메뉴 건너뛰기




Volumn 4, Issue 3, 2013, Pages

Human Wharton's jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; MESSENGER RNA; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; ACTIN; CADHERIN; CULTURE MEDIUM; SMOOTH MUSCLE ACTIN, RAT;

EID: 84878388234     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/scrt215     Document Type: Article
Times cited : (70)

References (36)
  • 1
    • 84925869881 scopus 로고    scopus 로고
    • Pathophysiology of acute kidney injury to chronic kidney disease: Maladaptive repair
    • 21921619
    • Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. Yang L, Humphreys BD, Bonventre JV, Contrib Nephrol 2011 174 149 155 21921619
    • (2011) Contrib Nephrol , vol.174 , pp. 149-155
    • Yang, L.1    Humphreys, B.D.2    Bonventre, J.V.3
  • 3
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • 10.1172/JCI39104 19487818
    • The basics of epithelial-mesenchymal transition. Kalluri R, Weinberg RA, J Clin Invest 2009 119 1420 1428 10.1172/JCI39104 19487818
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 4
    • 77955602944 scopus 로고    scopus 로고
    • Resolved: EMT produces fibroblasts in the kidney
    • 10.1681/ASN.2010060616 20651165
    • Resolved: EMT produces fibroblasts in the kidney. Zeisberg M, Duffield JS, J Am Soc Nephrol 2010 21 1247 1253 10.1681/ASN.2010060616 20651165
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1247-1253
    • Zeisberg, M.1    Duffield, J.S.2
  • 5
    • 78149298226 scopus 로고    scopus 로고
    • Mechanisms of tubulointerstitial fibrosis
    • 10.1681/ASN.2010080793 20864689
    • Mechanisms of tubulointerstitial fibrosis. Zeisberg M, Neilson EG, J Am Soc Nephrol 2010 21 1819 1834 10.1681/ASN.2010080793 20864689
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1819-1834
    • Zeisberg, M.1    Neilson, E.G.2
  • 6
    • 0034785496 scopus 로고    scopus 로고
    • Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    • Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Yang J, Liu Y, Am J Pathol 2001 159 1465 1475 10.1016/S0002-9440(10)62533-3 11583974 (Pubitemid 32947976)
    • (2001) American Journal of Pathology , vol.159 , Issue.4 , pp. 1465-1475
    • Yang, J.1    Liu, Y.2
  • 7
    • 16844371760 scopus 로고    scopus 로고
    • A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition
    • DOI 10.1681/ASN.2003090795
    • A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. Yang J, Dai C, Liu Y, J Am Soc Nephrol 2005 16 68 78 15537870 (Pubitemid 43073158)
    • (2005) Journal of the American Society of Nephrology , vol.16 , Issue.1 , pp. 68-78
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 8
    • 2942635909 scopus 로고    scopus 로고
    • Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms of action
    • DOI 10.1152/ajprenal.00451.2003
    • Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action. Liu Y, Am J Physiol Renal Physiol 2004 287 7 F16 10.1152/ajprenal.00451.2003 15180923 (Pubitemid 38780577)
    • (2004) American Journal of Physiology - Renal Physiology , vol.287
    • Liu, Y.1
  • 9
    • 77649091092 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A new therapeutic tool for AKI
    • 10.1038/nrneph.2009.229 20186233
    • Mesenchymal stem cells: a new therapeutic tool for AKI. Togel FE, Westenfelder C, Nat Rev Nephrol 2010 6 179 183 10.1038/nrneph.2009.229 20186233
    • (2010) Nat Rev Nephrol , vol.6 , pp. 179-183
    • Togel, F.E.1    Westenfelder, C.2
  • 10
    • 73849109910 scopus 로고    scopus 로고
    • Paracrine/endocrine mechanism of stem cells on kidney repair: Role of microvesicle-mediated transfer of genetic information
    • 10.1097/MNH.0b013e328332fb6f 19823086
    • Paracrine/endocrine mechanism of stem cells on kidney repair: role of microvesicle-mediated transfer of genetic information. Camussi G, Deregibus MC, Tetta C, Curr Opin Nephrol Hypertens 2010 19 7 12 10.1097/MNH.0b013e328332fb6f 19823086
    • (2010) Curr Opin Nephrol Hypertens , vol.19 , pp. 7-12
    • Camussi, G.1    Deregibus, M.C.2    Tetta, C.3
  • 11
    • 84861999021 scopus 로고    scopus 로고
    • Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: Can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?
    • 10.1038/leu.2011.389 22182853
    • Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies? Ratajczak MZ, Kucia M, Jadczyk T, Greco NJ, Wojakowski W, Tendera M, et al. Leukemia 2012 26 1166 1173 10.1038/leu.2011.389 22182853
    • (2012) Leukemia , vol.26 , pp. 1166-1173
    • Ratajczak, M.Z.1    Kucia, M.2    Jadczyk, T.3    Greco, N.J.4    Wojakowski, W.5    Tendera, M.6
  • 12
    • 84861999021 scopus 로고    scopus 로고
    • Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: Can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?
    • 10.1038/leu.2011.389 22182853
    • Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies? Ratajczak MZ, Kucia M, Jadczyk T, Greco NJ, Wojakowski W, Tendera M, et al. Leukemia 2012 26 1166 1173 10.1038/leu.2011.389 22182853
    • (2012) Leukemia , vol.26 , pp. 1166-1173
    • Ratajczak, M.Z.1    Kucia, M.2    Jadczyk, T.3    Greco, N.J.4    Wojakowski, W.5    Tendera, M.6
  • 13
    • 77955102398 scopus 로고    scopus 로고
    • The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine
    • 10.2183/pjab.86.588 20551596
    • The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine. Nakamura T, Mizuno S, Proc Jpn Acad Ser B Phys Biol Sci 2010 86 588 610 10.2183/pjab.86.588 20551596
    • (2010) Proc Jpn Acad ser B Phys Biol Sci , vol.86 , pp. 588-610
    • Nakamura, T.1    Mizuno, S.2
  • 14
    • 84867629610 scopus 로고    scopus 로고
    • The alleviation of acute and chronic kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemia-reperfusion injury via an endocrine mechanism
    • 10.3109/14653249.2012.711471 22920838
    • The alleviation of acute and chronic kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemia-reperfusion injury via an endocrine mechanism. Du T, Cheng J, Zhong L, Zhao XF, Zhu J, Zhu YJ, et al. Cytotherapy 2012 14 1215 1227 10.3109/14653249.2012.711471 22920838
    • (2012) Cytotherapy , vol.14 , pp. 1215-1227
    • Du, T.1    Cheng, J.2    Zhong, L.3    Zhao, X.F.4    Zhu, J.5    Zhu, Y.J.6
  • 17
    • 60749137389 scopus 로고    scopus 로고
    • EMT and proteinuria as progression factors
    • 10.1038/ki.2008.425 18716603
    • EMT and proteinuria as progression factors. Strutz FM, Kidney Int 2009 75 475 481 10.1038/ki.2008.425 18716603
    • (2009) Kidney Int , vol.75 , pp. 475-481
    • Strutz, F.M.1
  • 18
    • 78049369136 scopus 로고    scopus 로고
    • Renal fibrosis: Novel insights into mechanisms and therapeutic targets
    • 20838416
    • Renal fibrosis: novel insights into mechanisms and therapeutic targets. Boor P, Ostendorf T, Floege J, Nat Rev Nephrol 2010 6 643 656 20838416
    • (2010) Nat Rev Nephrol , vol.6 , pp. 643-656
    • Boor, P.1    Ostendorf, T.2    Floege, J.3
  • 19
    • 84857111725 scopus 로고    scopus 로고
    • The origin of interstitial myofibroblasts in chronic kidney disease
    • 10.1007/s00467-011-1772-6 21311912
    • The origin of interstitial myofibroblasts in chronic kidney disease. Grgic I, Duffield JS, Humphreys BD, Pediatr Nephrol 2012 27 183 193 10.1007/s00467-011-1772-6 21311912
    • (2012) Pediatr Nephrol , vol.27 , pp. 183-193
    • Grgic, I.1    Duffield, J.S.2    Humphreys, B.D.3
  • 21
    • 79955639920 scopus 로고    scopus 로고
    • Arterially delivered mesenchymal stem cells prevent obstruction-induced renal fibrosis
    • 10.1016/j.jss.2010.06.022 20850784
    • Arterially delivered mesenchymal stem cells prevent obstruction-induced renal fibrosis. Asanuma H, Vanderbrink BA, Campbell MT, Hile KL, Zhang H, Meldrum DR, et al. J Surg Res 2011 168 51 e59 10.1016/j.jss.2010.06.022 20850784
    • (2011) J Surg Res , vol.168
    • Asanuma, H.1    Vanderbrink, B.A.2    Campbell, M.T.3    Hile, K.L.4    Zhang, H.5    Meldrum, D.R.6
  • 22
    • 57149122959 scopus 로고    scopus 로고
    • Renal recovery following acute kidney injury
    • 10.1097/MCC.0b013e328317ee6e 19005306
    • Renal recovery following acute kidney injury. Macedo E, Bouchard J, Mehta RL, Curr Opin Crit Care 2008 14 660 665 10.1097/MCC.0b013e328317ee6e 19005306
    • (2008) Curr Opin Crit Care , vol.14 , pp. 660-665
    • Macedo, E.1    Bouchard, J.2    Mehta, R.L.3
  • 24
    • 77952174830 scopus 로고    scopus 로고
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    • 1p following 143 10.1038/nm.2144 20436483
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV, Nat Med 2010 16 535 543 1p following 143 10.1038/nm.2144 20436483
    • (2010) Nat Med , vol.16 , pp. 535-543
    • Yang, L.1    Besschetnova, T.Y.2    Brooks, C.R.3    Shah, J.V.4    Bonventre, J.V.5
  • 25
    • 73949096744 scopus 로고    scopus 로고
    • Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    • 10.2353/ajpath.2010.090517 20008127
    • Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, et al. Am J Pathol 2010 176 85 97 10.2353/ajpath.2010. 090517 20008127
    • (2010) Am J Pathol , vol.176 , pp. 85-97
    • Humphreys, B.D.1    Lin, S.L.2    Kobayashi, A.3    Hudson, T.E.4    Nowlin, B.T.5    Bonventre, J.V.6
  • 26
    • 34250733867 scopus 로고    scopus 로고
    • The role of tubular epithelial-mesenchymal transition in progressive kidney disease
    • DOI 10.1159/000101323
    • The role of tubular epithelial-mesenchymal transition in progressive kidney disease. Burns WC, Kantharidis P, Thomas MC, Cells Tissues Organs 2007 185 222 231 10.1159/000101323 17587828 (Pubitemid 46956862)
    • (2007) Cells Tissues Organs , vol.185 , Issue.1-3 , pp. 222-231
    • Burns, W.C.1    Kantharidis, P.2    Thomas, M.C.3
  • 27
    • 77949351029 scopus 로고    scopus 로고
    • New insights into epithelial-mesenchymal transition in kidney fibrosis
    • 10.1681/ASN.2008121226 20019167
    • New insights into epithelial-mesenchymal transition in kidney fibrosis. Liu Y, J Am Soc Nephrol 2010 21 212 222 10.1681/ASN.2008121226 20019167
    • (2010) J Am Soc Nephrol , vol.21 , pp. 212-222
    • Liu, Y.1
  • 28
    • 24644487312 scopus 로고    scopus 로고
    • TGF-β and epithelial-to-mesenchymal transitions
    • DOI 10.1038/sj.onc.1208927, PII 1208927
    • TGF-beta and epithelial-to-mesenchymal transitions. Zavadil J, Bottinger EP, Oncogene 2005 24 5764 5774 10.1038/sj.onc.1208927 16123809 (Pubitemid 43086136)
    • (2005) Oncogene , vol.24 , Issue.37 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 29
    • 0036138824 scopus 로고    scopus 로고
    • Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
    • Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. Yang J, Liu Y, J Am Soc Nephrol 2002 13 96 107 11752026 (Pubitemid 34042016)
    • (2002) Journal of the American Society of Nephrology , vol.13 , Issue.1 , pp. 96-107
    • Yang, J.1    Liu, Y.2
  • 30
    • 0033746079 scopus 로고    scopus 로고
    • Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways
    • 10.1111/j.1523-1755.2000.00375.x 11044223
    • Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways. Liu Y, Rajur K, Tolbert E, Dworkin LD, Kidney Int 2000 58 2028 2043 10.1111/j.1523-1755.2000.00375.x 11044223
    • (2000) Kidney Int , vol.58 , pp. 2028-2043
    • Liu, Y.1    Rajur, K.2    Tolbert, E.3    Dworkin, L.D.4
  • 31
    • 0036378179 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy
    • 10.1111/j.1523-1755.2002.kid579.x 12234294
    • Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy. Gao X, Mae H, Ayabe N, Takai T, Oshima K, Hattori M, et al. Kidney Int 2002 62 1238 1248 10.1111/j.1523-1755.2002.kid579.x 12234294
    • (2002) Kidney Int , vol.62 , pp. 1238-1248
    • Gao, X.1    Mae, H.2    Ayabe, N.3    Takai, T.4    Oshima, K.5    Hattori, M.6
  • 32
    • 0035070420 scopus 로고    scopus 로고
    • Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy
    • DOI 10.1046/j.1523-1755.2001.0590041304.x
    • Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Mizuno S, Matsumoto K, Nakamura T, Kidney Int 2001 59 1304 1314 10.1046/j.1523-1755.2001.0590041304.x 11260391 (Pubitemid 32281218)
    • (2001) Kidney International , vol.59 , Issue.4 , pp. 1304-1314
    • Mizuno, S.1    Matsumoto, K.2    Nakamura, T.3
  • 34
    • 67651242478 scopus 로고    scopus 로고
    • The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth
    • 10.1080/08977190902834077 19301208
    • The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth. Esposito C, Parrilla B, Cornacchia F, Grosjean F, Mangione F, Serpieri N, et al. Growth Factors 2009 27 173 180 10.1080/08977190902834077 19301208
    • (2009) Growth Factors , vol.27 , pp. 173-180
    • Esposito, C.1    Parrilla, B.2    Cornacchia, F.3    Grosjean, F.4    Mangione, F.5    Serpieri, N.6
  • 35
    • 77950557390 scopus 로고    scopus 로고
    • Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury
    • 20049901
    • Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury. Morigi M, Rota C, Montemurro T, Montelatici E, Lo Cicero V, Imberti B, et al. Stem Cells 2010 28 513 522 20049901
    • (2010) Stem Cells , vol.28 , pp. 513-522
    • Morigi, M.1    Rota, C.2    Montemurro, T.3    Montelatici, E.4    Lo Cicero, V.5    Imberti, B.6
  • 36
    • 65649089130 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived microvesicles protect against acute tubular injury
    • 10.1681/ASN.2008070798 19389847
    • Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, Collino F, et al. J Am Soc Nephrol 2009 20 1053 1067 10.1681/ASN.2008070798 19389847
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1053-1067
    • Bruno, S.1    Grange, C.2    Deregibus, M.C.3    Calogero, R.A.4    Saviozzi, S.5    Collino, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.