The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

Pharmacological Research

Volumn 73, Issue , 2013, Pages 44-54

  Talman, Virpi ^a,c   Amadio, Marialaura ^b   Osera, Cecilia ^b   Sorvari, Salla ^a   Boije Af Gennäs, Gustav ^a   Yli Kauhaluoma, Jari ^a   Rossi, Daniela ^b   Govoni, Stefano ^b   Collina, Simona ^b   Ekokoski, Elina ^a   Tuominen, Raimo K ^a   Pascale, Alessia ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF PAVIA   (Italy)

^c Chemical Products Surveillance Group   (Finland)

Author keywords

ERK; GAP 43; Isophthalate; Neurite outgrowth; Protein kinase C; SH SY5Y cells

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; BIOLOGICAL MARKER; HMI 1A3; HMI 1B11; ISOENZYME; ISOPHTHALIC ACID; MI 40; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N 15E; NEUROMODULIN; PROTEIN KINASE C ALPHA; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CELL SURVIVAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; GAP 43 GENE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MICROARRAY ANALYSIS; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING; UPREGULATION; WNT SIGNALING PATHWAY;

CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; GAP-43 PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEURITES; NEUROBLASTOMA; PHTHALIC ACIDS; PROTEIN KINASE C-ALPHA; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY;

EID: 84878389915     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.04.008     Document Type: Article

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