-
1
-
-
0026025755
-
Growth factors in development, transformation, and tumorigenesis
-
Cross M and Dexter TM. Growth factors in development, transformation, and tumorigenesis. Cell 1991; 64: 271-280.
-
(1991)
Cell
, vol.64
, pp. 271-280
-
-
Cross, M.1
Dexter, T.M.2
-
2
-
-
0022800838
-
Insulinlike growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that deEne functional speciEcity
-
Ullrich A, Gray A, Tam AW, et al. Insulinlike growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that deEne functional speciEcity. EMBO J 1986; 5: 2503-2512.
-
(1986)
EMBO J
, vol.5
, pp. 2503-2512
-
-
Ullrich, A.1
Gray, A.2
Tam, A.W.3
-
3
-
-
34047174592
-
The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
-
Belfiore A. The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr Pharm Des 2007; 13: 671-686.
-
(2007)
Curr Pharm Des
, vol.13
, pp. 671-686
-
-
Belfiore, A.1
-
4
-
-
79954614279
-
Targeting the insulin-like growth factor network in cancer therapy
-
Heidegger I, Pircher A, Klocker H, et al. Targeting the insulin-like growth factor network in cancer therapy. Cancer Biol Ther 2011; 11: 701-707.
-
(2011)
Cancer Biol Ther
, vol.11
, pp. 701-707
-
-
Heidegger, I.1
Pircher, A.2
Klocker, H.3
-
5
-
-
23044493251
-
Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
-
Hofmann F and García-Echeverría C. Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov Today 2005; 10: 1041-1047.
-
(2005)
Drug Discov Today
, vol.10
, pp. 1041-1047
-
-
Hofmann, F.1
-
7
-
-
77957777648
-
The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma
-
Ewing GP and Goff LW. The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma. Clin Colorectal Cancer 2010; 9: 219-223.
-
(2010)
Clin Colorectal Cancer
, vol.9
, pp. 219-223
-
-
Ewing, G.P.1
Goff, L.W.2
-
8
-
-
83255162011
-
Receptor tyrosine kinases and targeted cancer therapeutics
-
Takeuchi K and Ito F. Receptor tyrosine kinases and targeted cancer therapeutics. Biol Pharm Bull 2011; 34: 1774-1180.
-
(2011)
Biol Pharm Bull
, vol.34
, pp. 1180-1774
-
-
Takeuchi, K.1
Ito, F.2
-
9
-
-
0028957113
-
Molecular and cellular aspects of the insulin-like growth factor I receptor
-
LeRoith D, Werner H, Beitner-Johnson D, et al. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995; 16: 143-163.
-
(1995)
Endocr Rev
, vol.16
, pp. 143-163
-
-
Leroith, D.1
Werner, H.2
Beitner-Johnson, D.3
-
10
-
-
0033906634
-
Structure and function of the type 1 insulinlike growth factor receptor
-
Adams TE, Epa VC, Garrett TP, et al. Structure and function of the type 1 insulinlike growth factor receptor. Cell Mol Life Sci 2000; 57: 1050-1093.
-
(2000)
Cell Mol Life Sci
, vol.57
, pp. 1050-1093
-
-
Adams, T.E.1
Epa, V.C.2
Garrett, T.P.3
-
11
-
-
0020315756
-
The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor
-
Massagué J and Czech MP. The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. J Biol Chem 1982; 257: 5038-5045.
-
(1982)
J Biol Chem
, vol.257
, pp. 5038-5045
-
-
Massagué, J.1
Czech, M.P.2
-
12
-
-
0029692479
-
The role of the insulin-like growth factor system in human cancer
-
Werner H and LeRoith D. The role of the insulin-like growth factor system in human cancer. Adv Cancer Res 1996; 68: 183-223.
-
(1996)
Adv Cancer Res
, vol.68
, pp. 183-223
-
-
Werner, H.1
Leroith, D.2
-
13
-
-
0030054870
-
Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin- like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth
-
Carlberg M, Dricu A, Blegen H, et al. Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin- like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth. J Biol Chem 1996; 271: 17453-17462.
-
(1996)
J Biol Chem
, vol.271
, pp. 17453-17462
-
-
Carlberg, M.1
Dricu, A.2
Blegen, H.3
-
14
-
-
0035185571
-
Structure and autoregulation of the insulinlike growth factor 1 receptor kinase
-
Favelyukis S, Till JH, Hubbard SR, et al. Structure and autoregulation of the insulinlike growth factor 1 receptor kinase. Nat Struct Biol 2001; 8: 1058-1063.
-
(2001)
Nat Struct Biol
, vol.8
, pp. 1058-1063
-
-
Favelyukis, S.1
Till, J.H.2
Hubbard, S.R.3
-
15
-
-
10044220898
-
The genetics of human longevity
-
Browner WS, Kahn AJ, Ziv E, et al. The genetics of human longevity. Am J Med 2004; 117: 851-860.
-
(2004)
Am J Med
, vol.117
, pp. 851-860
-
-
Browner, W.S.1
Kahn, A.J.2
Ziv, E.3
-
16
-
-
0141925483
-
Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution
-
Munshi S, Hall DL, Kornienko M, et al. Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution. Acta Crystallogr D Biol Crystallogr 2003; 59: 1725-1730.
-
(2003)
Acta Crystallogr D Biol Crystallogr
, vol.59
, pp. 1725-1730
-
-
Munshi, S.1
Hall, D.L.2
Kornienko, M.3
-
17
-
-
0024358352
-
Insulin-like growth factor I receptor β-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers
-
Moxham CP, Duronio V and Jacobs S. Insulin-like growth factor I receptor β-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers. J Biol Chem 1989; 264: 13238-13244.
-
(1989)
J Biol Chem
, vol.264
, pp. 13238-13244
-
-
Moxham, C.P.1
Duronio, V.2
Jacobs, S.3
-
18
-
-
0024465470
-
Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors
-
Soos MA and Siddle K. Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors. Biochem J 1989; 263: 553-563.
-
(1989)
Biochem J
, vol.263
, pp. 553-563
-
-
Soos, M.A.1
Siddle, K.2
-
19
-
-
0024816512
-
Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro
-
Treadway JL, Morrison BD, GoldEne ID, et al. Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro. J Biol Chem 1989; 264: 21450-21453.
-
(1989)
J Biol Chem
, vol.264
, pp. 21450-21453
-
-
Treadway, J.L.1
Morrison, B.D.2
Goldene, I.D.3
-
20
-
-
0037131385
-
Insulin/ insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
-
Pandini G, Frasca F, Mineo R, et al. Insulin/ insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem 2002; 277: 39684-39695.
-
(2002)
J Biol Chem
, vol.277
, pp. 39684-39695
-
-
Pandini, G.1
Frasca, F.2
Mineo, R.3
-
21
-
-
0032800850
-
Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling
-
Pandini G, Vigneri R, Costantino A, et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 1999; 5: 1935-1944.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1935-1944
-
-
Pandini, G.1
Vigneri, R.2
Costantino, A.3
-
22
-
-
0036669037
-
Control of cell survival by IGF signaling pathways
-
Vincent AM and Feldman EL. Control of cell survival by IGF signaling pathways. Growth Horm IGF Res 2002; 12: 193-197.
-
(2002)
Growth Horm IGF Res
, vol.12
, pp. 193-197
-
-
Vincent, A.M.1
Feldman, E.L.2
-
23
-
-
69249096951
-
Differential roles of insulin-like growth factor receptor- and insulin receptormediated signaling in the phenotypes of hepatocellular carcinoma cells
-
Chen YW, Boyartchuk V and Lewis BC. Differential roles of insulin-like growth factor receptor- and insulin receptormediated signaling in the phenotypes of hepatocellular carcinoma cells. Neoplasia 2009; 11: 835-845.
-
(2009)
Neoplasia
, vol.11
, pp. 835-845
-
-
Chen, Y.W.1
Boyartchuk, V.2
Lewis, B.C.3
-
24
-
-
41449090278
-
Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor
-
Gauguin L, Klaproth B, Sajid W, et al. Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor. J Biol Chem 2008; 283: 2604-2613.
-
(2008)
J Biol Chem
, vol.283
, pp. 2604-2613
-
-
Gauguin, L.1
Klaproth, B.2
Sajid, W.3
-
25
-
-
0036111682
-
Insulin-like growth factors and cancer
-
Fürstenberger G and Senn HJ. Insulin-like growth factors and cancer. Lancet Oncol 2002; 3: 298-302.
-
(2002)
Lancet Oncol
, vol.3
, pp. 298-302
-
-
Fürstenberger, G.1
Senn, H.J.2
-
26
-
-
0025352515
-
Chromaffin cells express two types of insulin- like growth factor receptors
-
Danielsen A, Larsen E and Gammeltoft S. Chromaffin cells express two types of insulin- like growth factor receptors. Brain Res 1990; 518: 95-100.
-
(1990)
Brain Res
, vol.518
, pp. 95-100
-
-
Danielsen, A.1
Larsen, E.2
Gammeltoft, S.3
-
27
-
-
0020565482
-
Levels of insulin-like growth factors I and II in human cord blood
-
Bennett A, Wilson DM, Liu F, et al. Levels of insulin-like growth factors I and II in human cord blood. J Clin Endocrinol Metab 1983; 57: 609-612.
-
(1983)
J Clin Endocrinol Metab
, vol.57
, pp. 609-612
-
-
Bennett, A.1
Wilson, D.M.2
Liu, F.3
-
28
-
-
0032538802
-
Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): Implications for IGF and IGF-I receptor interactions
-
Kalus W, Zweckstetter M, Renner C, et al. Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. EMBO J 1998; 17: 6558-6572.
-
(1998)
EMBO J
, vol.17
, pp. 6558-6572
-
-
Kalus, W.1
Zweckstetter, M.2
Renner, C.3
-
29
-
-
0036905115
-
Cellular actions of the insulin-like growth factor binding proteins
-
Firth SM and Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 2002; 23: 824-854.
-
(2002)
Endocr Rev
, vol.23
, pp. 824-854
-
-
Firth, S.M.1
Baxter, R.C.2
-
30
-
-
33748367666
-
Structural basis for the inhibition of insulinlike growth factors by insulin-like growth factor-binding proteins
-
Sitar T, Popowicz GM, Siwanowicz I, et al. Structural basis for the inhibition of insulinlike growth factors by insulin-like growth factor-binding proteins. Proc Natl Acad Sci USA 2006; 103: 13028-13033.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 13028-13033
-
-
Sitar, T.1
Popowicz, G.M.2
Siwanowicz, I.3
-
31
-
-
33746867442
-
Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2- overexpressing breast tumors and potentiates Herceptin activity in vivo
-
Jerome L, Alami N, Belanger S, et al. Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2- overexpressing breast tumors and potentiates Herceptin activity in vivo. Cancer Res 2006; 66: 7245-7252.
-
(2006)
Cancer Res
, vol.66
, pp. 7245-7252
-
-
Jerome, L.1
Alami, N.2
Belanger, S.3
-
32
-
-
56749144704
-
Insulin-like growth factor binding protein-2 is a novel therapeutic target associated with breast cancer
-
So AI, Levitt RJ, Eigl B, et al. Insulin-like growth factor binding protein-2 is a novel therapeutic target associated with breast cancer. Clin Cancer Res 2008; 14: 6944-6954.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6944-6954
-
-
So, A.I.1
Levitt, R.J.2
Eigl, B.3
-
33
-
-
34248363956
-
Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer
-
Mehrian-Shai R, Chen CD, Shi T, et al. Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer. Proc Natl Acad Sci U S A 2007; 104: 5563-5568.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 5563-5568
-
-
Mehrian-Shai, R.1
Chen, C.D.2
Shi, T.3
-
34
-
-
25644446718
-
PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2
-
Levitt RJ, Georgescu MM and Pollak M. PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2. Biochem Biophys Res Commun 2005; 336: 1056-1061.
-
(2005)
Biochem Biophys Res Commun
, vol.336
, pp. 1056-1061
-
-
Levitt, R.J.1
Georgescu, M.M.2
Pollak, M.3
-
35
-
-
57149142363
-
IGF binding proteins (IGFBPs) and regulation of breast cancer biology
-
Perks CM and Holly JM. IGF binding proteins (IGFBPs) and regulation of breast cancer biology. J Mammary Gland Biol Neoplasia 2008; 13: 455-469.
-
(2008)
J Mammary Gland Biol Neoplasia
, vol.13
, pp. 455-469
-
-
Perks, C.M.1
Holly, J.M.2
-
37
-
-
5644252461
-
Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells
-
Shelton JG, Steelman LS, White ER and McCubrey JA. Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. Cell Cycle 2004; 3: 372-379.
-
(2004)
Cell Cycle
, vol.3
, pp. 372-379
-
-
Shelton, J.G.1
Steelman, L.S.2
White, E.R.3
McCubrey, J.A.4
-
38
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
-
39
-
-
33749076673
-
SIN1/ MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto E, Facchinetti V, Liu D, et al. SIN1/ MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006; 127: 125-137.
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
-
40
-
-
77952557041
-
The GH/IGF1 axis and signaling pathways in the muscle and bone: Mechanisms underlying age-related skeletal muscle wasting and osteoporosis
-
Perrini S, Laviola L, Carreira MC, et al. The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis. J Endocrinol 2010; 205: 201-210.
-
(2010)
J Endocrinol
, vol.205
, pp. 201-210
-
-
Perrini, S.1
Laviola, L.2
Carreira, M.C.3
-
41
-
-
0029939164
-
SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways
-
Chen D, Water SB, Holt KH, et al. SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways. J Biol Chem 1996; 271: 6328-6332.
-
(1996)
J Biol Chem
, vol.271
, pp. 6328-6332
-
-
Chen, D.1
Water, S.B.2
Holt, K.H.3
-
42
-
-
0348049997
-
Ets ternary complex transcription factors
-
Buchwalter G, Gross C and Wasylyk B. Ets ternary complex transcription factors. Gene 2004; 324: 1-14.
-
(2004)
Gene
, vol.324
, pp. 1-14
-
-
Buchwalter, G.1
Gross, C.2
Wasylyk, B.3
-
44
-
-
77951184638
-
Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation
-
Sunami T, Byrne N, Diehl RE, et al. Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J Biol Chem 2010; 285: 4587-4594.
-
(2010)
J Biol Chem
, vol.285
, pp. 4587-4594
-
-
Sunami, T.1
Byrne, N.2
Diehl, R.E.3
-
45
-
-
84855885822
-
Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy
-
Tognon CE and Sorensen PH. Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy. Expert Opin Ther Targets 2012; 16: 33-48.
-
(2012)
Expert Opin Ther Targets
, vol.16
, pp. 33-48
-
-
Tognon, C.E.1
Sorensen, P.H.2
-
46
-
-
70449512625
-
Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy
-
Mahmoudabady M, Mathieu M, Touihri K, et al. Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy. BMC Cardiovasc Disord 2009; 9: 49.
-
(2009)
BMC Cardiovasc Disord
, vol.9
, pp. 49
-
-
Mahmoudabady, M.1
Mathieu, M.2
Touihri, K.3
-
47
-
-
33846874575
-
The role of the IGF system in cancer growth and metastasis: Overview and recent insights
-
Samani A, Yakar S, LeRoith D, et al. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007; 28: 20-47.
-
(2007)
Endocr Rev
, vol.28
, pp. 20-47
-
-
Samani, A.1
Yakar, S.2
Leroith, D.3
-
48
-
-
0027496895
-
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
-
Liu JP, Baker J, Perkins AS, et al. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993; 75: 59-72.
-
(1993)
Cell
, vol.75
, pp. 59-72
-
-
Liu, J.P.1
Baker, J.2
Perkins, A.S.3
-
49
-
-
33847216159
-
Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function
-
Laustsen PG, Russell SJ, Cui L, et al. Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol 2007; 27: 1649-1664.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 1649-1664
-
-
Laustsen, P.G.1
Russell, S.J.2
Cui, L.3
-
50
-
-
0035719947
-
Distinct and overlapping functions of insulin and IGF-I receptors
-
Nakae J, Kido Y and Accili D. Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev 2001; 22: 818-835.
-
(2001)
Endocr Rev
, vol.22
, pp. 818-835
-
-
Nakae, J.1
Kido, Y.2
Accili, D.3
-
51
-
-
28844432459
-
The insulin-like growth factor system and its pleiotropic functions in brain
-
Russo VC, Gluckman PD, Feldman EL, et al. The insulin-like growth factor system and its pleiotropic functions in brain. Endocr Rev 2005; 26: 916-943.
-
(2005)
Endocr Rev
, vol.26
, pp. 916-943
-
-
Russo, V.C.1
Gluckman, P.D.2
Feldman, E.L.3
-
52
-
-
0344013487
-
The complex biology of the receptor for the insulin-like growth factor-1
-
Romano G. The complex biology of the receptor for the insulin-like growth factor-1. Drug News Perspect 2003; 16: 525-531.
-
(2003)
Drug News Perspect
, vol.16
, pp. 525-531
-
-
Romano, G.1
-
53
-
-
61649120594
-
Sex steroids upregulate the IGF-1R in prostate cancer cells through a nongenotropic pathway
-
Pandini G, Genua M, Frasca F, et al. Sex steroids upregulate the IGF-1R in prostate cancer cells through a nongenotropic pathway. Ann N Y Acad Sci 2009; 1155: 263-267.
-
(2009)
Ann N Y Acad Sci
, vol.1155
, pp. 263-267
-
-
Pandini, G.1
Genua, M.2
Frasca, F.3
-
54
-
-
79959283607
-
Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer
-
Tamimi RM, Colditz GA, Wang Y, et al. Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer. Breast Cancer Res Treat 2011; 128: 243-250.
-
(2011)
Breast Cancer Res Treat
, vol.128
, pp. 243-250
-
-
Tamimi, R.M.1
Colditz, G.A.2
Wang, Y.3
-
55
-
-
80053238900
-
Expression of IGF-1R in colorectal polyps and its role in colorectal carcinogenesis
-
Shan HB, Zhang R, Li Y, et al. Expression of IGF-1R in colorectal polyps and its role in colorectal carcinogenesis. Technol Cancer Res Treat 2011; 10: 381-389.
-
(2011)
Technol Cancer Res Treat
, vol.10
, pp. 381-389
-
-
Shan, H.B.1
Zhang, R.2
Li, Y.3
-
56
-
-
0035857042
-
Aberrant expression and activation of insulin- like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF- 1R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2
-
Nair PN, De Armond DT, Adamo ML, et al. Aberrant expression and activation of insulin- like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF- 1R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2. Oncogene 2001; 20: 8203-8214.
-
(2001)
Oncogene
, vol.20
, pp. 8203-8214
-
-
Nair, P.N.1
de Armond, D.T.2
Adamo, M.L.3
-
57
-
-
84455203061
-
Prognostic associations of insulin-like growth factor-1 receptor in primary uveal melanoma
-
Al-Jamal RT and Kivelä T. Prognostic associations of insulin-like growth factor-1 receptor in primary uveal melanoma. Can J Ophthalmol 2011; 46: 471-476.
-
(2011)
Can J Ophthalmol
, vol.46
, pp. 471-476
-
-
Al-Jamal, R.T.1
Kivelä, T.2
-
58
-
-
82555194601
-
Gene expression profiling in multiple myeloma - reporting of entities, risk, and targets in clinical routine
-
Meissner T, Seckinger A, Rème T, et al. Gene expression profiling in multiple myeloma - reporting of entities, risk, and targets in clinical routine. Clin Cancer Res 2011; 17: 7240-7247.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7240-7247
-
-
Meissner, T.1
Seckinger, A.2
Rème, T.3
-
59
-
-
84865544289
-
Efficacy of anti-insulin-like growth factor I receptor monoclonal antibody cixutumumab in mesothelioma is highly correlated with insulin growth factor-I receptor sites/cell
-
Kalra N, Zhang J, Yu Y, et al. Efficacy of anti-insulin-like growth factor I receptor monoclonal antibody cixutumumab in mesothelioma is highly correlated with insulin growth factor-I receptor sites/cell. Int J Cancer 2012; 131: 2143-2152.
-
(2012)
Int J Cancer
, vol.131
, pp. 2143-2152
-
-
Kalra, N.1
Zhang, J.2
Yu, Y.3
-
60
-
-
80051597880
-
Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β
-
Bielen A, Perryman L, Box GM, et al. Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β. Mol Cancer Ther 2011; 10: 1407-1418.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1407-1418
-
-
Bielen, A.1
Perryman, L.2
Box, G.M.3
-
61
-
-
33644555493
-
Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: Implications for antiinsulin- like growth factor therapy in breast cancer
-
Sachdev D, Singh R, Fujita-Yamaguchi Y, et al. Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for antiinsulin- like growth factor therapy in breast cancer. Cancer Res 2006; 66: 2391-2402.
-
(2006)
Cancer Res
, vol.66
, pp. 2391-2402
-
-
Sachdev, D.1
Singh, R.2
Fujita-Yamaguchi, Y.3
-
62
-
-
33745069283
-
Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II
-
Schernhammer ES, Holly JM, Hunter DJ, et al. Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II. Endocr Relat Cancer 2006; 13: 583-592.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 583-592
-
-
Schernhammer, E.S.1
Holly, J.M.2
Hunter, D.J.3
-
63
-
-
0034974302
-
IGF-I receptor signalling in transformation and differentiation
-
Valentinis B and Baserga R. IGF-I receptor signalling in transformation and differentiation. Mol Pathol 2001; 54: 133-137.
-
(2001)
Mol Pathol
, vol.54
, pp. 133-137
-
-
Valentinis, B.1
Baserga, R.2
-
64
-
-
0242594016
-
The IGF- 1 receptor in cancer biology
-
Baserga R, Peruzzi F and Reiss K. The IGF- 1 receptor in cancer biology. Int J Cancer 2003; 107: 873-877.
-
(2003)
Int J Cancer
, vol.107
, pp. 873-877
-
-
Baserga, R.1
Peruzzi, F.2
Reiss, K.3
-
65
-
-
57149093206
-
Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma
-
Friedrichs N, Küchler J, Endl E, et al. Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma. J Pathol 2008; 216: 428-439.
-
(2008)
J Pathol
, vol.216
, pp. 428-439
-
-
Friedrichs, N.1
Küchler, J.2
Endl, E.3
-
66
-
-
1042301373
-
A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells
-
Sachdev D, Hartell JS, Lee AV, et al. A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells. J Biol Chem 2004; 279: 5017-5024.
-
(2004)
J Biol Chem
, vol.279
, pp. 5017-5024
-
-
Sachdev, D.1
Hartell, J.S.2
Lee, A.V.3
-
67
-
-
0036797073
-
Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer
-
Reinmuth N, Fan F, Liu W, et al. Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer. Lab Invest 2002; 82: 1377-1389.
-
(2002)
Lab Invest
, vol.82
, pp. 1377-1389
-
-
Reinmuth, N.1
Fan, F.2
Liu, W.3
-
68
-
-
0142117228
-
Increased expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo
-
Lee JS, Weiss J, Martin JL, et al. Increased expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo. Int J Cancer 2003; 107: 564-570.
-
(2003)
Int J Cancer
, vol.107
, pp. 564-570
-
-
Lee, J.S.1
Weiss, J.2
Martin, J.L.3
-
69
-
-
0036682286
-
Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility
-
Zhang X and Yee D. Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility. Cancer Res 2002; 62: 4369-4375.
-
(2002)
Cancer Res
, vol.62
, pp. 4369-4375
-
-
Zhang, X.1
Yee, D.2
-
70
-
-
84863787049
-
Human monoclonal antibodies targeting nonoverlapping epitopes on insulin-like growth factor II as a novel type of candidate cancer therapeutics
-
Chen W, Feng Y, Zhao Q, et al. Human monoclonal antibodies targeting nonoverlapping epitopes on insulin-like growth factor II as a novel type of candidate cancer therapeutics. Mol Cancer Ther 2012; 11: 1400-1410.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 1400-1410
-
-
Chen, W.1
Feng, Y.2
Zhao, Q.3
-
71
-
-
4344591505
-
Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligandspecific antibody to human insulin-like growth factors
-
Goya M, Miyamoto S, Nagai K, et al. Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligandspecific antibody to human insulin-like growth factors. Cancer Res 2004; 64: 6252-6258.
-
(2004)
Cancer Res
, vol.64
, pp. 6252-6258
-
-
Goya, M.1
Miyamoto, S.2
Nagai, K.3
-
72
-
-
54049108939
-
Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials
-
Rodon J, DeSantos V, Ferry RJ Jr, et al. Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials. Mol Cancer Ther 2008; 7: 2575-2588.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2575-2588
-
-
Rodon, J.1
Desantos, V.2
Ferry Jr., R.J.3
-
73
-
-
75749094341
-
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma
-
Yin S, Girnita A, Strömberg T, et al. Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma. Neuro Oncol 2010; 12: 19-27.
-
(2010)
Neuro Oncol
, vol.12
, pp. 19-27
-
-
Yin, S.1
Girnita, A.2
Strömberg, T.3
-
74
-
-
27544479318
-
Role of tyrosine kinase inhibitors in cancer therapy
-
Arora A and Scholar EM. Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther 2005; 315: 971-979.
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 971-979
-
-
Arora, A.1
Scholar, E.M.2
-
75
-
-
54349093798
-
Insulin, insulin-like growth factors and neoplasia
-
Pollak M. Insulin, insulin-like growth factors and neoplasia. Best Pract Res Clin Endocrinol Metab 2008; 22: 625-638.
-
(2008)
Best Pract Res Clin Endocrinol Metab
, vol.22
, pp. 625-638
-
-
Pollak, M.1
-
76
-
-
33645989468
-
The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours
-
Höpfner M, Baradari V, Huether A, et al. The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours. Endocr Relat Cancer 2006; 13: 135-149.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 135-149
-
-
Höpfner, M.1
Baradari, V.2
Huether, A.3
-
77
-
-
33847271170
-
Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma
-
Slomiany MG, Black LA, Kibbey MM, et al. Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma. Cancer Lett 2007; 248: 269-279.
-
(2007)
Cancer Lett
, vol.248
, pp. 269-279
-
-
Slomiany, M.G.1
Black, L.A.2
Kibbey, M.M.3
-
78
-
-
12144285705
-
In vivo antitumor activity of NVPAEW541 - a novel, potent, and selective inhibitor of the IGF-IR kinase
-
García-Echeverría C, Pearson MA, Marti A, et al. In vivo antitumor activity of NVPAEW541 - a novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 2004; 5: 231-239.
-
(2004)
Cancer Cell
, vol.5
, pp. 231-239
-
-
García-Echeverría, C.1
Pearson, M.A.2
Marti, A.3
-
79
-
-
20944447905
-
Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVPAEW541 in musculoskeletal tumors
-
Scotlandi K, Manara MC, Nicoletti G, et al. Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVPAEW541 in musculoskeletal tumors. Cancer Res 2005; 65: 3868-3876.
-
(2005)
Cancer Res
, vol.65
, pp. 3868-3876
-
-
Scotlandi, K.1
Manara, M.C.2
Nicoletti, G.3
-
80
-
-
33646040417
-
Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells
-
Höpfner M, Huether A, Sutter AP, et al. Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells. Biochem Pharmacol 2006; 71: 1435-1448.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1435-1448
-
-
Höpfner, M.1
Huether, A.2
Sutter, A.P.3
-
81
-
-
33747371111
-
Effects of insulin-like growth factor-1 receptor inhibition in mesothelioma. Thoracic Surgery Directors Association Resident Research Award
-
Whitson BA, Jacobson BA, Frizelle S, et al. Effects of insulin-like growth factor-1 receptor inhibition in mesothelioma. Thoracic Surgery Directors Association Resident Research Award. Ann Thorac Surg 2006; 82: 996-1002.
-
(2006)
Ann Thorac Surg
, vol.82
, pp. 996-1002
-
-
Whitson, B.A.1
Jacobson, B.A.2
Frizelle, S.3
-
82
-
-
33750139113
-
Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer
-
Höpfner M, Sutter AP, Huether A, et al. Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. World J Gastroenterol 2006; 12: 5635-5643.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 5635-5643
-
-
Höpfner, M.1
Sutter, A.P.2
Huether, A.3
-
83
-
-
33845313289
-
Downregulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo
-
Tanno B, Mancini C, Vitali R, et al. Downregulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res 2006; 12: 6772-6780.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6772-6780
-
-
Tanno, B.1
Mancini, C.2
Vitali, R.3
-
84
-
-
33947262154
-
Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma
-
Manara MC, Landuzzi L, Nanni P, et al. Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma. Clin Cancer Res 2007; 13: 1322-1330.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1322-1330
-
-
Manara, M.C.1
Landuzzi, L.2
Nanni, P.3
-
85
-
-
42249114184
-
The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells
-
Maiso P, Ocio EM, Garayoa M, et al. The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells. Br J Haematol 2008; 141: 470-482.
-
(2008)
Br J Haematol
, vol.141
, pp. 470-482
-
-
Maiso, P.1
Ocio, E.M.2
Garayoa, M.3
-
86
-
-
46049100584
-
Inhibition of insulin-like growth factor- I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis
-
Moser C, Schachtschneider P, Lang SA, et al. Inhibition of insulin-like growth factor- I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis. Eur J Cancer 2008; 44: 1577-1586.
-
(2008)
Eur J Cancer
, vol.44
, pp. 1577-1586
-
-
Moser, C.1
Schachtschneider, P.2
Lang, S.A.3
-
87
-
-
46149104384
-
Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
-
Tarn C, Rink L, Merkel E, et al. Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proc Natl Acad Sci USA 2008; 105: 8387-8392.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 8387-8392
-
-
Tarn, C.1
Rink, L.2
Merkel, E.3
-
88
-
-
49849098247
-
Insulinlike growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas
-
Piao W, Wang Y, Adachi Y, et al. Insulinlike growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Mol Cancer Ther 2008; 7: 1483-1493.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1483-1493
-
-
Piao, W.1
Wang, Y.2
Adachi, Y.3
-
89
-
-
56749118600
-
The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer
-
Lisztwan J, Pornon A, Chen B, et al. The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer. Breast Cancer Res 2008; 10: R56.
-
(2008)
Breast Cancer Res
, vol.10
-
-
Lisztwan, J.1
Pornon, A.2
Chen, B.3
-
90
-
-
1642494838
-
Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth
-
Girnita A, Girnita L, Del Prete F, et al. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res 2004; 64: 236-242.
-
(2004)
Cancer Res
, vol.64
, pp. 236-242
-
-
Girnita, A.1
Girnita, L.2
Del Prete, F.3
-
91
-
-
7644223079
-
The cyclolignan PPP induces activation loopspecific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway
-
Vasilcanu D, Girnita A, Girnita L, et al. The cyclolignan PPP induces activation loopspecific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene 2004; 23: 7854-7862.
-
(2004)
Oncogene
, vol.23
, pp. 7854-7862
-
-
Vasilcanu, D.1
Girnita, A.2
Girnita, L.3
-
92
-
-
34548058890
-
A novel, potent, and selective insulinlike growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor-dependent tumor growth in vivo
-
Ji QS, Mulvihill MJ, Rosenfeld-Franklin M, et al. A novel, potent, and selective insulinlike growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor-dependent tumor growth in vivo. Mol Cancer Ther 2007; 6: 2158-2167.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2158-2167
-
-
Ji, Q.S.1
Mulvihill, M.J.2
Rosenfeld-Franklin, M.3
|