Computational model combined with in vitro experiments to analyse mechanotransduction during mesenchymal stem cell adhesion

European Cells and Materials

Volumn 25, Issue , 2012, Pages 97-113

  Milan, Jean Louis ^a   Lavenus, Sandrine ^b   Pilet, Paul ^b   Louarn, Guy ^b   Wendling, Sylvie ^a   Heymann, Dominique ^b   Layrolle, Pierre ^b   Chabrand, Patrick ^a  

^a AIX MARSEILLE UNIVERSITÉ   (France)

^b UNIVERSITÉ DE NANTES   (France)

Author keywords

Cell adhesion; Cell morphology; Computational cell adhesion model; Cytoskeleton; Mechanical forces; Mechanotransduction; Mesenchymal stem cells

Indexed keywords

ARTICLE; CELL ADHESION; CELL COMPONENT; CELL DIFFERENTIATION; CELL SHAPE; CELL SPREADING; CELL STIMULATION; CELL STRUCTURE; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOSKELETON; FILOPODIUM; FOCAL ADHESION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IN VITRO STUDY; INTRACELLULAR TONUS; MATHEMATICAL MODEL; MECHANOTRANSDUCTION; MESENCHYMAL STEM CELL; NUCLEAR DEFORMATION; NUCLEOSKELETON; QUANTITATIVE ANALYSIS; ALGORITHM; BIOLOGICAL MODEL; BIOMECHANICS; CELL CULTURE; COMPUTER SIMULATION; MESENCHYMAL STROMA CELL; NUCLEAR SHAPE; PHYSIOLOGY; SINGLE CELL ANALYSIS;

ALGORITHMS; BIOMECHANICS; CELL ADHESION; CELL NUCLEUS SHAPE; CELL SHAPE; CELLS, CULTURED; COMPUTER SIMULATION; CYTOSKELETON; FOCAL ADHESIONS; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MESENCHYMAL STROMAL CELLS; MODELS, BIOLOGICAL; SINGLE-CELL ANALYSIS;

MLCS; MLOWN;

EID: 84878379005     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Balaban NQ, Schwarz US, Riveline D, Goichberg P, Tzur G, Sabanay I, Mahalu D, Safran S, Bershadsky A, Addadi L, Geiger B (2001) Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat Cell Biol 3: 466-472.
2. Bhadriraju K, Yang M, Alom Ruiz S, Pirone D, Tan J, Chen CS (2007) Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp. Cell Res 313: 3616-3623.
3. Boal D (2002) Mechanics of the Cell. Cambridge University Press, Cambridge.
4. Brangwynne CP, MacKintosh FC, Kumar S, Geisse NA, Talbot J, Mahadevan L, Parker KK, Ingber DE, Weitz DA (2006) Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol 173: 733-741.
5. Cohen A, Liu-Synder P, Storey D, Webster T (2007) Decreased fibroblast and increased osteoblast functions on ionic plasma deposited nanostructured Ti coatings. Nanoscale Res Lett 2: 385-390.
6. Dahl KN, Ribeiro AJS, Lammerding J (2008) Nuclear shape, mechanics, and mechanotransduction. Circ Res 102: 1307-1318.
7. Deguchi S, Ohashi T, Sato M (2006)Tensile properties of single stress fibers isolated from cultured vascular smooth muscle cells. J Biomech 39: 2603-2610.
8. Del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MP (2009) Stretching single talin rod molecules activates vinculin binding. Science 323: 638-641.
9. Dubois F, Jean M (2006) The non smooth contact dynamic method: recent LMGC90 software developments and application. In: Analysis and Simulation of Contact Problems. Lecture Notes in Applied and Computational Mechanics 27: 375-378.
10. Engler AJ, Sen S, Sweeney HL, Discher DE (2006) Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689.
11. Enomoto T (1996) Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the rho signal cascade. Cell Struct. Funct. 21: 317-326.
12. Freitas RA (1999) Basic Capabilities. In: Nanomedicine, Volume I: Basic Capabilities (Freitas RA, ed), Landes Bioscience, Georgetown, TX.
13. Fu J, Wang Y-K, Yang MT, Desai RA, Yu X, Liu Z, Chen CS (2010) Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nat Methods 7: 733-736.
14. Fudge DS, Gardner KH, Forsyth VT, Riekel C, Gosline JM (2003) The mechanical properties of hydrated intermediate filaments: insights from hagfish slime threads. Biophys J 85: 2015-2027.
15. Green KJ, Talian JC, Goldman RD (1986) Relationship between intermediate filaments and microfilaments in cultured fibroblasts: evidence for common foci during cell spreading. Cell Motil Cytoskeleton 6: 406-418.
16. Hu S, Chen J, Wang N (2004) Cell spreading controls balance of prestress by microtubules and extracellular matrix. Front Biosci 9: 2177-2182.
17. Itano N, Okamoto S, Zhang D, Lipton SA, Ruoslahti E (2003) Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus. Proc Natl Acad Sci USA 100: 5181-5186.
18. Jean M (1999) The non-smooth contact dynamics method. Comput Methods Appl Mech Engng 177: 235-257.
19. Kilian KA, Bugarija B, Lahn BT, Mrksich M (2010) Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci USA 107: 4872-4877.
20. Krylyshkina O, Anderson KI, Kaverina I, Upmann I, Manstein DJ, Small JV, Toomre DK (2003) Nanometer targeting of microtubules to focal adhesions. J Cell Biol 161: 853-859.
21. Kurachi M, Hoshi M, Tashiro H (1995) Buckling of a single microtubule by optical trapping forces: direct measurement of microtubule rigidity. Cell Motil Cytoskeleton 30: 221-228.
22. Lavenus S, Ricquier J-C, Louarn G, Layrolle P (2010) Cell interaction with nanopatterned surface of implants. Nanomedicine (Lond) 5: 937-947.
23. Lavenus S, Pilet P, Guicheux J, Weiss P, Louarn G, Layrolle P (2011) Behaviour of mesenchymal stem cells, fibroblasts and osteoblasts on smooth surfaces. Acta Biomater 7: 1525-1534.
24. Le Guéhennec L, Soueidan A, Layrolle P, Amouriq Y (2007) Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater 23: 844-854.
25. Lodish H, Berk A, Zipursky S, Matsudaira P, Baltimore D, Darnell J (2000) Molecular Cell Biology, 4th ed, WH Freeman, New York.
26. Maurin B, Cañadas P, Baudriller H, Montcourrier P, Bettache N (2008) Mechanical model of cytoskeleton structuration during cell adhesion and spreading. J Biomech 41: 2036-2041.
27. McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6: 483-495.
28. McNamara LE, McMurray RJ, Biggs MJP, Kantawong F, Oreffo ROC, Dalby MJ (2010) Nanotopographical control of stem cell differentiation. J Tissue Eng 2010: 120623.
29. McNamara LE, Burchmore R, Riehle MO, Herzyk P, Biggs MJP, Wilkinson CDW, Curtis ASG, Dalby MJ (2012) The role of microtopography in cellular mechanotransduction. Biomaterials 33: 2835-2847.
30. Milan JL, Wendling-Mansuy S, Jean M, Chabrand P (2007) Divided medium-based model for analyzing the dynamic reorganization of the cytoskeleton during cell deformation. Biomech Model Mechanobiol 6: 373-390.
31. Murphy-Ullrich JE (2001) The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state? J Clin Invest 107: 785-790.
32. Nathan AS, Baker BM, Nerurkar NL, Mauck RL (2011) Mechano-topographic modulation of stem cell nuclear shape on nanofibrous scaffolds. Acta Biomater 7: 57-66.
33. Riveline D, Zamir E, Balaban NQ, Schwarz US, Ishizaki T, Narumiya S, Kam Z, Geiger B, Bershadsky AD (2001) Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J. Cell Biol 153: 1175-1186.
34. Slomka N, Gefen A (2010) Confocal microscopy-based three-dimensional cell-specific modeling for large deformation analyses in cellular mechanics. J Biomech 43: 1806-1816.
35. Sultan C, Stamenović D, Ingber DE (2004) A computational tensegrity model predicts dynamic rheological behaviors in living cells. Ann Biomed Eng 32: 520-530.
36. Tan JL, Tien J, Pirone DM, Gray DS, Bhadriraju K, Chen CS (2003) Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci USA 100: 1484-1489.
37. Van der Flier A, Sonnenberg A (2001) Function and interactions of integrins. Cell Tissue Res 305: 285-298.
38. Von der Mark K, Park J, Bauer S, Schmuki P (2010) Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix. Cell Tissue Res 339: 131-153.
39. Wang N, Stamenović D (2000) Contribution of intermediate filaments to cell stiffness, stiffening, and growth. Am J Physiol Cell Physiol 279: C188-194.
40. Wang N, Tytell JD, Ingber DE (2009) Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol 10: 75-82.
41. Yamada KM, Geiger B (1997) Molecular interactions in cell adhesion complexes. Curr Opin Cell Biol 9: 76-85.