Contributions of body mass index and exercise habits on inflammatory markers: A cohort study of middle-aged adults living in the USA

BMJ Open

Volumn 3, Issue 5, 2013, Pages

  Strohacker, Kelley ^a   Wing, Rena R ^a   McCaffery, Jeanne M ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FACTOR; BIOLOGICAL MARKER; C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN; INTERLEUKIN 6; INTERLEUKIN 6 SOLUBLE RECEPTOR; SOLUBLE E SELECTIN AND SOLUBLE INTRACELLULAR ADHESION MOLECULE 1; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; BODY MASS; BODY WEIGHT; COHORT ANALYSIS; DRUG USE; EXERCISE; FEMALE; HEALTH SURVEY; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PHYSICAL ACTIVITY; PRACTICE GUIDELINE; RACE; SEX DIFFERENCE; SMOKING; UNITED STATES;

EID: 84878439957     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2013-002623     Document Type: Article

References (42)

1. Blair SN, Brodney S. Effects of physical inactivity and obesity on morbidity and mortality: current evidence and research issues. Med Sci Sports Exerc 1999;31(11 Suppl):S646-62.
2. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-7. (Pubitemid 46024993)
3. Koenig W, Khuseyinova N, Baumert J, et al. Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-Aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Arterioscler Thromb Vasc Biol 2006;26:2745-51.
4. Papageorgiou N, Tousoulis D, Siasos G, et al. Is fibrinogen a marker of inflammation in coronary artery disease? Hellenic J Cardiol 2010;51:1-9.
5. Schmidt C, Hulthe J, Fagerberg B. Baseline ICAM-1 and VCAM-1 are increased in initially healthy middle-Aged men who develop cardiovascular disease during 6.6 years of follow-up. Angiology 2009;60:108-14.
6. Demerath E, Towne B, Blangero J, et al. The relationship of soluble ICAM-1, VCAM-1, P-selectin and E-selectin to cardiovascular disease risk factors in healthy men and women. Ann Hum Biol 2001;28:664-78. (Pubitemid 33066057)
7. Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 2009;6:399-409.
8. Calabro P, Yeh ET. Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ. Subcell Biochem 2007;42:63-91.
9. Pou KM, Massaro JM, Hoffmann U, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation 2007;116:1234-41. (Pubitemid 47517534)
10. Mathieu P, Poirier P, Pibarot P, et al. Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease. Hypertension 2009;53:577-84.
11. Reuben DB, Judd-Hamilton L, Harris TB, et al. The associations between physical activity and inflammatory markers in high-functioning older persons -MacArthur studies of successful aging. J Am Geriatr Soc 2003;51:1125-30. (Pubitemid 36993471)
12. King DE, Carek P, Mainous AG III, et al. Inflammatory markers and exercise: differences related to exercise type. Med Sci Sports Exerc 2003;35:575-81. (Pubitemid 36417846)
13. Wannamethee SG, Lowe GD, Whincup PH, et al. Physical activity and hemostatic and inflammatory variables in elderly men. Circulation 2002;105:1785-90. (Pubitemid 34408887)
14. Abramson JL, Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-Aged and older US adults. Arch Intern Med 2002;162:1286-92. (Pubitemid 34595035)
15. Geffken DF, Cushman M, Burke GL, et al. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol 2001;153:242-50. (Pubitemid 32958648)
16. Taaffe DR, Harris TB, Ferrucci L, et al. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 2000;55:M709-15. (Pubitemid 32175753)
17. Starkie R, Ostrowski SR, Jauffred S, et al. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-Alpha production in humans. FASEB J 2003;17:884-6.
18. Pedersen BK, Steensberg A, Fischer C, et al. Exercise and cytokines with particular focus on muscle-derived IL-6. Exerc Immunol Rev 2001;7:18-31. (Pubitemid 32911041)
19. Pedersen BK, Steensberg A, Fischer C, et al. The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Proc Nutr Soc 2004;63:263-7. (Pubitemid 38787476)
20. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-55. (Pubitemid 40277057)
21. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta 2010;411:785-93.
22. USDHHS, ed. 2008 Physical activity guidelines for Americans. Washington DC, 2008.
23. Ryff C, Almeida DM, Ayanian JS, et al. National Survey of Midlife Development in the United State (MIDUS II), 2004-2006.
24. Inter-university Consortium for Political and Social Research (ICPSR) [distributor]. 2011.
25. Kraemer H. How many participants? Statistical power analysis in research. SAGE Publications, Inc, 1987.
26. Cohen J. Statistical power analysis for the behavioral sciences. 2nd edn. Lawrence Erlbaum Associates, 1998.
27. Bassuk SS, Rifai N, Ridker PM. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol 2004;29:439-93. (Pubitemid 39055635)
28. Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-Alpha and IL-6. Diabetes Res Clin Pract 2005;69:29-35. (Pubitemid 40813409)
29. Bastard JP, Jardel C, Bruckert E, et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 2000;85:3338-42.
30. Ditschuneit HH, Flechtner-Mors M, Adler G. Fibrinogen in obesity before and after weight reduction. Obes Res 1995;3:43-8.
31. Straczkowski M, Lewczuk P, Dzienis-Straczkowska S, et al. Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-Alpha system activity. Metabolism 2002;51:75-8. (Pubitemid 34092440)
32. Autenrieth C, Schneider A, Doring A, et al. Association between different domains of physical activity and markers of inflammation. Med Sci Sports Exerc 2009;41:1706-13.
33. Majka DS, Chang RW, Vu TH, et al. Physical activity and high-sensitivity C-reactive protein: the multi-ethnic study of atherosclerosis. Am J Prev Med 2009;36:56-62.
34. Day CP. From fat to inflammation. Gastroenterology 2006;130:207-10. (Pubitemid 43049850)
35. Fain JN, Madan AK, Hiler ML, et al. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 2004;145:2273-82. (Pubitemid 38535056)
36. Castell JV, Gomez-Lechon MJ, David M, et al. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 1989;242:237-9. (Pubitemid 19020112)
37. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990;265:621-36. (Pubitemid 20053863)
38. Pradhan AD, Manson JE, Rifai N, et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001;286:327-34. (Pubitemid 32656163)
39. Mathieu P, Lemieux I, Despres JP. Obesity, inflammation, and cardiovascular risk. Clin Pharmacol Ther 2010;87:407-16.
40. Hjelstuen A, Anderssen SA, Holme I, et al. Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension. Am J Hypertens 2006;19:669-75. (Pubitemid 43928517)
41. Church TS, Barlow CE, Earnest CP, et al. Associations between cardiorespiratory fitness and C-reactive protein in men. Arterioscler Thromb Vasc Biol 2002;22:1869-76. (Pubitemid 35315775)
42. Arsenault BJ, Cartier A, Cote M, et al. Body composition, cardiorespiratory fitness, and low-grade inflammation in middle-Aged men and women. Am J Cardiol 2009;104:240-6.