Supramolecular organization and release properties of phospholipid-hyaluronan microparticles encapsulating dexamethasone

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 1, 2008, Pages 116-126

  Gómez Gaete, Carolina ^a,b   Tsapis, Nicolas ^a   Silva, Lídia ^a   Bourgaux, Claudie ^a   Besnard, Madeleine ^a   Bochot, Amélie ^a   Fattal, Elias ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

Dexamethasone; DPPC; Hyaluronic acid; Microparticles; Spray drying

Indexed keywords

DEXAMETHASONE; EXCIPIENT; HYALURONIC ACID; PHOSPHOLIPID;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; HYDRATION; IN VITRO STUDY; PARTICLE SIZE; SPRAY DRYING; X RAY DIFFRACTION;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ANTI-INFLAMMATORY AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DEXAMETHASONE; DRUG CARRIERS; DRUG COMPOUNDING; HYALURONIC ACID; KINETICS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PARTICLE SIZE; POWDERS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 50149114276     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.04.013     Document Type: Article

References (40)

1. Munoz-Fernandez S., and Martin-Mola E. Uveitis. Best Pract. Res. Clin. Rheumatol. 20 (2006) 487-505
2. Machemer R., Sugita G., and Tano Y. Treatment of intraocular proliferations with intravitreal steroids. Trans. Am. Ophthalmol. Soc. 77 (1979) 171-180
3. Ishibashi T., Miki K., Sorgente N., Patterson R., and Ryan S.J. Effects of intravitreal administration of steroids on experimental subretinal neovascularization in the subhuman primate. Arch. Ophthalmol. 103 (1985) 708-711
4. Ferrante P., Ramsey A., Bunce C., and Lightman S. Clinical trial to compare efficacy and side-effects of injection of posterior sub-Tenon triamcinolone versus orbital floor methylprednisolone in the management of posterior uveitis. Clin. Exp. Ophthalmol. 32 (2004) 563-568
5. Young S., Larkin G., Branley M., and Lightman S. Safety and efficacy of intravitreal triamcinolone for cystoid macular oedema in uveitis. Clin. Exp. Ophthalmol. 29 (2001) 2-6
6. Tamura H., Miyamoto K., Kiryu J., Miyahara S., Katsuta H., Hirose F., Musashi K., and Yoshimura N. Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. Invest. Ophthalmol. Vis. Sci. 46 (2005) 1440-1444
7. Velez G., and Whitcup S.M. New developments in sustained release drug delivery for the treatment of intraocular disease. Br. J. Ophthalmol. 83 (1999) 1225-1229
8. Hainsworth D.P., Pearson P.A., Conklin J.D., and Ashton P. Sustained release intravitreal dexamethasone. J. Ocul. Pharmacol. Ther. 12 (1996) 57-63
9. Jaffe G.J., Martin D., Callanan D., Pearson P.A., Levy B., and Comstock T. Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study. Ophthalmology 113 (2006) 1020-1027
10. Jaffe G.J., Pearson P.A., and Ashton P. Dexamethasone sustained drug delivery implant for the treatment of severe uveitis. Retina 20 (2000) 402-403
11. Martinez-Sancho C., Herrero-Vanrell R., and Negro S. Poly (d,l-lactide-co-glycolide) microspheres for long-term intravitreal delivery of aciclovir: influence of fatty and non-fatty additives. J. Microencapsul. 20 (2003) 799-810
12. Moritera T., Ogura Y., Honda Y., Wada R., Hyon S.H., and Ikada Y. Microspheres of biodegradable polymers as a drug-delivery system in the vitreous. Invest. Ophthalmol. Vis. Sci. 32 (1991) 1785-1790
13. Herrero-Vanrell R., and Refojo M.F. Biodegradable microspheres for vitreoretinal drug delivery. Adv. Drug Deliv. Rev. 52 (2001) 5-16
14. Hickey T., Kreutzer D., Burgess D.J., and Moussy F. Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices. Biomaterials 23 (2002) 1649-1656
15. Galeska I., Kim T.K., Patil S.D., Bhardwaj U., Chatttopadhyay D., Papadimitrakopoulos F., and Burgess D.J. Controlled release of dexamethasone from PLGA microspheres embedded within polyacid-containing PVA hydrogels. Aaps. J. 7 (2005) E231-E240
16. Gomez-Gaete C., Tsapis N., Besnard M., Bochot A., and Fattal E. Encapsulation of dexamethasone into biodegradable polymeric nanoparticles. Int. J. Pharm. 331 (2007) 153-159
17. Giunchedi P., Alpar H.O., and Conte U. PDLLA microspheres containing steroids: spray-drying, o/w and w/o/w emulsifications as preparation methods. J. Microencapsul. 15 (1998) 185-195
18. Pavanetto F., Genta I., Giunchedi P., Conti B., and Conte U. Spray-dried albumin microspheres for the intra-articular delivery of dexamethasone. J. Microencapsul. 11 (1994) 445-454
19. Colombo G., Langer R., and Kohane D.S. Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J. Biomed. Mater. Res. A 68 (2004) 651-659
20. Bosquillon C., Lombry C., Preat V., and Vanbever R. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. J. Control Release 70 (2001) 329-339
21. Codrons V., Vanderbist F., Ucakar B., Preat V., and Vanbever R. Impact of formulation and methods of pulmonary delivery on absorption of parathyroid hormone (1-34) from rat lungs. J. Pharm. Sci. 93 (2004) 1241-1252
22. Gervelas C., Serandour A.L., Geiger S., Grillon G., Fritsch P., Taulelle C., Le Gall B., Benech H., Deverre J.R., Fattal E., and Tsapis N. Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: effect on lung and systemic decorporation of plutonium. J. Control Release 118 (2007) 78-86
23. Ionita M.A., Ion R.M., and Carstocea B. Photochemical and photodynamic properties of vitamin B2-riboflavin and liposomes. Oftalmologia 58 (2003) 29-34
24. Lajavardi L., Bochot A., Camelo S., Goldenberg B., Naud M.C., Behar-Cohen F., Fattal E., and de Kozak Y. Downregulation of endotoxin-induced uveitis by intravitreal injection of vasoactive intestinal Peptide encapsulated in liposomes. Invest. Ophthalmol. Vis. Sci. 48 (2007) 3230-3238
25. Surendrakumar K., Martyn G.P., Hodgers E.C., Jansen M., and Blair J.A. Sustained release of insulin from sodium hyaluronate based dry powder formulations after pulmonary delivery to beagle dogs. J. Control Release 91 (2003) 385-394
26. Kim S.J., Hahn S.K., Kim M.J., Kim D.H., and Lee Y.P. Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles. J. Control Release 104 (2005) 323-335
27. de Belder A.N., and Wik K.O. Preparation and properties of fluorescein-labelled hyaluronate. Carbohydr. Res. 44 (1975) 251-257
28. Gómez-Gaete C., Tsapis N., Silva L., Bourgaux C., and Fattal E. Morphology, structure and supramolecular organization of hybrid 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine-hyaluronic acid microparticles prepared by spray drying. Eur. J. Pharm. Sci. (2008)
29. Kodama M., Numaga J., Yoshida A., Kaburaki T., Oshika T., Fujino Y., Wu G.S., Rao N.A., and Kawashima H. Effects of a new dexamethasone-delivery system (Surodex) on experimental intraocular inflammation models. Graefes. Arch. Clin. Exp. Ophthalmol. 241 (2003) 927-933
30. Russell R. Bioerodable eye implant may help treat macular edema. Pharmaceut. Sci. Technol. News (2003) 223-224
31. Keller G., Lavigne F., Forte L., Andrieux K., Dahim M., Loisel C., Ollivon M., Bourgaux C., and Lesieur P. DSC and X-ray diffraction coupling - specifications and applications. J. Thermal Anal. Calorimetry 51 (1998) 783-791
32. Brubach J.B., Jannin V., Mahler B., Bourgaux C., Lessieur P., Roy P., and Ollivon M. Structural and thermal characterization of glyceryl behenate by X-ray diffraction coupled to differential calorimetry and infrared spectroscopy. Int. J. Pharm. 336 (2007) 248-256
33. Tsapis N., Bennett D., Jackson B., Weitz D.A., and Edwards D.A. Trojan particles: large porous carriers of nanoparticles for drug delivery. Proceedings of the National Academy of Sciences of the United States of America 99 (2002) 12001-12005
34. Tsapis N., Dufresne E.R., Sinha S.S., Riera C.S., Hutchinson J.W., Mahadevan L., and Weitz D.A. Onset of buckling in drying droplets of colloidal suspensions. Phys. Rev. Lett. 94 (2005) 018302
35. Tardieu A., Luzzati V., and Reman F.C. Structure and polymorphism of the hydrocarbon chains of lipids: a study of lecithin-water phases. J. Mol. Biol. 75 (1973) 711-733
36. Lohner K. Effects of small organic molecules on phospholipid phase transitions. Chem. Phys. Lipids 57 (1991) 341-362
37. Videira R.A., Antunes-Madeira M.C., and Madeira V.M. Biophysical perturbations induced by ethylazinphos in lipid membranes. Chem. Phys. Lipids 97 (1999) 139-153
38. Kostecka-Gugala A., Latowski D., and Strzalka K. Thermotropic phase behaviour of alpha-dipalmitoylphosphatidylcholine multibilayers is influenced to various extents by carotenoids containing different structural features - evidence from differential scanning calorimetry. Biochim. Biophys. Acta 1609 (2003) 193-202
39. Korkmaz F., and Severcan F. Effect of progesterone on DPPC membrane: evidence for lateral phase separation and inverse action in lipid dynamics. Arch. Biochem. Biophys. 440 (2005) 141-147
40. Engelke M., Tykhonova S., Zorn-Kruppa M., and Diehl H. Tamoxifen induces changes in the lipid composition of the retinal pigment epithelium cell line D407. Pharmacol. Toxicol. 91 (2002) 13-21