Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 45, Issue , 2013, Pages 28-33

  Lima Ojeda, Juan M ^a   Vogt, Miriam A ^a   Pfeiffer, Natascha ^a   Dormann, Christof ^a   Köhr, Georg ^a,b   Sprengel, Rolf ^b   Gass, Peter ^a   Inta, Dragos ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Antidepressant; GluN2B; MK 801; Neurotoxicity; Retrosplenial cortex

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; CASPASE 3; DIZOCILPINE; HEAT SHOCK PROTEIN 70; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ADULT ANIMAL; AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; FEMALE; HYPERACTIVITY; NEUROTOXICITY; NONHUMAN; PERINATAL PERIOD; PROTEIN EXPRESSION; PSYCHOSIS; PSYCHOTOMIMETIC ACTIVITY; RAT; RETROSPLENIAL CORTEX;

ANTIDEPRESSANT; DENTATE GYRUS; DG; GLUN2B; HEAT SHOCK PROTEIN 70; HSP70; I.P; INTRAPERITONEAL; MK-801; N-METHYL-D-ASPARTATE RECEPTORS; NEUROTOXICITY; NMDAR; P7; POSTNATAL DAY 7; RETROSPLENIAL CORTEX;

AGE FACTORS; ANIMALS; ANTIDEPRESSIVE AGENTS; CASPASE 3; DIZOCILPINE MALEATE; DRUG INTERACTIONS; FEMALE; GYRUS CINGULI; HALLUCINOGENS; HSP70 HEAT-SHOCK PROTEINS; MALE; MICE; MOTOR ACTIVITY; NERVE DEGENERATION; PHENOLS; PIPERIDINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84878356520     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.04.017     Document Type: Article

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