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Volumn 41, Issue 3, 2013, Pages 487-502

Triterpenoid-rich fraction from ilex hainanensis merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats

Author keywords

Ilex hainanensis Merr; Inflammation; Insulin Resistance; NAFLD Rats; Oxidative Stress; Triterpenoid Rich Fraction

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CYTOCHROME P450 2E1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ILEX HAINANENSIS EXTRACT; INSULIN; LIVER PROTECTIVE AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLANT EXTRACT; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TRITERPENOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84878388930     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500353     Document Type: Article
Times cited : (23)

References (36)
  • 1
    • 34548392209 scopus 로고    scopus 로고
    • Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)
    • DOI 10.1016/j.drudis.2007.07.009, PII S1359644607002760
    • Ahmed, M.H. and C.D. Byrne. Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD). Drug Discov. Today 12: 740-747, 2007. (Pubitemid 47362786)
    • (2007) Drug Discovery Today , vol.12 , Issue.17-18 , pp. 740-747
    • Ahmed, M.H.1    Byrne, C.D.2
  • 3
    • 0037369729 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
    • DOI 10.1053/jhep.2003.50095
    • Chalasani, N., J.C. Gorski, M.S. Asghar, A. Asghar, B. Foresman, S.D. Hall and D.W. Crabb. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Hepatology 37: 544-550, 2003. (Pubitemid 36258775)
    • (2003) Hepatology , vol.37 , Issue.3 , pp. 544-550
    • Chalasani, N.1    Gorski, J.C.2    Asghar, M.S.3    Asghar, A.4    Foresman, B.5    Hall, S.D.6    Crabb, D.W.7
  • 4
    • 72549104258 scopus 로고    scopus 로고
    • Triterpenes and flavonoids from Ilex hainanensis Merr. (Aquifoliaceae)
    • Chen, X.Q., K. Zan, H. Liu, J. Yang, M.X. Lai and Q. Wang. Triterpenes and flavonoids from Ilex hainanensis Merr. (Aquifoliaceae). Biochem. Syst. Ecol. 37: 678-682, 2009.
    • (2009) Biochem. Syst. Ecol , vol.37 , pp. 678-682
    • Chen, X.Q.1    Zan, K.2    Liu, H.3    Yang, J.4    Lai, M.X.5    Wang, Q.6
  • 5
    • 8744254513 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): Diagnosis and clinical course
    • DOI 10.1016/j.bpg.2004.06.021, PII S1521691804000824
    • Cortez-Pinto, H. and M.E. Camilo. Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): diagnosis and clinical course. Best Pract. Res. Clin. Gastroenterol. 18: 1089-1104, 2004. (Pubitemid 39517694)
    • (2004) Best Practice and Research: Clinical Gastroenterology , vol.18 , Issue.6 SPEC.ISS. , pp. 1089-1104
    • Cortez-Pinto, H.1    Camilo, M.E.2
  • 6
    • 37549022688 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • DOI 10.1016/j.febslet.2007.11.057, PII S0014579307012082
    • de Luca, C. and J.M. Olefsky. Inflammation and insulin resistance. FEBS Lett. 582: 97-105, 2008. (Pubitemid 50010731)
    • (2008) FEBS Letters , vol.582 , Issue.1 , pp. 97-105
    • De Luca, C.1    Olefsky, J.M.2
  • 7
    • 84873254850 scopus 로고
    • Department of Health of Guangxi Zhuang Minority Autonomous Region Guangxi Science and Technology Press, Nanning
    • Department of Health of Guangxi Zhuang Minority Autonomous Region. In: Chinese Medicinal Materials Standard of Guangxi, 1990 edition. Guangxi Science and Technology Press, Nanning, 1992, pp. 20-21.
    • (1992) Chinese Medicinal Materials Standard of Guangxi 1990 Edition , pp. 20-21
  • 8
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
    • DOI 10.1002/hep.20251
    • Dixon, J.B., P.S. Bhathal, N.R. Hughes and P.E. O'Brien. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology 39: 1647-1654, 2004. (Pubitemid 38702666)
    • (2004) Hepatology , vol.39 , Issue.6 , pp. 1647-1654
    • Dixon, J.B.1    Bhathal, P.S.2    Hughes, N.R.3    O'Brien, P.E.4
  • 10
    • 0041764982 scopus 로고    scopus 로고
    • CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease
    • DOI 10.1053/jhep.2003.50342
    • Emery, M.G., J.M. Fisher, J.Y. Chien, E.D. Kharasch, E.P. Dellinger, K.V. Kowdley and K.E. Thummel. CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Hepatology 38: 428-435, 2003. (Pubitemid 36919864)
    • (2003) Hepatology , vol.38 , Issue.2 , pp. 428-435
    • Emery, M.G.1    Fisher, J.M.2    Chien, J.Y.3    Kharasch, E.D.4    Dellinger, E.P.5    Kowdley, K.V.6    Thummel, K.E.7
  • 11
    • 84866427009 scopus 로고    scopus 로고
    • Effects of the ethanol extract from Ilex hainanensis Merr. on experimental hyperlipidemia in rats
    • Fang, R.T. and T.S. Wei. Effects of the ethanol extract from Ilex hainanensis Merr. on experimental hyperlipidemia in rats. Northwest. Pharm. J. 26: 123-125, 2011.
    • (2011) Northwest. Pharm. J , vol.26 , pp. 123-125
    • Fang, R.T.1    Wei, T.S.2
  • 12
    • 33646812161 scopus 로고    scopus 로고
    • Fenofibrate, a peroxisome proliferators-activated receptor-agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver shionogi mice with hereditary fatty liver
    • Harano, Y., K. Yasui, T. Toyama, T. Nakajima, H. Mitsuyoshi, M. Mimani, T. Hirasawa, Y. Itoh and T. Okanoue. Fenofibrate, a peroxisome proliferators-activated receptor-agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver shionogi mice with hereditary fatty liver. Liver Int. 26: 613-620, 2006.
    • (2006) Liver Int , vol.26 , pp. 613-620
    • Harano, Y.1    Yasui, K.2    Toyama, T.3    Nakajima, T.4    Mitsuyoshi, H.5    Mimani, M.6    Hirasawa, T.7    Itoh, Y.8    Okanoue, T.9
  • 13
    • 33846113313 scopus 로고    scopus 로고
    • Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty liver disease
    • DOI 10.1111/j.1440-1681.2007.04547.x
    • Hong, X.Z., L.D. Li and L.M. Wu. Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty liver disease. Clin. Exp. Pharmacol. Physiol. 34: 27-35, 2007. (Pubitemid 46069582)
    • (2007) Clinical and Experimental Pharmacology and Physiology , vol.34 , Issue.1-2 , pp. 27-35
    • Hong, X.Z.1    Li, L.D.2    Wu, L.M.3
  • 14
    • 84861492925 scopus 로고    scopus 로고
    • Protective effects of total flavonoids from Litsea coreana on alcoholic fatty liver in rats associated with down-regulation adipose differentiation- related protein expression
    • Hu, C.M., Q. Cao, X.W. Lv, W.M. Cheng, R. Li and J. Li. Protective effects of total flavonoids from Litsea coreana on alcoholic fatty liver in rats associated with down-regulation adipose differentiation-related protein expression. Am. J. Chin. Med. 40: 599-610, 2012.
    • (2012) Am. J. Chin. Med , vol.40 , pp. 599-610
    • Hu, C.M.1    Cao, Q.2    Lv, X.W.3    Cheng, W.M.4    Li, R.5    Li, J.6
  • 15
    • 84864256344 scopus 로고    scopus 로고
    • Zhenqing recipe improves glucose metabolism and insulin sensitivity by repressing hepatic FOXO1 in type 2 diabetic rats
    • Huang, W., J. Yu, X. Jia, L. Xiong, N. Li and X. Wen. Zhenqing recipe improves glucose metabolism and insulin sensitivity by repressing hepatic FOXO1 in type 2 diabetic rats. Am. J. Chin. Med. 40: 721-733, 2012.
    • (2012) Am. J. Chin. Med , vol.40 , pp. 721-733
    • Huang, W.1    Yu, J.2    Jia, X.3    Xiong, L.4    Li, N.5    Wen, X.6
  • 17
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq, I.A., G.C. Farrell, J. Field, D.R. Bell, F.J. Gonzalez and G.R. Robertson. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J. Clin. Invest. 105: 1067-1975, 2000.
    • (2000) J. Clin. Invest , vol.105 , pp. 1067-1975
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 18
    • 78751549143 scopus 로고    scopus 로고
    • Hypotensive, hypolipidemic, and vascular protective effects of Morus alba L. in rats fed an atherogenic diet
    • Lee, Y.J., D.H. Choi, E.J. Kim, H.Y. Kim, T.O. Kwon, D.G. Kang and H.S. Lee. Hypotensive, hypolipidemic, and vascular protective effects of Morus alba L. in rats fed an atherogenic diet. Am. J. Chin. Med. 39: 39-52, 2011.
    • (2011) Am. J. Chin. Med , vol.39 , pp. 39-52
    • Lee, Y.J.1    Choi, D.H.2    Kim, E.J.3    Kim, H.Y.4    Kwon, T.O.5    Kang, D.G.6    Lee, H.S.7
  • 19
    • 84892673425 scopus 로고
    • Clinical effects of Shanlvcha on hypertension and hyperlipidemia
    • Li, J.M. and B.H. Lu. Clinical effects of Shanlvcha on hypertension and hyperlipidemia. Guangxi Med. J. 7: 287-290, 1985.
    • (1985) Guangxi Med. J , vol.7 , pp. 287-290
    • Li, J.M.1    Lu, B.H.2
  • 20
    • 84875581602 scopus 로고    scopus 로고
    • Pharmacodynamics of Shanlucha antihypertension tablets for the treatment of hypertension with vertigo and headache
    • Liu, Y., H.Y. Wei, J.C. Long and Z.O. Jiang. Pharmacodynamics of Shanlucha antihypertension tablets for the treatment of hypertension with vertigo and headache. Chin. J. Exp. Tradit. Med. Formul. 16: 86-87, 2010.
    • (2010) Chin. J. Exp. Tradit. Med. Formul , vol.16 , pp. 86-87
    • Liu, Y.1    Wei, H.Y.2    Long, J.C.3    Jiang, Z.O.4
  • 21
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig, J., T.R. Viggiano, D.B. McGill and B.J. Oh. Non-alcoholic steatohepatitis: mayo clinic experiences with a hitherto unnamed disease. Mayo. Clin. Proc. 55: 434-438, 1980. (Pubitemid 10057164)
    • (1980) Mayo Clinic Proceedings , vol.55 , Issue.7 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Ott, B.J.4
  • 22
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
    • DOI 10.1016/S0016-5085(99)70506-8
    • Matteoni, C.A., Z.M. Younosis, T. Gramlich, N. Boparai, Y.C. Liu and A.J. McCullough. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116: 1413-1419, 1999. (Pubitemid 29258890)
    • (1999) Gastroenterology , vol.116 , Issue.6 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3    Boparai, N.4    Yao Chang Liu5    McCullough, A.J.6
  • 23
    • 3342958806 scopus 로고    scopus 로고
    • Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis
    • DOI 10.2337/diacare.27.8.2057
    • Medina, J., L.I. Fernández-Salazar, L. García-Buey and R. Moreno-Otero. Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis. Diabetes Care 27: 2057-2066, 2004. (Pubitemid 38989257)
    • (2004) Diabetes Care , vol.27 , Issue.8 , pp. 2057-2066
    • Medina, J.1    Fernandez-Salazar, L.I.2    Garcia-Buey, L.3    Moreno-Otero, R.4
  • 25
    • 2942738940 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease (NAFLD): A comprehensive review
    • Salt, W.B. 2nd. Nonalcoholic fatty liver disease (NAFLD): a comprehensive review. J. Insur. Med. 36: 27-41, 2004.
    • (2004) J. Insur. Med , vol.36 , pp. 27-41
    • Salt, W.B.1
  • 27
    • 0037898380 scopus 로고    scopus 로고
    • Diabetic dyslipidaemia: From basic research to clinic practice
    • Taskinen, M.R. Diabetic dyslipidaemia: from basic research to clinic practice. Diabetologia 46: 733-749, 2003.
    • (2003) Diabetologia , vol.46 , pp. 733-749
    • Taskinen, M.R.1
  • 28
    • 33748111665 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance
    • DOI 10.1053/j.gastro.2006.05.054, PII S0016508506012078
    • Tilg, H. and G.S. Hotamisligil. Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 131: 934-945, 2006. (Pubitemid 44307061)
    • (2006) Gastroenterology , vol.131 , Issue.3 , pp. 934-945
    • Tilg, H.1    Hotamisligil, G.S.2
  • 29
    • 80052624987 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid
    • Tsai, J.C., W.H. Peng, T.H. Chiu, S.C. Lai and C.Y. Lee. Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. Am. J. Chin. Med. 39: 943-956, 2011.
    • (2011) Am. J. Chin. Med , vol.39 , pp. 943-956
    • Tsai, J.C.1    Peng, W.H.2    Chiu, T.H.3    Lai, S.C.4    Lee, C.Y.5
  • 30
    • 84875599401 scopus 로고    scopus 로고
    • Effect of hainan holly leaf total flavonoids on serum lipids based on hyperlipidemia mice
    • Wei, J. and Y. Sun. Effect of hainan holly leaf total flavonoids on serum lipids based on hyperlipidemia mice. J. Yangzhou Univ. (Agric. Life Sci. ed.) 30: 64-70, 2009.
    • (2009) J. Yangzhou Univ. (Agric. Life Sci. Ed.) , vol.30 , pp. 64-70
    • Wei, J.1    Sun, Y.2
  • 31
    • 84866365058 scopus 로고    scopus 로고
    • Preventive effects of flavonoid extracts from Ilex hainanensis Merr. on rats with hepatic steatosis induced by a high-fat diet
    • Wei, X.L., X.Q. Chen, R.T. Fang, X.Y. Sun, C.S. Zhu, J. Yang, X. Xue and Q. Wang. Preventive effects of flavonoid extracts from Ilex hainanensis Merr. on rats with hepatic steatosis induced by a high-fat diet. Drug Develop. Res. 73: 308-316, 2012.
    • (2012) Drug Develop. Res , vol.73 , pp. 308-316
    • Wei, X.L.1    Chen, X.Q.2    Fang, R.T.3    Sun, X.Y.4    Zhu, C.S.5    Yang, J.6    Xue, X.7    Wang, Q.8
  • 32
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
    • DOI 10.1002/hep.510270121
    • Weltman, M.D., G.C. Farrell, P. Hall, M. Ingelman-Sundberg and C. Liddle. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27: 128-133, 1998. (Pubitemid 28041545)
    • (1998) Hepatology , vol.27 , Issue.1 , pp. 128-133
    • Weltman, M.D.1    Farrell, G.C.2    Hall, P.3    Ingelman-Sundberg, M.4    Liddle, C.5
  • 33
    • 78049376733 scopus 로고    scopus 로고
    • Determination of total triterpene saponins in Cyclocarya paliurus (Batal.) Iljinskaja by sprctrophotometry
    • Xu, R.Y., Y.P. Hong, X.C. Shangguan, Z.P. Yin, Y. Jiang and M.S. Chen. Determination of total triterpene saponins in Cyclocarya paliurus (Batal.) Iljinskaja by sprctrophotometry. Acta Agric. Univ. Jiangxi 29: 449-453, 2007.
    • (2007) Acta Agric. Univ. Jiangxi , vol.29 , pp. 449-453
    • Xu, R.Y.1    Hong, Y.P.2    Shangguan, X.C.3    Yin, Z.P.4    Jiang, Y.5    Chen, M.S.6
  • 34
    • 0036348363 scopus 로고    scopus 로고
    • Ectopic fat accumulation: An important cause of insulin resistance in humans
    • Yki-Järvinen, H. Ectopic fat accumulation: an important cause of insulin resistance in humans. J. R. Soc. Med. 42: 39-45, 2002. (Pubitemid 34879130)
    • (2002) Journal of the Royal Society of Medicine, Supplement , vol.95 , Issue.42 , pp. 39-45
    • Yki-Jarvinen, H.1
  • 35
    • 33646440029 scopus 로고    scopus 로고
    • Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-α activators: Clinical and experimental evidence
    • DOI 10.1161/01.ATV.0000204327.96431.9a, PII 0004360520060500000007
    • Zambon, A., P. Gervois, P. Pauletto, J.C. Fruchart and B. Staels. Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-acticators clinical and experimental evidence. Arterioscler. Thromb. Vasc. Biol. 26: 977-986, 2006. (Pubitemid 43732101)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.5 , pp. 977-986
    • Zambon, A.1    Gervois, P.2    Pauletto, P.3    Fruchart, J.-C.4    Staels, B.5
  • 36
    • 33846637401 scopus 로고    scopus 로고
    • Triterpenoids from the leaves of Ilex hainanensis
    • Zhou, S.X., J.S. Yang, F.C. Liu and P.F. Tu. Triterpenoids from the leaves of Ilex hainanensis. Helv. Chim. Acta 90: 121-126, 2007.
    • (2007) Helv. Chim. Acta , vol.90 , pp. 121-126
    • Zhou, S.X.1    Yang, J.S.2    Liu, F.C.3    Tu, P.F.4


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