Simvastatin local drug delivery in smokers with chronic periodontitis: A randomized controlled clinical trial

Australian Dental Journal

Volumn 58, Issue 2, 2013, Pages 156-162

  Rao, N S ^a   Pradeep, A R ^a   Bajaj, P ^a   Kumari, M ^a   Naik, S B ^a  

^a Research Institute   (India)

Author keywords

chronic periodontitis; drug delivery systems; Simvastatin; smoking; wound healing

Indexed keywords

BONE DENSITY CONSERVATION AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN;

ADJUVANT CHEMOTHERAPY; ADULT; ALVEOLAR BONE LOSS; ARTICLE; CHRONIC PERIODONTITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; GEL; HUMAN; MALE; MIDDLE AGED; PERIODONTICS; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; SMOKING;

ADULT; ALVEOLAR BONE LOSS; BONE DENSITY CONSERVATION AGENTS; CHEMOTHERAPY, ADJUVANT; CHRONIC PERIODONTITIS; DELAYED-ACTION PREPARATIONS; DENTAL SCALING; GELS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PERIODONTAL INDEX; ROOT PLANING; SIMVASTATIN; SMOKING;

EID: 84878419066     PISSN: 00450421     EISSN: 18347819     Source Type: Journal    
DOI: 10.1111/adj.12042     Document Type: Article

References (42)

1. Laine ML, Crielaard W, Loos BG,. Genetic susceptibility to periodontitis. Periodontol 2000 2012; 58: 37-68.
2. Grossi SG, Zambon JJ, Ho AW, et al,. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol 1994; 65: 260-267.
3. Grossi SG, Genco RJ, Machtei EE, et al,. Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss. J Periodontol 1995; 66: 23-29.
4. Ryder MI, Pons B, Adams D, et al,. Effect of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing. J Clin Periodontol 1999; 26: 283-291.
5. Esha A, Pradeep AR, Bajaj P, Naik SB., Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of chronic periodontitis subjects among smokers-a randomized controlled clinical trial. J Periodontol 2012 Jan 16. [Epub ahead of print].
6. Paquette D, Oringer R, Lessem J, et al,. Locally delivered minocycline microspheres for the treatment of periodontitis in smokers. J Clin Periodontol 2003; 30: 787-794.
7. Kirmizis D, Chatzidimitriou D,. Pleiotropic vasoprotective effects of statins: the chicken or the egg? Drug Des Dev Ther 2009; 3: 191-204.
8. Pleiner J, Schaller G, Mittermayer F, et al,. Simvastatin prevents vascular hyporeactivity during inflammation. Circulation 2004; 110: 3349-3354.
9. Preufer D, Makowski J, Schnell M, et al,. Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha-toxin. Circulation 2002; 106: 2104-2110.
10. Shishehbor MH, Brennan ML, Aviles RJ, et al,. Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation 2003; 108: 426-431.
11. Mangat S, Agarwal S, Rosendorff C,. Do statins lower blood pressure? J Cardiovasc Pharmacol Ther 2007; 12: 112-123.
12. Koh KK, Son JW, Ahn JY, et al,. Comparative effects of diet and statin on NO bioactivity and matrix metalloproteinases in hypercholesterolemic patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2002; 22: e19-e23.
13. Nagashima H, Aoka Y, Sakomura Y, et al,. A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdominal aortic aneurysm wall. J Vasc Surg 2002; 36: 158-163.
14. Garlet GP, Martins W Jr, Fonseca BA, Ferreira BR, Silva JS,. Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal disease. J Clin Periodontol 2004; 31: 671-679.
15. Mundy G, Garrett R, Harris S, et al,. Stimulation of bone formation in vitro and in rodents by statins. Science 1999; 286: 1946-1949.
16. Ohnaka K, Shimoda S, Nawata H, et al,. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun 2001; 287: 337-342.
17. Stein D, Lee Y, Schmid MJ, et al,. Local simvastatin effects on mandibular bone growth and inflammation. J Periodontol 2005; 76: 1861-1870.
18. Sakoda K, Yamamoto M, Negishi Y, Liao JK, Node K, Izumi Y,. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. J Dent Res 2006; 85: 520-523.
19. Nyan M, Sato D, Oda M, et al,. Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect. J Pharmacol Sci 2007; 104: 384-386.
20. Pradeep AR, Thorat MS,. Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial. J Periodontol 2010; 81: 214-222.
21. Armitage GC,. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999; 4: 1-6.
22. Kamma JJ, Giannopoulou C, Vasdekis VGS, Mombelli A,. Cytokine profile in gingival crevicular fluid of aggressive periodontitis: influence of smoking and stress. J Clin Periodontol 2004; 31: 894-902.
23. Mombelli A, Van Oosten MA, Schurch E, Lang NP,. The microbiota associated with successful or failing implants. Oral Microbiol Immunol 1987; 2: 145-151.
24. Silness J, Loe H,. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964; 22: 121-135.
25. Sharma A, Pradeep AR,. Clinical efficacy of 1% alendronate gel as local drug delivery system in the treatment of chronic periodontitis-a randomized controlled clinical trial. J Periodontol 2012; 83: 11-18.
26. Ayukawa Y, Yasukawa E, Moriyama Y, et al,. Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 336-342.
27. Lindy O, Suomalainen K, Mäkelä M, Lindy S,. Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 2008; 8: 16.
28. Rosenson RS, Tangney CC, Levine DM, Parker TS, Gordon BR,. Association between reduced low density lipoprotein oxidation and inhibition of monocyte chemoattractant protein-1 production in statin-treated subjects. J Lab Clin Med 2005; 145: 83-87.
29. Huang KC, Chen CW, Chen JC, Lin WW,. HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages. J Biomed Sci 2003; 10: 396-405.
30. Takeuchi S, Kawashima S, Rikitake Y, et al,. Cerivastatin suppresses lipopolysaccharide-induced ICAM-1 expression through inhibition of Rho GTPase in BAEC. Biochem Biophys Res Commun 2000; 269: 97-102.
31. Li JJ, Chen XJ,. Simvastitin inhibits interleukin-6 release in human monocytes stimulated by C-reactive protein and lipopolysaccharide. Coron Artery Dis 2003; 14: 329-334.
32. Ayukawa Y, Okamura A, Koyano K,. Simvastatin promotes osteogenesis around titanium implants. Clin Oral Implants Res 2004; 15: 346-350.
33. Kasugai S,. Local application of statin for bone augmentation. Clin Calcium 2005; 15: 67-72.
34. Junqueira JC, Mancini MN, Carvalho YR, Anbinder AL, Balducci I, Rocha RF,. Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels. J Oral Sci 2002; 44: 117-124.
35. Pytlik M, Janiec W, Misiarz-Myrta M, Gubala I,. Effects of simvastatin on the development of osteopenia caused by ovariectomy in rats. Pol J Pharmacol 2003; 55: 63-71.
36. Chan KA, Andrade SE, Boles M, et al,. Inhibitors of hydroxymethylglutaryl coenzyme A reductase and risk of fracture among older women. Lancet 2000; 355: 2185-2188.
37. Wang PS, Solomon DH, Mogun H, Avorn J,. HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. JAMA 2000; 283: 3211-3216.
38. LaCroix AZ, Cauley JA, Jackson R, et al,. Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women's Health Initiative Observational Study. Ann Intern Med 2003; 15: 97-104.
39. Van Staa TP, Wegman SLJ, Leufkens HGM, Cooper C,. Use of statins and risk of fractures. JAMA 2001; 285: 1850-1855.
40. Kaldahl WB, Johnson GK, Patil KD, Kalkwarf KL,. Levels of cigarette consumption and response to periodontal therapy. J Periodontol 1996; 67: 675-681.
41. Giannopovlou C, Geinoz A, Cimasoni G., Effects of nicotine on periodontal ligament fibroblasts in vitro. J Clin Periodontol 1999; 26: 49-55.
42. Greenstein G,. Local drug delivery in the treatment of periodontal diseases: assessing the clinical significance of the results. J Periodontol 2006; 77: 565-578.