Crystal and solution studies reveal that the transcriptional regulator AcnR of Corynebacterium glutamicum is regulated by citrate-Mg2+ binding to a non-canonical pocket

Journal of Biological Chemistry

Volumn 288, Issue 22, 2013, Pages 15800-15812

  García Nafría, Javier ^a   Baumgart, Meike ^b   Turkenburg, Johan P ^a   Wilkinson, Anthony J ^a   Bott, Michael ^b   Wilson, Keith S ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL SIGNIFICANCE; CORYNEBACTERIUM GLUTAMICUM; DNA BINDING DOMAIN; INDUSTRIAL BACTERIA; LIGAND-BINDING SITES; PRECURSOR SUPPLY; SEQUENCE IDENTITY; TRANSCRIPTIONAL REGULATOR;

LIGANDS;

BINDING ENERGY;

BACTERIAL DNA; BACTERIAL PROTEIN; CITRIC ACID; LIGAND; MAGNESIUM ION; PROTEIN ACNR; REPRESSOR PROTEIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; CRYSTAL STRUCTURE; DNA BINDING; GENE TARGETING; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CORYNEBACTERIALES; CRYSTAL STRUCTURE; GENE REGULATION; LIGAND-BINDING PROTEIN; METABOLIC REGULATION; STRUCTURAL BIOLOGY; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BINDING SITES; CITRIC ACID; CORYNEBACTERIUM GLUTAMICUM; CRYSTALLOGRAPHY, X-RAY; DNA, BACTERIAL; MAGNESIUM; PROTEIN BINDING; TRANSCRIPTION FACTORS;

BACTERIA (MICROORGANISMS); CORYNEBACTERIUM GLUTAMICUM;

EID: 84878390220     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.462440     Document Type: Article

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