Adenovirus-mediated overexpression of Tcfe3 ameliorates hyperglycaemia in a mouse model of diabetes by upregulating glucokinase in the liver

Diabetologia

Volumn 56, Issue 3, 2013, Pages 635-643

  Kim, M Y ^a   Jo, S H ^a   Park, J M ^a   Kim, T H ^a   Im, S S ^b   Ahn, Y H ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Keimyung University School of Medicine   (South Korea)

Author keywords

Liver type glucokinase (Gck); Streptozotocin; TFE3; Transcription factor E3; Transcriptional regulation; Type 1 diabetes mellitus

Indexed keywords

GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATE; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYLASE; REGULATOR PROTEIN;

ADENOVIRUS 2; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE CONTROL; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GLUCOSE 6 PHOSPHATE GENE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; LIVER PARENCHYMA; LIVER TYPE GLUCOKINASE GENE; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHOSPHOENOLPYRUVATE CARBOXYLASE GENE; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION FACTOR E3 GENE; TRANSCRIPTION REGULATION; UPREGULATION;

ADENOVIRIDAE; ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CHROMATIN IMMUNOPRECIPITATION; DIABETES MELLITUS, EXPERIMENTAL; GLUCOKINASE; GLUCOSE TOLERANCE TEST; HEP G2 CELLS; HUMANS; HYPERGLYCEMIA; INSULIN; LIVER; MALE; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING;

EID: 84878351825     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2807-7     Document Type: Article

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