Finite element analysis of microneedle insertion into skin

Micro and Nano Letters

Volumn 7, Issue 12, 2012, Pages 1206-1209

  Chen, Shuhu ^a   Li, Nannan ^a   Chen, Jing ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMECHANICAL PROPERTIES; DIFFERENT GEOMETRY; FORCE AND DISPLACEMENTS; FORCE-DISPLACEMENT; MICRONEEDLES; MOUSE SKIN; NON-LINEAR FINITE ELEMENT MODEL;

BIOMECHANICS; FINITE ELEMENT METHOD;

NEEDLES;

ARTICLE; FINITE ELEMENT ANALYSIS; MICRONEEDLE;

EID: 84878367537     PISSN: None     EISSN: 17500443     Source Type: Journal    
DOI: 10.1049/mnl.2012.0585     Document Type: Article

References (20)

1. - 10.1023/B:PHAM.0000029282.44140.2e Martanto W. Davis S. Holiday H. Wang J. Gill H. Prausnitz M. Transdermal delivery of insulin using microneedles in vivo Pharm. Res. 2004 21 6 947-952
2. - 10.1016/j.addr.2003.10.023 Prausnitz M. Microneedles for transdermal drug delivery Adv. Drug Deliv. Rev. 2004 56 5 581-587
3. - 10.1109/84.911086 Griss P. Enoksson P. Tolvanen-Laakso H. Merilainen P. Ollmar S. Stemme G. Micromachined electrodes for biopotential measurements J. Microelectromech. Syst. 1057-7157 2001 10 1 10-16
4. - 10.1109/JMEMS.2003.820293 Gardeniers H. Luttge R. Berenschot E. Silicon micromachined hollow microneedles for transdermal liquid transport J. Microelectromech. Syst. 1057-7157 2003 12 6 855-862
5. - 10.1109/TBME.2005.845240 Davis S. Martanto W. Allen M. Prausnitz M. Hollow metal microneedlesfor insulin delivery to diabetic rats IEEE Trans. Biomed. Eng. 0018-9294 2005 52 5 909-915
6. - 10.1016/j.jbiomech.2003.12.010 Davisa S.P. Landisa B.J. Adamsa Z.H. Allenb M.G. Prausnitza M.R. Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force J. Biomech. 0021-9290 2004 37 1155-1163
7. - 10.1109/TBME.2005.847548 DiMaio S.P. Salcudean S.E. Interactive simulation of needle insertion models IEEE Trans. Robot. 1552-3098 2005 52 7 1167-1179
8. Alterovitz R. Goldberg K. Pouliot J. Taschereau R. Hsu I.-C. Needle insertion and radioactive seed implantation in human tissues: simulation and sensitivity analysis Proc. IEEE Int. Conf. Robotics and Automation 2003 Taipei Taiwan 1793-1799
9. Nienhuy H.-W. van der Stappen F.A. A computational technique for interactive needle insertions in 3d nonlinear material Proc. IEEE Int. Conf. Robotics and Automation 2004 New Orleans LA USA 2061-2067
10. - 10.1109/JMEMS.2007.907461 Roxhead N. Gasser T.C. Griss P. Holzapfel G.A. Stemme G. Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery MEMS 2007 16 6 1429-1439
11. - 10.1016/S1672-6529(08)60111-0 Kong X.Q. Wu C.W. Measurement and prediction of insertion force for the mosquitofascicle penetrating into human skin J. Bionic Eng. 2009 6 143-152
12. - 10.1109/84.749406 Lin L. Pisano A.P. Silicon-processed microneedles IEEE J. Microelectromech. Syst. 1999 8 1 78-84
13. Parker E.R. Bulk titanium microneedles with embedded microfluidic networks for transdermal drug delivery Proc. 19th IEEE Int. Conf. MEMS 2006 Istanbul Turkey 498-501
14. - 10.4028/www.scientific.net/KEM.483.532 Li W. Zhang Y.M. Chen J. Design, fabrication and characterization of in-plane titanium microneedles for drug delivery Key Eng. Mat. 2011 483 532-536
15. - 10.1016/j.medengphy.2005.07.001 Hendriks F.M. Brokken D. Oomens C.W.J. Bader D.L. Baaijens F.P.T. The relative contributions of different skin layers to the mechanical behavior of human skin in vivo using suction experiments Elsevier Med. Eng. Phys. 2006 28 259-266
16. - 10.1016/j.biomaterials.2011.03.012 Crichton M.L. Donose B.C. Chen X.F. Raphael A.P. Huang H. Kendall M.A.F. The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers Biomaterials 0142-9612 2011 32 4670-4681
17. - 10.1034/j.1600-0846.2003.00019.x Hendriks F.M. Brokken D. Eemeren J.T.W.M. Oomens C.W.J. Baaijens F.P.T. Horsten J.B.A.M. A numerical-experimental method to characterize the non-linear mechanical behavior of human skin Skin Res. Technol. 2003 9 274-283
18. - 10.1034/j.1600-0846.2001.70408.x Gardner T.N. Briggs G.A.D. Biomechanical measurements in microscopically thin stratum corneum using acoustics Skin Res. Technol. 2001 7 4 254-261
19. Mehta A.K. Wong F. Measurement of flammability and burn potential of fabrics Massachusetts Institute of Technology, Cambridge: Full Report from Fuels Research Laboratory 1973
20. Duck F.A. Physical properties of tissue: a comprehensive reference book Academic Press New York 1990