., Rivollier, A., Olsson, S., Santoro, A., Speziani, C., Azocar, O., Flacher, M., Djebali, S., Tebib, J., Brytting, M., Egeler, R.M., Rabourdin-Combe, C., Henter, J.I., Arico, M. & Delprat, C. (2008) Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nature Medicine, 14, 81-87.
8. Das Roy, L., Pathangery, L.B., Tinder, T.L., Schettini, J.L., Gruber, H.E. & Mukherjee, P. (2009) Breast cancer associated metastasis is significantly increased in a model of autoimmune arthritis. Breast Cancer Research, 11, R56.
9. Dhodapkar, K.M., Barbuto, S., Matthews, P., Kukreja, A., Mazumder, A., Vesole, D., Jagannath, S. & Dhodapkar, M.V. (2008) Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood, 112, 2878-2885.
10. Eychene, A., Rocques, N. & Pouponnot, C. (2008) A new MAFia in cancer. Nature Reviews Cancer, 8, 683-693.
11. Gaffen, S.L. (2004) Biology of recently discovered cytokines: Interleukin-17 - a unique inflammatory cytokine with roles in bone biology and arthritis. Arthritis research and therapy, 6, 240-247.
12. Gaffen, S.L. (2009) Structure and signaling in the IL-17 receptor superfamily. Nature Reviews Immunology, 9, 556-567.
13. Gallois, A., Lachuer, J., Yvert, G., Wierinckx, A., Brunet, F., Rabourdin-Combe, C., Delprat, C., Jurdic, P. & Mazzorana, M. (2010) Genome-wide expression analyses establish dendritic cells as a new osteoclast precursor able to generate bone-resorbing cells more efficiently than monocytes. Journal of Bone and Mineral Research, 25, 661-672.
14. Giuliani, N., Rizzoli, V. & Roodman, G.D. (2006) Multiple myeloma bone disease: pathophysiology of osteoblast inhibition. Blood, 108, 3992-3996.
15. Ji, J.D., Park-Min, K.H., Shen, Z., Fajardo, R.J., Goldring, S.R., McHugh, K.P. & Ivashkiv, L.B. (2009) Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors. The Journal of immunology, 183, 7223-7233.
16. Kim, K., Kim, J.H. & Lee, J. (2007) Mi Jin H, Kook H, Kim KK, Young See S, Kim N. Maf-B negatively regulates RANK-L mediated osteoclast differentiation. Blood, 109, 3253-3259.
17. Kobayashi, K., Takahashi, N., Jimi, E., Udagawa, N., Takami, M., Kotake, S., Nakagawa, N., Kinosaki, M., Yamaguchi, K., Shima, N., Yasuda, H., Morinaga, T., Higashio, K., Martin, T.J. & Suda, T. (2000) Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. Journal of Experimental Medicine, 191, 275-286.
18. Koenders, M.I., Marijnissen, R.J., Devesa, I., Lubberts, E., Joosten, L.A., Roth, J., van Lent, P.L., van de Loo, F.A. & van den Berg, W.B. (2011) Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis. Arthritis and Rheumatism, 63, 2329-2339.
19. Kotake, S. & Kamatani, N. (2002) The role of IL-17 in joint destruction. Drug news and perspectives, 15, 17-23.
20. Kukreja, A., Hutchinson, A., Dhodapkar, K., Mazumder, A., Vesole, D., Angitapalli, R. & Jagannath, S. (2006) Dhodapkar MV Enhancement of clonogenicity of human myeloma by dendritic cells. Journal of Experimental Medicine, 203, 1859-1865.
21. Kukreja, A., Radfar, S., Sun, B.H., Insogna, K. & Dhodapkar, M.V. (2009) Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease. Blood, 114, 3413-3421.
22. Mitsiades, C.S., McMillin, D.W., Klippel, S., Hideshima, T., Chauhan, D., Richardson, P.G., Munshi, N.C. & Anderson, K.C. (2007) The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies. Hematology/oncology Clinics of North America, 21, 1007-1034.
23. Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, D. & Borrello, I. (2010) A novel role of IL-17 producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood, 116, 3554-3563.
24. Prabhala, R.H., Pelluru, D., Fulciniti, M., Prabhala, H.K., Nanjappa, P., Song, W., Pai, C., Amin, S., Tai, Y.T., Richardson, P.G., Ghobrial, I.M., Treon, S.P., Daley, J.F., Anderson, K.C., Kutok, J.L. & Munshi, N.C. (2010a) Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma. Blood, 115, 5385-5392.
25. Prabhala, R.H., Fulciniti, M.T., Pelluru, D., Nanjappa, P., Pai, C., Lee, S., Prabhala, N., Song, W., Mitsiades, C.S., Lefkimmiatis, K., Tai, Y., Ghobrial, I., Richardson, P., Daley, J., Anderson, K.C., Ettenberg, S., di Padova, F. & Munshi, N.C. (2010b) Human monoclonal antibody targeting IL-17A (AIN457) down-regulates MM cell growth and survival and inhibits osteoclast development in vitro and in vivo: a potential novel therapeutic application in myeloma. Blood (ASH Annual Meeting Abstract), 116, 456.
26. Rivollier, A., Mazzorana, M., Tebib, J., Piperno, M., Aitsiselmi, T., Rabourdin-Combe, C., Jurdic, P. & Servet-Delprat, C. (2004) Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironment. Blood, 104, 4029-4037.
27. Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadomo, Y., Tamaka, S., Kodama, T., Akira, S. & Iwakura, Y. (2003) Cua Dj. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. Journal of Experimental Medicine, 12, 2673-2682.
28. Sezer, O. (2005) Myeloma bone disease. Hematology, 10 S1, 19-24
29. Shahrara, S., Pickens, S.R., Mandelin, A.M., Karpus, W., Huang, O. & Kolls, J.K. (2010) Pope RM Il-17-mediated monocyte migration occurs partially through CCL2/MCP-1 induction. The Journal of immunology, 184, 4479-4487.
30. Smink, J.J. & Leutz, A. (2010) Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases. Journal of Molecular Medicine, 88, 227-233.
31. Smink, J.J., Bégay, V., Schoenmaker, T., Sterneck, E., de Vries, T. & Leutz, A. (2009) Transcription factor C/EBP isoform ratio regulates osteoclastogenesis through MafB. The EMBO Journal, 28, 1769-1781.
32. Smink, J.J., Tun, P. & Leutz, A. (2012) Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the CEBPB-MafB axis. Journal of Molecular Medicine, 90, 25-30.
33. Tsukada, J., Yoshida, Y., Kominato, Y. & Auron, P.E. (2011) The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation. Cytokine, 54, 6-19.
34. Tucci, M., Stucci, S., Strippoli, S., Dammacco, F. & Silvestris, F. (2011a) Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression? The oncologist, 16, 1040-1048.
35. Tucci, M., Ciavarella, S., Strippoli, S., Dammacco, F. & Silvestris, F. (2011b) Immature dendritic cells from patients with multiple myeloma are prone to osteoclast differentiation in vitro. Experimental Hematology, 39, 773-783.
36. Wakkach, A., Mansour, A. & Dacquin, R. (2008) Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts. Blood, 112, 5074-5083.
37. Willman, K. & Dunne, J.F. (2000) Flow-cytometry immune function assay for human peripheral blood dendritic cells. Journal of leukocyte biology, 67, 536-544.