Paracrine/endocrine mechanism of stem cells on kidney repair: Role of microvesicle-mediated transfer of genetic information

Current Opinion in Nephrology and Hypertension

Volumn 19, Issue 1, 2010, Pages 7-12

  Camussi, Giovanni ^a   Deregibus, Maria Chiara ^a   Tetta, Ciro ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b FRESENIUS MEDICAL CARE   (Germany)

Author keywords

Microvesicles; Renal injury; Renal repair; Stem cells

Indexed keywords

MESSENGER RNA; MICRORNA; PROSTAGLANDIN E2;

ADULT; ADULT STEM CELL; ALPORT SYNDROME; BONE MARROW CELL; CELL ACTIVATION; CELL COMMUNICATION; CELL CYCLE; CELL DAMAGE; CELL DEDIFFERENTIATION; CELL MEMBRANE; CELL TRANSDIFFERENTIATION; CELL VACUOLE; COCULTURE; EMBRYONIC STEM CELL; ENDOCRINE FUNCTION; ENDOTHELIUM CELL; GENE EXPRESSION; GENE FUNCTION; GENE TRANSFER; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HUMAN; INTERNALIZATION; KIDNEY; KIDNEY INJURY; MACROPHAGE; MESENCHYMAL STEM CELL; MICROENVIRONMENT; PARACRINE SIGNALING; PARENCHYMA; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TARGET CELL; TISSUE INJURY; TISSUE REPAIR;

ADULT; ADULT STEM CELLS; ANIMALS; CELL DIFFERENTIATION; CELL-DERIVED MICROPARTICLES; ENDOCRINE GLANDS; HUMANS; KIDNEY; MICRORNAS; MODELS, BIOLOGICAL; PARACRINE COMMUNICATION; REGENERATION; RNA, MESSENGER; STEM CELL NICHE;

EID: 73849109910     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328332fb6f     Document Type: Review

References (50)

1. Bussolati B, Tetta C, Camussi G. Contribution of stem cells to kidney repair. Am J Nephrol 2008; 28:813-822.
2. Vogetseder A, Picard N, Gaspert A, et al. The proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells. Am J Physiol Cell Physiol 2008; 294:C22-C28.
3. Humphreys BD, Valerius MT, Kobayashi A, et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008; 2:284-291.
4. Poulsom R, Forbes SJ, Hodivala-Dilke K, et al. Bone marrow contributes to renal parenchymal turnover and regeneration. J Pathol 2001; 195:229-235.
5. Fang TC, Otto WR, Rao J, et al. Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl2-induced acute tubular injury. Cell Prolif 2008; 41:575-591.
6. Qian H, Yang H, Xu W, et al. Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial- like cells. Int J Mol Med 2008; 22:325-332.
7. Fujigaki Y, Goto T, Sakakima M, et al. Kinetics and characterization of initially regenerating proximal tubules in s3 segment in response to various degrees of acute tubular injury. Nephrol Dial Transplant 2006; 21:41-50.
8. Ronconi E, Sagrinati C, Angelotti ML, et al. Regeneration of glomerular podocytes by human renal progenitors. J Am Soc Nephrol 2009; 20:322-332.
9. Kinomura M, Kitamura S, Tanabe K, et al. Amelioration of cisplatin-induced acute renal injury by renal progenitor-like cells derived from the adult rat kidney. Cell Transplant 2008; 17:143-158.
10. Duffield JS, Park KM, Hsiao LL, et al. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest 2005; 115:743-755.
11. Togel F, Hu Z, Weiss K, et al. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005; 289:31-42.
12. Liu KD, Brakeman PR. Renal repair and recovery. Crit Care Med 2008; 36:S187-S192.
13. Bi B, Guo J, Marlier A, et al. Erythropoietin expands a stromal cell population that can mediate renoprotection. Am J Physiol Renal Physiol 2008; 295:F1017-F1022.
14. Cantaluppi V, Biancone L, Romanazzi GM, et al. Macrophage stimulating protein may promote tubular regeneration after acute injury. J Am Soc Nephrol 2008; 19:1904-1918.
15. Imberti B, Morigi M, Tomasoni S, et al. Insulin-like growth factor-1 sustains stem cell mediated renal repair. J Am Soc Nephrol 2007; 18:2921-2928.
16. Tögel F, Zhang P, Hu Z, Westenfelder C. VEGF is a mediator of the renoprotective effects of multipotent marrow stromal cells in acute kidney injury. J Cell Mol Med 2008. [Epub ahead of print]
17. Humphreys BD, Bonventre JD. Mesenchymal stem cells in acute kidney injury. Annu Rev Med 2008; 59:311-325.
18. Morigi M, Introna M, Imberti B, et al. Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice. Stem Cells 2008; 26:2075-2082.
19. Tögel F, Cohen A, Zhang P, et al. Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury. Stem Cells Dev 2009; 18:475-485.
20. Choi S, Park M, Kim J, et al. The role of mesenchymal stem cells in the functional improvement of chronic renal failure. Stem Cells Dev 2009; 18:521-529.
21. Yokoo T, Ohashi T, Shen JS, et al. Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues. Proc Natl Acad Sci U S A 2005; 102:3296-3300.
22. Herrera MB, Bussolati B, Bruno S, et al. Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury. Kidney Int 2007; 72:430-441.
23. Kunter U, Rong S, Djuric Z, et al. Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis. J Am Soc Nephrol 2006; 17:2202-2212.
24. Wong CY, Cheong SK, Mok PL, Leong CF. Differentiation of human mesenchymal stem cells into mesangial cells in postglomerular injury murine model. Pathology 2008; 40:52-57.
25. Sugimoto H, Mundel TM, Sund M, et al. Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci U S A 2006; 103:7321-7326.
26. Németh K, Leelahavanichkul A, Yuen PS, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009; 15:42-49.
27. Bi B, Schmitt R, Israilova M, et al. Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol 2007; 18:2486-2496.
28. Ratajczak J, Wysoczynski M, Hayek F, et al. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia 2006; 20:1487-1495.
29. Quesenberry PJ, Colvin G, Dooner G, et al. The stem cell continuum: cell cycle, injury, and phenotype lability. Ann NY Acad Sci 2007; 1106:20-29.
30. Quesenberry PJ, Aliotta JM. The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles. Stem Cell Rev 2008; 4:137-147.
31. Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: artefacts no more. Cell Biol 2009; 19:43-51.
32. Kostin S, Popescu LM. A distinct type of cell in myocardium: interstitial Cajal-like cells. J Cell Mol Med 2009; 13:295-308.
33. Janowska-Wieczorek A, Majka M, Kijowski J, et al. Platelet-derived microparticles bind to hematopoietic progenitor cells and enhance their engraftment. Blood 2001; 98:3143-3149.
34. Morel O, Toti F, Hugel B, Freyssinet JM. Cellular microparticles: a disseminated storage pool of bioactive vascular effectors. Curr Opin Hematol 2004; 11:156-164.
35. Schorey JS, Bhatnagar S. Exosome function: from tumor immunology to pathogen biology. Traffic 2008; 9:871-881.
36. Ratajczak J, Miekus K, Kucia M, et al. Embryonic stem cells-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 2006; 20:847-856.
37. Deregibus MC, Cantaluppi V, Calogero R, et al. Endothelial progenitor cell-derived microvescicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood 2007; 110:2440-2448.
38. Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9:654-659.
39. Weyrich AS, Kraiss LW, Zimmerman GA. Trading places: mRNA transfer between cells. Blood 2007; 110:2219.
40. Yuan A, Farber EL, Rapoport AL, et al. Transfer of microRNAs by embryonic stem cell microvesicles. PLoS ONE 2009; 4:e4722.
41. Nomura S, Ishii K, Inami N, et al. Alpha 4-integrin-positive microvesicles and SDF-1 in peripheral blood stem cell harvest. Bone Marrow Transplant 2008; 41:1071-1072.
42. Chen J, Park HC, Addabbo F, et al. Kidney-derived mesenchymal stem cells contribute to vasculogenesis, angiogenesis and endothelial repair. Kidney Int 2008; 74:879-889.
43. Gupta S, Rosenberg ME. Do stem cells exist in the adult kidney? Am J Nephrol 2008; 28:607-613.
44. Bruno S, Bussolati B, Grange C, et al. Isolation and characterization of resident mesenchymal stem cells in human glomeruli. Stem Cells Dev 2009; 18:867-880.
45. Aliotta JM, Sanchez-Guijo FM, Dooner GJ, et al. Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation. Stem Cells 2007; 25:2245-2256.
46. Dooner MS, Aliotta JM, Pimentel J, et al. Conversion potential of marrow cells into lung cells fluctuates with cytokine-induced cell cycle. Stem Cells Dev 2008; 17:207-219.
47. Baer PC, Bereiter-Hahn J, Missler C, et al. Conditioned medium from renal tubular epithelial cells initiates differentiation of human mesenchymal stem cells. Cell Prolif 2009; 42:29-37.
48. Bruno S, Grange C, Deregibus MC, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009; 20:1053-1067.
49. Bonventre JV. Microvesicles from mesenchymal stromal cells protect against acute kidney injury. J Am Soc Nephrol 2009; 20:927-928.
50. Kunter U, Rong S, Boor P, et al. Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes. J Am Soc Nephrol 2007; 18:1754-1764.