The mitochondrial ATP-sensitive potassium channel blocker 5-hydroxydecanoate inhibits toxicity of 6-hydroxydopamine on dopaminergic neurons

Neurotoxicity Research

Volumn 15, Issue 1, 2009, Pages 82-95

  Rodriguez Pallares, J ^a,b   Parga, J A ^a,b   Joglar, B ^a,b   Guerra, M J ^a,b   Labandeira Garcia, Jose Luis ^a,b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

6 OHDA; Dopamine; Mitochondria; Mitok(ATP) channels; Neurodegeneration; Oxidative stress; Parkinson's disease

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; DIAZOXIDE; DOPAMINE; GLIBENCLAMIDE; OXIDOPAMINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINE UPTAKE; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; DRUG SCREENING; EMBRYO; MESENCEPHALON; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC AGENTS; ANALYSIS OF VARIANCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZIMIDAZOLES; CARBOCYANINES; CELL COUNT; CELLS, CULTURED; DECANOIC ACIDS; DIAZOXIDE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO, MAMMALIAN; ETHIDIUM; GLYBURIDE; HYDROXY ACIDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESENCEPHALON; NEURONS; OXIDOPAMINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; REACTIVE OXYGEN SPECIES; RHODAMINES; TIME FACTORS; TRITIUM; TYROSINE 3-MONOOXYGENASE;

EID: 70349734691     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12640-009-9010-8     Document Type: Article

References (74)

1. 2 in chromaffin cells. Eur J Pharmacol 293:55-64
2. Andersen JK (2004) Oxidative stress in neurodegeneration: Cause or consequence. Nat Med 10:S18-S25
3. Andrew R, Watson DG, Best SA, Midgley JM, Wenlong H, Petty RKH (1993) The determination of hydroxydopamines and other trace amines in the urine of parkinsonian patients and normal controls. Neurochem Res 18:1175-1177
4. Andrukhiv A, Costa AD, West IC, Garlid KD (2006) Opening mitoKATP increases superoxide generation from complex I of the electron transport chain. Am J Physiol Heart Circ Physiol 291:H2067-H2074
5. + (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release. Proc Natl Acad Sci USA 100:11729-11734
6. Avshalumov MV, Chen BT, Marshall SP, Peña DM, Rice ME (2003) Glutamate-dependent inhibition of dopamine release in striatum is mediated by a new diffusible messenger, H2O2. J Neurosci 23:2744-2750
7. Avshalumov MV, Chen BT, Koós T, Tepper JM, Rice ME (2005) Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels. J Neurosci 25:4222-4231
8. Berretta N, Freestone PS, Guatteo E, de Castro D, Geracitano R, Bernardi G, Mercuri NB, Lipski J (2005) Acute effects of 6-hydroxydopamine on dopaminergic neurons of the rat substantia nigra pars compacta in vitro. Neurotoxicology 26:869-881
9. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3:1301-1306
10. Block ML, Hong JS (2005) Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism. Prog Neurobiol 76:77-98
11. Blum D, Torch S, Nissou MF, Benabid AL, Verna JM (2000) Extracellular toxicity of 6-hydroxydopamine on PC12 cells. Neurosci Lett 283:193-196
12. Brown PC, Sokolove PM, McCann DJ, Stevens JL, Jones TW (1996) Induction of a permeability transition in rat kidney mitochondria by pentachlorobutadienyl cysteine: A beta-lyase-independent process. Arch Biochem Biophys 331:225-231
13. Busija DW, Lacza Z, Rajapakse N, Shimizu K, Kis B, Bari F, Domoki F, Horiguchi T (2004) Targeting mitochondrial ATP-sensitive potassium channels-a novel approach to neuroprotection. Brain Res Brain Res Rev 46:282-294
14. Costa AD, Garlid KD (2008) Intramitochondrial signaling: Interactions among mitoKATP, PKCepsilon, ROS, and MPT. Am J Physiol Heart Circ Physiol 295:H874-H882
15. Dodel RC, Du Y, Bales KR, Ling Z, Carvey PM, Paul SM (1999) Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death. Brain Res Mol Brain Res 64:141-148
16. + channel activity. Free Radic Biol Med 40:469-479
17. Gao HM, Liu B, Zhang W, Hong JS (2003a) Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: Relevance to the etiology of Parkinson's disease. FASEB J 17:1957-1959
18. Gao HM, Hong JS, Zhang W, Liu B (2003b) Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: Relevance to the etiology of Parkinson's disease. J Neurosci 23:1228-1236
19. Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, Grover GJ (1997) Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ Res 81:1072-1082
20. Gáspár T, Snipes JA, Busija AR, Kis B, Domoki F, Bari F, Busija DW (2008) ROS-independent preconditioning in neurons via activation of mitoK(ATP) channels by BMS-191095. J Cereb Blood Flow Metab 28:1090-1103
21. Glinka YY, Youdim MB (1995) Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine. Eur J Pharmacol 292:329-332
22. Glinka Y, Tipton KF, Youdim MB (1996) Nature of inhibition of mitochondrial respiratory complex I by 6-Hydroxydopamine. J Neurochem 66:2004-2010
23. Glinka Y, Gassen M, Youdim MB (1997) Mechanism of 6-hydroxydopamine neurotoxicity. J Neural Transm Suppl 50:55-66
24. Gonzalez-Hernandez T, Barroso-Chinea P, De La Cruz Muros I, Del Mar Perez-Delgado M, Rodriguez M (2004) Expression of dopamine and vesicular monoamine transporters and differential vulnerability of mesostriatal dopaminergic neurons. J Comp Neurol 479:198-215
25. Gottlieb E, Armour SM, Harris MH, Thompson CB (2003) Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ 10:709-717
26. Graham DG, Tiffany SM, Bell WR Jr, Gutknecht WF (1978) Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol Pharmacol 14:644-653
27. Han J, Kim N, Park J, Seog DH, Joo H, Kim E (2002) Opening of mitochondrial ATP-sensitive potassium channels evokes oxygen radical generation in rabbit heart slices. J Biochem 131:721-727
28. Hanley PJ, Daut J (2005) K(ATP) channels and preconditioning: A re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms. J Mol Cell Cardiol 39:17-50
29. Hanrott K, Gudmunsen L, O'Neill MJ, Wonnacott S (2006) 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. J Biol Chem 281:5373-5382
30. Hirsch EC, Faucheux B, Damier P, Mouatt-Prigent A, Agid Y (1997) Neuronal vulnerability in Parkinson's disease. J Neural Transm Suppl 50:79-88
31. Irwin I, Langston JW (1995) Endogenous toxins as potential etiologic agents in Parkinson's disease. In: Ellenberg JH, Koller WC, Langston JW (eds) Etiology of Parkinson's disease. Marcel Dekker Inc., New York, pp 153-201
32. Jellinger KA (2000) Cell death mechanisms in Parkinson's disease. J Neural Transm 107:1-29
33. Jellinger K, Linert L, Kienzl E, Herlinger E, Youdim MBH (1995) Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease. J Neural Transm 46:297-314
34. + channels induced by HMG CoA reductase inhibitor in ischemic rabbit hearts. Hypertens Res 24:573-577
35. Kimura S, Zhang GX, Nishiyama A, Shokoji T, Yao L, Fan YY, Rahman M, Suzuki T, Maeta H, Abe Y (2005a) Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II. Hypertension 45:860-866
36. Kimura S, Zhang GX, Nishiyama A, Shokoji T, Yao L, Fan YY, Rahman M, Abe Y (2005b) Mitochondria-derived reactive oxygen species and vascular MAP kinases: Comparison of angiotensin II and diazoxide. Hypertension 45:438-444
37. Kis B, Rajapakse NC, Snipes JA, Nagy K, Horiguchi T, Busija DW (2003) Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons. J Neurochem 87:969-980
38. Kumar R, Agarwal AK, Seth PK (1995) Free radical-generated neurotoxicity of 6-hydroxydopamine. J Neurochem 64:1703-1707
39. Linert W, Herlinger E, Jameson RF, Kienzl E, Jellinger K, Youdim MBH (1996) Dopamine, 6-hydroxydopamine, iron, dioxygen - their mutual interactions and possible implication in the development of Parkinson's disease. Biochim Biophys Acta 1316:160-168
40. Liss B, Haeckel O, Wildmann J, Miki T, Seino S, Roeper J (2005) K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nat Neurosci 8:1742-1751
41. Liu Y, Gutterman DD (2002) The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation. Vascul Pharmacol 38:43-49
42. Lotharius J, Dugan LL, O'Malley KL (1999) Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci 19:1284-1293
43. Luthman J, Fredriksson A, Sundstrom E, Jonsson G, Archer T (1989) Selective lesion of central dopamine or noradrenaline neuron systems in the neonatal rat: Motor behavior and monoamine alterations at adult stage. Behav Brain Res 33:267-277
44. Mattson MP, Liu D (2003) Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem Biophys Res Commun 304:539-549
45. McCullough JR, Normandin DE, Conder ML, Sleph PG, Dzwonczyk S, Grover GJ (1991) Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate. Circ Res 69:949-958
46. McRitchie DA, Hardman CD, Halliday GM (1996) Cytoarchitectural distribution of calcium binding proteins in midbrain dopaminergic regions of rats and humans. J Comp Neurol 364:121-150
47. Michel PP, Ruberg M, Agid G (1997) Rescue of mesencephalic dopamine neurons by anticancer drug cytosine arabinoside. J Neurochem 69:1459-1507
48. Minners J, Lacerda L, Yellon DM, Opie LH, McLeod CJ, Sack MN (2007) Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning. Mol Cell Biochem 294:11-18
49. Obata T, Yamanaka Y (2000) Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium. Arch Biochem Biophys 378:195-200
50. Oldenburg O, Cohen MV, Yellon DM, Downey JM (2002) Mitochondrial K(ATP) channels: Role in cardioprotection. Cardiovasc Res 55:429-437
51. Przedborski S, Jackson-Lewis V (1998) Experimental developments in movement disorders: Update on proposed free radical mechanisms. Curr Opin Neurol 11:335-339
52. 2O in biomembranes. Biochim Biophys Acta 694:69-93
53. Reinhardt R, Manaenko A, Guenther A, Franke H, Dickel T, Garcia de Arriba S, Muench G, Schneider D, Wagner A, Illes P (2003) Early biochemical and histological alterations in rat corticoencephalic cell cultures following metabolic damage and treatment with modulators of mitochondrial ATP-sensitive potassium channels. Neurochem Int 43:563-571
54. Rodriguez-Pallares J, Parga JA, Muñoz A, Rey P, Guerra MJ, Labandeira-Garcia JL (2007) Mechanism of 6-hydroxydopamine neurotoxicity: The role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons. J Neurochem 103:145-156
55. Rogers JH (1992) Immunohistochemical markers in rat brain: colocalization of calretinin and calbindin-D28k with tyrosine hydroxylase. Brain Res 587:203-210
56. Sachs C, Jonsson G (1975) Mechanisms of action of 6-hydroxydopamine. Biochem Pharmacol 24:1-8
57. Senoh S, Creveling CR, Udenfriend S, Witkop B (1959) Chemical, enzymatic and metabolic studies on the mechanism of oxidation of dopamine. J Am Chem Soc 81:6236-6240
58. Simola N, Morelli M, Carta AR (2007) The 6-hydroxydopamine model of Parkinson's disease. Neurotox Res 11:151-167
59. Soto-Otero R, Méndez-Álvarez E, Hermida-Ameijeiras A, Muñoz-Patiño A, Labandeira-García JL (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: Potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem 74:1605-1612
60. Storch A, Kaftan A, Burkhardt K, Schwarz J (2000) 6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism. J Neural Transm 107:81-93
61. Sugrue MM, Wang Y, Rideout HJ, Chalmers-Redman RM, Tatton WG (1999) Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence. Biochem Biophys Res Commun 261:123-1230
62. Thomzig A, Wenzel M, Karschin C, Eaton MJ, Skatchkov SN, Karschin A, Veh RW (2001) Kir6.1 is the principal pore-forming subunit of astrocyte but not neuronal plasma membrane K-ATP channels. Mol Cell Neurosci 18:671-690
63. Tokube K, Kiyosue T, Arita M (1998) Effects of hydroxyl radicals on KATP channels in guinea-pig ventricular myocytes. Pflugers Arch 437:155-157
64. Wadia JS, Chalmers-Redman RM, Ju WJ, Carlile GW, Phillips JL, Fraser AD, Tatton WG (1998) Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: Time course and modification by (-)-deprenyl. J Neurosci 18:932-947
65. Wu Y, Blum D, Nissou MF, Benabid AL, Verna JM (1996) Unlike MPP+, apoptosis induced by 6-OHDA in PC12 cells is independent of mitochondrial inhibition. Neurosci Lett 221:69-71
66. Wu J, Hu J, Chen YP, Takeo T, Suga S, Dechon J, Liu Q, Yang KC, St John PA, Hu G, Wang H, Wakui M (2006) Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta. J Pharmacol Exp Ther 319:155-164
67. Xia Y, Haddad GG (1991) Major differences in CNS sulfonylurea receptor distribution between the rat (newborn, adult) and turtle. J Comp Neurol 314:278-289
68. Yamauchi T, Kashii S, Yasuyoshi H, Zhang S, Honda Y, Akaike A (2003) Mitochondrial ATP-sensitive potassium channel: A novel site for neuroprotection. Invest Ophthalmol Vis Sci 44:2750-2756
69. Yellon DM, Downey JM (2003) Preconditioning the myocardium: From cellular physiology to clinical cardiology. Physiol Rev 83:1113-1151
70. Zhang HY, McPherson BC, Liu H, Baman TS, Rock P, Yao Z (2002) H(2)O(2) opens mitochondrial K(ATP) channels and inhibits GABA receptors via protein kinase C-epsilon in cardiomyocytes. Am J Physiol Heart Circ Physiol 282:H1395-H1403
71. Zhang L, Li L, Prabhakaran K, Borowitz JL, Isom GE (2006) Trimethyltin-induced apoptosis is associated with upregulation of inducible nitric oxide synthase and Bax in a hippocampal cell line. Toxicol Appl Pharmacol 216:34-43
72. Zhang GX, Lu XM, Kimura S, Nishiyama A (2007) Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation. Cardiovasc Res 76:204-212
73. Zhou M, Tanaka O, Suzuki M, Sekiguchi M, Takata K, Kawahara K, Abe H (2002) Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells. Brain Res Mol Brain Res 101:23-32
74. Zini S, Tremblay E, Pollard H, Moreau J, Ben-Ari Y (1993) Regional distribution of sulfonylurea receptors in the brain of rodent and primate. Neuroscience 55:1085-1091