Impact of Low Blood Lead Concentrations on IQ and School Performance in Chinese Children

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Liu, Jianghong ^a   Li, Linda ^a   Wang, Yingjie ^a   Yan, Chonghuai ^b   Liu, Xianchen ^c,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c INDIANA UNIVERSITY   (United States)

^d SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD;

ACADEMIC ACHIEVEMENT; AGE DISTRIBUTION; ARTICLE; CHILD; CHINESE; COGNITION; COGNITIVE DEFECT; COMMUNICATION SKILL; DEVELOPING COUNTRY; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; LEAD BLOOD LEVEL; LONGITUDINAL STUDY; MALE; PRESCHOOL CHILD; SCHOOL CHILD; WECHSLER INTELLIGENCE SCALE;

ACHIEVEMENT; ANALYSIS OF VARIANCE; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; CHILD, PRESCHOOL; CHINA; FEMALE; HUMANS; INTELLIGENCE; INTELLIGENCE TESTS; LEAD; LONGITUDINAL STUDIES; MALE;

EID: 84878442103     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065230     Document Type: Article

References (65)

1. Needleman HL, Schell A, Bellinger D, Leviton A, Allred EN, (1990) The long-term effects of exposure to low doses of lead in childhood. An 11-year follow-up report. N Engl J Med 322: 83-88.
2. Dietrich KN, Ris MD, Succop PA, Berger OG, Bornschein RL, (2001) Early exposure to lead and juvenile delinquency. Neurotoxicol Teratol 23: 511-8.
3. Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, et al. (2005) Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect 113: 894-899.
4. Canfield RL, Henderson CR Jr, Cory-Slechta DA, Cox C, Jusko TA, et al. (2003) Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med 348: 1517-1526.
5. Jusko TA, Henderson CR, Lanphear BP, Cory-Slechta DA, Parsons PJ, et al. (2008) Blood lead concentrations <10 microg/dL and child intelligence at 6 years of age. Environ Health Perspect 116: 243-248.
6. Bellinger DC, (2008) Very low lead exposures and children's neurodevelopment. Curr Opin Pediatr 20: 172-177.
7. Chen A, Rogan WJ, (2005) Improving behavior of lead-exposed children: micronutrient supplementation, chelation, or prevention. J Pediatr 147: 570-571.
8. Miranda ML, Kim D, Galeano MA, Paul CJ, Hull AP, et al. (2007) The relationship between early childhood blood lead levels and performance on end-of-grade tests. Environ Health Perspect 115: 1242-1247.
9. Kordas K, Canfield RL, Lopez P, Rosado JL, Vargas GG, et al. (2006) Deficits in cognitive function and achievement in Mexican first-graders with low blood lead concentrations. Environ Res 100: 371-386.
10. Surkan PJ, Zhang A, Trachtenberg F, Daniel DB, McKinlay S, et al. (2007) Neuropsychological function in children with blood lead levels <10 microg/dL. Neurotoxicology 28: 1170-1177.
11. Chandramouli K, Steer CD, Ellis M, Emond AM, (2009) Effects of early childhood lead exposure on academic performance and behaviour of school age children. Arch Dis Child 94: 844-848.
12. Wang CL, Chuang HY, Ho CK, Yang CY, Tsai JL, et al. (2002) Relationship between blood lead concentrations and learning achievement among primary school children in Taiwan. Environmental Research 89: 12-18.
13. Burns J, Baghurst PA, Sawyer MG, McMichael A, Tong S, (1999) Lifetime low-level exposure to environmental lead and children's emotional and behavioral development at ages 11-13 years: The Port Pirie Cohort Study. Am J Epidemiol 149: 740-749.
14. Fergusson DM, Boden JM, Horwood LJ, (2008) Dentine lead levels in childhood and criminal behaviour in late adolescence and early adulthood. J Epidemiol Community Health 62: 1045-1050.
15. Mazumdar M, Bellinger DC, Gregas M, Abanilla K, Bacic J, et al. (2011) Low-level environmental lead exposure in childhood and adult intellectual function: a follow-up study. Environ Health 10: 24.
16. White RF, Diamond R, Proctor S, Morey C, Hu H, (1993) Residual cognitive deficits 50 years after lead poisoning during childhood. Br J Ind Med 50: 613-622.
17. Wright JP, Dietrich KN, Ris MD, Hornung RW, Wessel SD, et al. (2008) Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood. Plos Medicine 5: 732-740.
18. Gilbert SG, Weiss B, (2006) A rationale for lowering the blood lead action level from 10 to 2 microg/dL. Neurotoxicology 27: 693-701.
19. Centers for Disease Control (2012) Low level lead exposure harms children: a renewed call for primary prevention. Centers for Disease Control.
20. Bellinger D, Hu H, Kalaniti K, Thomas N, Rajan P, et al. (2005) A pilot study of blood lead levels and neurobehavioral function in children living in Chennai, India. Int J Occup Environ Health 11: 138-143.
21. Solon O, Riddell TJ, Quimbo SA, Butrick E, Aylward GP, et al. (2008) Associations between cognitive function, blood lead concentration, and nutrition among children in the central Philippines. J Pediatr 152 (2) (): 237-243.
22. Liu J, McCauley LA, Zhao Y, Zhang H, Pinto-Martin J, (2010) Cohort Profile: The China Jintan Child Cohort Study. Int J Epidemiol 39: 668-674.
23. Liu J, McCauley L, Leung P, Wang B, Needleman H, et al. (2011) Community-based participatory research (CBPR) approach to study children's health in China: experiences and reflections. Int J Nurs Stud 48 (7) (): 904-913.
24. Liu J, McCauley L, Compher C, Yan C, Shen X, et al. (2011) Regular breakfast and blood lead levels among preschool children. Environ Health 10: 28.
25. Liu J, Ai Y, McCauley L, Pinto-Martin J, Yan C, et al. (2012) Blood Lead Levels and associated sociodemographic factors among preschool children in the south eastern region of China. Paediatric and Perinatal Epidemiology 26: 61-69.
26. Shen XM, Zhou JD, Yan CH, (1994) The methodology of BPb level measurement by flamele GF-AAS. J Trace Element Res 11: 43-48.
27. Yan C, Shen X, Zhang Y, (1998) An epidemiological survey on blood lead level and high risk factors for lead poisoning of children in Shanghai. Chin J Pediatr 36: 142-144.
28. Wechsler D (1989). Wechsler Preschool and Primary Scale of Intelligence San Antonio, TX: The Psychological Corporation.
29. Gong Y, Dai X, (1988) China-Wechsler younger children scale of intelligence. Acta Psychologica Sinica 20: 364-376.
30. Gong YX, Dai XY, (1986) China-Wechsler Younger Children Scale of Intelligence (C-WYCSI). Psychological Science 2: 23-30.
31. Yang LL, Liu ML, Townes BD, (1994) Neuropsychological and behavioral status of Chinese children with acyanotic congenital heart disease. Int J Neurosci 74: 109-115.
32. Zhu YM, Lu SY, Tang CH, (1984) The employment of the Wechsler Pre-school and Primary Scale of Intelligence in urban Shanghai. Information on Psychology Science 5: 22-29.
33. Liu J, Lynn R, (2011) Factor structure and sex differences on the Wechsler Preschool and Primary Scale of Intelligence in China, Japan and United States. Personality and Individual Differences 50: 1222-1226.
34. Liu J, Yang H, Li L, Chen T, Lynn R, (2012) An increase of intelligence measured by the WPPSI in China, 1984-2006. Intelligence 40: 139-144.
35. Liu J, Yue A, Hanlon A, Shi Z, Dickerman B, et al. (2011) Micronutrients deficiency and associated sociodemographic factors in Chinese children. World J Pediatr 7: 217-233.
36. Baron RM, Kenny DA, (1986) The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51 (6) (): 1173-1182.
37. Ye X, Fu H, Guidotti T, (2007) Environmental exposure and children's health in China. Arch Environ Occup Health 62: 61-73.
38. Centers for Disease Control and Prevention (2009) Lab 06 nutritional biochemistries (1999-2000); Lab 06 nutritional biochemistries (2001-2002); Blood lead and blood cadmium (2003-2004); Blood lead and blood cadmium (2005-2006); Blood cadmium and lead (2007-2008). National Center for Health Statistics, National Health and Nutrition Examination Survey.
39. Graber LK, Asher D, Anandaraja N, Bopp RF, Merrill K, et al. (2010) Childhood lead exposure after the phaseout of leaded gasoline: an ecological study of school-age children in Kampala, Uganda. Environ Health Perspect 118: 884-889.
40. He K, Wang S, Zhang J, (2009) Blood lead levels of children and its trend in China. [Review]. Science of the Total Environment 407: 3986-3993.
41. Batty GD, Deary IJ, Gottfredson LS, (2007) Premorbid (early life) IQ and later mortality risk: Systematic review. Annals of Epidemiology 17: 278-288.
42. Kenkel D, Lillard D, Mathios A, (2006) The roles of high school completion and GED receipt in smoking and obesity. Journal of Labor Economics 24: 635-660.
43. Zax JS, Rees DI, (2002) IQ, Academic Performance, Environment, and Earnings. Review of Economics and Statistics 84: 600-616.
44. Cory-Slechta DA, Garcia-Osuna M, Greenamyre JT, (1997) Lead-induced changes in NMDA receptor complex binding: correlations with learning accuracy and with sensitivity to learning impairments caused by MK-801 and NMDA administration. Behav Brain Res 85: 161-174.
45. Schneider JS, Anderson DW, Talsania K, Mettil W, Vadigepalli R, (2012) Effects of developmental lead exposure on the hippocampal transcriptome: influences of sex, developmental period, and lead exposure level. Toxicol Sci 129 (1) (): 108-125.
46. Cecil KM, Brubaker CJ, Adler CM, Dietrich KN, Altaye M, et al. (2008) Decreased brain volume in adults with childhood lead exposure. PLoS Med 5: e112.
47. Trope I, Lopez-Villegas D, Cecil KM, Lenkinski RE, (2001) Exposure to lead appears to selectively alter metabolism of cortical gray matter. Pediatrics 107: 1437-1442.
48. Verina T, Rohde CA, Guilarte TR, (2007) Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats. Neuroscience 145: 1037-1047.
49. Yuan W, Holland SK, Cecil KM, Dietrich KN, Wessel SD, et al. (2006) The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function. Pediatrics 118: 971-977.
50. Bleecker ML, Ford DP, Vaughan CG, Walsh KS, Lindgren KN, (2007) The association of lead exposure and motor performance mediated by cerebral white matter change. Neurotoxicology 28 (2) (): 318-323.
51. Duckworth AL, Seligman MEP, (2005) Self-discipline outdoes IQ in predicting academic performance of adolescents. Psychological Science 16: 939-944.
52. Dietrich K, Succop PA, Berger OG, Hammond PB, Bornschein RL, (1991) Lead exposure and the cognitive development of urban preschool children: the Cincinnati Lead Study cohort at age 4 years. Neurotoxicology and Teratology 13 (2) (): 203-211.
53. Factor-Litvak P, Wasserman G, Kline JK, Graziano J, (1999) The Yugoslavia Prospective Study of environmental lead exposure. Environ Health Perspect 107: 9-15.
54. Stiles KM, Bellinger DC, (1993) Neuropsychological correlates of low-level lead exposure in school-age children: a prospective study. Neurotoxicol Teratol 15: 27-35.
55. Tong S, Baghurst P, McMichael A, Sawyer M, Mudge J, (1996) Lifetime exposure to environmental lead and children's intelligence at 11-13 years: the Port Pirie cohort study. BMJ 312: 1569-1575.
56. Lucchini RG, Zoni S, Guazzetti S, Bontempi E, Micheletti S, et al. (2012) Inverse association of intellectual function with very low blood lead but not with manganese exposure in Italian adolescents. Environ Res 118: 65-71.
57. Haavisto M-L, Lehto JE, (2005) Fluid/spatial and crystallized intelligence in relation to domain-specific working memory: A latent-variable approach. Learning and Individual Differences 15: 1-21.
58. Lidsky TI, Schneider JS, (2003) Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126: 5-19.
59. Hornung RW, Lanphear BP, Dietrich KN, (2009) Age of greatest susceptibility to childhood lead exposure: a new statistical approach. Environ Health Perspect 117: 1309-1312.
60. Needleman HL, Gatsonis CA, (1990) Low-level lead exposure and the IQ of children. A meta-analysis of modern studies. [Meta-Analysis Research Support, U.S. Gov't, P.H.S.]. JAMA 263: 673-678.
61. Hubbs-Tait L, Nation JR, Krebs NF, Bellinger DC, (2005) Neurotoxicants, micronutrients, and social environments: individual and combined effects on children's development. Psychological Science in the Public Interest 6 (3) (): 57-121.
62. Needleman HL, Leviton A, (1979) Lead and neurobehavioral deficit in children. Lancet 2: 104.
63. Needleman H, Riess JA, Tobin MJ, Biesecker GE, Greenhouse JB, (1996) Bone lead levels and delinquent behavior. JAMA 275 (5) (): 363-369.
64. Peters JL, Kubzansky LD, Ikeda A, Spiro A 3rd, Wright RO, et al. (2011) Childhood and adult socioeconomic position, cumulative lead levels, and pessimism later in life: the VA Normative Aging Study. Am J Epidemiol 174: 1345-53.
65. Rutter M, Giller H, Hagell A (1998) Antisocial behavior by young people. New York, NY: Cambridge University Press.