Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm

Hippocampus

Volumn 12, Issue 4, 2002, Pages 457-464

  Young, Elizabeth ^a   Cesena, Teresa ^a   Meiri, Karina F ^b   Perrone Bizzozero, Nora I ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Learning and memory; PKC 11; PKC ; Synaptic plasticity

Indexed keywords

ISOENZYME; NEUROMODULIN; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C EPSILON; PRKCE PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BRAIN FUNCTION; CONDITIONING; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEAR; HIPPOCAMPUS; LEARNING; MEMORY; NERVE CELL MEMBRANE; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STIMULUS RESPONSE; TRAINING; ANIMAL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMAL; BIOLOGICAL TRANSPORT; CONDITIONING (PSYCHOLOGY); FEAR; GAP-43 PROTEIN; HIPPOCAMPUS; ISOENZYMES; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; PROTEIN KINASE C-EPSILON;

EID: 0035994832     PISSN: 10509631     EISSN: None     Source Type: Journal    
DOI: 10.1002/hipo.10015     Document Type: Article

References (75)

1. PKCγ-mutant mice exhibit mild deficits in spatial and contextual learning
2. Modified hippocampal long-term potentiation in PKCγ-mutant mice
3. Translocation of protein kinase C activity may mediate hippocampal long-term potentiation
4. Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: Within-subjects examination
5. Hippocampus and contextual fear conditioning: Recent controversies and advances
6. Hippocampal long-term potentiation in vivo induces translocation of protein kinase C γ
7. Classical conditioning induces long-term translocation of protein kinase C in rabbit hippocampal CA1 cells
8. LTP saturation and spatial learning disruption: Effects of task variables and saturation levels
9. The expression of GAP-43 in relation to neuronal growth and plasticity: When, where, how, and why?
10. GAP-43: An intrinsic determinant of neuronal development and plasticity
11. Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain
12. Localization of the growth-associated phosphoprotein GAP-43 (B-50, F1) in the human cerebral cortex
13. A synaptic model of memory: Long-term potentiation in the hippocampus
14. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
15. B-50/GAP-43 phosphorylation and PKC activity are increased in rat hippocampal synaptosomal membranes after an inhibitory avoidance training
16. Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms
17. Translocation of protein kinase C γ occurs during the early phase of acquisition of food rewarded spatial learning
18. Linear relationship between the maintenance of hippocampal long-term potentiation and retention of an associative memory
19. Experimental input alters the phosphorylation of specific proteins in brain membranes
20. Associative vs topographical accounts of the immediate shock-freezing deficit in rats: Implications for the response selection rules governing species-specific defensive reactions
21. Factors governing one-trial contextual conditioning
22. The dorsal hippocampus is essential for context discrimination but not for contextual conditioning
23. Phosphorylation of the presynaptic protein B-50 (GAP-43) is increased during electrically induced long-term potentiation
24. Immunological demonstration of PKCε murine tissue distribution, ontogeny, cellullar localization and translocation
25. Behavioral LTP during learning in rat hippocampal CA3
26. Pharmacological evidence for a role of long-term potentiation in memory
27. Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and-long-term contextual fear
28. Mechanism of protein kinase C activation during the induction and maintenance of long-term potentiation probed using a selective peptide substrate
29. PKC activation rescues LTP from NMDA receptor blockade
30. Electron microscopic localization of γ- and βII-subspecies of protein kinase C in rat hippocampus
31. Demonstration of presynaptic protein kinase C activation after long-term potentiation in rat hippocampal slices
32. Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task
33. Enhancement of contextual fear-conditioning by putative (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators and N-methyl-D-aspartate (NMDA) receptor antagonists in DBA/2J mice
34. Potentiation of synaptic transmission in the hippocampus by phorbol esters
35. Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats
36. Distinctions between hippocampus of mouse and rat: Protein F1/GAP-43 gene expression, promoter activity, and spatial memory
37. Protein kinase C and F-1/GAP-43 gene expression in hippocampus inversely related to synaptic enhancement lasting 3 days
38. Protein F-1/GAP-43 and PKC gene expression patterns in hippocampus are altered 1-2 h after LTP
39. Increased expression of the ELAV-like GAP-43 mRNA binding protein HuD in the rat hippocampus after contextual fear conditioning
40. Monoclonal antibodies show that kinase C phosphorylation of GAP-43 during axonogenesis is both spatially and temporally restricted in vivo
41. Is learning blocked by saturation of synaptic weights in the hippocampus?
42. Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: Differences between oligopeptide and polypeptide phosphorylation
43. A role for protein kinase C in associative learning
44. Age-related deficits on the radial maze and in fear conditioning, hippocampal processing and consolidation
45. Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains
46. Long-term potentiation and synaptic protein phosphorylation
47. Acute phorbol ester treatment improves spatial learning performance in rats
48. DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning
49. Developmental differences in place-learning performance between C57BL/6 and DBA/2 mice parallel the ontogeny of hippocampal protein
50. Posttranscriptional regulation of GAP-43 gene expression in PC12 cells through protein kinase C-dependent stabilization of the mRNA
51. Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia
52. Prenatal ethanol exposure decreases GAP-43 phosphorylation and protein kinase C activity in the hippocampus of adult rat offspring
53. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning
54. Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function
55. Differential changes in the phosphorylation of the protein kinase C substrates myristoylated alanine-rich C kinase substrate and growth-associated protein-43/B-50 after Schaffer collateral long-term depression
56. Substrate phosphorylation in the protein kinase Cγ knockout mouse
57. In vitro phosphorylation of a 41000-MW protein band is selectively increased 24 hr after footshock or learning
58. Selective increase in phosphorylation state of a 47 kDa protein (F1) directly related to long-term potentiation
59. Enhanced learning after genetic overexpression of a brain growth protein
60. Auditory thalamus, dorsal hippocampus, basolateral amygdala, and perirhinal cortex role in the consolidation of conditioned freezing to context and to acoustic conditioned stimulus in the rat
61. Immunocytochemical localization of βII subspecies of protein kinase C in rat brain
62. Cellular and intracellular localization of ε-subspecies of protein kinase C in the rat brain; presynaptic localization of the ε-subspecies
63. Prenatal ethanol exposure diminishes activity-dependent potentiation of amino acid neutrotransmitter release in adult rat offspring
64. Neuron-specific protein F1/GAP-43 shows substrate specificity for the beta subtype of protein kinase C
65. Learning selectively increases protein kinase C substrate phosphorylation in specific regions of the chick brain
66. Evidence for the co-identification of GAP-43, a growth-associated protein, and F1, a plasticity-associated protein
67. The translocation and involvement of protein kinase C in mossy fiber-CA3 long-term potentiation in hippocampus of rat brain
68. Time course and involvement of protein kinase C-mediated phosphorylation of F1/GAP-43 in area CA3 after mossy fiber stimulation
69. Prenatal ethanol exposure to moderate levels of ethanol can have long-lasting effects on hippocampal synaptic plasticity in adult offspring
70. Protein kinase C in rat brain synaptosomes: βII-subspecies as a major isoform associated with membrane-skeleton elements
71. A role for the β isoform of protein kinase C in fear conditioning
72. Fear conditioning-induced alterations of phospholipase C-β1 a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex
73. Hippocampal protein kinase C activity is reduced in poor spatial learners
74. Alterations in hippocampal GAP-43 phosphorylation and protein level after contextual fear conditioning
75. Phosphorylation changes after weakly reinforced learning and ACTH-induced memory consolidation for a weak learning experience