Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: Effect on lung and systemic decorporation of plutonium

Journal of Controlled Release

Volumn 118, Issue 1, 2007, Pages 78-86

  Gervelas, C ^a,b   Serandour, A L ^c   Geiger, S ^a,b   Grillon, G ^c   Fritsch, P ^c   Taulelle, C ^c   Le Gall, B ^c   Benech, H ^d   Deverre, J R ^e   Fattal, E ^a,b   Tsapis, N ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

^c CEA DIF   (France)

^d Institut National de la Recherche Agronomique   (France)

^e DIF   (France)

Author keywords

Decorporation; Lung delivery; Plutonium; Porous particles; Spray drying

Indexed keywords

AERODYNAMICS; BIOLOGICAL ORGANS; CHELATION; CONTAMINATION; PLUTONIUM;

DECORPORATION; LUNG DELIVERY; NUCLEAR ACCIDENT; POROUS PARTICLES; SPRAY-DRYING;

BIOMEDICAL ENGINEERING;

AMMONIUM DERIVATIVE; BICARBONATE; DIPALMITOYLPHOSPHATIDYLCHOLINE; LEUCINE; PENTETIC ACID; PLUTONIUM; PLUTONIUM DIOXIDE PU 239;

AEROSOL; ANIMAL EXPERIMENT; ARTICLE; CHELATION; COMPLEX FORMATION; CONTROLLED STUDY; DECORPORATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; DRY POWDER; LUNG ALVEOLUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAY DRYING; URINARY EXCRETION;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; CHELATING AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; LUNG; MALE; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; PENTETIC ACID; PLUTONIUM; POROSITY; POWDERS; RATS; RATS, SPRAGUE-DAWLEY; X-RAY DIFFRACTION;

EID: 33847151714     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.11.027     Document Type: Article

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