SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells

Molecular Biology Reports

Volumn 40, Issue 4, 2013, Pages 2947-2953

  Gao, Ganglong ^a   Kun, Tao ^b   Sheng, Youhua ^a   Qian, Min ^a   Kong, Fanzhi ^c   Liu, Xiaoguang ^d   Yu, Zhenfeng ^a   Zhang, Haiqin ^a   Zhang, Qiang ^a   Gu, Jianping ^a   Zhang, Xueli ^a  

^a Central Hospital of Fengxian District   (China)

^b Changning District Central Hospital   (China)

^c SOOCHOW UNIVERSITY   (China)

^d Longsai Hospital   (China)

Author keywords

Akt phosphorylation; Akt signaling; Beta TrCP; Gastric cancer; PHLPP1; SGT1

Indexed keywords

BETA TRCP; F BOX PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; PROTEIN PHLPP1; REGULATOR PROTEIN; SMALL INTERFERING RNA; SUPPRESSOR OF G2 ALLELE OF SKP1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER TISSUE; CARCINOGENESIS; CELL GROWTH; COLONY FORMATION; CONTROLLED STUDY; ENZYME BINDING; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; ENZYME STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH CANCER;

BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CELL CYCLE PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NUCLEAR PROTEINS; ONCOGENE PROTEIN V-AKT; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEOLYSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 84878389344     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-2363-8     Document Type: Article

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