Protective effects of total flavonoids from Litsea coreana on alcoholic fatty liver in rats associated with down-regulation adipose differentiation- related protein expression

American Journal of Chinese Medicine

Volumn 40, Issue 3, 2012, Pages 599-610

  Hu, Cheng Mu ^a   Cao, Qi ^a   Lv, Xiong Wen ^a   Cheng, Wen Ming ^a   Li, Rong ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Adipose Differentiation Related Protein (ADRP); Alcoholic Fatty Liver (AFL); Flavonoids; Insulin; Litsea coreana L. (TFLC); TNF

Indexed keywords

ADIPOPHILIN; CATECHOL DERIVATIVE; CHOLESTEROL; EPICATECHIN; FLAVONOID; GLUCOSE; INSULIN; KAEMPFEROL DERIVATIVE; LITSEA COREANA EXTRACT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; QUERCETIN DERIVATIVE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; LITSEA; LITSEA COREANA; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BLOOD GLUCOSE; DOWN-REGULATION; ETHANOL; FATTY LIVER, ALCOHOLIC; FLAVONOIDS; HYPOLIPIDEMIC AGENTS; INSULIN; LIPIDS; LITSEA; LIVER; MALE; MEMBRANE PROTEINS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84861492925     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X12500450     Document Type: Article

References (26)

1. Bharrhan, S., A. Koul, K. Chopra and P. Rishi. Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. PloS One 6: e20635, 2011.
2. Bujanda, L., E. Hijona, M. Larzabal, M. Beraza, P. Aldazabal, N. Garcia-Urkia, C. Sarasqueta, A. Cosme, B. Irastorza, A. Gonzalez and J.I. Arenas. Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol. 8: 40, 2008.
3. Chang, B.H., L. Li, P. Saha and L. Chan. Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice. J. Lipid Res. 51: 2132-2142, 2010.
4. El-Banhawey, M.A., M.A. Ashry, A.K. El-Ansary and S.A. Aly. Effect of Curcuma longa or parziquantel on Schistosoma mansoni infected mice liver-histological and histochemical study. Indian J. Exp. Biol. 45: 877-889, 2007.
5. Federico, A., E. D'Aiuto, F. Borriello, G. Barra, A.G. Gravina, M. Romano and R. De Palma. Fat: A matter of disturbance for the immune system. World J. Gastroenterol. 16: 4762-4772, 2010.
6. Grasselli, E., A. Voci, C. Pesce, L. Canesi, E. Fugassa, G. Gallo and L. Vergani. PAT protein mRNA expression in primary rat hepatocytes: effects of exposure to fatty acids. Int. J. Mol. Med. 25: 505-512, 2010.
7. Hines, I.N. and M.D. Wheeler. Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G310-G314, 2004. (Pubitemid 38955249)
8. Hu, C.M., C. Lin and R. Li. Immunomodulatory property of total flavonoids from Litsea coreana leveille on immunosuppressivemic. Chin. Pharmacol. Bull. 23: 804-808, 2007.
9. Huang, C., T. Ma, X.M. Meng, Y.X. Lv, L. Zhang, J.Q. Wang and J. Li. Potential protective effects of a traditional Chinese herb, Litsea coreana Levl., on liver fibrosis in rats. J. Pharm. Pharmacol. 62: 223-230, 2010.
10. Johnsen, G.M., M.S. Weedon-Fekjaer, K.A. Tobin, A.C. Staff and A.K. Duttaroy. Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. Placenta 30: 1037-1044, 2009.
11. Lee, T.F., K.M. Mak, O. Rackovsky, Y.L. Lin, A.J. Kwong, J.C. Loke and S.L. Friedman. Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP). J. Cell Physiol. 223: 648-657, 2010.
12. Listenberger, L.L., A.G. Ostermeyer-Fay, E.B. Goldberg, W.J. Brown and D.A. Brown. Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover. J. Lipid Res. 48: 2751-2761, 2007. (Pubitemid 350272859)
13. Lu, Y.X., Q. Zhang, J. Li, Y.X. Sun, L.Y. Wang, W.M. Cheng and X.Y. Hu. Antidiabetic effects of total flavonoids from Litsea coreana leve on fat-fed, streptozotocin-induced type 2 diabetic rats. Am. J. Chin. Med. 38: 713-725, 2010.
14. Mak, K.M., C. Ren, A. Ponomarenko, Q. Cao and C.S. Lieber. Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats. Alcohol. Clin. Exp. Res. 32: 683-689, 2008. (Pubitemid 351430433)
15. Nohara, A., S. Okada, K. Ohshima, J.E. Pessin and M. Mori. Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor- -induced insulin resistance. J. Biol. Chem. 286: 33457-33465, 2011.
16. Pickens, M.K., J.S. Yan, R.K. Ng, H. Ogata, J.P. Grenert, C. Beysen, S.M. Turner and J.J. Maher. Dietary sucrose is essential to the development of liver injury in the methionine-cholinedeficient model of steatohepatitis. J. Lipid Res. 50: 2072-2082, 2009.
17. Qin, Y. and Y.P. Tian. Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice. J. Transl. Med. 8: 120, 2010.
18. Rivera, C.A., S.H. Abrams, M.H. Tcharmtchi, M. Allman, T.T. Ziba, M.J. Finegold and C.W. Smith. Feeding a corn oil/sucrose-enriched diet enhances steatohepatitis in sedentary rats. Am. J. Physiol. 290: G386-G393, 2006.
19. Seufi, A.M., S.S. Ibrahim, T.K. Elmaghraby and E.E. Hafez. Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences. J. Exp. Clin. Cancer Res. 28: 80, 2009.
20. Tam, J., J. Liu, B. Mukhopadhyay, R. Cinar, G. Godlewski and G. Kunos. Endocannabinoids in liver disease. Hepatology 53: 346-355, 2011.
21. Tolstrup, J.S., J. Halkjaer, B.L. Heitmann, A.M. Tjonneland, K. Overvad, T.I. Sorensen and M.N. Gronbaek. Alcohol drinking frequency in relation to subsequent changes in waist circumference. Am. J. Clin. Nutr. 87: 957-963, 2008. (Pubitemid 351549241)
22. Uysal, K.T., S.M. Wiesbrock, M.W. Marino and G.S. Hotamisligil. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389: 610-614, 1997. (Pubitemid 27446179)
23. Varela, G.M., D.A. Antwi, R. Dhir, X. Yin, N.S. Singhal, M.J. Graham, R.M. Crooke and R.S. Ahima. Inhibition of ADRP prevents diet-induced insulin resistance. Am. J. Physiol. 295: G621-G628, 2008.
24. Wang, J.Q., J. Li, Y.H. Zou, W.M. Cheng, C. Lu, L. Zhang, J.F. Ge, C. Huang, Y. Jin, X.W. Lv, C. M. Hu and L.P. Liu. Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet. J. Ethnopharmacol. 121: 54-60, 2009.
25. Yamamoto, Y. and A. Yasuoka. Welsh onion attenuates hyperlipidemia in rats fed on high-fat highsucrose diet. Biosci. Biotechnol. Biochem. 74: 402-404, 2010.
26. Ye, H., L.Q. Jin and J.P. Yu. Research on the mechanism of antioxidation of flavonoids from leaves of Litsea coreana. J. Wenzhou Med. Coll. 36: 424-427, 2006.