One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity

Neurotoxicity Research

Volumn 24, Issue 1, 2013, Pages 94-101

  Villa, Monica ^a   Muñoz, Patricia ^a   Ahumada Castro, Ulises ^a,c   Paris, Irmgard ^a,b   Jiménez, Ana ^c   Martínez, Isabel ^c   Sevilla, Francisca ^c   Segura Aguilar, Juan ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD SANTO TOMÁS   (Chile)

^c RESEARCH GROUP ON QUALITY   (Spain)

Author keywords

6 Hydroxydopamine; Dopamine; Glutathione; Oxidation; Parkinson's disease; Quinone; Quinone metabolism

Indexed keywords

6 HYDROXYDOPAMINE QUINONE; ADENOSINE TRIPHOSPHATE; GLUTATHIONE; OXIDOPAMINE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SMALL INTERFERING RNA; TOPAMINEQUINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOOXIDATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DEATH; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRONS; GLUTATHIONE; HYDROXYDOPAMINES; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; OXIDOPAMINE; OXYGEN CONSUMPTION; QUINONES; RATS; SUBSTANTIA NIGRA;

EID: 84878377226     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-013-9382-7     Document Type: Article

References (35)

1. Arriagada A, Paris I, Sanchez de las Matas MJ, Cardenas S, Castañeda P, Graumann R, Perez-Pastene C, Olea-Azar C, Couve E, Herrero MT, Caviedes P, Segura-Aguilar J (2004) On the neurotoxicity of leukoaminochrome o-semiquinone radical derived of dopamine oxidation: mitochondria damage, necrosis and hydroxyl radical formation. Neurobiol Dis 16:468-477
2. Fernandez-Gomez FJ, Pastor MD, Garcia-Martinez EM, Melero-Fernandez de Mera R, Gou-Fabregas M, Gomez-Lazaro M, Calvo S, Soler RM, Galindo MF, Jordán J (2006) Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression. Neurobiol Dis 24(2):296-307
3. Fuentes P, Paris I, Nassif M, Caviedes P, Segura-Aguilar J (2007) Inhibition of VMAT-2 and DT-Diaphorase induce cell death in a substantia nigra-derived cell line-an experimental cell model for dopamine toxicity studies. Chem Res Toxicol 20:776-783
4. Gee P, Davison AJ (1984) 6-hydroxydopamine does not reduce molecular oxygen directly, but requires a coreductant. Arch Biochem Biophys 231:164-168
5. Glinka Y, Gassen M, Youdim MB (1997) Mechanism of 6-hydroxydopamine neurotoxicity. J Neural Transm Suppl 50:55-66
6. Gregorio ML, Wietzikoski EC, Ferro MM, Silveira JL, Vital MA, Da Cunha C (2009) Nicotine induces sensitization of turning behavior in 6-hydroxydopamine lesioned rats. Neurotox Res 15:359-366
7. Hara H, Ohta M, Ohta K, Kuno S, Adachi T (2003) Increase of antioxidative potential by tert-butylhydroquinone protects against cell death associated with 6-hydroxydopamine-induced oxidative stress in neuroblastoma SH-SY5Y cells. Brain Res Mol Brain Res 119:125-131
8. Hardie DG (2000) Metabolic control: a new solution to an old problem. Curr Biol 10:757-759
9. Heikkila R, Cohen G (1971) Inhibition of biogenic amine uptake by hydrogen peroxide: a mechanism for toxic effects of 6-hydroxydopamine. Science 172:1257-1258
10. Heikkila RE, Cohen G (1973) 6-Hydroxydopamine: evidence for superoxide radical as an oxidative intermediate. Science 181:456-457
11. Jia Z, Zhu H, Misra HP, Li Y (2008) Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-nonenal, or hydrogen peroxide. Brain Res 1197:159-169
12. Kasture S, Pontis S, Pinna A, Schintu N, Spina L, Longoni R, Simola N, Ballero M, Morelli M (2009) Assessment of symptomatic and neuroprotective efficacy of mucuna pruriens seed extract in rodent model of Parkinson's disease. Neurotox Res 15:111-122
13. LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe DJ (2005) Dopamine covalently modifies and functionally inactivates parkin. Nat Med 11:1159-1161
14. Lozano J, Muñoz P, Nore BF, Ledoux S, Segura-Aguilar J (2010) Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity. Chem Res Toxicol 3:1492-1496
15. Martí MC, Florez-Sarasa I, Camejo D, Pallol B, Ortiz A, Ribas-Carbó M, Jiménez A, Sevilla F (2012) Response of mitochondrial antioxidant system and respiratory pathways to reactive nitrogen species in pea leaves. Physiol Plant. doi: 10.1111/j.1399-3054.2012.01654.x
16. Muñoz P, Huenchuguala S, Paris I, Cuevas C, Villa M, Caviedes P, Segura-Aguilar J, Tizabi Y (2012a) Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease. Neurotox Res 22:177-180
17. Muñoz P, Paris I, Sanders LH, Greenamyre JT, Segura-Aguilar J (2012b) Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. Biochim Biophys Acta 1822:1125-1136
18. Muñoz P, Huenchuguala S, Paris I, Segura-Aguilar J (2012c) Dopamine oxidation and autophagy. Parkinsons Dis. 2012:920953. Epub 26 Aug 2012
19. Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H, Lee VM (2005) Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J Biol Chem 280:21212-21219
20. Napolitano A, Crescenzi O, Pezzella A, Prota G (1995) Generation of the neurotoxin 6-hydroxydopamine by peroxidase/H2O2 oxidation of dopamine. J Med Chem 38:917-922
21. Nowak P, Kostrzewa RA, Skaba D, Kostrzewa RM (2009) Acute L: -DOPA effect on hydroxyl radical- and DOPAC-levels in striatal microdialysates of parkinsonian rats. Neurotox Res 17:299-304
22. Paris I, Dagnino-Subiabre A, Marcelain K, Bennett LB, Caviedes P, Caviedes R, Olea-Azar C, Segura-Aguilar J (2001) Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line. J Neurochem 77:519-529
23. Paris I, Martinez-Alvarado P, Perez-Pastene C, Vieira MN, Olea-Azar C, Raisman-Vozari R, Cardenas S, Graumann R, Caviedes P, Segura-Aguilar J (2005) Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra. J Neurochem 92:1021-1032
24. Paris I, Lozano J, Cardenas S, Perez-Pastene C, Saud K, Fuentes P, Caviedes P, Dagnino-Subiabre A, Raisman-Vozari R, Shimahara T, Kostrzewa JP, Chi D, Kostrzewa RM, Caviedes R, Segura-Aguilar J (2008) The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism. Neurotox Res 13:221-230
25. Paris I, Lozano J, Perez-Pastene C, Muñoz P, Segura-Aguilar J (2009a) Molecular and neurochemical mechanisms in PD pathogenesis. Neurotox Res 16:271-279
26. Paris I, Lozano J, Perez-Pastene C, Muñoz P, Segura-Aguilar J (2009b) Molecular and neurochemical mechanisms in PD pathogenesis. Neurotox Res 16:271-279
27. Paris I, Perez-Pastene C, Couve E, Caviedes P, Ledoux S, Segura-Aguilar J (2009c) Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death. J Biol Chem 284:13306-13315
28. Paris I, Perez-Pastene C, Cardenas S, Iturriaga-Vasquez P, Muñoz P, Couve E, Caviedes P, Segura-Aguilar J (2010) Aminochrome induces disruption of actin, alpha-, and beta-tubulin cytoskeleton networks in substantia-nigra- derived cell line. Neurotox Res 18:82-92
29. Paris I, Muñoz P, Huenchuguala S, Couve E, Sanders LH, Greenamyre JT, Caviedes P, Segura-Aguilar J (2011) Autophagy protects against aminochrome-induced cell death in substantia nigra derived cell line. Toxicol Sci 121:376-388
30. Rauch F, Schwabe K, Krauss JK (2010) Effect of deep brain stimulation in the pedunculopontine nucleus on motor function in the rat 6-hydroxydopamine Parkinson model. Behav Brain Res 210:46-53
31. Redman PT, Jefferson BS, Ziegler CB, Mortensen OV, Torres GE, Levitan ES, Aizenman E (2006) A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience 143:1-6
32. Rodriguez-Pallares J, Parga JA, Joglar B, Guerra MJ, Labandeira-Garcia JL (2009) The mitochondrial ATP-sensitive potassium channel blocker 5-hydroxydecanoate inhibits toxicity of 6-hydroxydopamine on dopaminergic neurons. Neurotox Res 15:82-95
33. Segura-Aguilar J, Kaiser R, Lind C (1992) Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol. Biochim Biophys Acta 1120:33-42
34. Van Laar VS, Mishizen AJ, Cascio M, Hastings TG (2009) Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells. Neurobiol Dis 34:487-500
35. Walsh S, Mnich K, Mackie K, Gorman AM, Finn DP, Dowd E (2010) Loss of cannabinoid CB(1) receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat. Brain Res Bull 81:543-548