Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 2065-2076

  Tobar Grande, Blanca ^a   Godoy, Ricardo ^a   Bustos, Paulina ^a   von Plessing, Carlos ^a   Fattal, Elias ^b,c   Tsapis, Nicolas ^b,c   Olave, Claudia ^a   Gómez Gaete, Carolina ^a  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c UNIV PARIS SUD   (France)

Author keywords

Chondroitin sulfate; Cytotoxic assays; Hyaluronic acid; Methylprednisolone; Microparticles; Spray drying

Indexed keywords

ALBUMIN; CHONDROITIN SULFATE; EXCIPIENT; HYALURONIC ACID; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE;

ARTHRITIS; ARTICLE; BIODEGRADABILITY; CELL VIABILITY; CONTROLLED DRUG RELEASE; CYTOKINE RELEASE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW RATE; HUMAN; IN VITRO STUDY; INFLAMMATION; MEMBRANE DAMAGE; MICROPARTICLE; NANOENCAPSULATION; PARTICLE SIZE; PROCESS OPTIMIZATION; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; THERMAL ANALYSIS; THERMOGRAVIMETRY; X RAY DIFFRACTION; ZETA POTENTIAL;

CHONDROITIN SULFATE; CYTOTOXIC ASSAYS; HYALURONIC ACID; METHYLPREDNISOLONE; MICROPARTICLES; SPRAY-DRYING;

CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; CHONDROITIN SULFATES; DESICCATION; DRUG CARRIERS; HUMANS; HYALURONIC ACID; INTERLEUKIN-1BETA; METHYLPREDNISOLONE; PARTICLE SIZE; X-RAY DIFFRACTION;

EID: 84878464161     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S39327     Document Type: Article

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