Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells

Neuroscience Letters

Volumn 544, Issue , 2013, Pages 36-40

  Li, Yexin ^a   Nie, Hui ^a   Wu, Danhong ^b   Zhang, Jie ^a,b   Wei, Xunbin ^a,b   Ying, Weihai ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

ATP; Cell death; Microglia; Poly(ADP ribose) polymerase; SIRT2

Indexed keywords

ADENOSINE TRIPHOSPHATE; AGK 2; HYDROLASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SIRTUIN 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; MICROGLIA; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELL LINE; DOWN-REGULATION; ENZYME ACTIVATION; FURANS; MICE; MICROGLIA; POLY ADENOSINE DIPHOSPHATE RIBOSE; QUINOLINES; SIRTUIN 2;

EID: 84878396726     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.03.032     Document Type: Article

References (21)

1. Chen J., Zhou Y., Mueller-Steiner S., Chen L.F., Kwon H., Yi S., Mucke L., Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J. Biol. Chem. 2005, 280:40364-40374.
2. D'Amours D., Desnoyers S., D'Silva I., Poirier G.G. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem. J. 1999, 342(Pt 2):249-268.
3. Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Gene. Dev. 2000, 14:1021-1026.
4. Harting K., Knoll B. SIRT2-mediated protein deacetylation: an emerging key regulator in brain physiology and pathology. Eur. J. Cell Biol. 2010, 89:262-269.
5. He X., Nie H., Hong Y., Sheng C., Xia W., Ying W. SIRT2 activity is required for the survival of C6 glioma cells. Biochem. Biophys. Res. Commun. 2012, 417:468-472.
6. Lai A.Y., Todd K.G. Microglia in cerebral ischemia: molecular actions and interactions. Can. J. Physiol. Pharmacol. 2006, 84:49-59.
7. Li W., Zhang B., Tang J., Cao Q., Wu Y., Wu C., Guo J., Ling E.A., Liang F. Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. J. Neurosci. 2007, 27:2606-2616.
8. Li Y., Matsumori H., Nakayama Y., Osaki M., Kojima H., Kurimasa A., Ito H., Mori S., Katoh M., Oshimura M., Inoue T. SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis. Genes Cells 2011, 16:34-45.
9. Milne J.C., Denu J.M. The Sirtuin family: therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol. 2008, 12:11-17.
10. Narayan N., Lee I.H., Borenstein R., Sun J., Wong R., Tong G., Fergusson M.M., Liu J., Rovira I.I., Cheng H.L., Wang G., Gucek M., Lombard D., Alt F.W., Sack M.N., Murphy E., Cao L., Finkel T. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature 2012, 492:199-204.
11. Nie H., Chen H., Han J., Hong Y., Ma Y., Xia W., Ying W. Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. Int. J. Physiol. Pathophysiol. Pharmacol. 2011, 3:65-70.
12. Outeiro K.E.T.F., Altmann S.M., Kufareva I., Strathearn K.E., Amore A.M., Volk C.B., Maxwell M.M., Rochet J.C., McLean P.J., Young A.B., Abagyan R., Feany M.B., Hyman B.T., Kazantsev A.G. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 2007, 317:516-519.
13. Pandithage R., Lilischkis R., Harting K., Wolf A., Jedamzik B., Luscher-Firzlaff J., Vervoorts J., Lasonder E., Kremmer E., Knoll B., Luscher B. The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J. Cell Biol. 2008, 180:915-929.
14. Tang B.L., Chua C.E. SIRT2, tubulin deacetylation, and oligodendroglia differentiation. Cell Motil. Cytoskel. 2008, 65:179-182.
15. Virag L., Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol. Rev. 2002, 54:375-429.
16. Xia W., Han J., Huang G., Ying W. Inflammation in ischaemic brain injury: current advances and future perspectives. Clin. Exp. Pharmacol. Physiol. 2010, 37:253-258.
17. + and NADH in brain functions, brain diseases and brain aging. Front. Biosci. 2007, 12:1863-1888.
18. + and NADH in cellular functions and cell death. Front. Biosci. 2006, 11:3129-3148.
19. +/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid. Redox Signal. 2008, 10:179-206.
20. + repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochem. Biophys. Res. Commun. 2003, 308:809-813.
21. Zong W.X., Ditsworth D., Bauer D.E., Wang Z.Q., Thompson C.B. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev. 2004, 18:1272-1282.